CV CWierenga - Department of Psychiatry

Christina E. Wierenga, Ph.D.
[email protected]
OFFICE ADDRESS
Eating Disorders Treatment and Research Center
University of California, San Diego
Department of Psychiatry
4510 Executive Drive, Suite 315
San Diego, CA 92121
Phone: (858) 534-8047
Fax: (858) 534-8316
VA San Diego Healthcare System
3350 La Jolla Village Drive, 151B
San Diego, CA 92161
Phone: (858) 552-8585 x2579
Fax: (858) 642-1218
ACADEMIC POSITIONS
July 2014 – present
Associate Professor of Psychiatry
University of California San Diego, School of Medicine
2009 – present
Research Psychologist
Veterans Affairs San Diego Healthcare System, CA
2009 – June 2014
Assistant Professor of Psychiatry
University of California San Diego, School of Medicine
2007 – 2009
Assistant Project Scientist
University of California San Diego, Department of Psychiatry
POST-DOCTORAL FELLOWSHIP
2005 – 2007
NIH T32 Postdoctoral Fellowship in Biological Psychiatry and
Neuroscience
University of California San Diego, Department of Psychiatry
EDUCATION
2005
Ph.D. in Clinical Psychology
University of Florida
Specialty Track: Neuropsychology, Neurorehabilitation, and Clinical
Neuroscience
Dissertation Chair: Bruce Crosson
Age-Related Changes in Word Retrieval: Executive-Frontal vs SemanticTemporal Substrates
2004 – 2005
UCSD/VA Psychology Internship
VA Neuropsychological Assessment Unit/UCSD Child and Adolescent
Psychiatry
2001
M.S. in Clinical Psychology
University of Florida
Christina E. Wierenga, Ph.D.
Specialty Track: Neuropsychology
1998
B.A. in Psychology and English
Calvin College, Grand Rapids, MI
CERTIFICATION AND LICENSURE
Licensed Clinical Psychologist PSY22247
PREVIOUS PROFESSIONAL EXPERIENCE
2007 – 2009
Clinical Psychologist
Neuropsychological Assessment Unit, VA San Diego Healthcare System
2006 – 2007
Lecturer
San Diego State University, Department of Psychology
Undergraduate level courses developed and taught:
PSY380 Cognitive Psychology
PSY260 Introduction to Physiological Psychology
PSY499 Special Study in Neuropsychological Research
OTHER CLINICAL EXPERIENCE
2011 – present
Clinical Neuropsychologist and Practicum Supervisor
UCSD Eating Disorders Treatment and Research Center
2010 – present
Clinical Neuropsychologist and Practicum Supervisor
UCSD Neuropsychological Associates
RESEARCH FUNDING and AWARDS
Current:
2013 – 2016
Principal Investigator
$1,237,285
Merit Award: VA CSR&D
Cognitive and Brain Changes in Preclinical Alzheimer’s Disease
2012 – 2014
Co-Investigator
$1,011,040
RO1; NIA/NIH (Bondi)
Cognitive Abilities of At-Risk Elderly for Dementia
2013 – 2015
Consultant
$275,000
R21; NIH (Rhee)
Promoting Child Inhibitory Control Skills around Food
2011 – 2014
Faculty Co-Sponsor (for SDSU/UCSD JDP student Lindsay Clark)
F31 (NRSA; NIH)
Neural Correlates of Memory Encoding in Subtypes of Mild Cognitive
Impairment
2011 – 2015
Faculty Co-Sponsor (for SDSU/UCSD JDP student Gali Weissberger)
F31 (NRSA; NIH)
Executive Control in the Bilingual Brain
2
Christina E. Wierenga, Ph.D.
Past:
2009 – 2012
3
Principal Investigator
$501,600
Career Development Award: VA CSR&D
Biological Underpinnings of the FMRI Signal by Alzheimer’s Disease Risk
2009 – 2012
Principal Investigator
$80,000
Alzheimer’s Association New Investigator Research Grant
Impact of APOE on Cerebral Perfusion and BOLD Response to Word
Retrieval
2003 – 2004
Principal Investigator
$18,500
VA Pre-Doctoral Associated Health Rehabilitation Research Fellowship,
Age-Related Changes in Word Retrieval: Executive-Frontal vs SemanticTemporal Substrates
PUBLICATIONS
Wierenga, C.E., Hays, C., Zlatar, Z.Z. (in press). Cerebral blood flow measured by arterial spin
labeling MRI as a preclinical marker of Alzheimer’s disease. Journal of Alzheimer’s Disease.
Wierenga, C.E., Bischoff-Grethe, A., Melrose, J., Grenesko-Stevens, E., Irvine, L., Wagner, A.,
Simmons, A., Matthews, S., Yau, W-Y.W., Fennema-Notestine, C., Kaye, W. (2014). Altered
BOLD response during inhibitory and error processing in adolescents with anorexia nervosa.
PLoS ONE. 9(3); e92017
Bangen, K., Nation, D., Clark, L., Harmell, A., Wierenga, C.E., Dev, S., Delano-Wood, L.,
Zlatar, Z.Z., Salmon, D., Liu, T.T., Bondi, M.W. (2014). Interactive effects of vascular risk
factors and advanced age on cerebral blood flow. Frontiers in Aging Neuroscience.
Filoteo, J.V., Paul, E.J., Ashby, F.G., Frank, G.K., Helie, S., Rockwell, R., Bischoff-Grethe, A.,
Wierenga, C., Kaye, W.H. (2014). Simulating category learning and set shifting deficits in
patients weight-restored from anorexia nervosa. Neuropsychology. [Epub ahead of print].
Zlatar, Z.Z., Wierenga, C.E., Bangen, K.J., Liu, T.T., Jak, A.J. (2014). Increased hippocampal
blood flow in sedentary older adults at genetic risk for Alzheimer’s disease. Journal of
Alzheimer’s Disease. [Epub ahead of print].
Bangen, K.J., Bergheim, M., Kaup, A.R., Mirzakhanian, H., Wierenga, C.E., Jeste, D.V., Eyler,
L.T. (2014). Brains of optimistic older adults respond less to fearful faces. The Journal of
Neuropsychiatry and Clinical Neurosciences, 26, 156-63.
Bischoff-Grethe, A., McCurdy, D., Grenesko-Stevens, E., Irvine, L.E., Wagner, A., Yau, W.Y.,
Fennema-Notestine, C., Wierenga, C.E., Fudge, J.L., Delgado, M.R., Kaye, W.H. (2013).
