Curriculum Vitae PERSONAL INFORMATION Adrian Thomas WORK EXPERIENCE July 2002–Present Expert Biological Pharmaceutical Assessor in Biologicals/Biotechnology Unit Medicines & Healthcare Products Regulatory Agency, (United Kingdom) Past Acting Head of Unit Lead professional quality assessor for biological & biotechnology products. Assessment of applications for marketing authorisation and post-marketing changes. Provision of scientific advice to sponsors of biological and biotechnology products at both European (CHMP) and national (MHRA) level. Evaluation of TSE risk associated with biological & biotechnology products. June 1997–July 2002 Senior Pharmaceutical Assessor, Biological & Biotechnology Unit Medicines Control Agency, (United Kingdom) Assessment of applications for marketing authorisation and post-marketing regulatory matters for biological and biotechnology products June 1990–June 1997 Principal Pharmaceutical Assessor, AbridgedMedicines Unit Medicines Control Agency, (United Kingdom) Assessment of abridged applications for marketing authorisation includes chemicals, radiopharmaceuticals, dental and surgical materials. June 1976–June 1990 Senior Scientist, Division of Antibiotics and Chemistry National Institute for Biological Standards & Control (NIBSC), (United Kingdom) Responsible for the bioassay, analytical control and standardisation of antibiotics including: establishment of WHO Reference Standards, development of pharmacopoeial monographs and the development replacement chemical assays. September 1968–June 1976 Scientist, Division of Biological Standards National Institute for Medical Research (NIMR) , (United Kingdom) Advice to Department of Health under Therapeutic Substances Act and to British Pharmacopoeia Commission on the control of antibiotics. Laboratory research on mode of action and resistance of antibiotics. Laboratory control (qualitative and quantitative analysis) of antibiotics. September 1966–July 1968 Lecturer, Pharmacy Department Heriot-Watt University, Edinburgh, (United Kingdom) Lecturer in pharmaceutical microbiology and dispensing. EDUCATION AND TRAINING September 1960–July 1963 Bachelor of Pharmacy (B. Pharm) 2.i. School of Pharmacy, University of London, (United Kingdom) Pharmacy course, Main subjects in final year pharmaceutical science and pharmacology. September 1963–August 1966 Doctor of Philosophy (PH.D) Medical Sciences School of Pharmacy, University of London, (United Kingdom) 6/1/15 © European Union, 2002-2014 | http://europass.cedefop.europa.eu Page 1 / 4 Curriculum Vitae Adrian Thomas Pharmaceutical microbiology, inactivation of bacterial viruses (bacteriophage) ADDITIONAL INFORMATION Expertise Quality aspects of biological and biotechnology products including blood products, and vaccines. TSE risk assessments of biological and biotechnology products. Publications Brown WRL & Thomas A H J Pharm. Pharmacol., 1966, 18, Suppl., 42S-44S The effect of peptone on the inactivation of a bacteriophage by chemical agents. Thomas A H & Broadbridge R A Analyst (London), 1970, 95, 459-462 The electrophoretic separation of penicillins and penicilloic acids. Thomas A H & Broadbridge R A J Gen. Microbiol., 1972, 70, 231-241 The nature of carbenicillin resistance in Pseudomonas aeruginosa. Lightbown J W, Thomas A H & Berryman I L Bull. Wld Hlth Org., 1973, 48, 81-84 The second international reference preparation of lymecycline. Lightbown J W, Thomas A H & Berryman I L Bull. Wld Hlth Org., 1973, 48, 85-90 The second international standard for polymyxin B. Lightbown J W, Thomas A H & Berryman I L Bull. Wld Hlth Org., 1973, 48, 99-105 The second international standard for tetracycline. Thomas A H & Tappin S D J Chromatog., 1974, 97, 280-283 Separation of gentamicin complex by ion-exchange column chromatography. Thomas A H Analyst (London), 1976, 101, 321-340 Analysis and assay of polyene antifungal antibiotics. Ndzinge I, Peters S D & Thomas A H Analyst (London), 1977, 102, 328-332 Assay of nystatin based on the measurement of potassium released from Saccharomyces cerevisiae. Thomas A H & Peters S D Analyst (London), 1977, 102, 333-339 Microbiological assay of the polyene antibiotics amphotericin B, candicidin and nystatin. Calam D H, Gilbert JNT, Lightbown J W, Powell J W & Thomas A H J Pharm. Pharmacol., 1978, 30, 220-223 Control of the composition of gentamicin sulphate by proton magnetic resonance spectrometry. Thomas A H J Pharm. Pharacol., 1978, 30, 378-379 Comparison of three