GOG SYMPOSIUM “CLINICAL TRIALS FOR RARE GYNECOLOGIC CANCERS” SAN DIEGO,CA - FEBRUARY 6, 2014 Program Chairs David M. Gershenson, MD The University of Texas, MD Anderson Can Ctr. Allan Covens, MD Toronto Sunnybrook Regional Can. Ctr. PROGRAM DESCRIPTION: The winter 2014 Gynecologic Oncology Group Educational Symposium is titled “Clinical Trials for Rare Gynecologic Cancers,” with noted Oncologists and Scientists serving as speakers and moderators. The targeted audiences are members and non-members of the GOG research teams to include: Gynecologic Oncologists, Medical Oncologists, Radiation Oncologists, Pathologists and other MDs engaged in gynecologic oncology research and/or clinical practice; Oncology Nurses, Nurse-practitioners, and other interested Allied Health professionals. The speakers will focus their presentations on the unique aspects of formally and scientifically evaluating rare tumors, the distinctive clinical and molecular aspects of a variety of rare tumors, and current philosophies and research directions for them. LEARNING OBJECTIVES:  Apply strategies to accrue patients to rare tumor studies and evaluate therapies  Apply learned principles for managing the clinical, pathological, and molecular characteristics of rare tumors GOG COMMITTEE ON EDUCATIONAL ACTIVITIES Ronald Alvarez, MD (Committee Chair) University of Alabama School of Medicine Birmingham, AL Frederick Stehman, MD (Co-Chairman) Indiana University School of Medicine Indianapolis, IN Sarah Bernstein, RN, MS, AOCN Walter Reed National Military Med Ctr. Bethesda, MD John H. Farley, MD, COL (ret) St. Joseph Hospital and Medical Center Phoenix, AZ Neil Horowitz, MD Brigham and Women’s Hospital Dana Farber Partners Cancer Care Boston, MA William Tew, MD Memorial Sloan Kettering Cancer Center New York, NY Michelle N. Small, BSHA (Staff) Assoc. Director, Education Programs & CME Compliance GOG Education Program [email protected] Jill Reese (Staff) CME Administrator GOG Education Program [email protected] Symposium Agenda Time Title SPEAKER/MODERATOR 7:00 AM REGISTRATION 8:00 AM WELCOME 8:05-8:45 SESSION I: Statistical Methods for the Study of Rare Tumors Moderator: Allan Covens, MD – Toronto Sunnybrook Reg. Cancer Center 8:05-8:25 Clinical Trial Methodology for Rare Tumors including Novel Designs Lawrence Rubinstein, PhD – National Cancer Institute 8:25-8:45 Studying Rare Tumors: Clinical Trial Versus Tumor Registry William Brady, PhD – GOG Statistical and Data Center 8:45-10:40 SESSION II: Rare Uterine Cancers Moderator: John O. Schorge, MD – Dana Farber Partners Cancer Care 8:45-9:05 Beyond TCGA: Intelligent Clinical Trial Design Douglas A. Levine, MD – Memorial SloanKettering Cancer Center 9:05-9:25 Separate Clinical Trials Should be Developed for UPSC--Pro Matthew A. Powell, MD – Washington University School of Medicine 9:25-9:45 Separate Clinical Trials Should be Developed for UPSC--Con David S. Miller, MD – UT Southwestern Medical Center at Dallas 9:45-10:05 Uterine Leiomyosarcoma: Is there a Role for Adjuvant Therapy? Martee L. Hensley, MD – Memorial SloanKettering Cancer Center 10:05-10:25 Low Risk Gestational Trophoblastic Neoplasia: Looking Beyond Cure Julian C. Schink, MD – Spectrum Health 10:25-10:40 QUESTIONS AND ANSWERS 10:40-10:55 BREAK 10:55-12:15 SESSION III: Rare Ovarian Cancers Program Chairs Moderator: David M. Gershenson, MD – The Univ. of Texas - MD Anderson Can. Ctr. 10:55-11:15 Ovarian Germ Cell Tumors: Surveillance vs Treatment Jean Hurteau, MD – Evanston Northwestern Healthcare 11:15-11:35 Ovarian Sex Cord-Stromal Tumors: Current Controversies and Future Directions Jubilee Brown – MD Anderson Cancer Center 11:35-11:55 Clear Cell Carcinoma of the Ovary: What is the Optimal Adjuvant Therapy? John K. Chan, MD – University of California, San Francisco 11:55-12:15 Low-Grade Serous Carcinoma of the Ovary: Is Chemotherapy Beneficial? Amanda Nickles-Fader, MD – Johns Hopkins Hospital 12:15-12:30 12:30-1:15 QUESTIONS AND ANSWERS BREAK (LUNCH) 1:15-2:15 SESSION IV: Rare Cancers of the Female Lower Genital Tract Moderator: John H. Farley, MD, COL (ret) St. Joseph Hospital and Medical Center 1:15-1:35 Endometriosis Associated Pelvic Cancers: Are They Different from Ovarian Cancers? Matthew Cesari, MD /Lilian T. Gien, MD Sunnybrook Health Science Center 1:35-1:55 Vulvovaginal Melanoma: How Should We Manage It? Mario Leitao, MD – Memorial Sloan-Kettering Cancer Center 1:55-2:15 Challenges in the Diagnosis and Management of Cervical Neuroendocrine Carcinomas Michael M. Frumovitz, MD – MD Anderson Cancer Center 2:15-2:30 QUESTIONS AND ANSWERS