FROM PATHOGENESIS TO CURE

IPF
FROM PATHOGENESIS TO CURE
Rome, Italy
Chairmen: V. Poletti, L. Richeldi, C. Saltini
PRELIMINARY PROGRAM
May 9-10, 2014
Palazzo delle Esposizioni
IPF:
FROM PATHOGENESIS TO CURE
Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive fibrosing
interstitial pneumonia of unknown cause, occurring primarily in older adults, and limited to the
lungs. It is characterized by progressive worsening of dyspnea and lung function and is associated
with a poor prognosis.
The pathogenesis of IPF is still unclear and a complex series of pathological events, many of which
shared by other forms of pulmonary and systemic idiopathic fibrosing disorders, have been shown
to be involved in the development of the typical Usual Interstitial Pneumonia (UIP) pulmonary
lesions. Among them, increased local production of reactive oxygen species, abnormal wound
healing in response to multiple microscopic injury, epithelial activation and hyperplasia, presence
of cellular de-differentiation and epithelial to mesenchymal transition, imbalance in angiogenetic/
angiostatic process, unusual proliferation of mesenchymal cells with matrix deposition, disruption of
coagulation pathway and increase of capillary permeability. On the research side, a growing number
of studies have been aimed at the identification of the susceptibility gene(s) or the environmental
exposures that could drive the pathogenic process of IPF. On the other hand, several controlled
clinical trials have been carried out and new effective agents are -or will be soon- available for the
treatment of IPF affected patients. In addition, considerable efforts have been made by scientific
societies and associations to improve upon diagnostic and treatment standards for IPF patients and
a simpler approach to the diagnosis have emerged from these efforts. Most importantly, interest in
IPF basic and clinical research alike is continuously growing.
The purpose of this meeting is to provide an update on recent advances in the field of the basic
and clinical science of IPF. The most recent advancements in the understanding of the biological
processes responsible for IPF pathogenesis will be critically reviewed and the most recent criteria
for diagnosing and treating the disease, both in research and real life settings, will be discussed.
Venerino Poletti, Luca Richeldi, Cesare Saltini
RAZIONALE
Rome, May 9-10
2014
FACULTY
Carlo Agostini, Padova
Carlo Albera, Torino
Raffaele Antonelli Incalzi, Roma
Vittorio Enrico Avvedimento, Napoli
Joan Albert Barberà, Barcelona (ES)
Marco Chilosi, Verona
Marco Confalonieri, Trieste
Elena Corradini, Modena
Fausto De Michele, Napoli
Wonder Puryear Drake, Nashville - TN (USA)
Gianfranco Farinelli, Roma
Andrew J. Ghio, Chapel Hill – NC (USA)
Paolo Graziano, San Giovanni Rotondo (FG)
Sergio Alfonso Harari, Milano
Maurizio Luisetti, Pavia
Fernando J. Martinez, Ann Arbor - MI (USA)
Gennaro Mazzarella, Napoli
Carlo Mereu, Pietra Ligure (SV)
Augusto Orlandi, Roma
Francesco Pallone, Roma
Leonardo Palombi, Roma
Franco Pasqua, Monte Compatri (RM)
Venerino Poletti, Forlì
Ermanno Puxeddu, Roma
Luca Richeldi, Southampton (UK)
Paola Rottoli, Siena
Cesare Saltini, Roma
Federica Sangiuolo, Roma
David Schwartz, Aurora – CO (USA)
Roberto Testi, Roma
Carlo Vancheri, Catania
Dominique Valeyre, Paris (FR)
Maurizio Zompatori, Bologna
IPF:
Rome, May 9-10
FROM PATHOGENESIS TO CURE
FRIDAY, May 9th
09.30-10.00
10.00-10.30
SATURDAY, May 10th
Welcome Coffee
Welcome
Introduction
G. Novelli, Rector University Rome “Tor Vergata”
C. Saltini
SESSION 1
IDIOPATHIC FIBROSING DISORDERS-1
Chairs: F. Pallone, F. Pasqua
10.30-11.00
11.00-11.30
11.30-12.00
12.00-12.30
IgG4 related Disease
Sarcoidosis
Pulmonary alveolar proteinosis
Friedreich’s ataxia
P. Graziano
W. P. Drake
M. Luisetti
R. Testi
SESSION 2
PATHOGENESIS OF IPF: INSIGHTS AND PROSPECTIVES
Familial Interstitial Pneumonia
Mucin genes
Lunch
Chairs: R. Antonelli Incalzi, F. Sangiuolo
12.30-13.00
13.00-13.30
13.30-14.30
P. Rottoli
D. Schwartz
SESSION 3
VASCULAR ABNORMALITIES IN PULMONARY FIBROSIS
Vascular abnormalities in smokers and COPD
J. A. Barberà
Alveolar iron in IIPs: hemorrhage or inhalation?
