http://utomir.lib.u-toyama.ac.jp/dspace/ Title Waon therapy

 Waon therapy attenuates cardiac hypertrophy and
fibrosis and promotes myocardial capillary growth
in hypertensive rats.
Title
Author(s)
庵, 弘幸
Citation
Issue Date
2014-03-21
Type
Article
Text version
URL
http://hdl.handle.net/10110/12953
Rights
http://utomir.lib.u-toyama.ac.jp/dspace/
Waon Therapy Attenuates Cardiac Hypertrophy and Fibrosis and
Promotes Myocardial Capillary Growth in Hypertensive Rats.
NO
NO
NO
eNOS
eNOS
7
(LS)
8%
8%
(HS)
(WT)
1
15
34
1
(FL)
4
39
20
9
WT
(10mg/kg/day)
FL
4
PCR
tail-cuff
(
)
(
[HE
)
CD31
RT-PCR
VEGF(
) eNOS(
gp91phox(
LS
HS
ANP, BNP(
)
NO
)
(
(
p22phox,
eNOS
3
WT
(p<0.01)
LS
HS
(p<0.01) WT
HS
LS
(p<0.01)
m)
)
) NADPH
mRNA
3
]
(5-10
TGF-
)
WT
(p<0.05)
(p<0.01)
HS
(p<0.01)
WT
ANP
WT
BNP mRNA
(p<0.05)
eNOS mRNA
eNOS
(p<0.01)
LS
HS
WT
(p<0.01)
TGF-
GP91-phox
1
p22-phox
mRNA
(p<0.05, p<0.05, p<0.01)
LS
(p<0.01)
HS
WT
VEGF mRNA
FL
(p<0.05)
eNOS
WT
FL
WT
7
NO
Rho
GTP
eNOS
ANP
BNP
VEGF