TRIGUARD Trial Brochure - "Tried, Tested and Proven"

Tried, Tested and Proven
A SANOFI COMPANY
Delivering Advanced Formulations
Merial Australia have been providing innovative animal
health products to Australian agriculture for over 40 years,
with a focus on delivering advanced formulations, and
pioneering products for Australian sheep producers.
In 2003, Merial launched Australia’s first triple
combination sheep drench. By combining the three major
broad-spectrum drench families into a single product,
it enabled Australian sheep producers to maintain
productivity, and importantly – delay resistance.
Since then we’ve developed nearly a decade of experience
and expertise with multi-active products and triple
combination drenches.
More recently Merial have released TRIGUARD Triple
Combination Drench for Sheep, with a potent
Abamectin-based triple active formulation.
Triple Combination TRIGUARD –
out in a class of its own.
TRIGUARD combines three broad-spectrum drench families:
•
•
•
Abamectin (ML)
Levamisole (clear)
Oxfendazole (white)
These are combined into a stable, multi-active formulation,
acting as an essential tool for managing drench resistance, and
maintaining productivity.
Guarding against resistance
TRIGUARD helps guard against resistance by combining 3
short-acting drenches that are absorbed rapidly, act quickly to
kill parasites and then are eliminated quickly. The similarity in
persistence ensures each active is protecting the others whilst
worms are exposed to them.
Broad-spectrum Activity Against Resistant Worms
With high potency, triple-active protection, TRIGUARD can deliver highly effective worm control
over a broad spectrum of worms, even where high levels of resistance are present.
TRIGUARD is active against sheep roundworms that have single or dual resistance to the ML
(including moxidectin), benzimidazole or imidazothiazole (levamisole) families of chemicals.
Tried, Tested And Proven – Under Australian
Farming Conditions
The TRIGUARD formulation has been tested and proven in numerous trials in Australia as well as
New Zealand, to control sheep worm populations even where single or dual resistance – including
moxidectin resistance – is present in a single worm species.1
Merial have been measuring the performance if its triple active combination drenches for more
than a decade, and will continue to test and prove the TRIGUARD formulation through ongoing
monitoring and field trials. Producers can therefore be assured of the proven performance of
TRIGUARD under Australian farming conditions.
Using products with reduced efficacy reduces productivity. One recent study confirms that drench
resistance could be costing farmers significant production and profitability losses, with reductions in
lamb growth rates of up to 24% possible.2 Choosing the right drench is even more important than ever.
Proven Performance
Results have been collected from numerous recent field trials3 where TRIGUARD has been used
to treat worm populations with high levels of resistance. Some results from these trials are
presented below.
TRIGUARD was highly effective on all of the properties tested, even when significant ML (including
moxidectin), BZ or LEV resistance was present (Graph 1). In fact, TRIGUARD demonstrated an
average faecal egg count reduction efficacy of 99.7% across all the properties tested.
Drench performance against high resistance levels
100.00
90.00
80.00
% Efficacy
Graph 1: Efficacy of
TRIGUARD on
8 properties tested
where resistance
to ML, BZ or LEV
was present.
70.00
60.00
50.00
40.00
30.00
1
2
3
4
5
Property
IVM
BZ
LEV
6
TRIGUARD
7
8
The field trials also clearly demonstrated that TRIGUARD was still highly effective even on properties
where moxidectin resistance was present (Graph 2). Moreover, these studies found that moxidectin
was actually only effective (>95% efficacy#) on 55% of all the properties tested, while TRIGUARD
was effective on 100% of properties tested.
Graph 2: Efficacy
of TRIGUARD on 7
properties compared
to moxidectin drench.
Drench performance against moxidectin resistance
100.00
90.00
% Efficacy
80.00
70.00
60.00
50.00
40.00
30.00
1
2
3
4
5
6
7
Property
Cydectin®
TRIGUARD
Even where high levels of resistance to MLs (IVM or ABA) were present on a property, TRIGUARD
still outperformed a triple combination of NAP (naphthalophos), BZ and LEV on tested properties3
(Graph 3).
Drench performance comparison with NAP/BZ/LEV combinations
100.00
90.00
80.00
% Efficacy
70.00
60.00
50.00
40.00
30.00
20.00
10.00
0.00
1
2
3
4
Property
IVM or ABA
NAP/BZ/LEV
TRIGUARD
The results from the field trials above demonstrate the ability of TRIGUARD to achieve
high efficacy, despite evidence of resistance to all 3 chemical groups (ML, BZ, LEV), and
even where a triple combination of NAP, BZ and LEV was not effective.
The results reinforce the ability of TRIGUARD to:
•maintain high efficacy, even in the face of significant resistance (including moxidectin)
or where resistance status is unknown.
•slow the development of resistance, whether resistance is present already or not.
Graph 3: Efficacy
of TRIGUARD on 4
properties compared to a
NAP/BZ/LEV combination
and an ML (IVM on
properties 1-2, and ABA
on properties 3 and 4).
A Single Stable
Formulation
TRIGUARD is formulated using silica
adsorption technology to allow the three
different actives to be combined into a
single, stable formulation. This ensures
reliable delivery of the right levels of actives
in each dose and avoids the potential for
inaccuracies that can be associated with the
mixing of chemicals on-farm.
TRIGUARD components do not rapidly
settle or separate, unlike some other
multi-active drench formulations, so you
can rely on the combination of actives
being delivered in the right proportions for
consistent and reliable dosing to
Every Sheep,
Every Dose,
Every Time.
KEY BENEFITS
4Combined power of 3
actives together
4Stable high quality
formulation
4Proven performance in
the field1,3
4 No risky on-farm mixing
4Kills worms resistant to white,
clear, or ML drenches
4 Delays resistance*
4High potency with
broad-spectrum activity
4Accurate delivery of 3 actives*
Why on-farm
mixing isn’t
the same
To guarantee optimal triple-active efficacy
and the cross protection from each active,
mixing must ensure that throughout the
drum the right levels of each active are
present in exactly the right proportions
needed. To reliably achieve this with
on-farm mixing is extremely difficult
as any inaccuracies in the addition and
mixing process will ensure that this is not
the case. As a result, on-farm mixing can
lead to relative under- or overdosing of
one or more actives.4,5
Variations in operator techniques,
estimation of volumes added, time
and technique in mixing the drum all
contribute to difficulties in producing
uniform distribution of actives throughout
the drench during on-farm mixing.
www.merial.com
1. Data on File. 2. Leathwick et al (2008)
3. Data on File: results from 44 FECRT conducted
between 2010-2012 on separate properties around
Australia. 4. Data on File. 5.Farquharson (1989)
# The currently accepted industry definition of drench
resistance, as measured in a Faecal Egg Count Reduction
Test (FECRT), is a reduction in worm egg count of less
than 95%. (www.wool.com/Grow_WormBoss.htm)
* See product label for full claim details and instructions.
Merial Australia Pty Ltd, Building D, 12-24 Talavera Road, Macquarie Park NSW 2113. ABN 53 071 187 285.
®
TRIGUARD is a registered trademark of Merial Limited. ®Cydectin is a registered trademark of Virbac (Australia) Pty Ltd.
©2012 Merial Limited. All rights reserved. TRIG-12-016
A SANOFI COMPANY

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