Data Blitz - Department of Psychology

WELCOME TO THE 18th ANNUAL NEUROSCIENCE AT STORRS, 2014!
This is a unique opportunity to bring together the diverse neuroscience research
community from across several Schools and Departments at UConn. Neuroscience at Storrs
provides a venue for faculty, postdoctoral fellows, graduate and undergraduate students to meet
and share their research, as well as attend a guest lecture describing cutting-edge research in
the field. This year, we are fortunate to have Dr. Garret Stuber from the University of North
Carolina - Chapel Hill as our keynote speaker. Participating Departments include Physiology
and Neurobiology, Psychology, Pharmaceutical Sciences, Biomedical Engineering and
Neuroscience (UConn Health Center). This year's Steering Committee is comprised of Drs.
Debra Kendall (Pharm.), Heather Read (Psych. and BME), Anastasios Tzingounis (PNB) and
Alexander Jackson (PNB). A special thanks to the UConn Research Foundation, Olympus
America Inc. and participating Departments for making Neuroscience at Storrs 2014 possible.
LOCATION: Oak Hall, Room 101
ITINERARY:
330-430 pm: Data Blitz…………………………………………………………………………….Page 3
The Data Blitz is a fun way for trainees to present their research in a concise manner to
a diverse audience by encapsulating their work in a 3 minute long presentation and
limited to only 3 powerpoint slides. A cowbell will be rung at the end of the 3 minutes,
which means a quick exit, stage left! A prize will be given for best presentation.
5-6 pm: Keynote Lecture……………………………………………………………………….Page 4
Garret Stuber, PhD
University of North Carolina - Chapel Hill
"Dissecting the Neural Circuits that Mediate Motivated Behavior"
6-8 pm: Poster Session & Reception………………………………………………………...Page 5
During the poster session, participants from across campus will present their work in
poster format and is good chance to interact informally over food and drinks. A prize will
be given for best poster.
2
Data Blitz:
Oak Hall Room 101, 330 pm
Krithika Abiraman1, Anastasios Tzingounis1,2 and George Lykotrafitis1,3
Departments of Biomedical Engineering1 and Physiology and Neurobiology2
“Single Molecule Atomic force microscopy and toxin pharmacology”
Nicholas Bannon and Maxim Volgushev
Departments of Biomedical Engineering1, Physiology and Neurobiology2 and Mechanical
Engineering3
“Modulation of heterosynaptic plasticity by adenosine receptors in the rat neocortex in vitro”
Samantha Yohn and John Salamone,
“Not all antidepressants are created equal: studies with animal models of motivation”
Department of Psychology, Behavioral Neuroscience
Rebecca Acabchuk and Joanne Conover
Department of Physiology and Neurobiology
“Repeated concussions cause region-specific cellular changes in mouse models ”
Zachary Niday and Anastasios Tzingounis
Department of Physiology and Neurobiology
“Seizing the brake!”
Fred Murphy and Andrew Moiseff
Department of Physiology and Neurobiology
“Firefly Visual system”
Lauren Long and James Chrobak
Department of Psychology, Behavioral Neuroscience
“Novel sounds alter theta rhythm coding in hippocampus”
Fatemeh Khatami1, Monty Escabi1,2
“Biologically plausible noise robust speech discrimination”
Departments of Biomedical1 and Electrical Engineering2
Joshua Green and Inge-Marie Eigsti
Department of Psychology, Division of Clinical Psychology
“Oxytocin and Autism”
3
Keynote Lecture:
Oak Hall Room 101, 5 pm
Garret Stuber, Ph.D.