Psychiatry Research, 214, 331-40.
Wierenga, C.E., Clark, L.R., Dev, S.I., Shin, D., Jurick, S., Rissman, R., Liu, T.T., & Bondi,
M.W. (2013). Interaction of age and APOE genotype on cerebral blood flow at rest. Journal
of Alzheimer’s Disease, 34, 921-935.
Nation, D.A., Wierenga, C.E., Clark, L.R., Dev, S.I., Stricker, N.H., Jak, A.J., Salmon, D.P.,
Delano-Wood, L., Liu, T.T., Bondi, M.W. (2013). Cortical and subcortical cerebrovascular
resistance index in mild cognitive impairment and Alzheimer’s disease. Journal of
Alzheimer’s Disease, 36, 689-98.
Kaye, W.H., Wierenga, C.E., Bailer, U.F., Simmons, A.N., Bischoff-Grethe, A. (2013). Nothing
tastes as good as skinny feels: The neurobiology of anorexia nervosa. Trends in
Neurosciences, 36, 110-20.
Kaye, W.H., Wierenga, C.E., Bailer, U.F., Simmons, A.N., Wagner, A., & Bischoff-Grethe, A.
(2013). Does a shared neurobiology for foods and drugs of abuse contribute to extremes of
food ingestion in anorexia and bulimia nervosa? Biological Psychiatry, 73, 836-42.
Christina E. Wierenga, Ph.D.
4
PUBLICATIONS (continued)
Wierenga, C.E., Dev, S.I., Shin, D.D., Clark, L.R., Bangen, K.J., Jak, A.J., Rissman, R.A., Liu,
T.T., Salmon, D.P. & Bondi, M.W. (2012). Effect of mild cognitive impairment and APOE
genotype on resting cerebral blood flow and its association with cognition. Journal of
Cerebral Blood Flow & Metabolism, 32, 1589-99.
Weissberger, G.H., Wierenga, C.E., Bondi, M.W., & Gollan, T.H. (2012). Partially overlapping
mechanisms of language and task control in young and older bilinguals. Psychology and
Aging, 27, 959-74.
Bangen, K.J., Restom, K., Liu, T.T., Wierenga, C.E., Jak, A.J., Salmon, D.P., Bondi, M.W.
(2012). Assessment of Alzheimer’s disease risk with functional magnetic resonance
imaging: An arterial spin labeling study. Journal of Alzheimer’s Disease, 31, S59-74.
Jacobus, J., Goldenberg, D., Wierenga, C.E., Tolentino, N., Liu, T.T., & Tapert, S.F. (2012).
Altered cerebral blood flow and neurocognitive correlates in adolescent cannabis users.
Psychopharmacology, 222, 675-84.
Nation, D.A., Delano-Wood, L., Bangen, K.J., Wierenga, C.E., Jak, A.J., Hansen, L.A., Galasko,
D.R., Salmon, D.P., Bondi, M.W. (2012). Antemortem pulse pressure elevation predicts
cerebrovascular disease in autopsy-confirmed Alzheimer’s disease. Journal of Alzheimer's
Disease, 30, 595-603.
Bangen, K.J., Kaup, A.R., Mirzakhanian, H., Wierenga, C.E., Jeste, D.V., & Eyler, L.T. (2012).
Compensatory brain activity during encoding among older adults with better recognition
memory for face-name pairs: An integrative functional, structural, and perfusion imaging
study. Journal of the International Neuropsychological Society, 18, 402-13.
Wierenga, C.E., & Bondi, M.W. (2011). Dementia and Alzheimer’s disease: What we know now.
Generations: Journal of the American Society on Aging, 35(2), 37-45.
Wierenga, C.E., Stricker, N.H., McCauley, A., Simmons, A., Jak, A.J., Chang, Y-L, Nation, D.A.,
Bangen, K.J., Salmon, D.P., Bondi, M.W. (2011). Altered brain response for semantic
knowledge in Alzheimer’s disease. Neuropsychologia, 49, 392-404.
Tolentino, N.J., Wierenga, C.E., Hall, S., Tapert, S.F., Paulus, M.P., Liu, T.T., Smith, T.L.,
Schuckit, M.A. (2011). Alcohol effects on cerebral blood flow in subjects with low and high
responses to alcohol. Alcoholism: Clinical and Experimental Research, 35, 1034-40.
Nation, D.A., Wierenga, C.E., Delano-Wood, L., Jak, A.J., Delis, D.C., Bondi, M.W. (2010).
Elevated pulse pressure is associated with age-related decline in language ability. Journal of
the International Neuropsychological Society, 16, 933-8.
Bangen, K.J., Delano-Wood, L., Wierenga, C.E., Hesselink, J.R., Bondi, M.W. (2010).
Dementia following herpes zoster encephalitis: Neuroradiological and neuropsychological
findings of a case report. The Clinical Neuropsychologist, 24, 1193-203.
Wierenga, C.E., Stricker, N.H., McCauley, A., Simmons, A., Jak, A.J., Chang, Y-L, DelanoWood, L., Bangen, K.J., Salmon, D.P., Bondi, M.W. (2010). Increased functional brain
response during word retrieval in cognitively intact older adults at genetic risk for Alzheimer’s
disease. NeuroImage, 51, 1222-33.
Bangen, K.J., Delano-Wood, L., Wierenga, C.E., McCauley, A., Salmon, D.P., Bondi, M.W.
(2010). Associations between stroke risk and cognition in normal aging and Alzheimer's
disease with and without depression. International Journal of Geriatric Psychiatry. 25, 175182.
Delano-Wood, L., Bondi, M.W., Jak, A.J., Horne, N.R., Schweinsburg, B.C., Frank, L.R.,
Wierenga, C.E., Delis, D.C., Theilman, R.J., & Salmon, D.P. (2010). Stroke risk modifies
regional white matter differences in Mild Cognitive Impairment. Neurobiology of Aging, 31,
1721-31.
Crosson, B., Bacon Moore, A., McGregor, K.M., Chang, Y-L., Benjamin, M., Gopinath, K.,
Sherod, M.E., Wierenga, C.E., A., Peck, K.K., Briggs, R.W., Gonzalez Rothi, L.J., White,
Christina E. Wierenga, Ph.D.
