rd
3 International Conference on Immune Tolerance | Oral Programme
Oral Programme
th
Sunday 28 September 2014
11:00
Registration Desk Opens
13:00 -13:15
Opening Remarks
Plenary Session 1: Immune Homeostasis | Location: The Grand Ballroom
Session Chair: F. Geissmann
13:15-13:50
[IS1.1] Transcriptional control of autoimmunity and immune homeostasis
N. Restifo, National Institutes of Health (NIH), USA
13:50-14:25
[IS1.2] Macrophage identities and in vivo functions
F. Geissmann, King's College, UK
14:25-15:00
[IS1.3] Molecular and cellular mechanisms of differentiation and function of regulatory T cells
A. Rudensky, Memorial Sloan-Kettering Cancer Center, USA
15:00-15:15
[O1.1] Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses
during acute LCMV infection and promote effector cell resistance to Treg cells in inflammatory
disease
1 ,2
1 ,2
1 ,2
2 1
D.J. Campbell* , S. Srivastava , M.A. Koch , M. Pepper , Benaroya Research Institute, USA,
2
University of Washington, USA
[O1.2] HIV infection of human regulatory T cells (Treg) downregulates Foxp3 expression and produces
a loss of the suppressive capacity of these cells
J. López-Abente, D. Jaramillo-Ruiz, M. Martínez-Bonet, M. Pion*, M.A. Muñoz-Fernández, R. CorreaRocha, Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Spain
15:15-15:30
15:30-15:45
15:45-16:15
+
[O1.3] Increased frequencies of insulin-specific Foxp3 Tregs in islet-autoantibody positive children
associate with slow progression to Type 1 Diabetes
1
2
1
2
2
3
2
I. Serr , P. Achenbach , F. Goekmen , A. Knopff , F. Haupt , R. Willis , A-G. Ziegler , C.
1 1
2
Daniel* , Helmholtz Zentrum Muenchen, Germany, Helmholtz Zentrum Muenchen GmbH, Germany,
3
Emory University, USA
Coffee Break
Plenary Session 2 : Immune Modulation of Tumors | Location: The Grand Ballroom
Session Chair: G. Kroemer
16:15-16:50
[IS2.1] Myeloid-dependent tolerance: Cells and molecular mechanisms
V. Bronte, Verona University Hospital, Italy
16:50-17:25
[IS2.2] Autophagy in tumor cells: Shaping natural and therapy-induced immunosurveillance
1 ,2 1
2
3
G. Kroemer , University of Paris Descartes, France, Institut Gustave Roussy, France, Hopital
Européen George Pompidou, France
17:25-17:40
[O2.1] Induction of transplantation tolerance by engraftment of mismatched donor stem cells
followed by deletion of donor- and host-reactive T cells for safer organ transplantation and posttransplant immunotherapy of cancer by activated donor NK cells
S. Slavin*, C. Brodie, International Center for Cell Therapy & Cancer Immunotherapy (CTCI), Israel
17:40-17:55
[O2.2] CD45-mediated TCR tuning of naïve and memory CD8 T cells
1 ,2
1 ,2
1 ,2
1 1
J-H. Cho , H-O. Kim , C.D. Surh , J. Sprent* , Garvan Institute of Medical Research, Australia,
2
Academy of Immunology and Microbiology, Republic of Korea
17:55-18:10
[O2.3] T-cell regulation by the CD52-HMGB1-Siglec-10 trimolecular complex
1
2
1
1 1
2
E. Bandala-Sanchez* , N.L. Stone , T.L. Adams , L.C. Harrison , WEHI, Australia, CSIRO, Australia
rd
3 International Conference on Immune Tolerance | Oral Programme
18:10- 19:30
Welcome Drinks Reception & Poster Viewing Session 1 | Location: Wintergarden
th
Monday 29 September 2014
Plenary Session 3: Central nervous system-targeted autoimmunity | Location: The Grand Ballroom
Session Chair: J. Goverman
8:30-9:05
[IS3.1] The role of TH1 and TH17 cells in shaping neuroinflammatory patterns in EAE and MS
J. Goverman*, M. Johnson, E. Pierson, S. Simmons, University of Washington, USA
09:05-09:40
[IS3.2] Functional analysis of the role of IL-17 in CNS autoimmunity
T. Regen, N. Yogev, I. Mufazalov, A. Waisman*, University of Mainz, Germany
09:40-09:55
[O3.1] The pathogenic role of CD20+ B cells analyzed in a non-human primate EAE model
1 ,2
1
1
1
1 ,3 1
B.A. 't Hart* , K. Dijkman , S. Hofman , S.A. Jagessar , Y.S. Kap , BPRC, Rijswijk, The Netherlands,
2
3
University of Groningen, Groningen, The Netherlands, Erasmus Medical Center, The Netherlands
09:55-10:10
[O3.2] A forebrain-immune cell pathway for the maintenance of CNS immune tolerance
1
1
2
1
1
3
1
M.G. Mohammad , V.V.W. Tsai , M.J. Ruitenberg , M. Hassanpour , H. Li , P.H. Hart , S.N. Breit , P.E.
