John K. Doe - Safety Pharmacology Society

John K. Doe
123 Main Street
New York NY 12345
Phone (212) 555-1234
E-mail: [email protected]
OBJECTIVE
To continue a challenging career in applied research by using the skills I have acquired in safety
pharmacology, animal research and a graduate education.
EDUCATION
Ph.D., Pharmaceutical Sciences, Graduated with honors, University of California, Berkeley,
December 2001
MS Biochemistry, University of Nevada, Reno, January 1999
BS Biochemistry, University of Missouri, June 1996
EXPERIENCE
2004 - Present
Head, In Vitro Pharmacology - Pharmacology Department
XYZ Laboratories, Inc., San Francisco CA
* Provide direction for in vitro cardiovascular pharmacology group. Assess new drug
candidates for cardiovascular risk; including QT prolongation/Torsades, AV conduction
block, negative inotropy, and arrhythmias. Interaction with clients to discuss study results,
next step strategies. Prepare appropriate text for inclusion in IND submissions if required.
* Assure GLP compliance and high quality of studies.
* Project planning, calculation of pricing structure, review of contracts, reporting financial
milestones, training and collaboration with sales staff.
* Assist in analysis of telemetry data.
2001 - 2004
Group Leader, Cardiac Electrophysiology - Safety Pharmacology
ABC Services, New York NY
* Study Director role; design, direct, evaluate and report results of cardiovascular
pharmacology studies evaluating the effects of new drug candidates on cardiac action
potentials. Provide technical direction and leadership to staff involved in the conduct of these
studies, adapt and/or adopt new techniques for in vitro pharmacology; consult and interact
with clients. Participate in IACUC activities.
1999 - 2001
Associate Scientist - ADME Department
Acme Pharmaceuticals, Inc, Chicago IL
* Design and help conduct experiments to evaluate drug effects on cytochrome P450 (CYP)
enzymes. This includes assessment of a compounds ability to cause induction of CYP
expression or inhibition of specific CYP activity, as well as predicting drug/drug interactions.
Techniques include incubation of drugs in hepatocytes (whole or homogenized), microsome
preparation and incubations, assessment of microsomal protein levels and P450 content,
programming for the Hamilton liquid handling system, Western immunoblotting, enzyme
activity assays, and LC/MS quantitation of metabolites. Knowledge of GLP procedures is
required. Responsibilities include protocol and report generation and project representation.
PROFESSIONAL SOCIETIES:
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California Veterinary Medical Association
American Veterinary Medical Association
Phi Zeta (Veterinary Honor Society)
Undergraduate Phi Kappa Phi Graduate Student
Electee, New York Academy of Science
Safety Pharmacology Society
Society of Toxicology
American Thoracic Society
AWARDS
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Outstanding Scientific and Technical Team Award, ABC Services - 2004
Appreciation Certificate, Institutional Animal Care and Use Committee, ABC Services -2002
Key Contributor Award, ABC Services - 2001
University of California Scholarship in Pharmaceutical Sciences - 2001.
PUBLICATIONS
PEER-REVIEWED MANUSCRIPTS
Doe JK and Olson LP. Adenosinergic Vasoactivity in Isolated Vessels and Perfused Gills of
Salmonids in vitro. Manuscript in preparation for Journal of Comparative Physiology.
Smith SJ, Weber DM, Jones RS, Brown PD, Doe JK, and Woods JE. 1996. Cardiovascular and
Pharmacokinetic Interactions of Tirilizad Plus Nimodipine in Dogs. Drug Development Research.
22(6): 140-159.
Doe JK, Smith BV, Conway LA, Wolf AM, Smith SJ, Watts MA, and Gross VE. 1995.
Synthesis and Biological Activity of Spirocyclic Benzopyran Imidazolones Potassium Channel
Openers. Journal of Medicinal Chemistry. 33: 1455-1469.
Clarke MF, Doe JK, and Long JH. 1994. Unique Natriuretic Effects of Glyburide in Conscious
Rats. Journal of Pharmacology and Experimental Therapeutics. 267(4): 930-947.
Doe JK, Humphrey BJ, Khan MA, and Jones AS. 1993. 4-Morpholinecarboximidine-N-1adamantyl-N*-cyclohexylhydrochloride (U-37883A): Pharmacological Characterization of a
Novel Antagonist of Vascular ATP-sensitive K+ Channel Openers. Journal of Pharmacology and
Experimental Therapeutics. 267(5): 625-636.
Doe JK, Humphrey BJ, Kerns AW, and Matthews RP. 1993. In Vitro and in Vivo Effects of Snitrosothiols: Comparison to and Interactions with Standard Nitrovasodilators. Methods and
Findings in Experimental and Clinical Pharmacology. 11(5): 333-345.
Doe JK, Humphrey BJ, and Jackson HL. 1993. Selective in vivo Antagonism of Pinacidilinduced Hypotension by the Guanidine U37883A in Anesthetized Rats. Pharmacology. 51: 333345.
Humphrey BJ, Doe JK,, Buchanan VA, Gibson PL, and Khan MA and. 1992. Cardiovascular
Effects of the K+-ATP Channel Blocker U-37883A and Structurally Related
Morpholinoguanidines. Methods and Findings in Experimental and Clinical Pharmacology.
19(7): 147-160.
Doe JK, Russell JM, Wines TL and Olson LP. 1991. Effects of Hypoxia on Isolated Vessels and
Perfused Gills of Rainbow Trout. Comparative Biochemistry and Physiology Part A: Molecular
& Integrative Physiology. 136: 271-281.
Humphrey BJ, Doe JK, and Walters BA. 1991. Cardiovascular Effects of the R- and SEnantiomers of Ibutilide in Conscious Beagle Dogs. Methods and Findings in Clinical
Pharmacology. 29(2): 149-155.
Doe JK, Kerr TJ, Wines TL and Olson LP. 1990. Effect of pH on Rainbow Trout Blood Vessels
and Gill Vascular Resistance. Journal of Experimental Biology. 219(3): 586-594.
ABSTRACTS AND POSTERS
Frank JP, McDonald TM, Doe JK and Olson LP. Adenosinergic Vasoactivity in Isolated Vessels
and Perfused Gills of Salmonids in vitro. Manuscript in preparation for Journal of Comparative
Physiology.
October, 1986. Atrial Natriuretic Peptide (ANP) in Fetal Sheep: an Electron Microscopical Study.
Poster presented at the 1991 Annual Meeting of the Society for Gynecologic Investigation.
Doe JK, Humphrey BJ, Kerns SW and Matthews PL. March 9, 1990. Cardiovascular Effects of a
series of stable S-nitrosothiols. Poster presented at the 1994 Biology-Biochemistry Associates'
Symposium, Western Michigan University.
Humphrey BJ, Doe JK, Brown MA, Block LP and Lunds SE. November 20, 1990.
Cardiovascular Drug Interactions Between Acute i.v. Tirilizad Mesylate (U-74006F) and Chronic
Oral Nimodipine in Conscious Beagle Dogs. Presented at the 1994 Biology Symposium, Western
Michigan University.
Doctoral Dissertation
Doe JK. 2001. Sympathetic and Parasympathetic Nerve Activity: Effect on Vasoactivity in
Isolated Vessels and Perfused Gills of Salmonids in vitro.
LANGUAGES SPOKEN AND WRITTEN
French and English
REFERENCES
Available upon request

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