innate immune modulation in

Cover Page
The handle http://hdl.handle.net/1887/29988 holds various files of this Leiden University
dissertation
Author: Wezel, Anouk
Title: Innate immune modulation in atherosclerosis and vascular remodelling
Issue Date: 2014-12-11
Innate
immune modulation in
atherosclerosis and vascular
remodelling
Anouk Wezel
Innate immune modulation in atherosclerosis and vascular
remodelling
Anouk Wezel
Leiden Academic Center for Drug Research and Department of Surgery,
LUMC, 11 december 2014
Cover design: Dante Tatipata
ISBN: 978-94-6203-693-2
Printing: Wöhrmann Print Service
Proefschrift Leiden
Met literatuur opgave - met samenvatting in het Nederlands
© 2014, Anouk Wezel
No part of this thesis may be reproduced or transmitted in any form or by
any means, without permission of the author.
Innate
immune modulation in
atherosclerosis and vascular remodelling
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op donderdag 11 december 2014
klokke 13.45 uur
door
Anouk Wezel
Geboren te Zaanstad
in 1986
Cover Page
The handle http://hdl.handle.net/1887/29988 holds various files of this Leiden University
dissertation
Author: Wezel, Anouk
Title: Innate immune modulation in atherosclerosis and vascular remodelling
Issue Date: 2014-12-11
Promotiecommissie
Promotoren:
Prof. dr. J. Kuiper
Prof. dr. P.H.A. Quax
Co-promotor: Dr. I. Bot
Overige leden: Prof. dr. P. Kovanen
(Wihuri Research Institute)
Prof. dr. A.J. Rabelink
(LUMC)
Prof. dr. J.F. Hamming
(LUMC)
Prof. dr. P.H. van der Graaf
(LACDR)
The research described in this thesis was supported by a grant of the Dutch
Heart Foundation (DHF 2010-B029) and was performed at the Division of
Biopharmaceutics, Leiden Academic Center for Drug Research, Leiden University,
Leiden, The Netherlands, and the department of of Surgery, Leiden University
Medical Center, Leiden, The Netherlands. Financial support by the Dutch Heart
Foundation for publication of this thesis is gratefully acknowledged.
The realization of this thesis was also financially supported by:
- LACDR
- Leiden University
- Chipsoft
- Greiner Bio-One
Measure what can be measured, and make
measurable what cannot be measured
-Galileo Galilei-
Aan mijn ouders
Table of contents
Chapter 1
General introduction
9
Chapter 2
The role of mast cells in atherosclerosis
37
Chapter 3
Complement factor C5a as mast cell activator mediates
vascular remodelling in vein graft disease
53
Hämostaseologie, in press
Cardiovasc Res. 2013;97:311-20
Chapter 4
Complement factor C5a induces atherosclerotic plaque
disruptions
75
J Cell Mol Med. 2014;18:2020-30.
Chapter 5
Mast cells mediate neutrophil recruitment during
atherosclerotic plaque progression
95
Submitted for publication
Chapter 6
RP105 deficiency aggravates vein graft disease and
lesion instability via increased inflammation and mast cell
activation
111
Submitted for publication
Chapter 7
RP105 deficiency attenuates early atherosclerosis via
decreased monocyte influx in a CCR2 dependent manner
131
Conditionally accepted by Atherosclerosis
Chapter 8
Inhibition of microRNA-494 reduces atherosclerotic lesion
development and increases plaque stability
153
Submitted for publication
Chapter 9
General summary and perspectives
179
Nederlandse samenvatting
189
Curriculum Vitae
197
Publications
199

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