Departments of Psychiatry and Cell Biology and Physiology
University of North Carolina, Chapel Hill
“Dissecting the Neural Circuits that Mediate
Motivated Behavior”
Abstract: In order to survive and effectively navigate an ever-changing and unpredictable
environment, organisms must readily adapt their behavior to seek out needed resources, while
simultaneously avoiding life-threatening situations. These opposing processes are controlled by
neural circuitry that is readily engaged by both environmental and physiological factors to promote
behavioral output. The work of my lab studies the precise neural circuits that control both reward
and aversive-related behavioral responses. By utilizing optogenetic and other circuit mapping tools,
we aim to delineate the precise functional synaptic connections between molecularly distinct
neuronal populations that are critical for the generation of these critical behavioral states. A holistic
understanding of the interconnected neural circuit elements that mediate diverse motivational
behaviors will likely provide important insight into a variety of complex neurological and
neuropsychiatric illnesses such as drug addiction, anxiety, depression, and eating disorders.
Biography: Dr. Stuber received his BS in Psychology with a minor in Chemistry from the University
of Washington in 2000. He then completed his Ph.D. in Neurobiology at the University of North
Carolina at Chapel Hill in 2005 where he studied rapid dopamine dynamics during cocaine selfadministration with Drs. R. Mark Wightman and Regina Carelli. For his postdoctoral work, Dr. Stuber
joined the lab of Dr. Antonello Bonci, then at the Ernest Gallo Clinic and Research Center and the
University of California, San Francisco, where he studied how excitatory synaptic transmission in the
ventral tegmental area is altered following reward-related learning. While still at the Gallo Center Dr.
Stuber began collaborating with members of the Deisseroth lab at Stanford University to adopt
optogenetic techniques to study reward related behaviors. Dr. Stuber started his own lab in 2010 in
the Departments of Psychiatry and Cell Biology and Physiology and Neuroscience Center at the
University of North Carolina at Chapel Hill. The Stuber lab’s research focuses on the synaptic and
neural circuit mechanisms that underlie adaptive and maladaptive behavioral states that mediate
reward-related as well as stress and anxiety-related behaviors. To accomplish this, the laboratory
employs multiple cutting-edge techniques both in vivo and in vitro. The Stuber lab’s ultimate
research goal is to gain a better understanding of the alterations in behavior, cell physiology, and
neurotransmitter release that occur within genetically defined neural circuits.
4
Poster Presentations:
Oak Hall Atrium and Surrounds, 6-8 pm
1. Title: Effects of adenosine on inhibitory synaptic transmission and excitation-inhibition balance
Authors: *P. ZHANG1, N. BANNON2, V. ILIN2, M. CHISTYAKOVA2, M. VOLGUSHEV2;
1
Dept. Physiology and Neurobiology and 2Dept. Psychology, Univ. of Connecticut, Storrs, CT
2. Title: Improving allostery of the CB1 receptor by modification of the chemical functionalities of
indole-2-carboxamides
Authors: *L. KHURANA1, K.H. AHN1, H.I. ALI2, T. OLSZEWSKA2, A. DAMARAJU2, D. LU2, D.A.
KENDALL1;
1
Dept. Pharmaceutical Sciences, University of Connecticut, Storrs, CT and 2 Dept. Pharmaceutical
Sciences, Health Science Center, Texas A&M University, Kingsville, TX
3. Title: The beneficial effect of cooling on neonatal male and female rats with induced hypoxiaischemia
Authors: *A.L. SMITH1, H. GARBU1, T.S. ROSENKRANTZ2, R. H. FITCH1;
1
Dept. Psychology, University of Connecticut, Storrs, CT and 2Dept. Pediatrics, University of
Connecticut Health Center, Farmington, CT
4. Title: Dynamic affective and neural responses to expressive timing fluctuations in music
Authors: *N.K. FLAIG1, T.P. ZANTO2, H.L. CHAPIN3, E.W. LARGE1;
1
Dept. Psychology, University of Connecticut, Storrs, CT, 2Dept. Neurology, University of California,
San Francisco, CA and 3Florida Atlantic University , Boca Raton, FL
5. Title: RNF34 interacts with and promotes GABAA receptor degradation via ubiquitination of the γ2
subunit
Authors: H. JIN, T. CHIOU, C.P. MIRALLES, A.L. DE BLAS;
Dept. Physiology and Neurobiology, University of Connecticut, Storrs, CT
6. Title: Parkinsonism induced by the VMAT-2 inhibitor tetrabenazine is exacerbated by coadministration of the SSRI fluoxetine in rodents
Authors: S.J. PODURGIEL, M.N. MILLIGAN, L.J. PURCELL, S.E. YOHN, M. CORREA, J.D.