4
1 ,4 1
Sawchenko , D.A. Brown* , St Vincent’s Centre for Applied Medical Research and University of New
2
3
South Wales, Australia, The University of Queensland, Australia, Telethon Institute for Child Health
4
Research, University of Western Australia, Australia, The Salk Institute for Biological Studies, USA
10:10–10:40
Coffee Break | Location: Wintergarden
Plenary Session 4: Tissue-specific autoimmunity: interplay of immune effector and tissue resident cells | Location:
The Grand Ballroom
Session Chair: N. Sarvetnick
10:40-11:15
[IS4.1] How T cells instruct myeloid cells in autoimmune disease
B. Becher, University of Zurich, Switzerland
11:15-11:50
[IS4.2] Altered immune homeostasis in human T1D
R. Harms, K. Lorenzo- Arteaga, N. Sarvetnick*, University of Nebraska Medical Center, USA
11:50-12:05
Antigen-specific immunoregulation by IL-35Ig-transfected dendritic cells
M.L. Belladonna*, C. Volpi, M. Gargaro, A. De Luca, R. Bianchi, F. Fallarino, C. Orabona, G. Mondanelli,
U. Grohmann, P. Puccetti, University of Perugia, Italy
12:05-12:20
DC-10 are central determinants in HLA-G-mediated tolerance
1
1
1
1 ,3
2
1 1
G. Amodio , M. Comi , A. Mugione , M.G. Roncarolo , P. Panina , S. Gregori* , San Raffaele Telethon
2
3
Institute for Gene Therapy (HSR-TIGET), Italy, IRCCS Ospedale San Raffaele, Italy, Vita-Salute San
Raffaele University, Italy
12:20-12:35
A role for exhausted-like T cells in CD3 antibody-induced allotolerance
1 ,2
1 ,3
1 ,2
1 ,2
1 ,2
1 ,2
1 ,2
S. You* , M. Baas , A. Besançon , T. Goncalves , F. Valette , E. Waeckel-Enée , B. Sawitzki , H.
4
5
1 ,2 1
2
Yagita , P. Van Endert , L. Chatenoud , Institut Necker-Enfants Malades, France, Université Paris
3
4
Descartes, France, Radboud University Medical Centre, The Netherlands, Institute of Medical
5
Immunology, Germany, Juntendo University, Japan
12:35 -13:35
Lunch | Location: Wintergarden
13:35-14:35
Poster Session 2 (& lunch continued) | Location: Wintergarden
Plenary Session 5: B cell differentiation pathways and disease susceptibility | Location: The Grand Ballroom
Session Chair: B. Diamond
14:35-15:10
[IS5.1] Blimp-1 and SLE
1
1
2
2 1
B. Diamond* , S.J. Kim , S. Schaetzle , G. Georgiou , The Feinstein Institute for Medical Research, USA,
2
The University of Texas at Austin, USA
rd
3 International Conference on Immune Tolerance | Oral Programme
15:10-15:45
[IS5.2] T cell activation, migration, and immune regulation
1
1
1
1
1 ,2
1 1
C. Basso , F. Ronchi , L. Perlini , S. Preite , A. Lanzavecchia , F. Sallusto* , Università della Svizzera
2
Italiana, Italy, ETH Zurich, Switzerland
15:45-16:00
[O5.1] Decreased activation-induced TIM+ and IL-10+ B cells in systemic sclerosis patients
1
1
1
1
1
1
1
1 ,2
O. Aravena* , A. Ferrier , E. Fonseca , P. Vega , J. Berendsen , K. Pino-Lagos , J.C. Aguillón , L. Soto , D.
1 1
Catalán , Universidad de Chile and Millennium Institute on Immunology and Immunotherapy, Chile,
2
Universidad de Chile, Chile
16:00-16:30
Coffee Break | Location: Wintergarden
Plenary Session 5 Cont. B cell differentiation pathways and disease susceptibility | Location: The Grand Ballroom
Session Chair: B. Diamond
16:30-17:05
[IS5.3] MicroRNA-mediated repression of T follicular helper cells and germinal centers
