（株）食環境衛生研究所 略称/英文社名: (株）食環研/Shokukanken Inc. April 2014 Profile • • • • • President： Kazuhiro Kubo Capital: 10,000,000 yen Founding: 21 July 1998 Employee: 52staffs (8 veterinarians) Location: – Head office – Analysis center for foods and drugs Head office: 561-21 Arakuchi-machi, Maebashi-shi, Gunma 379-2107, Japan Head office Analysis center for foods and drugs: 5 minutes from head office by car Animal facilities (1) Animal facilities (2) Animal facilities (3) Safety Evaluation Center Organization • Study/Examination Group – Agriculture/livestock exam, food/environment exam (micro-bacterial exam, genetic diagnosis, residue of pesticide, antibiotic analysis) • Testing/Research Group – GLP, GCP and GPSP studies to get or maintain the approvals of veterinary medicine • Livestock Marketing Group – Sales of feed additives and soil improvement agent – Consulting • Food/Environmental Health Marketing Group – Hygiene control training of the restaurants based upon micro-bacterial exam – Consulting • Agriculture Business Group – Management of entrusted farm land/vegetable farm based on the soil and pesticide residue exam Organization (1) President 代表取締役社長 Food/Environmental Health Marketing Group 食品・環境衛生営業部 Livestock Marketing Group 畜産営業部 Agriculture Business Group アグリビジネス部 Organization (2) President 代表取締役社長 Testing/Research Group 受託試験部 Study/Examination Group 研究検査部 QAU 信頼性保証部 Testing/Research Group 受託試験部 • General tests 一般受託試験 – Evaluation of anti-microbial activity – Identification of micro organisms – Challenge test using pathogens etc. • Studies according to GCP or GLP 動物用 医薬品試験（GCP・GLP） GLP/GCP License • Veterinary Medicine GLP Dec 2011 Residue analytical study (Swine) • Veterinary Medicine GLP Mar 2012 Safety and Residue (Ruminant, Swine and Avian) • Veterinary Medicine GCP in 2014 Activities in Swine and Avian Fields • Management consultant Swine Farm: 100 (All prefecture except Okinawa) Poultry Farm: 12 (Kanto and Tohoku area ) • Presentations and Publications (2011 to 2012) 6 presentations: – Japanese Society of Veterinary Science 2 publications: – Journal of the Japan Veterinary Medical Association Serialize articles: – The pig magazine and Pig Journal Activities Examination/Studies around animal health • GLP/GCP studies for veterinary drugs – Tissue residue: 20/year – Target animal safety: 2/year – Field trials: 10 – 20/year • Others – Bacteria isolation and identification – Diagnosis of infectious disease – Antibody titration: – Quality control • Test for release • Stability • Basic study for setting up of specification and QC methods Study/Examination Group 研究検査部 食品分野 Food • • • • • • • • • • • • • • 検便検査 Examination of feces レジオネラ属検査 Detection of Legionella 一般栄養成分等分析 Examination of general nutrient component 香港栄養成分分析 Examination of nutrient component according to Hong Kong method 食品保存試験 Food preservation test 異物異臭検査 Examination for foreign particles and odor アレルギー物質検査 Detection of allergic substances ペットフード検査 Examination of pet foods 細菌・ウイルス検査 Bacterial and viral detection カビ毒分析 Analysis of fungal toxin 水質検査 Water examination 放射能検査 Examination for radioactivity 残留農薬分析 Analysis of residual pesticide 残留動物用医薬品分析 Analysis of residual veterinary drugs 畜産分野 Livestock • 鶏 Chicken – – – • 豚 Swine – – – • 抗体検査 Antibody titration 病性鑑定・細菌検査 Diagnosis (including bacterial detection) 豚品種識別検査 Examination of swine breed identification 牛 Bovine – – • 抗体検査 Antibody titration 病性鑑定・細菌検査 Diagnosis (including bacterial detection) 卵検査 (Egg examination) 抗体検査 Antibody titration 病性鑑定・細菌検査 Diagnosis (including bacterial detection) その他 Other – – – – 畜産環境 Environment 飼料分析 Analysis of feed 肥料分析 Analysis of fertilizer 肉質検査 Examination of carnosity Chicken: Antibody titration Dise ase Abbr e viat io n Mycoplasma gallisepticum infection MG Mycoplasma synoviae infection MS Newcastle disease Infectious coryza serogroup A Infectious coryza serogroup C Egg drop syndrome-1976 ND IC-A IC-C EDS-76 Infectious bronchitis IB Infectious laryngotracheitis ILT Infectious brusal disease IBD Salmonella pullorum infection SP Salmonella enteritidis infection Avian encephalomyelitis Avian influenza Turkey rhinotracheitis Leucocytozoonosis RSA: Rapid slide agglutination ELISA: Enzyme-linked immunosorbent assay NT: Neutralization test SE AE ＡＩ TRT Leuco Method RSA RSA HI RSA RSA HI HI HI HI ELISA AGP ELISA ELISA AGP RSA AGP ELISA ELISA AGP NT AGP HI: Hemagglutination