SALAMONE;
Dept. Psychology, University of Connecticut, Storrs, CT
7. Title: Learning delays in a mouse model of Autism Spectrum Disorder
Authors: *A.R. RENDALL, D.T. TRUONG, R.H. FITCH;
Dept. Psychology, University of Connecticut, Storrs, CT
8. Title: Modulation of heterosynaptic plasticity by adenosine receptors in the rat neocortex in vitro
Authors: N.M. BANNON, M. CHISTYAKOVA, M. VOLGUSHEV;
Dept. Psychology, University of Connecticut, Storrs, CT
9. Title: The ability of orally ingested curcumin to attenuate shifts in effort-related choice behavior
induced by the VMAT-2 inhibitor tetrabenazine
Authors: S.E. YOHN1, A. MISTRY1, S. COLLINS1, L. XIE2, A. MANCHANDA3, B. BOLLING2, R.
BOGNER3, Merce CORREA1,4, J.D. SALAMONE1;
1
Behavioral Neuroscience Division, Dept. Psychology, University of Connecticut, Storrs, CT, 2Dept.
Nutritional Sciences, University of Connecticut, Storrs, CT, 3Dept. Pharmaceutical Sciences,
University of Connecticut, Storrs, CT, and 4Dept. Psychology, University Jaume I, Castello, Spain
5
10. Title: Human conditioned place preference using secondary reinforcers
Authors: *R.S. ASTUR, A. PALMISANO, A. CAREW, B. DEATON, F. KUHNEY, R. NIEZRECKI, E.
HUDD, K. MENDICINO, C. RITTER;
Dept. of Psychology, University of Connecticut, Storrs, CT
11. Title: Electrophysiological characterization of CRISPR induced mutations in epilepsy associated
genes (Scn1a and Chd2) in mice by In-Utero Electroporation.
Authors: R.U. GOZ1, J.J. LOTURCO2, A.V. TSINGOUNIS2;
1
Dept. Psychology, and 2Dept. Physiology and Neurobiology, University of Connecticut, Storrs, CT
12. Title: The role of histone methylation in oligodendrocyte progenitor cell fate
Authors: *K.D. PATEL1, A. NISHIYAMA;
Dept. Physiology and Neurobiology, University of Connecticut, Storrs, CT
13. Title: Auditory network optimized for sound discrimination predicts hierarchical trends of the
auditory system
Authors: F. KHATAMI1, M. A. ESCABI1,2;
1
Dept. Biomedical Engineering, and 2Dept. Electrical Engineering, University of Connecticut, Storrs,
CT.
14. Title: Deep sequencing of the developing mouse retina revealed shifts in molecular programs
augmented by alternative splicing
Authors: D.K.P. KARUNAKARAN1, S. AL SEESI2, A.R. BANDAY1, M. BAUMGARTNER1, A.
OLTHOF1, C. LEMOINE1, I. MANDOIU2, R. KANADIA1;
1
Dept. Physiology and Neurobiology, and 2Dept. Computer Science and Engineering, University of
Connecticut, Storrs, CT
15. Title: Dopamine and serotonin in effort-related decision making: The antidepressant fluoxetine
potentiates effort-related impairments induced by the dopamine depleting agent tetrabenazine
Authors: *M.A. ROWLAND1, H.M. CONTRERAS1, S.E. YOHN1, M.I. CORREA,2 J.D. SALAMONE1
1
Dept. of Psychology, University of Connecticut, Storrs, CT and 2Department of Psicobiology,
University Jaume I Castelló, Spain.