A. Pratama, M. Srivastava, N. Williams, I. Papa, S. Lee, X.T. Dinh, W. Ouyang, A. Hutloff, M. Jordan, J.
Zhao, R. Casellas, V. Athanasopoulos, C. Vinuesa*, Australian National University, Australia
17:05-17:20
[O5.2] Innate pro-B cell progenitors activated via TLR-9 protect against ongoing experimental
autoimmune encephalomyelitis
1
1
1
2
3
1 1
S. Korniotis , R. Montandon , C. Gras , S. Luther , S. Fillatreau , F. Zavala* , Necker Enfants Malades
2
3
Institute, France, Lausanne University, Switzerland, Deutsches Rheuma-Forschungszentrum Berlin,
Germany
Gala Dinner (optional – tickets can be purchased) | Location: The Five Flies
19:00-22:00
th
Tuesday 30 September 2014
Plenary Session 6: Transplant rejection and engraftment | Location: The Grand Ballroom
Session Chair: F.H.J Claas
8:30 -9:05
[IS6.1] Mechanisms of Allograft Tolerance Achieved with Hematopoietic Cell Transplantation
1
1
1
2
3
1
1 1
M. Sykes* , S. DeWolf , T. Kawai , H. Morris , H. Robins , Y. Shen , B. Sprangers , Columbia University,
2
3
USA, Harvard Medical School, USA, Fred Hutchinson Cancer Research Center, USA
09:05-09:40
[IS6.2] Pregnancy as a model for transplantation tolerance
F.H.J Claas, Leiden University Medical Center, The Netherlands
09:40-09:55
[O6.1] CGEN-15001, a novel immunemodulatory Fc fusion protein is efficacious in models of
autoimmune diseases and induces immune tolerance
1
1
1
1
2
2
3
3
I. Hecht* , I. Vaknin , G. Rotman , E. Neria , A. Keren , A. Gilhar , K. Mcnamee , R. Williams , S.D.
4
4 1
2
3
Miller , J.R. Podojil , Compugen Ltd., Israel, Technion Institute of Technology, Israel, University of
4
Oxford, UK, Northwestern University, USA
09:55-10:10
[O6.2] In vivo enrichment of regulatory T cells by targeting the intrinsic apoptosis pathway to induce
mixed chimerism and transplantation tolerance
1 ,2
1 ,2
3
2 1
2
S.S. Gabriel* , J. Chen , T. Fehr , P.E. Cippà , University of Zurich, Switzerland, University Hospital
3
Zurich, Switzerland, Cantonal Hospital Graubunden, Switzerland
10:10-10:40
Coffee Break | Location: Wintergarden
Plenary Session 7: Next Generation immune-based therapies | Location: The Grand Ballroom
Session Chair: J. Bluestone
10:40-11:15
[IS7.1] T regulatory type 1 (Tr1) cells: from bench to bedside and back
1 1
2
M.G. Roncarolo , San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Italy, Vita-Salute San
Raffaele University, Italy
11:15-11:50
[IS7.2] The multifunctional ‘T-Body' approach: Redirects Teff to reject tumors and Treg to suppress
inflammatory responses
1 ,2 1
2
Z. Eshhar , The Weizmann Institute, Israel, Tel Aviv Sourasky Medical Center, Israel
rd
3 International Conference on Immune Tolerance | Oral Programme
11:50-12:25
[IS7.3] Rebalancing the immune system through Treg biology
1
1
2
2
1
1
1
1
J. Bluestone* , E. Trotta , N. Crellins , I. Rondon , K. Lee , A. Putnam , W. Liu , M. Lee , Q.
1 1
2
Tang , University of California, USA, Pfizer-CTI, USA
12:25-12:40
[O7.1] MARCO-targeting carboxylated PLG nanoparticles promote therapeutic tolerance induction
and suppression of inflammatory monocytes
S.D. Miller*, Z.N. Hunter, D. McCarthy, C. Harp, R. Terrry, S. Prasad, W. Yap, N.J.C. King, L. Shea, D.
Getts, Northwestern University Medical School, USA
12:40-12:55
[O7.2] Generation and functional properties of engineered antigen-specific human T regulatory cells
to suppress anti-FVIII responses in hemophilia A
1
1
1
2
1 1
Y.C. Kim , A.H. Zhang , K.P. Pratt , E.M. Shevach , D.W. Scott* , Uniformed Services University of the
2
Health Sciences, USA, National Institute of Allergy & Infectious Diseases, National Institutes of Health,
USA
[O7.3] Tolerogenic synthetic nanoparticles for the prevention of anti-drug antibodies
1
1
1
1
1
1
2
T.K. Kishimoto* , R.A. Maldonado , R. LaMothe , J.D. Ferrari , A. Griset , C. O'Neil , A.H. Zhang , R.J.
2
1
1 1
2
Rossi , D. Altreuter , L. Johnston , Selecta Biosciences, USA, Uniformed Services University, USA,
3
Harvard Medical School, USA
12:55-13:10
13:10-13:15
Closing Remarks
13:15
End of Conference

8th Introductory Course Microbiology and Immunology January 13

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