rd 3 International Conference on Immune Tolerance | Oral Programme Oral Programme th Sunday 28 September 2014 11:00 Registration Desk Opens 13:00 -13:15 Opening Remarks Plenary Session 1: Immune Homeostasis | Location: The Grand Ballroom Session Chair: F. Geissmann 13:15-13:50 [IS1.1] Transcriptional control of autoimmunity and immune homeostasis N. Restifo, National Institutes of Health (NIH), USA 13:50-14:25 [IS1.2] Macrophage identities and in vivo functions F. Geissmann, King's College, UK 14:25-15:00 [IS1.3] Molecular and cellular mechanisms of differentiation and function of regulatory T cells A. Rudensky, Memorial Sloan-Kettering Cancer Center, USA 15:00-15:15 [O1.1] Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection and promote effector cell resistance to Treg cells in inflammatory disease 1 ,2 1 ,2 1 ,2 2 1 D.J. Campbell* , S. Srivastava , M.A. Koch , M. Pepper , Benaroya Research Institute, USA, 2 University of Washington, USA [O1.2] HIV infection of human regulatory T cells (Treg) downregulates Foxp3 expression and produces a loss of the suppressive capacity of these cells J. López-Abente, D. Jaramillo-Ruiz, M. Martínez-Bonet, M. Pion*, M.A. Muñoz-Fernández, R. CorreaRocha, Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Spain 15:15-15:30 15:30-15:45 15:45-16:15 + [O1.3] Increased frequencies of insulin-specific Foxp3 Tregs in islet-autoantibody positive children associate with slow progression to Type 1 Diabetes 1 2 1 2 2 3 2 I. Serr , P. Achenbach , F. Goekmen , A. Knopff , F. Haupt , R. Willis , A-G. Ziegler , C. 1 1 2 Daniel* , Helmholtz Zentrum Muenchen, Germany, Helmholtz Zentrum Muenchen GmbH, Germany, 3 Emory University, USA Coffee Break Plenary Session 2 : Immune Modulation of Tumors | Location: The Grand Ballroom Session Chair: G. Kroemer 16:15-16:50 [IS2.1] Myeloid-dependent tolerance: Cells and molecular mechanisms V. Bronte, Verona University Hospital, Italy 16:50-17:25 [IS2.2] Autophagy in tumor cells: Shaping natural and therapy-induced immunosurveillance 1 ,2 1 2 3 G. Kroemer , University of Paris Descartes, France, Institut Gustave Roussy, France, Hopital Européen George Pompidou, France 17:25-17:40 [O2.1] Induction of transplantation tolerance by engraftment of mismatched donor stem cells followed by deletion of donor- and host-reactive T cells for safer organ transplantation and posttransplant immunotherapy of cancer by activated donor NK cells S. Slavin*, C. Brodie, International Center for Cell Therapy & Cancer Immunotherapy (CTCI), Israel 17:40-17:55 [O2.2] CD45-mediated TCR tuning of naïve and memory CD8 T cells 1 ,2 1 ,2 1 ,2 1 1 J-H. Cho , H-O. Kim , C.D. Surh , J. Sprent* , Garvan Institute of Medical Research, Australia, 2 Academy of Immunology and Microbiology, Republic of Korea 17:55-18:10 [O2.3] T-cell regulation by the CD52-HMGB1-Siglec-10 trimolecular complex 1 2 1 1 1 2 E. Bandala-Sanchez* , N.L. Stone , T.L. Adams , L.C. Harrison , WEHI, Australia, CSIRO, Australia rd 3 International Conference on Immune Tolerance | Oral Programme 18:10- 19:30 Welcome Drinks Reception & Poster Viewing Session 1 | Location: Wintergarden th Monday 29 September 2014 Plenary Session 3: Central nervous system-targeted autoimmunity | Location: The Grand Ballroom Session Chair: J. Goverman 8:30-9:05 [IS3.1] The role of TH1 and TH17 cells in shaping neuroinflammatory patterns in EAE and MS J. Goverman*, M. Johnson, E. Pierson, S. Simmons, University of Washington, USA 09:05-09:40 [IS3.2] Functional analysis of the role of IL-17 in CNS autoimmunity T. Regen, N. Yogev, I. Mufazalov, A. Waisman*, University of Mainz, Germany 09:40-09:55 [O3.1] The pathogenic role of CD20+ B cells analyzed in a non-human primate EAE model 1 ,2 1 1 1 1 ,3 1 B.A. 