5
PUBLICATIONS (continued)
K.D. (2009). Regional changes in word-production laterality after a naming treatment
designed to produce a rightward shift in frontal activity. Brain and Language, 111, 73-85.
Jak, A.J., Bangen, K.J., Wierenga, C.E., Delano-Wood, L., Corey-Bloom, J., & Bondi, M.W.
(2009). Contributions of neuropsychology and neuroimaging to understanding clinical
subtypes of mild cognitive impairment. International Review of Neurobiology, Neurobiology
of Dementia, 84, 81-103.
Stricker, N.H., Schweinsburg, B.C., Delano-Wood, L., Wierenga, C.E., Bangen, K.J., Haaland,
K.Y., Frank, L.R., Salmon, D.P. & Bondi, M.W. (2009). Decreased white matter integrity in
late-myelinating fiber pathways in Alzheimer’s disease supports retrogenesis. NeuroImage,
45, 10-16.
Jak, A.J., Bondi, M.W., Delano-Wood, L., Wierenga, C.E., Corey-Bloom, J., Salmon, D.P.,
Delis, D.C. (2009). Quantification of five neuropsychological approaches to defining mild
cognitive impairment. American Journal of Geriatric Psychiatry, 17, 368-75.
Wierenga, C.E., Perlstein, W.M., Benjamin, M., Leonard, C., Gonzalez Rothi, L., Conway, T.,
Cato, M.A., Gopinath, K., Briggs, R., Crosson, B. (2009). Neural substrates of object
identification: fMRI evidence that category and visual attribute contribute to semantic
knowledge. Journal of the International Neuropsychological Society, 15, 169-181.
Gopinath, K., Crosson, B., Peck, K., Moore, A., Gaiefsky, M., Milsted, C., Wabnitz, A.,
Wierenga, C.E., White, K., Briggs, R. (2009). Selective detrending method for reducing
task-correlated motion artifact during speech in event-related FMRI. Human Brain Mapping,
30, 1105-19.
Bangen, K.J., Restom, K., Liu, T.T., Jak, A.J., Wierenga, C.E., Salmon, D.P., Bondi, M.W.
(2009). Differential age effects on cerebral blood flow and BOLD response to encoding:
Associations with cognition and stroke risk. Neurobiology of Aging, 30, 1276-87.
Lee, J., Hu, J., Gao, J., White, K.D., Peck, K.K., Wierenga, C.E., McGregor, K., & Crosson, B.
(2008). Discriminating brain activity from task-related artifacts in functional MRI: Fractal
scaling analysis simulation and application. NeuroImage, 40, 197-212.
Wierenga, C.E., Benjamin, M., Gopinath, K., Perlstein, W.M., Leonard, C., Gonzalez Rothi, L.J.,
Conway, T., Cato, M.A., Briggs, R., & Crosson, B. (2008). Age-related changes in word
retrieval: Role of bilateral frontal and subcortical networks. Neurobiology of Aging, 29, 436451.
Delano-Wood, L., Abeles, N., Sacco, J.M., Wierenga, C.E., Horne, N.R., Bozoki, A. (2008).
Regional white matter pathology in mild cognitive impairment: Differential influence of lesion
type on neuropsychological functioning. Stroke, 39, 794-799.
Crosson, B., McGregor, K., Gopinath, K.S., Conway, T.W., Benjamin, M., Chang, Y-L., Moore,
A.G., Raymer, A.M., Briggs, R.W., Sherod, M.G., Wierenga, C.E., White, K.D. (2007).
Functional MRI of language in aphasia: A review of the literature and methodological
challenges. Neuropsychology Review, 17, 157-77.
Wierenga, C.E., Bondi, M.W. (2007). Use of functional magnetic resonance imaging in early
identification of Alzheimer’s disease. Neuropsychology Review, 17,127-143.
Crosson, B., Fabrizio, K.,R., Singletary, F., Cato, M.A., Wierenga, C.E., Parkinson, R.B.,
Gaiefsky, M.E., Bacon Moore, A., Ciampetti, M., Holliway, E., Leon, S., Rodriguez, A.,
Kendall, D.L., Levy, I.F., & Rothi, L.J.G. (2007). Treatment of naming in nonfluent aphasia
through manipulation of intention and attention: A phase 1 comparison of two novel
treatments. Journal of the International Neuropsychological Society, 13, 582-594.
Wierenga, C.E., Maher, L.M., B., Moore, A.B., White, K.D., McGregor, K., Soltysik, D.A., Peck,
K.K., Gopinath, K., Singletary, F., Rothi, L.J.G., Briggs, R.W., & Crosson, B. (2006). Neural
substrates of syntactic mapping treatment: An fMRI study of two cases. Journal of the
International Neuropsychological Society, 12, 132-146.
Christina E. Wierenga, Ph.D.
6
PUBLICATIONS (continued)
Crosson, B., Moore, A.B., Gopinath, K., White, K.D., Wierenga, C.E., Gaiefsky, M., Fabrizio,
K.R., Peck, K.K., Soltysik, D., Milstead, C., Briggs, R.W., Conway, T.W., Gonzalez Rothi,
L.J. (2005). Role of right and left hemispheres in recovery of function during treatment of
intention in aphasia. Journal of Cognitive Neuroscience, 17, 392-406.
Peck, K.K., Wierenga, C.E., Moore, A.B, Crosson, B.C., Maher, L.M., Gopinath, K., Soltysik,
D.A., Rothi, L.J.G., & Briggs, R.W. (2004). Comparison of baseline conditions to investigate
syntactic production using fMRI. NeuroImage, 23, 104-110.
Cato, M.A., Crosson, B., Gokcay, D., Soltysik, D., Wierenga, C.E., Gopinath, K., Himes, N.,
Belanger, H., Bauer, R., Fischler, I., Gonzalez Rothi, L.J., & Briggs, R.W. (2004). Processing
emotional connotation during word generation: Laterality and effects on rostral frontal and
retrosplenial cortices. Journal of Cognitive Neuroscience, 16, 167-177.
Crosson, B., Benefield, H., Cato, M.A., Sadek, J.R., Moore, A.B., Wierenga, C.E., Gopinath, K.,
Soltysik, D., Bauer, R., Auerbach, E.J., Gokcay, D., Leonard, C.M., & Briggs, R.W. (2003).
Left and right basal ganglia and frontal activity during language generation: Contributions to
lexical, semantic, and phonological processes. Journal of the International
Neuropsychological Society, 9, 1061-1077.