16. Title: Calcium-dependent activation of Arf G-proteins by BRAG1, a protein associated with
intellectual disability
Authors: M.L. Himelright, R.S. Walikonis;
Dept. Physiology and Neurobiology, University of Connecticut, Storrs, CT
17. Title: In vivo analysis of the myelinogenic potential of iPS cells derived from primary progressive
multiple sclerosis patients
Authors: A. NICAISEi1, E. BANDA1, A. LO2, S. CROCKER1;
1
Dept. Neuroscience, University of Connecticut Health Center, Farmington, CT and 2The Mandell
MS Center, St. Francis Hospital, Hartford, CT.
18. Title: Impact of age and chronic ketamine treatment on parvalbumin expression in rats: Evidence
for variation in protein expression
Authors: *J.A. CORRIVEAU, C. MCMAHON, J.J. CHROBAK;
Dept. Psychology, University of Connecticut, Storrs, CT
19. Title: Temporal sequence learning by rats in a radial arm water maze
Authors: *S. LEE1, B. TIMMERMAN1, V. WICKENHEISSER1, S. PATEL1, E.J. MARKUS1;
1
Dept. Psychology, University of Connecticut, Storrs, CT.
6
20. Title: Stimulation in Inferior Colliculus for Improved Auditory Midbrain Implant
Authors: L. DULUC1, K. DUTTA2, A. NORRIS2, M. ESCABI1,2, H. READ1,2
1
Dept. Psychology, 2School of Engineering, University of Connecticut, Storrs, CT
21.Title: Spike-timing precision encodes sound envelope shape in ventral auditory cortical fields
Authors: *C.M. LEE1, A. OSMAN2, M. A. ESCABI2,3, H. L. READ1,2;
1
Dept. Psychology, 2Dept. Biomedical Engineering, and 3Dept. Electrical and Computer Engineering,
University of Connecticut, Storrs, CT
22. Title: Visual processing in V1 by fast and slow corticogeniculate neurons: axonal conduction
time matters
Authors:*Y.I. BERESHPOLOVA1, C.R. STOELZEL1, J. ZHUANG1, J.-M. ALONSO2,1, H.A.
SWADLOW 1,2;
1
Dept. Psychology, University of Connecticut, Storrs, CT and 2Dept. of Biological and Vision
Sciences, SUNY College of Optometry, New York, NY
23. Title: Long lasting modulation of excitability and synaptic dynamics in the awake geniculocortical
system
Authors: *C.R. STOELZEL1, J. HUFF1, Y. BERESHPOLOVA1, J. ZHUANG1, X. HEI1, J.-M.
ALONSO2,1, H.A. SWADLOW 1,2;
1
Dept. Psychology, University of Connecticut, Storrs, CT and 2Biological and Vision Sciences, SUNY
College of Optometry, New York, NY
24. Title: Brain state modulation of directional selective neurons in the awake LGN
Authors: *X. HEI1, C. R. STOELZEL1, J. ZHUANG1, Y. BERESHPOLOVA1, J. HUFF1, J.-M.