't Hart* , K. Dijkman , S. Hofman , S.A. Jagessar , Y.S. Kap , BPRC, Rijswijk, The Netherlands, 2 3 University of Groningen, Groningen, The Netherlands, Erasmus Medical Center, The Netherlands 09:55-10:10 [O3.2] A forebrain-immune cell pathway for the maintenance of CNS immune tolerance 1 1 2 1 1 3 1 M.G. Mohammad , V.V.W. Tsai , M.J. Ruitenberg , M. Hassanpour , H. Li , P.H. Hart , S.N. Breit , P.E. 4 1 ,4 1 Sawchenko , D.A. Brown* , St Vincent’s Centre for Applied Medical Research and University of New 2 3 South Wales, Australia, The University of Queensland, Australia, Telethon Institute for Child Health 4 Research, University of Western Australia, Australia, The Salk Institute for Biological Studies, USA 10:10–10:40 Coffee Break | Location: Wintergarden Plenary Session 4: Tissue-specific autoimmunity: interplay of immune effector and tissue resident cells | Location: The Grand Ballroom Session Chair: N. Sarvetnick 10:40-11:15 [IS4.1] How T cells instruct myeloid cells in autoimmune disease B. Becher, University of Zurich, Switzerland 11:15-11:50 [IS4.2] Altered immune homeostasis in human T1D R. Harms, K. Lorenzo- Arteaga, N. Sarvetnick*, University of Nebraska Medical Center, USA 11:50-12:05 Antigen-specific immunoregulation by IL-35Ig-transfected dendritic cells M.L. Belladonna*, C. Volpi, M. Gargaro, A. De Luca, R. Bianchi, F. Fallarino, C. Orabona, G. Mondanelli, U. Grohmann, P. Puccetti, University of Perugia, Italy 12:05-12:20 DC-10 are central determinants in HLA-G-mediated tolerance 1 1 1 1 ,3 2 1 1 G. Amodio , M. Comi , A. Mugione , M.G. Roncarolo , P. Panina , S. Gregori* , San Raffaele Telethon 2 3 Institute for Gene Therapy (HSR-TIGET), Italy, IRCCS Ospedale San Raffaele, Italy, Vita-Salute San Raffaele University, Italy 12:20-12:35 A role for exhausted-like T cells in CD3 antibody-induced allotolerance 1 ,2 1 ,3 1 ,2 1 ,2 1 ,2 1 ,2 1 ,2 S. You* , M. Baas , A. Besançon , T. Goncalves , F. Valette , E. Waeckel-Enée , B. Sawitzki , H. 4 5 1 ,2 1 2 Yagita , P. Van Endert , L. Chatenoud , Institut Necker-Enfants Malades, France, Université Paris 3 4 Descartes, France, Radboud University Medical Centre, The Netherlands, Institute of Medical 5 Immunology, Germany, Juntendo University, Japan 12:35 -13:35 Lunch | Location: Wintergarden 13:35-14:35 Poster Session 2 (& lunch continued) | Location: Wintergarden Plenary Session 5: B cell differentiation pathways and disease susceptibility | Location: The Grand Ballroom Session Chair: B. Diamond 14:35-15:10 [IS5.1] Blimp-1 and SLE 1 1 2 2 1 B. Diamond* , S.J. Kim , S. Schaetzle , G. Georgiou , The Feinstein Institute for Medical Research, USA, 2 The University of Texas at Austin, USA rd 3 International Conference on Immune Tolerance | Oral Programme 15:10-15:45 [IS5.2] T cell activation, migration, and immune regulation 1 1 1 1 1 ,2 1 1 C. Basso , F. Ronchi , L. Perlini , S. Preite , A. Lanzavecchia , F. Sallusto* , Università della Svizzera 2 Italiana, Italy, ETH Zurich, Switzerland 15:45-16:00 [O5.1] Decreased activation-induced TIM+ and IL-10+ B cells in systemic sclerosis patients 1 1 1 1 1 1 1 1 ,2 O. Aravena* , A. Ferrier , E. Fonseca , P. Vega , J. Berendsen , K. Pino-Lagos , J.C. Aguillón , L. Soto , D. 1 1 Catalán , Universidad de Chile and Millennium Institute on Immunology and Immunotherapy, Chile, 2 Universidad de Chile, Chile 16:00-16:30 Coffee Break | Location: Wintergarden Plenary Session 5 Cont. B cell differentiation pathways and disease susceptibility | Location: The Grand Ballroom Session Chair: B. Diamond 16:30-17:05 [IS5.3] MicroRNA-mediated repression of T follicular helper cells and germinal centers A. Pratama, M. Srivastava, N. Williams, I. Papa, S. Lee, X.T. Dinh, W. Ouyang, A. Hutloff, M. Jordan, J. Zhao, R. Casellas, V. Athanasopoulos, C. Vinuesa*, Australian National University, Australia 17:05-17:20 [O5.2] Innate pro-B cell progenitors activated