The Research Center for Animal Science (RCAS) Hiroshima University’s Promising Research Initiatives (recognized in 2014) Education & Research for advanced technological developments contributing to safe and high quality animal productions Presented by Dr Yukinori Yoshimura （Graduate School of Biosphere Science） Where is Hiroshima University? Hiroshima is best known as the first city in history to be destroyed by a nuclear weapon on August 6, 1945, near the end of World War II. Peace Memorial Park is a famous place to promise and learn the peace of the world. However, Hiroshima is now one of the biggest city in Japan. The population is more than 1 million. MAZDA that is automotive manufacture is based on Hiroshima. Hiroshima University has two campuses. Faculties: Hiroshima University Graduate Schools (12) Graduate Schl of Integrated Arts and Sci Faculties (11) Faculty of Integrated Arts and Sciences Faculty of Letters Faculty of Economics Faculty of Law Faculty of Education Faculty of Science Faculty of Engineering Faculty of Medicine Faculty of Dentistry Faculty of Pharmaceutical Sciences Faculty of Applied Biological Science Students Undergraduate:11,040 Master course:2,510 PhD course:1,750 Others:500 Foreign students:760 from 57 countries Graduate Schl of Letters Graduate Schl of Education Graduate Schl of Social Sciences Graduate Schl of Science Graduate Schl of Engineering Graduate Schl of Biomedical Sciences Graduate Schl of Health Sciences Graduate School of Biosphere Science Graduate Schl for International Development and Cooperation Graduate Schl of Advanced Sciences of Matter Staff Academic : 1,830 Non-academic: 1.440 Departments DEPARTMENT OF BIORESOURCE SCIENCE Animal Science, Aquatic Biology, Food and Resource Economics, Field Science DEPARTMENT OF BIOFUNCTIONAL SCIENCE AND TECHNOLOGY Molecular and Applied Biosciences, Food Science and Biofunctions Int’l summer school AIMS program DEPARTMENT OF ENVIRONMENTAL DYNAMICS AND MANAGEMENT Modeling, Management and Assessment of Environmental Dynamics Int’l symposium Short visit Vet Tech students DEPARTMENT OF BIORESOURCE SCIENCE Animal Science (Academic staff: 11) Animal breeding, Reproduction, Nutrition and Feed, Management and Behavior, Physiology and Histology Aquatic Biology (Academic staff: 14) Aquatic Biochemistry, Ecology, Pathology, Neurobiology, Biology of Aquatic Resources, Aquaculture Food and Resource Economics (Academic staff: 4) Food Production, Management, Agricultural Marketing Field Science (Academic staff: 4) Animal Farm, Aquatic field studies gene Animal Science Division Graduate School of Biosphere Science Hiroshima University The goal of this division is to discover novel functions in animals and applying such discoveries for the technological advancement of domestic animal production. The research will contribute to sustainable and efficient production of safe food for humans derived from animal products. Current research fields are: breeding and genetics based on modern genomic analysis, reproductive biology and biotechnology for enhanced reproductive performance, applied nutritional physiology and feed evaluation for improved nutritional management, ecology and neurophysiology for better animal management and viability, and fundamental histology and molecular physiology to enhance veterinary production and health.. Animal Breeding and Genetics Animal Reproduction Animal Nutrition and Feeding Animal Behavior and Physiology Animal Histophysiology Animal Farm The Research Center for Animal Science Hiroshima University’s Promising Research Initiatives (recognized in 2014) Presented by Dr Yukinori Yoshimura （Graduate School of Biosphere Science） Goals Contribution to development of technologies for safe and high quality animal products • Progression for animal nutrition, breeding and reproduction, and health • Contribution for food safety and security • Innovation for new agricultural science by crossdisciplinary research collaboration nutrition metabolism health productivity breeding reproduction well-being Background Problems in the World *Animal products are essential for human food *Rapid increase in human population in Asia and other countries, and in consumption of animal products *Increase in requirements of quality and safety of products for human food security *Importance of productivity enhancement for agricultural animals International Research net work *Each region in the world has techniques adaptive to the regional natural environment. *Fundamental research and advanced technology development are essential for the sustainable animal production in the future. *Collaborative works and sharing ideas will enable to do it. Importance to share the idea for sustainable and productive livestock agriculture systems Research Projects for Advanced Technology Development of Animal Production Project 1 Hostdefense and Genetic resources research, Creation of livestock disease-resistance Project 4 New research project ～From basic research to applied research～ Create new research projects by organizing an animal husbandry research consortium Project 2 Reproductive biology, Breeding technology development Project 3 Endocrinology, Physiology of nutrition, Animal management technology development International research collaboration Acceptance of graduate students & international students Outcomes 1. Development of scientific research in nutrition and metabolism, reproductive biology, genome and breeding, endocrinology and immunobiology. 2. Development of applied research in nutrition managements, artificial breeding, and health managements. 3. Establishment of the principles of life science and technology for animal production. 