Grote, C., Wierenga, C.E., Smith, M., Kanner, A., Bergen, D. (1999). Wada difference a day
makes: Interpretive cautions regarding same day injections. Neurology, 52, 1577-1582.
MANUSCRIPTS UNDER EDITORIAL REVIEW
Wierenga, C.E., Bischoff-Grethe, A., Melrose, A.J., Irvine, Z., Torres, L., Bailer, U., Simmons,
A.N., Fudge, J., McClure, S., Ely, A., Kaye, W.H. (under review). Hunger does not motivate
reward in women remitted from anorexia nervosa. Biological Psychiatry.
Wierenga, C.E., Ely, A., Bischoff-Grethe, A., Bailer, U., Simmons, A., Kaye, W.H. (under
review). Are extremes of consumption in eating disorders related to an altered balance
between reward and inhibition. Frontiers in Psychiatry (Behavioral Neuroscience).
Weissberger, G.H., Gollan, T.H., Bondi, M.W., Clark, L.R., Wierenga, C.E. (under review).
Language and task switching in the bilingual brain: Bilinguals are forever in a stay trial.
Neuropsychologia.
Gollan, T.H., Kleinman, D., Wierenga, C.E. (under review). What’s easier: Doing what you
want, or being told what to do? Cued versus voluntary language and task switching. Journal
of Experimental Psychology: General.
Boutelle, K., Wierenga, C.E., Bischoff-Grethe, A., Melrose, A., Grenesko-Stevens, E., Paulus,
M., Kaye, W.H. (under review). Increased brain response to appetitive tastes in the insula
and amygdala in obese compared to healthy weight children when sated. International
Journal of Obesity.
Clark, L.R., Nation, D.A., Wierenga, C.E., Bangen, K.J., Dev, S.I., Shin, D.D., Delano-Wood, L.,
Liu, T.T., Rissman, R.A., Bondi, M.W. (under review). Elevated cerebrovascular resistance
index is associated with cognitive dysfunction in the very-old. Alzheimer's Research &
Therapy.
Brown, G.G., Ostrowitzki, S., Stein, M.B., von Kienlin, M., Liu, T.T., Simmons, A., Wierenga,
C.E., Stein, O.Y., Bruns, A., Bischoff-Grethe, A., Paulus, M. (under review). Temporal profile
of brain response to alprazolam in patients with Generalized Anxiety Disorder.
Neuropsychopharmacology.
Melrose, A.J., Bailer, U., Torres, L., Grenesko-Stevens, E., Irvine, Z., Wierenga, C.E., BischoffGrethe, A., Divuuri, V., Paulus, M.P., Kaye, W.H. (under review). Amphetamine alters neural
response to sucrose in healthy women.
Christina E. Wierenga, Ph.D.
7
MANUSCRIPTS UNDER REVIEW (continued)
Dev, S., McKenna, B., Sutherland, A., Shin, D.D., Liu, T.T., Wierenga, C.E., Eyler, L. (under
review). Increased cerebral blood flow associated with better response inhibition in bipolar
disorder. Bipolar Disorders.
Kaye, W.H., Wierenga, C.E., Knatz, S., Liang, J., Boutelle, K., Hill, L., Eisler, I. (under review).
Temperament Based Treatment (TBT) for anorexia nervosa. European Eating Disorders
Review.
BOOK CHAPTERS
Crosson, B., Garcia, A., McGregor, K., Wierenga, C.E., & Meinzer, M. (2013). The impact of
aging on neural systems for language. In S. Koffler, J. Morgan, I.S. Baron, & M.F.
Greiffenstein (Eds.), Neuropsychology: Science and Practice (pp.149-188). New York:
Oxford University Press
Crosson, B., Moore, A. B., Wierenga, C.E. (2003). Syndromes Due to Acquired Basal Ganglia
Damage. In T. E. Feinberg & M. J. Farah (Eds.), Behavioral Neurology and
Neuropsychology. 2nd edition (pp. 411-418). New York: McGraw-Hill.
INVITED CONFERENCE TALKS
Crosson, B., Wierenga, C.E., Meinzer, M., McGregor, K.M., Benjamin, M., Cohen, M. (2009).
HAROLD and Lexical Retrieval: What is the Role of the Right Frontal Lobe? Proceedings
of the Academy of Aphasia (symposium abstract).
Wierenga, C.E. (2002). Functional neuroimaging in rehabilitation research: What is it telling us?
In L.J. Gonzalez-Rothi (Chair). A sampling of newly emerging treatment studies in
neurologic communication disorders in adulthood. Proceedings of the Meeting of Florida
Association of Speech-Language Pathologists and Audiologists (symposium abstract).
PAPER PRESENTATIONS AT CONFERENCE MEETINGS
Wierenga, C.E., Bischoff-Grethe, A., Melrose, A.J., Torres, L., Irvine, L., Bailer, U., Simmons,
A., Kaye, W.H. (2014). Impact of hunger and satiety on brain response during delay
discounting in recovered anorexia nervosa. Society of Biological Psychiatry. (symposium
abstract).
Kaye, W.H., Bischoff-Grethe, A., Wierenga, C.E., Melrose, A.J., & Simmons, A. (2013). Harm
avoidant behaviors and altered limbic and executive neural function in anorexia nervosa.
American College of Neuropsychopharmacology. (symposium abstract).
Wierenga, C.E., Dev, S., Shin, D.D., Clark, L.R., Jak, A.J., Rissman, R., Liu, T.T., Salmon,
D.P., & Bondi, M.W. (2012). Effect of mild cognitive impairment and APOE genotype on
resting cerebral blood flow and its association with cognition. Journal of the International
Neuropsychological Society (abstract).
Bangen, K.J., Sorg, S.F., Luc, N., Delano-Wood, L., Wierenga, C.E., Jak, A.J., & Bondi, M.W.
(2012). Neuroimaging biomarkers of mild cognitive impairment. Journal of the International
Neuropsychological Society (abstract).
Wierenga, C.E., Dev, S.I., Stricker, N.H., Jak, A.J., Bangen, K.J., Gravano, J., McCauley, A.,
Liu, T.T., Brown, G., Salmon, D.P., Bondi, M.W. (2011). Does increased resting cerebral
blood flow correspond to better cognitive performance in MCI? Journal of the International
Neuropsychological Society (abstract).
