Neurotransmitter Pathways - Functional Medicine University

NT Neurotransmitter Pathways
Tryptophan
Iron
MTHF
B3
Vitamin C
Vitamin D
Tyrosine
Iron
MTHF
B3
Vitamin C
Vitamin D
tryptophan hydroxylase
tyrosine hydroxylase
5-Hydroxytrytophan
(5-HTP)
L-Dopa
P5P
P5P
aromatic amino acid
decarboxylase
Serotonin
B2
B3
Iron
N-acetyl
transferase
SAMe
Dopamine
Vitamin C
Copper
B3
MAO
B2, B3
SAMe
Iron
dopamine
B-hydroxylase
Norepinephrine
SAMe
Cortisol
hydroxyindole-0methyltransferase
B2, B3
SAMe
Iron
phenylethanolamine
N-methyltransferase
Epinephrine
Melatonin
glutamine
synthetase
MAO
COMT
Metabolites
Glutamine
B2, B3
SAMe
Iron
glutaminase
glutamate
dehydrogenase (B3)
MAO
COMT
Metabolites
Glutamate
alpha-ketoglutarate
MAO
COMT
Metabolites
Metabolites
Acetylserotonin
aromatic amino acid
decarboxylase
aminotransferase (B6)
B6
glutamate
decarboxylase (GAD)
Note: aminotransferase aka transaminase
GABA
Glutamic Acid
KEY
P5P = (pyridoxal-5-phosphate) activated form of vitamin B6
MTHF = (methyltetrahydrofolate) active form of folate. MTHF is
required for the production of tetrahydrobiopterin, a cofactor in this
conversion.
MAO = monoamine oxidase
COMT = catechol-o-methyl-transferase
SAMe = endogenous levels can be supported with Mg, MTHF, and
methylcobalamin supplementation
Cofactors =
Enzymes =
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