4. Contribution to the society through the research for food safety and security. Kasetsart University （Thailand） Univ. Gadjah Mada （Indonesia） University of Alberta（Canada） Nutrition & metabolism Sichuan Agricultural Univ.; North West Agriculture and Forestry Univ.（China） Hiroshima University (Japan) Immunobiology Reproductive biology Behavior Genome and breeding Endocrinology International collaboration Members of The Research Center for Animal Science Members Leader Yukinori Yoshimura, PhD Institutes Grad Schl Biosphere Sci, HU Majors Immunodefense in poultry reproductive and digestive system Manager Masayuki Shimada, PhD Grad Schl Biosphere Sci, HU Reproductive Molecular Endocrinology Reproductive technology Manager Toshihisa Sugino, PhD Grad Schl Biosphere Sci, HU Ruminant metabolism and endocrinology Masaoki Tsudzuki, PhD Grad Schl Biosphere Sci, HU Genome of Japanese native chickens Masahide Nishibori, PhD Grad Schl Biosphere Sci, HU Genome and Polymorphism of Animals and Poultry Teruo Maeda, PhD Grad Schl Biosphere Sci, HU Manipulation of germ cells Yusuke Sotomaru, PhD Nat Sci Center Basic Res Dev, HU Animal developmental engineering Ikuo Miura, PhD Grad. Schl Sci, HU Sex determination and differentiation Taketo Obitsu, PhD Grad Schl Biosphere Sci, HU Ruminant nutrition and feed evaluation Takashi Bungo, PhD Grad Schl Biosphere Sci, HU Animal Behavior and Physiology Shin-ichi Kawakami, PhD Grad Schl Biosphere Sci, HU Animal management and neurology Naoki Isobe, PhD Grad Schl Biosphere Sci, HU Ruminant mastitis and mammary gland immune system Yuzo Kurokawa, PhD Grad Schl Biosphere Sci, HU Dairy milk production and grassland utilization Kensuke Kawamura, PhD IDEC, HU Grazing management and remote control system Soichi Tanabe, PhD Grad Schl Biosphere Sci, HU Gastro-protection by lactobacilli and bifidobacteria Noriyuki Yanaka, PhD Grad Schl Biosphere Sci, HU Nutritional factors and obesity Shiro Kushibiki, PhD Natl Agr Food Res Center Animal nutrition and metabolism Tetsuji Okazaki, PhD Oita Pref Animal Res Center Porcine reproductive technology JoAnne S. Richards, PhD Baylor College of Medicine, USA Animal reproduction Masahito Oba, PhD University of Alberta, Canada Animal nutrition 12 Research activities in RCAS Project 1. Hostdefense and genetic resources research (Example) Creation of livestock disease-resistance Natl. and prefectural institutes, Japan Kasetsart University （Thailand） Univ. Gadjah Mada （Indonesia） Domestic and international collaborations Innate immune function for Genome analysis and infection-resistance breeding in Japanese improvement native chickens Excellent genetic trait of Japanese native chickens. Sichuan Agricultural Univ.; North West Agriculture and Forestry Univ.（China） Fundamental studies on reproduction and development Finding of antimicrobial peptide in reproductive and digestive organs. Salmonella E Analysis of genetic locus for genome breeding New strategy for disease resistance improvement in chickens and other livestock. Avian β-defensin Development of new chicken breeds that are excellent in products quality, disease-resistance and reproductive performance. Contribution for sustainable development of poultry production in Asia and world. Fundamental studies on sex determination, developmental engineering, and reproductive endocrinology Research activities in RCAS Project 1. Hostdefense and genetic resources research (Example) Creation of high quality chickens Avian Research Team Development of the methods to evaluate phenotypes/functions Identification of useful genes for breeding Data base Genome-based breeding Dispatch to the world Establishment of new elite stocks of chickens Collaboration National institutes Prefectural institutes Domestic/foreign universities Private institutes Research activities in RCAS Project 2. Reproductive biology, (Example) Breeding technology development North West Agriculture and Forestry Univ.（China） Identification of sperm motility suppressing factors in semen Fe3+ Ca2+ ATP LH （ovulation stimli） Granulosa/ cumulus cells NRG1 ovulation AREG, Oocyte maturation Fertilizing ability Ca2+ Fertilizable ovum Determination of the fertilization mechanism Determination of ovulation mechanism and sperm cryopreservation techniques in pigs day0 day4 SNP analysis for genetic close-relations in pigs DNA analysis for determination of parent-child relationship and identification of individual origins sire pigs day6-9 Pig No. 0001 Pig No. 0002 SNP SNP SNP No. Genotype Genotype SNP1001 A SNP1001 A SNP1002 T SNP1002 C ↓ ↓ ↓ ↓ SNP1023 G SNP1023 A SNP1024 A SNP1024 G ↓ ↓ ↓ ↓ SNP1192 T SNP1192 T Individual Identification using SNP genotypes SNP No. Identification of heat (0h) AI optimum AI optimum time time Novel artificial insemination program in pigs Term possible for fertilization Sperm survival time Establishment of the novel pig breeding technology Contribution for sustainable development of pig production in Asia and world. Research activities in RCAS Project 3. Endocrinology, Physiology of nutrition, Animal management technology (Example) Animal management technology development Kasetsart University （Thailand） Nutrient metabolism in ruminants University of Alberta（Canada） Nutritional factors causing lifestyle disease and obesity Gastro-intestinal health and protection by probiotics Natl. and prefectural institutes, Japan Hiroshima University (Japan) Improvement of Analysis of body productivity in dairy score by 3D image milk using advanced and remote sensing robot system Work-saving management, High performance, Health enhancement and Safe products in Animal production Production and Tissue regulatory 3D image health analysis factors analysis analysis Milk amount and Body shape and Metabolism regulation quality, estrus cycle obesity evaluation by blood factors and identification etc. etc. hormones etc.
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