ALONSO2,1, H.A. SWADLOW 1,2;
1
Dept. Psychology, University of Connecticut, Storrs, CT and 2Dept. Biological and Vision Sciences,
SUNY College of Optometry, New York, NY
25. Title: Identification and analysis of astrocytic exosomes and their regulation during CNS
inflammation
Authors: C. WILLIS1*, K. JOHNSON1, E. JELLISON2, A. MENORET2, A. VELLA2, S. J. CROCKER1;
Departments of Neuroscience1 and Immunology2, University of Connecticut Health Center,
Farmington, CT
26. Title: Electrophysiological characterization of CRISPR induced mutations in epilepsy associated
genes (Scn1a and Chd2) in mice by in-utero electroporation
Authors: R.U. GOZ1, A.V. Tzingounis2, J.J. LOTURCO2;
1
Dept. Psychology and 2Dept. Physiology and Neurobiology, University of Connecticut, Storrs, CT
27. Title: Evaluation of new inverse agonists of the cannabinoid receptor one
Authors: S. GRAF1,2, K.H. AHN2, R. ABROL3,4, C. SCOTT4, W. GODDARD4 and D.A. KENDALL2;
1
Dept. Healthcare Management, University of Connecticut, Storrs, CT, 2Dept. Pharmaceutical
Sciences, University of Connecticut, Storrs, CT, 3Dept. Medicine, Cedars-Sinai Medical Center, Los
Angeles, CA and 4Dept. of Chemistry and Chemical Engineering, California Institute of Technology,
Pasadena, CA
28. Title: Blockade of NMDA Receptor affects proliferation and differentiation of human cortical
progenitors
Authors: I. BAGASRAWALA, N. RADONJIC, N. ZECEVIC;
Dept. Neuroscience, University Connecticut Health Center Health, Farmington, CT
7
29. Title: Improvement of the treatment of neurodegenerative diseases through applications of
nanotechnology and drug delivery
Authors: K. GRASSIE, L. MURPHY, D. PEDRICK, and S. VETRANO;
Dept. Biomedical Engineering, University of Connecticut, Storrs, CT
30. Title: Novel acoustic stimuli can alter locomotor speed-theta relationship across the
septotemporal axis of the hippocampus
Authors: *L. L. LONG1, A. A. NORRIS2, J. R. HINMAN3, C.-M. CHEN1, I. H. STEVENSON1, H. L.
READ1,2, M. A. ESCABI2, J. J. CHROBAK1;
1
Dept Psychology, 2Dept. Biomedical Engineering, Univ. of Connecticut, Storrs, CT and 3Ctr. for
Memory and Brain, Dept. Psychology, Boston Univ., Boston, MA
31. Title: Sound response properties of the optgenetically identified GABAergic neurons in the
inferior colliculus (IC) of mouse
Authors: M. ONO, D.C .BISHOP, D.L. OLIVER;
University of Connecticut Health Center, Farmington, CT
32. Title: Multiple functional areas exist within Te1 auditory cortex in rat.
Authors: K. J. DUTTA1, D. A. STORACE1,2, D. C. BISHOP1,2, N.C. HIGGINS1,2, D.L. OLIVER1,2,
H.L. READ1,2;
1
Dept. Psychology and 2Dept Biomedical Engineering, University of Connecticut, Storrs, CT
33. Title: Contribution of connexin hemichannels in the generation of spontaneous electrical activity
in the developing cortex
Authors: M.B. Singh, S. D. Antic;
Dept. Neuroscience, University Connecticut Health Center, Farmington, CT
34. Title: Dyx1c1 is essential for ciliary dynein assembly
Authors: A.Tarkar*, J. LoTurco;
Dept. Physiology and Neurobiology, University of Connecticut, Storrs, CT
35. Title: Disordered breathing in a mouse model of ischemic stroke
Authors: A. Patrizz13, A. Kolb3, D.l. Mulkey3, L.D. McCullough1,2;
Dept. Neuroscience,1 Dept. Neurology,2 University of Connecicut Health Center, Farmington, CT and
Dept. Physiology and Neurobiology, 3 University of Connecticut, Storrs, CT
36. Title: Effects of pitch input to monolingual infants on later word production
Authors: A.l. Dwyer1, K. Porter1, B. Sakowicz1, J. Fromson1, A. Garcia-Sierra1,3, N. RamirezEsparza2 P. Kuhl3;
1
Dept. Speech, Language and Hearing Sciences, 2Dept. Psychology, University of Connecticut,