methods of evaluating the composition of gentamicin sulphate. Thomas A H & Holloway I J Chromatog., 1978, 161, 417-420 Thin-layer chromatographic method for the identification of the polymyxins. Thomas A H & Dixon H J Biol. Stand., 1979, 7, 137-145 The international reference preparation of candicidin. Lightbown J W, Thomas A H, Grab B & Dixon H J Biol. Stand., 1979, 7, 227-238 The second international reference preparation of neomycin. Thomas A H & Thomas J M J Chromatog., 1980, 195, 297-302 Use of the image analyser Optomax for the quantitative evaluation of antibiotics separated by gel electrophoresis and thin-layer chromatography. Thomas A H & Thomas J M & Holloway I Analyst (London), 1980, 105, 1068-1075 Microbiological and chemical analysis of polymyxin B and polymyxin E (colistin) sulphates. Gutteridge JMC & Thomas A H Biochem. Med., 1980, 24, 194-200 Thiobarbituric acid reactivity of autoxidized candicidin. Thomas A H, Newland P & Quinlan G J J Chromatog., 1981, 216, 367-373 6/1/15 © European Union, 2002-2014 | http://europass.cedefop.europa.eu Page 2 / 4 Curriculum Vitae Adrian Thomas Identification and determination of the qualitative composition of nystatin using thin-layer chromatography and high-performance chromatography. Thomas A H, Newland P & Sharma N R Analyst (London), 1982, 107, 849-854 The heterogeneous composition of pharmaceutical-grade nystatin. Thomas A H & Dixon H J Biol. Stand., 1982, 10, 369-377 The second international standard for nystatin. Gutteridge JMC, Thomas A H & Cuthbert A J Appl. Biochem., 1983, 5, 53-58 Free radical damage to polyene antifungal antibiotics: changes in biological activity and thiobarbituric reactivity. Thomas A H, Newland P & Sharma N R J Chromatog., 1983, 291, 219-230 Chromatographic methods for the analysis of bleomycin complex. Thomas A H, Quinlan G J & Gutteridge JMC J Chromatog., 1984, 299, 489-494 Assay of doxorubicin and 4'-epidoxorubicin by reversed-phase ion-pair chromatography. Thomas A H & Newland P J Chromatog., 1986, 354, 317-324 Separation of aromatic heptaene antibiotics by high-performance liquid chromatography. Thomas A H, Mussett M V & Broadbridge R A J Biol. Stand., 1986, 14, 35-44 The international standard for kanamycin. Thomas A H J Antimicrob. Chemotherap., 1986, 17, 269-279 Suggested mechanisms for the antimycotic activity of the polyene antibiotics and the N-substituted imidazoles. Thomas A H J Pharmaceutical & Biomedical Analysis, 1987, 5, 319-324 Replacement of microbiological assay by high-performance liquid chromatographic assay for antibiotics. Thomas A H & Newland P J Chromatog., 1987, 410, 373-382 Chromatographic methods for the analysis of vancomycin. Thomas A H Chemistry in Britain, 1988, 24, 1031-1035 Quality control in genetic engineering Newland P, Bingham B, Tarelli E & Thomas A H J Chromatog., 1989, 483, 406-412 High-performance gel permeation chromatography of meningococcal polysaccharide. Thomas A H, Mussett M V & Broadbridge R A Biologicals, 1990, 18, 69-73 The International Standard for Netilmicin Thomas A H & Wong M Y Biologicals, 1991, 19, 233-236 The International Standard for Netilmicin Projects Memberships Professional Bodies Registered Pharmacist (MRPharmS), 1964. Designated Fellow of the Society for distinction in the Profession of Pharmacy, 2009. Member, 1975-2002, Royal Society of Chemistry (RSC). Joint Pharmaceutical Analysis Group, (RPharmS & RSC), Committee member: 1984-86 and 1993-95. Biological Methods Group, Analytical Division, RSC, Committee member including; Chairman, Secretary, Treasurer, 1975-95 Royal Society of Chemistry, Analytical Division Distinguished Service Award 1992. Membership of Advisory Committees Biologics Working Party 2005Principal Assessor, Commission on Human Medicines, Safety of Medicines, Biologicals and Vaccines 6/1/15 © European Union, 2002-2014 | http://europass.cedefop.europa.eu Page 3 / 4 Curriculum Vitae Adrian Thomas Expert Advisory Group (2004-7) Member, British Pharmacopoeia Commission, Antibiotics Committee (E) 1969-1998 Immunological Products (J) (2000-2006), Biological and Biotechnological Products (H) (2006-) Alternative member, European Pharmacopoeia, Group 7 (Antibiotics) 1975-1985 Temporary Consultant for the WHO, for analytical control of antibiotics July 1989, November 1997 Bangkok, and April 1990 Beijing Other Relevant Information 6/1/15 © European Union, 2002-2014 | http://europass.cedefop.europa.eu Page 4 / 4
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