via TLR-9 protect against ongoing experimental autoimmune encephalomyelitis 1 1 1 2 3 1 1 S. Korniotis , R. Montandon , C. Gras , S. Luther , S. Fillatreau , F. Zavala* , Necker Enfants Malades 2 3 Institute, France, Lausanne University, Switzerland, Deutsches Rheuma-Forschungszentrum Berlin, Germany Gala Dinner (optional – tickets can be purchased) | Location: The Five Flies 19:00-22:00 th Tuesday 30 September 2014 Plenary Session 6: Transplant rejection and engraftment | Location: The Grand Ballroom Session Chair: F.H.J Claas 8:30 -9:05 [IS6.1] Mechanisms of Allograft Tolerance Achieved with Hematopoietic Cell Transplantation 1 1 1 2 3 1 1 1 M. Sykes* , S. DeWolf , T. Kawai , H. Morris , H. Robins , Y. Shen , B. Sprangers , Columbia University, 2 3 USA, Harvard Medical School, USA, Fred Hutchinson Cancer Research Center, USA 09:05-09:40 [IS6.2] Pregnancy as a model for transplantation tolerance F.H.J Claas, Leiden University Medical Center, The Netherlands 09:40-09:55 [O6.1] CGEN-15001, a novel immunemodulatory Fc fusion protein is efficacious in models of autoimmune diseases and induces immune tolerance 1 1 1 1 2 2 3 3 I. Hecht* , I. Vaknin , G. Rotman , E. Neria , A. Keren , A. Gilhar , K. Mcnamee , R. Williams , S.D. 4 4 1 2 3 Miller , J.R. Podojil , Compugen Ltd., Israel, Technion Institute of Technology, Israel, University of 4 Oxford, UK, Northwestern University, USA 09:55-10:10 [O6.2] In vivo enrichment of regulatory T cells by targeting the intrinsic apoptosis pathway to induce mixed chimerism and transplantation tolerance 1 ,2 1 ,2 3 2 1 2 S.S. Gabriel* , J. Chen , T. Fehr , P.E. Cippà , University of Zurich, Switzerland, University Hospital 3 Zurich, Switzerland, Cantonal Hospital Graubunden, Switzerland 10:10-10:40 Coffee Break | Location: Wintergarden Plenary Session 7: Next Generation immune-based therapies | Location: The Grand Ballroom Session Chair: J. Bluestone 10:40-11:15 [IS7.1] T regulatory type 1 (Tr1) cells: from bench to bedside and back 1 1 2 M.G. Roncarolo , San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Italy, Vita-Salute San Raffaele University, Italy 11:15-11:50 [IS7.2] The multifunctional ‘T-Body' approach: Redirects Teff to reject tumors and Treg to suppress inflammatory responses 1 ,2 1 2 Z. Eshhar , The Weizmann Institute, Israel, Tel Aviv Sourasky Medical Center, Israel rd 3 International Conference on Immune Tolerance | Oral Programme 11:50-12:25 [IS7.3] Rebalancing the immune system through Treg biology 1 1 2 2 1 1 1 1 J. Bluestone* , E. Trotta , N. Crellins , I. Rondon , K. Lee , A. Putnam , W. Liu , M. Lee , Q. 1 1 2 Tang , University of California, USA, Pfizer-CTI, USA 12:25-12:40 [O7.1] MARCO-targeting carboxylated PLG nanoparticles promote therapeutic tolerance induction and suppression of inflammatory monocytes S.D. Miller*, Z.N. Hunter, D. McCarthy, C. Harp, R. Terrry, S. Prasad, W. Yap, N.J.C. King, L. Shea, D. Getts, Northwestern University Medical School, USA 12:40-12:55 [O7.2] Generation and functional properties of engineered antigen-specific human T regulatory cells to suppress anti-FVIII responses in hemophilia A 1 1 1 2 1 1 Y.C. Kim , A.H. Zhang , K.P. Pratt , E.M. Shevach , D.W. Scott* , Uniformed Services University of the 2 Health Sciences, USA, National Institute of Allergy & Infectious Diseases, National Institutes of Health, USA [O7.3] Tolerogenic synthetic nanoparticles for the prevention of anti-drug antibodies 1 1 1 1 1 1 2 T.K. Kishimoto* , R.A. Maldonado , R. LaMothe , J.D. Ferrari , A. Griset , C. O'Neil , A.H. Zhang , R.J. 2 1 1 1 2 Rossi , D. Altreuter , L. Johnston , Selecta Biosciences, USA, Uniformed Services University, USA, 3 Harvard Medical School, USA 12:55-13:10 13:10-13:15 Closing Remarks 13:15 End of Conference
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