Bangen, K.J., Restom, K., Liu, T.T., Wierenga, C.E., Jak, A.J., Bondi, M.W. (2011).
Assessment of Alzheimer’s disease risk with functional Magnetic Resonance Imaging: An
Christina E. Wierenga, Ph.D.
8
CONFERENCE PAPERS (continued)
arterial spin labeling study. Journal of the International Neuropsychological Society
(abstract).
Crosson, B., McGregor, K.M., Meinzer, M., Wierenga, C.E., Moore, A.B. (2011). Implications of
aging for functional neuroimaging in stroke and stroke rehabilitation. Journal of the
International Neuropsychological Society (abstract).
Delano-Wood L., Stricker, N.H., Schiehser, D., Jak, A.J., Chang, Y-L., Wierenga, C.E., Termini,
L., Salmon, D.P., Frank, L.R., Bondi, M.W. (2009). APOE ε4 genotype status predicts
reduced fornix integrity in Alzheimer’s Disease. Journal of the International
Neuropsychological Society (abstract).
Wierenga, C.E., Stricker, N.H., Delano-Wood, L., McCauley, A., Bangen, K.J., Jak, A.J.,
Salmon, D.P., Bondi, M.W. (2009). Changes in the neural substrates of semantic memory
in nondemented older APOE ε4 carriers. Journal of the International Neuropsychological
Society (abstract).
Delano-Wood, L., Kimbrell, K.I., Jak, A.J., Chang, Y-L., Schweinsburg, B., Horne, N.R.,
Wierenga, C.E., Salmon, D.P., Frank, L.R., Bondi, M.W. (2008). Disruption of posterior
cingulate integrity and associations with cognition in Mild Cognitive Impairment. Journal of
the International Neuropsychological Society. (abstract).
Wierenga, C.E., Perlstein, W., Benjamin, M., Leonard, C., Rothi, L.G.J., Conway, T., Cato,
M.A., Gopinath, K., Briggs, R., & Crosson, B. (2005). Age-related changes in word retrieval:
Frontal-executive vs. temporal-semantic substrates. Journal of the International
Neuropsychological Society (abstract).
Lee, J.M., Hu, J., Gao, J.B., White, K.D., Crosson, B., Wierenga, C.E., McGregor, K., & Peck,
K.K. (2005). Identification of brain activity by fractal scaling analysis of functional MRI data.
Proceedings of the Annual International Conference on Acoustic, Speech, and Signal
Processing (abstract).
Crosson, B., Rothi, L.J.G., Koehler, S.M., Richards, K.S., Wierenga, C.E., Moore, A.B.,
Singletary, F., Kendall, D.L., Fuller, R., Rodriquez, A., Leon, S., & Beaulieu, C. (2002).
Treatment of Intention in Aphasia: Preliminary Findings and Future Directions. Proceedings
of Meeting of the World Federation of Neurology Research Group on Aphasia and Cognitive
Disorders (abstract).
Cato, M., Crosson, B., Gokcay, D., Soltysik, D., Wierenga, C.E., Gopinath, K., Belanger, H.,
Himes, N., Bauer, R., Fischler, I., Gonzalez-Rothi, L.J., & Briggs, R. (2002). Emotional
connotation as semantic attribute: a whole brain fMRI study of emotional valence and sex
effects on word generation. Journal of the International Neuropsychological Society
(abstract).
Grote, C., Wierenga, C.E., Smith, M., Kanner, A., Bergen, D., Geremia, G., Greenlee, W.
(2000). Wada difference a day makes: interpretive cautions regarding same-day injections.
Journal of the International Neuropsychological Society (abstract).
PUBLISHED SCIENTIFIC ABSTRACTS
Wierenga, C.E., Zlatar, Z., Dev, S.I., Hays, C., Shin, D.D. (2014). Altered brain response to
object naming in Alzheimer’s disease risk: A simultaneous BOLD fMRI and
pseudocontinuous arterial spin labeling study at 3T. International Neuropsychological
Society. (abstract).
Clark, L.R., Weissberger, G.H., Jurick, S.M., Chang, Y., Schiehser, D.M., Wierenga, C.E., Han,
D., Gravano, J.T., Dev, S.I., & Bondi, M.W. (2014). Faulty adaptation to repeated face-name
associative pairs in mild cognitive impairment. International Neuropsychological Society.
(abstract).
Christina E. Wierenga, Ph.D.
9
PUBLISHED ABSTRACTS (continued)
Zlatar, Z.Z., Wierenga, C.E., Bangen, K.J., & Jak, A.J. (2014). Hippocampal cerebral blood flow
and sedentary behavior in older adults: An arterial spin labeling study. International
Neuropsychological Society. (abstract).
Ewald, I.J., Bangen, K.J., Clark, L.R., Nation, D.A., Wierenga, C.E., Weissberger, G.H., Dev,
S.I., Jurick, S.M., Sanderson-Cimino, M.E., & Bondi, M.W. (2014). Reduced cerebral blood
flow predicts subsequent cognitive decline in older adults: An arterial spin labeling MRI study.
International Neuropsychological Society. (abstract).
Wierenga, C.E., Bischoff-Grethe, A., Melrose, A.J., Torres, L., Irvine, L., Bailer, U., & Kaye,
W.H. (2013). Adults recovered from anorexia nervosa show altered brain response during
delay discounting in fasted and fed states. American College of Neuropsychopharmacology.
(abstract).
Wierenga, C.E., Bischoff-Grethe, A., Melrose, A.J., Torres, L., Irvine, L.Z., Bailer, U., & Kaye,
W.H. (2013). Altered brain response to a delayed discounting task in adults recovered from
anorexia nervosa during satiety and hunger. Society for Neuroscience (abstract).
Weissberger, G.H., Gollan, T.H., Bondi, M.W., Wierenga, C.E. (2013). Language and task
switching in the bilingual brain: Bilinguals are forever in a stay trial. Society for the
Neurobiology of Language. (abstract).
Nation, D.A., Clark, L.R., Wierenga, C.E., Delano-Wood, L., Dev, S.I., Bangen, K.J., & Bondi,
M.W. (2013). Cerebrovascular resistance and cognitive decline: Modulating effects of age.
American Academy of Neurology (abstract).
Clark, L.R., Wierenga, C.E., Dev, S.D., Shin, D., Jurick, S., Rissman, R., Liu, T.T., & Bondi,
M.W. (2012). Differential effects of aging and APOE genotype on cerebral blood flow at rest.
