Waon therapy attenuates cardiac hypertrophy and fibrosis and promotes myocardial capillary growth in hypertensive rats. Title Author(s) 庵, 弘幸 Citation Issue Date 2014-03-21 Type Article Text version URL http://hdl.handle.net/10110/12953 Rights http://utomir.lib.u-toyama.ac.jp/dspace/ Waon Therapy Attenuates Cardiac Hypertrophy and Fibrosis and Promotes Myocardial Capillary Growth in Hypertensive Rats. NO NO NO eNOS eNOS 7 (LS) 8% 8% (HS) (WT) 1 15 34 1 (FL) 4 39 20 9 WT (10mg/kg/day) FL 4 PCR tail-cuff ( ) ( [HE ) CD31 RT-PCR VEGF( ) eNOS( gp91phox( LS HS ANP, BNP( ) NO ) ( ( p22phox, eNOS 3 WT (p<0.01) LS HS (p<0.01) WT HS LS (p<0.01) m) ) ) NADPH mRNA 3 ] (5-10 TGF- ) WT (p<0.05) (p<0.01) HS (p<0.01) WT ANP WT BNP mRNA (p<0.05) eNOS mRNA eNOS (p<0.01) LS HS WT (p<0.01) TGF- GP91-phox 1 p22-phox mRNA (p<0.05, p<0.05, p<0.01) LS (p<0.01) HS WT VEGF mRNA FL (p<0.05) eNOS WT FL WT 7 NO Rho GTP eNOS ANP BNP VEGF
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