Cover Page The handle http://hdl.handle.net/1887/29988 holds various files of this Leiden University dissertation Author: Wezel, Anouk Title: Innate immune modulation in atherosclerosis and vascular remodelling Issue Date: 2014-12-11 Innate immune modulation in atherosclerosis and vascular remodelling Anouk Wezel Innate immune modulation in atherosclerosis and vascular remodelling Anouk Wezel Leiden Academic Center for Drug Research and Department of Surgery, LUMC, 11 december 2014 Cover design: Dante Tatipata ISBN: 978-94-6203-693-2 Printing: Wöhrmann Print Service Proefschrift Leiden Met literatuur opgave - met samenvatting in het Nederlands © 2014, Anouk Wezel No part of this thesis may be reproduced or transmitted in any form or by any means, without permission of the author. Innate immune modulation in atherosclerosis and vascular remodelling PROEFSCHRIFT ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker, volgens besluit van het College voor Promoties te verdedigen op donderdag 11 december 2014 klokke 13.45 uur door Anouk Wezel Geboren te Zaanstad in 1986 Cover Page The handle http://hdl.handle.net/1887/29988 holds various files of this Leiden University dissertation Author: Wezel, Anouk Title: Innate immune modulation in atherosclerosis and vascular remodelling Issue Date: 2014-12-11 Promotiecommissie Promotoren: Prof. dr. J. Kuiper Prof. dr. P.H.A. Quax Co-promotor: Dr. I. Bot Overige leden: Prof. dr. P. Kovanen (Wihuri Research Institute) Prof. dr. A.J. Rabelink (LUMC) Prof. dr. J.F. Hamming (LUMC) Prof. dr. P.H. van der Graaf (LACDR) The research described in this thesis was supported by a grant of the Dutch Heart Foundation (DHF 2010-B029) and was performed at the Division of Biopharmaceutics, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands, and the department of of Surgery, Leiden University Medical Center, Leiden, The Netherlands. Financial support by the Dutch Heart Foundation for publication of this thesis is gratefully acknowledged. The realization of this thesis was also financially supported by: - LACDR - Leiden University - Chipsoft - Greiner Bio-One Measure what can be measured, and make measurable what cannot be measured -Galileo Galilei- Aan mijn ouders Table of contents Chapter 1 General introduction 9 Chapter 2 The role of mast cells in atherosclerosis 37 Chapter 3 Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease 53 Hämostaseologie, in press Cardiovasc Res. 2013;97:311-20 Chapter 4 Complement factor C5a induces atherosclerotic plaque disruptions 75 J Cell Mol Med. 2014;18:2020-30. Chapter 5 Mast cells mediate neutrophil recruitment during atherosclerotic plaque progression 95 Submitted for publication Chapter 6 RP105 deficiency aggravates vein graft disease and lesion instability via increased inflammation and mast cell activation 111 Submitted for publication Chapter 7 RP105 deficiency attenuates early atherosclerosis via decreased monocyte influx in a CCR2 dependent manner 131 Conditionally accepted by Atherosclerosis Chapter 8 Inhibition of microRNA-494 reduces atherosclerotic lesion development and increases plaque stability 153 Submitted for publication Chapter 9 General summary and perspectives 179 Nederlandse samenvatting 189 Curriculum Vitae 197 Publications 199
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