Journal of the International Neuropsychological Society (abstract).
Weissberger, G.H., Gollan, T.H., Wierenga, C.E., & Bondi, M.W. (2011). Language and task
switching in young and older bilinguals. Proceedings of The Psychonomic Society (abstract).
Nation, D.A., Chang, Y-L., Delano-Wood, L., Wierenga, C.E., Bangen, K.J., Jak, A.J., & Bondi,
M.W. (2011). Pulse pressure elevation is associated with lower subcortical structural
volumes. Proceedings of the International Society of Vascular Behavioural and Cognitive
Disorders (abstract).
Nation, D.A., Delano-Wood, L., Wierenga, C.E., Jak, A.J., Delis, D.C., Salmon, D.P., McDonald,
C.R., & Bondi, M.W. (2011). Pulse pressure, cognition, and cerebrovascular disease in
autopsy-confirmed Alzheimer’s disease. Proceedings of the Society for Neuroscience
(abstract).
Jung, Y., Liu, T.T., Wierenga, C.E. (2011). White matter cerebral blood flow measurement in
mild cognitive impairment and Alzheimer’s disease using arterial spin labeling method
(2011). Proceedings of the International Society for Magnetic Resonance in Medicine,
(abstract).
Dev, S.I., Clark, L.R., Liu, T.T., Brown, G., Gravano, J.T., McCauley, A., Bondi, M.W., &
Wierenga, C.E. (2011). Reduced cerebral blood flow is associated with better cognitive
performance in younger and older adults. Journal of the International Neuropsychological
Society (abstract).
Dev, S., Wierenga, C.E., Gravano, J., McCauley, A., Bangen, K., Jak, A.J., Salmon, D.P., Delis,
D.C., Liu, T.T., Bondi, M.W. (2010). Genetic, cognitive, and sex effects on resting cerebral
blood flow. Annual Meeting of the American Psychological Association (abstract).
Bangen, K.J., Restom, K., Liu, T.T., Wierenga, C.E., Jak, A.J., Bondi, M.W. (2010). Resting
state cerebral blood flow and brain activation during memory encoding in mild cognitive
impairment: An arterial spin labeling study. Journal of the International Neuropsychological
Society (abstract).
Delano-Wood, L., Chang, Y-L., McCauley, A., Jak, A.J., Bangen, K.J., Schiehser, D., Stricker,
N., Wierenga, C.E., Nation, D., Lanni, E., Sorg, S., Luc, N., & Bondi, M.W. (2010).
Christina E. Wierenga, Ph.D. 10
PUBLISHED ABSTRACTS (continued)
Entorhinal cortex thickness differences by APOE genotype in MCI and normal aging. Journal
of the International Neuropsychological Society (abstract).
Lanni, E., Delano-Wood, L., Jak, A.J., Bangen, K.J., McCauley, A., Schiehser, D., Chang, Y-L.,
Stricker, N.H., Nation, D., Wierenga, C. E., Sorg, S., Clark, L., Luc, N., Delis, D.C., & Bondi,
M.W. (2010). Elevated stroke risk predicts lower hippocampal volumes in both normal aging
and mild cognitive impairment. Journal of the International Neuropsychological Society
(abstract).
Rasmussen, J.M., Liu, T.T., Mueller, B., Brown, G. Wierenga, C.E., Glover, G.H. (2010).
Measurement stability in arterial spin labeling investigated using multiple sites. Proceedings
of the International Society for Magnetic Resonance in Medicine, (abstract).
Bangen, K.J., Restom, K., Liu, T.T., Wierenga, C.E., Salmon, D.P., Bondi, M.W. (2009). Effect
of APOE genotype on brain activation during memory encoding: An arterial spin labeling
study. Journal of the International Neuropsychological Society (abstract).
Wierenga, C.E., Horne, N.R., Delano-Wood, L., McCauley, A., Bangen, K.A., Jak, A.J., Salmon,
D.P., Bondi, M.W. (2008). Changes in the neural substrates of semantic memory in
Alzheimer’s disease. Journal of the International Neuropsychological Society. (abstract).
Liu, T., Wierenga, C.E., Mueller, B., Wang, J., Glover, G., Voyvodic, J., Greve, D., Turner, J.,
Wible, C., Brown, G., and FBIRN. (2008). Reliability and reproducibility of arterial spin
labeling perfusion measures assessed with a multi-center study. Proceedings of the
International Society for Magnetic Resonance in Medicine, (abstract).
Horne, N. R., Schweinsburg, B. C., Delano-Wood, L., Wierenga, C. E., Bangen, K. J., Salmon,
D. P., Bondi, M. W. (2008). Decreased fractional anisotropy in late-myelinating fiber tracts in
Alzheimer’s disease: A tract-based spatial statistics study. Journal of the International
Neuropsychological Society. (abstract).
Bangen, K.J., Delano-Wood, L., Wierenga, C.E., Horne, N.R., McCauley, A., Kimbrell, K.,
Bondi, M.W. (2008). The relationship between stroke risk and cognition in normal aging and
Alzheimer’s disease. Journal of the International Neuropsychological Society. (abstract).
Jak, A.J., Delano-Wood, L., Wierenga, C.E., Corey-Bloom, J., Bondi, M.W. (2008).
Hippocampal volumes and relationship with cognition: Clinical subtypes of Mild Cognitive
Impairment. Journal of the International Neuropsychological Society. (abstract).
Wierenga, C.E., Stricker, J.L., Houston, W., Eyler, L.T., Lange, K., Brown, G.G., Bondi, M.W.
(2007). Functional connectivity of learning differs by APOE genotype in non-demented older
adults. Journal of the International Neuropsychological Society (abstract).
Delano-Wood, L., Wierenga, C.E., Abeles, N., Bozoki, A. (2007). Regional white matter
pathology in Mild Cognitive Impairment: Dissociation of lesion type and neuropsychological
functioning. Cognitive Neuroscience Society Abstracts. (abstract).
Crosson, B., McGregor, K.M., Benjamin, M., Chang, Y-L., Moore, A.B., Gopinath, K., Peck,
K.K., Wierenga, C.E., Gaiefsky, M.E., Soltysik, D.A., Milsted, C., Gonzalez Rothi, L.J.,
Briggs, R.W., White, K.D. (2007). Can manipulating intention change frontal lateralization for
word production during aphasia treatment. Cognitive Neuroscience Society Abstracts.