Storrs, CT and 3Dept. Speech and Hearing Sciences, University of Washington, Seattle, WA
37. Title: A multifaceted therapeutic approach towards cerebral palsy
Authors: *T. COTTON, K. GAILIUNAS, D.HONG, S. ZAMAN;
Dept. Biomedical Engineering, University of Connecticut, Storrs, CT
Title: EphA4 signaling regulates tangential migration of neuronal precursors
Authors: *M.B. EASTMAN1, K.A. BAKER1, N.B. GALLO, J.C. CONOVER1,2;
1
Dept. Physiology and Neurobiology and 2Stem Cell Institute, University of Connecticut, Storrs, CT
38. Title: EEG Mu rhythm in infancy: a frequency band analysis
Authors: L.J. BRYANT, K. VALERIO, K. CUEVAS;
Dept. Psychology, University of Connecticut, Waterbury, CT
8
39. Title: A multifaceted therapeutic approach towards cerebral palsy
Authors: *T. COTTON1, K. GAILIUNAS, D.HONG, S. ZAMAN;
Dept. Biomedical Engineering, University of Connecticut, Storrs, CT
40. Title: A relationship of voice onset time of bilingual caregivers when speaking English and
Spanish to their infant and its effects on later word production
Authors: R. ALBINO1, A. MAULE1, A. NELSON1, M. EYDELMAN1, A. GARCIA-SIERRA1,2;
1
University of Connecticut Storrs, Connecticut and 2Institute for Learning and Brain Sciences,
University of Washington, Seattle, WA
41. Title: Gender-specific multidrug-resistance transporter expression in choroid plexus
Authors: *K.M. FLORES1, J.L. RENFRO1, J. MANAUTOU2, A.M. BATAILLE2, S. PARKER1;
1
Dept. Physiology and Neurobiology and 2Dept. Pharmacology and Toxicology, University of
Connecticut, Storrs, CT
42. Title: The Relationship Between Bilingual Caregivers' VOT Production and Infant Speech
Discrimination
Authors: P. ACHUKA1, M. DWYER1, A. FISCHL1, S. KHAN2, A. GARCIA-SIERRA1;
1
Dept. Speech-Language-Hearing Sciences and 2Dept. Psychology, University of Connecticut,
Storrs, CT
43. Title: Repeated concussions cause region-specific cellular changes in mouse models
Authors: R. ACABCHUK1, R. WOLFERZ Jr1, M. STERN1, Y. LIANG1, M. SOLOWAY1, D. KUHN3, J.
CONOVER1,2;
1
Dept. of Physiology and Neurobiology, 2 Stem Cell Institute, University of Connecticut, Storrs, CT
and 3Wayne State University, Detroit, MI
44. Title: Brain computer interfaces - signal acquisition enhancement
Authors: C. BAUTISTA-BORRERO, B. QERIQI, S. SCHMIDT, D.l. YASOSHIMA;
Dept. Biomedical Engineering, University of Connecticut, Storrs, CT
45. Title: Selective loss of KCNQ2 channels from cortical L2/3 leads to pyramidal neuron
hyperexcitability
Authors: Z.P. NIDAY, H. SOH, and A. TZINGOUNIS
Dept. Physiology and Neurobiology, University of Connecticut, Storrs, CT
46. Title: Reprogramming of NG2 cells into neurons by transcription factor Dlx2
Authors: L. BOSHANS1, K. PATEL1, D. FACTOR2, P. TESAR2, A. NISHIYAMA1;
1
Dept. Physiology and Neurobiology, University of Connecticut, Storrs, CT and 2Dept. Genetics and
Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH
47. Title: Neuroprosthetics utilized to accomplish everyday goals
Authors: N. FARRELL, L. MATTAR, C. MILLS, N. PACHECO;
Dept. Biomedical Engineering, University of Connecticut, Storrs, CT
48. Title: Nano-engineered microglia and anti-inflammatory drug introduced into damaged nervous
tissue via hydrogel capsules
Authors: R. ELLER, G. LI, S. ELBKHAR;
Dept. Biomedical Engineering, University of Connecticut, Storrs, CT
9
49.Title: Effects of monoamine oxidase inhibitors in effort-related decision making and its potential
of reversing the effort-related impairments induced by DA depleting agent tetrabenazine
Authors: H. M. CONTRERAS-MORA1, M. A. ROWLAND1, S. E. YOHN1, M. W. JONES1, M.
CORREA2,1, J. D. SALAMONE1;
1
Psychology, Univ. of Connecticut, Storrs, CT and 2Psychobiology, Univ. Jaume I, Castello, Spain
10

Download Report