第5回頭脳循環セミナー1 - 名古屋市立大学大学院医学研究科・医学部

第５回名市大頭脳循環セミナー
NewPhotochemicalProbesforBreakthroughs
inBiomedicine
講師：IvanJ.Dmochowski 先生
Professor,
UniversityofPennsylvania,DepartmentofChemistry 日時：８月５日（金）17:00～18:00
場所：名古屋市立大学桜山キャンパス
医学研究科研究棟１１階講義室B
Abstract
My lab has developed light-activated
small-molecule and oligonucleotide probes
that make it possible to address
long-standing problems in Biology and
Biomedicine. In this talk I will first
highlight our efforts at an exciting frontier
in
molecular
pharmacology--the
identification of a functionally relevant
protein target of general anesthetics. This
work built on our discovery of the first
fluorescent
general
anesthetic,
1-aminoanthracene,
and
subsequent
Harvesting RNA with light. See
photo-crosslinking
experiments
with
http://www.the-scientist.com/?articles.view/article
No/39491/title/Molecular-Multitasker/
1-azidoanthracene. I will then highlight our
efforts
to
advance
the
field
of
transcriptomics by making it possible to elucidate how RNA populations vary
between different cells in living brain tissue. This work builds on my lab’s
long-standing interest in designing light-activated oligonucleotides to manipulate
gene expression with high spatiotemporal resolution. For capturing mRNA, we
developed Transcriptome In Vivo Analysis (TIVA) technology, which also employs
light microscopy to control the function of caged oligonucleotides. I will discuss
new TIVA constructs under development for harvesting mRNA within intact
living organisms.
世話人：中川秀彦（052-836-3407,[email protected]）

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