(abstract).
Delano-Wood, L., Jak, A.J., Schweinsburg, B.C., Wierenga, C.E., Horne, N.R., Salmon, D.P.,
Thal, L.J., Frank, L.R. & Bondi, M.W. (2007). Posterior white matter changes in MCI:
Associations with cognition and stroke risk. Journal of the International Neuropsychological
Society. (abstract).
Gopinath, K., Wierenga, C.E., Conway, T., Crosson, B., & Briggs, R. (2006). Differential BOLD
hemodynamics in young and elderly: Emphasis on post-stimulus undershoot. Proceedings
of the International Society for Magnetic Resonance in Medicine, (abstract).
Christina E. Wierenga, Ph.D. 11
PUBLISHED ABSTRACTS (continued)
Bondi, M.W., Wierenga, C.E., Stricker, J.L., Houston, W.S., Eyler, L.T., & Brown, G.G. (2006).
Functional connectivity comparisons of learning by APOE genotype among nondemented
older adults. Alzheimer’s & Dementia, 2 (Suppl. 1), P2-246 (abstract).
Delano-Wood, L., Schweinsburg, B., Wierenga, C.E., Jak, A.J., Salmon, D.P., Thal, L.J., Frank,
L.R., & Bondi, M.W. (2006). White matter integrity in nondemented older adults at-risk for
Alzheimer’s disease: A diffusion tensor imaging study. Journal of the International
Neuropsychological Society (abstract).
Cato, M., Wierenga, C.E., Parkinson, R.B., & Crosson, B. (2006). Pattern and rehabilitative
treatment success in aphasia: Comparison of quantitative voxel-based vs. qualitative lesion
rating approaches. Journal of the International Neuropsychological Society (abstract).
McGregor, K., White, K.D., Moore, A.B., Gaiefsky, M., Wierenga, C.E., Maher, L., Kurtzman,
M., Gopinath, K., Peck, K.K., Soltysik, D., Wabnitz, A., Briggs, R.W., & Crosson, B. (2006).
An fMRI investigation of sentence generation attempts by chronic nonfluent aphasics.
Journal of the International Neuropsychological Society (abstract).
Orynich, C., Perez, T., Wabnitz, A., Crosson, B., Moore, A.B., McGregor, K., Gopinath, K.,
Wierenga, C.E., Gaiefsky, M., Peck, K.K., Briggs, R.W., Conway, T., Gonzalez Rothi, L.J., &
White, K.D. (2006). Time courses of fMRI activations spanning the stimulus-response
interval during word generation by nonfluent aphasics. Journal of the International
Neuropsychological Society (abstract).
Gopinath, K., Wierenga, C.E., Crosson, B., Conway, T., & Briggs, R. (2005). Age-related
differences in the BOLD post-stimulus undershoot. Proceedings of the International Society
for Magnetic Resonance in Medicine (abstract).
Wabnitz, A., Jasper, B., Crosson, B., White, K.D., Moore, A.B., Gopinath, K., McGregor, K.,
Wierenga, C.E., Gaiefsky, M.E., Peck, K.K., Briggs, R.W., Conway, T.W., & Rothi, L.J.G.
(2005). FMRI reveals subcortical activations maintaining cortical ones over the stimulusresponse interval for nonfluent aphasics. Journal of the International Neuropsychological
Society (abstract).
Gaiefsky, M.E., Moore, A.B., McGregor, K.M., White, K., Wierenga, C.E., Peck, K.K., Gopinath,
K., Wabnitz, A., Raymer, A., Rothi, L.J.G., Briggs, R.W., & Crosson, B. (2005). FMRI of
language rehabilitation: Seeing versus saying. Journal of the International
Neuropsychological Society (abstract).
Cato, M., Parkinson, R.B., Wierenga, C.E., & Crosson, B. (2004). Lesion pattern relates to
rehabilitative treatment success in chronic nonfluent aphasia. Society for Neuroscience
Abstracts (abstract).
Cato, M., Parkinson, R., Wierenga, C.E., & Crosson, B. (2004). Predicting rehabilitative
treatment success in chronic nonfluent aphasia: Lesion and performance characteristics.
Journal of the International Neuropsychological Society (abstract).
Wierenga, C.E., Benjamin, M., Perlstein, W.M. & Crosson, B. (2003). Semantic category
identification as a function of parametric spatial frequency content. Society for Cognitive
Neuroscience (abstract).
Wierenga, C.E., Richards, K., Singletary, F., Rodriguez, A., Kendall, D.L., Leon, S., Gonzalez
Rothi, L.J., & Crosson, B. (2003). Intention and attention treatments of high functioning
nonfluent aphasia. Journal of the International Neuropsychological Society, 9, 193,
(abstract).
Richards, K.S., Wierenga, C.E., Singletary, F., Fuller, R., Rodriguez, A., Kendall, D.L.,
Gonzalez Rothi, L.J., & Crosson, B. (2003). Comparison of intention and attention
treatments in nonfluent aphasia. Journal of the International Neuropsychological Society, 9,
192, (abstract).
Moore, A.B., Crosson, B., Gaiefsky, M.E., Wierenga, C.E., Peck, K.K., Gopinath, K.S., White,
K., Soltysik, D., Rothi, L.J.G., & Briggs, R.W. (2003). Right hemisphere mobilization by
Christina E. Wierenga, Ph.D. 12
PUBLISHED ABSTRACTS (continued)
treatment of intention in aphasia: An FMRI study. Journal of the International
Neuropsychological Society, 9, 192, (abstract).
Wierenga, C.E., Moore, A.B., Crosson, B., Maher, L.M., Soltysik, D., Peck, K.K., Gopinath, K.,
Heilman, K.M., Rothi, L.J.G., Kendall, D., & Briggs, R.W. (2002). Changes in brain
activation with treatment of agrammatism: An fMRI study. Journal of the International
Neuropsychological Society, 8, 206 (abstract).
Gaiefsky, M.E., Crosson, B., White, K.D., Peck, K.K., Moore, A.B., Wierenga, C.E., Gopinath,
K.S., Soltysik, D., & Briggs, R. (2002). Imaging Overt Language Production in Aphasia
Using FMRI. Society for Neuroscience, (abstract).
Peck, K., Gopinath, K., Soltysik, D., Moore, A., Wierenga, C.E., Crosson, B., & Briggs, R.W.