Inhibition AGP: Agarose gel precipitation Chicken: Pathological Appraisal and Antigen Detection Exam in at io n Method Un it Re m ar k Salmonella characteristic 1 sample According to Journal of The Japanese Society on Poultry Diseases, vol. 37 (1) Salmonella serotype detection 1 sample According to Kauffmann-White scheme After isolation of Salmonella spp. Salmonella serotype detection (partial) 1 sample According to Kauffmann-White scheme S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, S. enterica serovar Infantis, S. enterica serovar Hadar 10 eggs (pooled) According to Journal of The Japanese Society on Poultry Diseases, vol. 37 (1) Egg content: Salmonella Egg shell: General bacteria population, coliform group, Salmonella Egg white and egg yolk: O-157 10 eggs (pooled) According to Journal of The Japanese Society on Poultry Diseases, vol. 37 (1) Egg content: Salmonella Egg shell: General bacteria population, coliform group, Salmonella Egg test-1 Egg test-2 10 eggs Parasites 1 sample Count of bacterial number 1 bacteria per sample Bacteria detection in organs 1 tissue Bacteria count with intestinal contents or feces1 bacteria per sample Infectious coryza isolation 1 swab sample Aerobic 1 bacteria Drug sensitivity test Microaerophilic 2 bacteria Anaerobic 3 bacteria Mycoplasma isolation 1 sample OPG count Stamp Nasal swab Disc Disc Disc Haugh unit, color chart of egg yolk, egg weight Coccidosis etc. E. coli, Staphylococcus aureus, Clostridium etc. E. coli, Staphylococcus aureus, Clostridium, Salmonella etc. E. coli, Clostridium, Salmonella etc. 10 discs, at least 10 discs, at least 10 discs, at least Cost for 1 kind of pathogens (MG、MS, mainly) Virus isolation 1 sample Cost for 1 kind of pathogens (IB、ILT、POX、ND、TRT, mainly) Detection by PCR 1 sample Cost for 1 kind of pathogens (IB、ILT、ND、TRT、MG、MS、CAV, mainly) Necropsy 5 chickens at most Macro observation Cost for disposal after necropsy Swine: Antibody titration Dise ase Abbr e viat io n Method Japanese encephalitis Swine parvovirus infection Getah virus infection JE PPV Getah HI HI HI Leptospirosis Lepto GA Toxoplasmosis Influenza (H1N1) Influenza (H3N2) Transmissible gastroenteritis Porcine pluropneumonia Bordetella bronchiseptica infection Toxo IF（H1N1） IF（H3N2） TGE App1 App2 App5 Bord Aujeszky disease AD Glasser's disease Swine erysipelas Hps SE AP PRRS PED Arcanobacterium pyogenes infection Porcine reproductive and respiratory syndrome Porcine epidemic diarrhea virus Swine enzootic pneumonia Pasteurella multocida infection Lawsonia intracellularis infection Circovirus type 2 infection Streptococcus suis type 2 infection Salmonella infection SEP Pm(DNT) PPE PCV2 S.suis2 Sal HI: Hemagglutination Inhibition NT: Neutralization test Latex: Latex agglutination Re m ar k L. canicola, L. icterohaemorrhagiae, L. hardjo, L. pomona, L. grippo-typhosa, L. bratislava Latex HI HI NT CF CF CF ＡＧ NT Latex Detection of antibody against field strain (g1+) g1-ELISA CF WP AGP ELISA NT CF ELISA Antibody detection against darmonecrotic toxin ELISA IFA ELISA ELISA ELISA ELISA ELISA: Enzyme-linked immunosorbent assay AGP: Agarose gel precipitation AG: Agglutination GA: Growth agglutination CF: Compliment fixation IFA: Immuno-fluorescent assay Swine: Pathological Appraisal and Antigen Detection Exam in at io n (Sam plin g o r gan ) Atrophic rhinitis Organ of respiration Blood and organs Intestinal content or feces Skin Bacteria isolation Bacteria isolation Detection with nasal swab Swab or stamp Bordetella bronchiseptica Hps App Pm Bacteria isolation 1 sample Stamp E. coli 1 sample Smear culture Vero toxin: Stx2e, ST, LT Fimbrial antigens: K88, K99, 987P, F18 Intimin Clostridium Salmonella spp. 1 sample 1 sample Smear culture Smear culture Salmonella identification 1 sample According to Kauffmann-White scheme Bacteria isolation Aerobic Microaerophilic Anaerobic 1 sample 1 bacteria per sample 1 bacteria 1 bacteria 1 bacteria 1 bacteria per sample MIC test Parasites 1 sample 1 sample Re m ar k Streptococcus spp., Erysipelothrix rhusiopathiae, Arcanobacterium pyogenes Bacteria isolation, others Drug sensitivity test Method Un it Intestinal content or feces 1 sample Intestinal mucosa 1 sample Rotavirus Mange Sampling of skin Disc 10 discs, at least Disc 10 discs, at least Disc 10 discs, at least Method established by Japanese Society of Antimicrobials for Animals OPG, microscopic