E. Puxeddu
A common signaling pathway drives fibrosis in lung and skin V. E. Avvedimento
Coffee Break
Chairs: M. Confalonieri, G. Mazzarella
14.30-15.00
15.00-15.30
15.30-16.00
16.00-16.30
SESSION 4
IDIOPATHIC FIBROSING DISORDERS-2
Chairs: A. Orlandi, C. Mereu
16.30-17.00
17.00-17.30
17.30-18.00
2014
Asbestosis
Hereditary hemochromatosis gene related diseases
Lung fibrosing damage
A. Ghio
E. Corradini
C. Saltini
SESSION 5
FROM GUIDELINES TO PATIENT MANAGEMENT: INTERACTIVE SESSION
Chairs: C. Agostini, G. Farinelli
Introduction
09.00-09.30 Radiologically confident IPF, real life
Ground Rounds - MDD presentation: the possible/inconsistent IPF
09.30-10.00 Histological patterns
10.00-10.30 The clinical picture
10.30-11.00 Coffee Break
Chair: L. Palombi
11.00-11.30 LECTURE
Guidelines implementation: National, European, International?
M. Zompatori
M. Chilosi
V. Poletti
D. Valeyre
SESSION 6
EVIDENCE BASED TREATMENT
Chairs: C. Albera, F. De Michele 11.30-12.00
12.00-12.30
12.30-13.00
13.00-13.30
From Ifigenia to Panther
Pirfenidone post-marketing studies
PH in IPF what to do: ERA, PDE5 inhibitors or palliation?
New therapeutic perspectives
13.30
Closing remarks
F. J. Martinez
C. Vancheri
S. A. Harari
L. Richeldi
IPF
IPF:
Rome, May 9-10
FROM PATHOGENESIS TO CURE
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2014
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CHAIRMEN
Venerino Poletti
U.O. Pneumologia
Ospedale G.B. Morgagni - L. Pierantoni, Forlì
Luca Richeldi
Professor of Respiratory Medicine
University of Southampton (UK)
Cesare Saltini
U.O. Malattie dell’Apparato Respiratorio
Policlinico Universitario “Tor Vergata”
Università degli Studi di Roma “Tor Vergata”
SCIENTIFIC SECRETARIAT
Gabriella Pezzuto, Roma
Ermanno Puxeddu, Roma
Cesare Saltini, Roma
CONFERENCE VENUE
Palazzo delle Esposizioni
Via Milano, 9 - Roma
CONTINUING MEDICAL EDUCATION
Continuing Medical Education (CME) accreditation will be available
for only Italian medical specialist.
The event has been insert in the Continuing Medical Education Planning AIPO 2014
Provider 442
ID Code: 89175
Partecipants: 60
CME: 10
Medical Doctor
Disciplines: Pneumology, Geriatrics, Internal Medicine, Thoracic Surgery, Clinical Pathology, Pathological Anatomy, Radiodiagnostics.
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