(2002). Comparison of functional time course patterns of Broca’s area and supplementary
motor area during a silent sentence generation task in fMRI. Proceedings of the
International Society for Magnetic Resonance in Medicine, 1491 (abstract).
Maher, L.M., Singletary, F., Swearingen, J.A., Clayton, M.C., Vincent, L.A., Moore, A.B.,
Wierenga, C.E., Crosson, B., Kendall, D., & Gonzalez-Rothi, L.J. (2002). An errorless
learning approach to sentence generation in aphasia. Journal of the International
Neuropsychological Society, 8, 177 (abstract).
Wierenga, C.E., Moore, A.B., Crosson, B., Peck, K.K., Gopinath, K., Himes, N., Soltysik, D.,
Maher, L., Gonzalez-Rothi, L.J., & Briggs, R.W. (2002). Comparison of baseline tasks to
investigate syntactic production with FMRI. VA Journal of Rehabilitation Research and
Development (abstract).
Wierenga, C.E., Moore, A.B., Crosson, B., Heilman, K.M., Maher, L.M., Soltysik, D., Peck, K.K.,
Gopinath, K., & Briggs, R.W. (2001). fMRI of Sentence Generation in Agrammatic Patients
and Healthy Adults. Society for Neuroscience (abstract).
Crosson, B.A., Cato, M.A., Benefield, H., Moore, A.B., Wierenga, C.E., Sadek, J.R., Gopinath,
K., Soltysik, D., Bauer, R.M., Auerbach, Gokcay, D., & Briggs, R.W. (2001). fMRI of Right
Basal Ganglia and Frontal Activity During Language Generation. Society for Neuroscience
(abstract).
Wierenga, C.E., Larson, E., & Nyenhuis, D. (1998). The Reliability and Validity of the Chicago
Multiscale Depression Inventory (CMDI) in Patients with Traumatic Head Injury. Proceedings
of the Midwestern Psychological Association (abstract).
Wierenga, C.E. (1998). Individual Differences in Need for Cognition and Learning Strategies as
Predictors of Performance on Cognitive Tasks. Proceedings of the Midwestern
Psychological Association (abstract).
HONORS AND AWARDS
2013
American College of Neuropsychopharmacology Travel Award
2012
Laird Cermak Award for Outstanding Research in Memory and Memory Disorders,
International Neuropsychological Society
2011
Appointed to the SDSU/UCSD Joint Doctoral Program Clinical Psychology Faculty
2010
Appointed as Research Scientist for the Veterans Medical Research Foundation
2008
Appointed to the UCSD Stein Institute for Research on Aging Faculty
2009–2012 Recipient of the VA Loan Repayment Program
2006–2009 Recipient of the National Institutes of Health Clinical Loan Repayment Program
2004
Robert and Phyllis Levitt Award for Excellence in Neuropsychology Research,
Department of Clinical and Health Psychology, University of Florida
2003
Molly Harrower Award for Excellence in Psychodiagnostic Assessment,
Department of Clinical and Health Psychology, University of Florida
2003
Shands Hospital Auxiliary Scholarship, in recognition of academic excellence
Christina E. Wierenga, Ph.D. 13
2003
2002
2001–2005
2001–2005
1999–2004
1996–1998
1994–1998
1994–1998
Shands Hospital Board of Directors Scholarship, in recognition of academic
excellence
Florence Shafer Memorial Award for Excellence in Psychotherapeutic Counseling,
Department of Clinical and Health Psychology, University of Florida
Annual Graduate Student Council Research Travel Award, University of Florida
The Honor Society of Phi Kappa Phi, University of Florida
Student Class Representative in the Department of Clinical and Health
Psychology, University of Florida
Psi Chi National Honor Society in Psychology, Calvin College
Presidential Scholarship, Calvin College
Dean’s List for Academic Excellence, Calvin College
PROFESSIONAL AFFILIATIONS
American Psychological Association (APA)
Society for Clinical Neuropsychology (former Division 40)
APA Division 40 Women in Neuropsychology (WIN)
International Neuropsychological Society (INS)
Academy for Eating Disorders
San Diego Psychological Association (SDPA)
Society for Neuroscience
The Psychonomic Society
Society for the Neurobiology of Language
AD HOC/INVITED REVIEWER
Editorial Boards: Journal of Alzheimer’s Disease (Associate Editor), Neuropsychology
(Consulting Editor)
Journals:
American Journal of Geriatric Psychiatry
American Journal of Neuroradiology
Archives of Clinical Neuropsychology
Archives of General Psychiatry
BMC Neurology
Brain
Brain and Language
Brain and Behavior
Brain Imaging and Behavior
Brain Research
Current Alzheimer Research
Human Brain Mapping
Journal of Cognitive Neuroscience
Journal of the International Neuropsychological Society
Neurobiology of Aging
Neuropsychologia
Psychiatry Research: Neuroimaging
Textbooks:
Oxford University Press
Grants:
Alzheimer’s Association, Graduate Women in Science Fellowship Program
Christina E. Wierenga, Ph.D. 14
PROFESSIONAL & UNIVERSITY SERVICE
UCSD Pre-doctoral Internship Training Committee, 2007-present.
SDSU/UCSD Joint Doctoral Program in Clinical Psychology Admissions Committee, 2012, 2014
San Diego VA Healthcare System Research Budget and Equipment Committee, 2014-2017
International Neuropsychological Society Program Committee, 2010-2012
TEACHING EXPERIENCE
Faculty Member
UCSD/SDSU Joint Doctoral Program in Clinical Psychology
UCSD Pre-doctoral Internship Training Program
Doctoral Student Committees
Dissertation committee: UCSD/SDSU JDP; Lindsay Clark
Dissertation committee: UCSD/SDSU JDP; Gali Weissberger
Post-Doctoral Fellows Trained (Research):
*Katherine Bangen, Ph.D.
*Daniel Nation, Ph.D.
*Zvinka Zlatar, Ph.D.
Graduate Students Trained (Research):
*Lindsay Clark (Ph.D. student; dissertation committee)
*Gali Weissberger (Ph.D. student; dissertation committee)
Undergraduates Trained (Research):
*Sheena Dev (current UCSD/SDSU JDP student)
*Chelsea Hays (incoming UCSD/SDSU JDP student)
*Ashley McCauley (current M.S. student)
*indicates trainee co-author on peer-reviewed publication

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