observation Microscopic observation after Giemsa staining Latex agglutination test Virus isolation 1 sample 1 sample 1 sample 1 sample 1 sample 1 bacteria per sample 1 bacteria per sample 1 virus per sample Detection by PCR 1 antigen per sample PCV2－subtyping by PCR PCV2-quantitive PCR test PRRS-quantitative PCR test E. coli Toxic factor detection E. coli adherent factor detection Necropsy 1 1 1 1 1 1 Brachyspira hyodysenteriae Influenza A or B Isolation of swine acid-fast microorganism Bacteria isolation Mycoplasma Detection by PCR sample sample sample sample sample pig Staphylococcus hyicus Stamp Whipworm, nematode, Eimeria, Balantidium, trichomonad etc. Isospora Microscopic observation after alkali treatment Microscopic observation Detection by diagnosis kit Culture and PCR Culture PCR M. hyopneumoniae M. hyorhinis IF、TGE、AD、PED PCR using 3 pairs of primers Q-PCR Q-PCR PCR PCR Macro observation PRRS、PCV2、TGE、PED、JE、PPV、AD、PPE、ＩＦ、Lepto、Pm （DNT）、M. hyopneumonia e、M. hyorhin is、MAC Group 1 or 2 Stx2e, ST, LT K88, K99, 987P, F18, Intimin Cost for disposal after necropsy Bovine: Antibody Titration Dise ase Parainfluenza type 3 Adenovirus type 7 Bovine leukemia Bovine RS virus disease Bovine rhinotracheitis Bovine viral diarrhea-mucosal disease Leptospirosis HI: Hemagglutination Inhibition NT: Neutralization test Abbr e viat io n Me t h o d PI3 AD7 BL ＲＳ ＩＢＲ BVD/MD NT HI AGP NT NT NT Lepto GA Re m ar k L. canicola, L. icterohaemorrhagiae, L. hardjo, L. pomona, L. grippo-typhosa, L. autumnalis, L. australis ELISA: Enzyme-linked immunosorbent assay GA: Growth agglutination AGP: Agarose gel precipitation Bovine: Pathological Appraisal and Antigen Detection Exam in at io n (Sam plin g o r gan ) Method Un it Re m ar k Nasal swab or organs Bacteria isolation 1 sample Swab, stamp Histophilus somni Mannheimia haemolytica Pasteurella multocida keratoconjunctival epitherium Bacteria isolation 1 sample Swab Moraxella bovis Smear culture Smear culture Smear culture According to Kauffmann-White scheme Latex Vero toxin, fimbrial antigens (K99) Intestinal content or feces E.coli 1 sample Clost 1 sample Salmonella isolation 1 sample Salmonella identification 1 sample Rotavirus detection 1 sample Bacteria (rapid ① 1 sample identification) ② Bacteria tests Basic treatment Staphylococcus Streptococcus Coliform group Pseudomonas aeruginosa , Pasteurella Mastitis 1 sample Arcanobacterium Smear culture S. aureus , CNS Streptococcus agalactiae, Non-agalactiae Streptococcus E. coli, coliform group According to a method established by National Agricultural Insurance Association Abortion Necrobacillosis Drug sensitivity test Parasites Identification of oxidase-positive Gram (-) rods Gram(+) rods (non-sporeforming, hemolytic, catalasenegative) Gram (+) rods (non-sporeforming, non-hemolytic, catalasepositive) Corynebacterium Clostridium Bacillus Somatic cell count Bacteria count Brucella isolation Campylobacter isolation Bacteria isolation Aerobic Microaerophilic Anaerobic Bacteria causing mastitis Coccidium egg Nematode egg, Coccidium egg Rapid test targeted Staphylococcus, Streptococcus, E. coli and coliform group Gram (+) rods (sporeforming, anaerobic) Gram (+) rods (sporeforming, aerobic) 1 sample 1 sample 1 sample Direct macroscopic SSC Rapid test for mastitis Smear culture Brucella abortus 1 sample Smear culture Campylobacter fetus 1 1 1 1 Smear culture Disc Disc Disc 10 discs, at least 10 discs, at least 1 bacteria Disc 10 discs, at least, selecting specific for mastitis treatment 1 sample OPG count 1 sample Wisconsin method modified sample bacteria bacteria bacteria Lungworm egg 1 sample Nematode egg identification 1 sample Trematode egg 1 sample Mycoplasma detection 1 sample per bacteria PCR検査 Necropsy 1 sample per bacteria 1 animal Fusobacterium necrophorum 10 discs, at least Emigration method Identification after culture Beads method M. bovirhinis M. bovis M. disper M. bovigenitalium U. diversum BVDV、BAV、RSV、PI3、IBR Macro observation Excluding cost for disposal after necropsy Main customers in Animal Health • • • • Zoetis Japan Novartis Pharma Japan Eli Lilly Boehringer Ingelheim Vetmedica Japan • Intervet • Kyoritsu Seiyaku • Research Institute for Animal Science in Biochemistry and Toxicology (RIAS) • Scientific Feed Laboratory Co. Ltd. • Nisseiken Co. Ltd. • Meiji Seika Pharma Co. Ltd.
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