For patients taking Deltyba® Tablets 50mg Produced under the supervision of Dr. Toru Mori, Director Emeritus at Research Institute, Japan Anti-Tuberculosis Association Attention to the following points is required when taking Deltyba. 1. Continue taking the medication until you have taken all of the prescribed doses. 2. Consult your doctor immediately if any symptoms occur, such as palpitations, dizziness, lightheadedness, fatigue or loss of consciousness. 1. Always take the medication as prescribed by your doctor. In the treatment of multidrug-resistant pulmonary tuberculosis, it is very important to stay with the treatment schedule and not miss the any of the medication prescribed by your doctor. Never take more than one doses at once. If you have taken more than the prescribed dose at one time by mistake, contact your doctor or pharmacist immediately. Oops! I should not have taken two doses at once! If you miss a dose Please take the medication right away when you realize you have missed a dose. However, if it is close to the scheduled time for the next dose, skip the missed dose and take one dose at the next scheduled time. 木曜日 24 I forgot to take the last dose! But, it’s not too late!! 1 Since the disappearance of symptoms does not mean a complete disappearance of the Mycobacterium tuberculosis, please do not reduce the dose or stop taking the medication at you own discretion without seeking the advice of your doctor. Although I have no symptoms, I must still take the medication. Can I reduce the dose? n’t! u ca yo No, Since the amount of drug absorbed into the body is influenced by food, the drug should always be taken after a meal. In addition, please avoid food with high-fat* content as much as possible when taking this drug. ＊Examples of meals with high-fat content: Sirloin steak, rice and miso soup; teriyaki burger, French fries (medium size) and cafe au lait; hamburger steak and fried shrimp. Avoid fat as much as possible. 2 ! 2.De lt y ba m ay c aus e th e s i d e ef f ect o f Q T p rolong ation. What is QT prolongation? QT prolongation is a heart abnormality detected by electrocardiography. When it is mild, there are no symptoms, but when it is severe, you may have palpitations or even lose consciousness. If you have any of the following symptoms, please do not wait until the next visit and consult your doctor immediately. Palpitations Dizziness /lightheadedness Fatigue Loss of consciousness For the early detection of QT prolongation, patients need to have periodic electrocardiograms. 3 The following types of patients are particularly prone to QT prolongation and must exercise caution when taking Deltyba. Such patients should consult their doctor or pharmacist. ■Patients who have a history of QT prolongation ■Patients who have a predisposition to QT prolongation (patients with marked bradycardia, patients with abnormal electrolytes such as hypokalaemia, hypomagnesaemia, and hypocalcaemia, etc., and patients with heart disease) ■Patients with hepatic function disorder ■Patients with hypoalbuminaemia ■Elderly patients ■Patients taking drugs that are known to cause QT prolongation Typical drugs known to cause QT prolongation Anti-arrhythmics, antibiotics, antipsychotics etc., antiprotozoals, antihistamines, antivirals, drugs for overactive bladder Note: If you would like to confirm whether or not the medications you are currently taking are known to cause QT prolongation, please consult your doctor or pharmacist. 4 What kind of drug is Deltyba ? (antitubercular chemotherapeutic agent) Deltyba is a medicine for multidrug-resistant pulmonary tuberculosis. ●Dosage and precautions of Deltyba: Please take two tablets each time after breakfast and after dinner daily. デルティバデルティバ 50 デルティバデルティバ 50 50 50 ●Effect of Deltyba: Deltyba has antibacterial effect against Mycobacterium tuberculosis, the bacterium that causes tuberculosis. ●How does Deltyba work? Deltyba stops the production of a fatty membrane called the cell wall which forms the outer part of the Mycobacterium tuberculosis. Cell wall Deltyba 50 Mycobacterium tuberculosis cell Administration The cell dies because it of Deltyba cannot create a cell wall ●Appearance of Deltyba/PTP sheet ! Deltyba should be kept in the aluminum push-through packages until use Please store Deltyba in PTP sheets because it is sensitive to air and humidity. Please take Deltyba immediately after removing the tablets from PTP sheets. 5 About multidrug-resistant pulmonary tuberculosis Multidrug-resistant pulmonary tuberculosis is a form of tuberculosis that no longer responds to at least the two anti-tuberculosis drugs isoniazid and rifampicin. It becomes very difficult to treat tuberculosis and also it takes a longer period of time to treat when these two drugs do not work. For treatment of multidrug-resistant pulmonary tuberculosis, patients generally take four or more drugs, not including isoniazid and rifampicin, for which efficacy can be expected in treating the disease. It is very hard to keep taking multiple medications for a long period in order to treat multidrug-resistant pulmonary tuberculosis, but let's not give up; you need to stay on the medication until the disease is completely cured. 6 Present your Deltyba card when you pick up Deltyba at an off-site pharmacy Deltyba card will be given to you by your doctor if you are picking up Deltyba at a pharmacy separate from the hospital. In such case, do not forget to take the card with you, and show it together with your prescription. Please return the Deltyba card to your doctor when treatment with Deltyba is completed. Until then, please be sure to keep it in a safe place so as not to lose it (if you lose it, please consult your doctor). への方です。済の方んに性確認患者さバ適格指導をルティの服薬は、デする旨れた方と服用持参さきちんードをを毎日このカれた薬。決めら下さい行って剤師・薬薬局 Pre scri pti デルティバカード院外薬局でデルティバ錠を受け取るときは、処方箋と一緒にこのカードを提示してください。 on 薬局・薬剤師の方へこのカードを持参された方は、デルティバ適格性確認済の方です。決められた薬を毎日きちんと服用する旨の服薬指導を患者さんに行って下さい。 Prepared in November 2014 DT1411019 (9209)FL