SFB Antrag Molecular Vorology.indd

PROGRAM
Symposium of the Research Unit 1202
„Mechanisms of persistence of hepatotropic viruses“:
Determinants of elimination and persistence of hepatitis viruses
May 19th – May 21st 2014
German Cancer Research Center Heidelberg, Germany
Sponsored by
Symposium of the Research Unit 1202
Symposium Chairs:
Prof. Dr. Ralf Bartenschlager
Department of Infectious Diseases, Molecular Virology,
Heidelberg University Hospital;
Research Division ‘Virus-associated Carcinogenesis’,
German Cancer Research Center Heidelberg;
German Centre for Infection Research (DZIF e.V.)
Prof. Dr. Robert Thimme
Department of Internal Medicine II,
University Hospital Freiburg
Prof. Dr. Ulrike Protzer
Institute of Virology,
TU München/ Helmholtz Zentrum München;
German Centre for Infection Research (DZIF e.V.)
Conference Language:
The conference language will be English.
Organizing Committee:
Prof. Dr. Ralf Bartenschlager
Prof. Dr. Robert Thimme
Prof. Dr. Ulrike Protzer
Dr. Sandra Bühler
Dr. Antje Reuter
Contact:
Sandra Bühler
Heidelberg University Hospital
Im Neuenheimer Feld 345
D-69120 Heidelberg
Tel.: +49 6221 56 4225
Fax: + 49 6221 56 4570
E-Mail: [email protected]
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Dear Colleagues,
It is a great pleasure to welcome you to the second symposium of the research unit „Mechanisms of persistence of hepatotropic viruses” (FOR 1202). Given the success and the very
positive feed-back from the participants in the course of the last meeting, we decided to
organize this symposium again in 2014. While keeping the primary thematic focus, we have
expanded the scope by integrating novel aspects such as systems biology of the immune
response and live cell / in vivo imaging.
The symposium is intended to bring together clinicians and basic scientists that are united
by their interest in the mechanisms utilized by hepatitis viruses to escape innate and
adaptive immune responses and thus, to establish persistence. The topic is at the interface
of virus – host interactions, and therefore includes in addition to immunology a substantial
amount of cell biology and molecular virology. In the light of this interdisciplinarity, a main
mission of the symposium is to foster collaborations and interactions in a relaxed and rather
informal atmosphere.
We would like to thank all our sponsors for their generous support of the symposium, which
would not be possible without their help. We are also very grateful to the German Cancer
Research Center in Heidelberg for hosting this meeting. Most important is the contribution
of all the speakers and chairpersons, whom we thank very much for taking their time out of
busy schedules and their active participation. Finally, we thank you all for coming to Heidelberg and we wish you an exciting and productive meeting as well as a pleasant stay.
Prof. Dr. Ralf Bartenschlager
Prof. Dr. Ulrike Protzer
Prof. Dr. Robert Thimme
Symposium of the Research Unit 1202
Determinants of elimination and persistence of hepatitis viruses
DKFZ Heidelberg, May 19th – May 21st 2014
Monday, May 19th 2014
11:00 - 11:10
Prof. Dr. Ralf Bartenschlager
Welcome address
Adaptive Immune Response
Chairman: PD Dr. Christoph Neumann-Haefelin
11:10 – 11:40
Prof. Dr. Barbara Rehermann
New insights into protective immunity in HCV infection
11:40 – 12:05
Prof. Dr. Percy Knolle
Consequences of local antigen presentation in the liver for
intrahepatic immunity
12:05 – 12:35
Prof. Dr. Antonio Bertoletti
The impact of age on HBV-specific T cell response
12:35 – 12:55
PD Dr. Christoph Neumann-Haefelin (FOR1202)
Viral escape in HBV infection
13:00 – 14:00
LUNCH
14:00 – 14:25
Prof. Dr. Marcus Altfeld
T and NK cell responses in chronic viral infection: lessons
learned from HIV
14:25 – 14:45
Prof. Dr. Robert Thimme (FOR1202)
HCV-specific CD8+ T cell restoration in patients undergoing
IFN-free antiviral therapy
14:45 – 15:10
Dr. Bijan Raziorrouh
The role of CD4+ T cells in viral hepatitis
15:10 – 15:35
Dr. Tobias Böttler
Follicular T helper cells in viral hepatitis
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15:45 – 16:15
COFFEE BREAK
Vaccine Development and Antiviral Therapy against HCV
Chairman: Prof. Dr. Ulrike Protzer
16:15 – 16:45
Prof. Dr. Matti Sällberg
Current state of HCV vaccine development
16:45 – 17:15
Dr. Mirjam Zeisel
Targeting host entry factors for prevention and treatment of
HCV infection
17:15 – 17:40
Prof. Dr. Christoph Eisenbach
Pathogenesis and therapy of hepatitis viral reinfection after LTx
17:40 – 18:10
Prof. Dr. Darius Moradpour
Treatment of chronic hepatitis C - From virus discovery to oral
combination therapy in 25 years
18:10 – 18:35
Dr. Christoph Welsch
Clinical relevance of HCV-DAA resistance
18:35 – 21:00
GET TOGETHER (open to all participants)
Foyer Conference Center DKFZ
Tuesday, May 20th 2014
Innate Immunity
Chairman: PD Dr. Volker Lohmann
09:00 – 09:25
Dr. Andreas Pichlmair
The proteome under viral attack
09:25 – 09:50
Dr. Georg Gasteiger
Help and control: Interactions of adaptive and innate
lymphocytes
09:50 – 10:15
Prof. Dr. Jacob Nattermann
Role of NK cells in the immunopathogenesis of HCV
Symposium of the Research Unit 1202
10:15 – 10:45
COFFEE BREAK
10:45 – 11:15
Prof. Dr. Paul Klenerman
CD161+/MAIT cells and the liver
11:15 – 11:35
PD Dr. Volker Lohmann (FOR1202)
Determinants of interferon-gamma response
11:35 – 11:55
Prof. Dr. Ralf Bartenschlager (FOR1202)
Virological and immunological mechanisms of HCV
persistence
11:55 – 12:20
Prof. Dr. Mathias Heikenwälder
Inflammation dependent and independent pathways in virally
induced liver pathogenesis
12:30 – 13:30
LUNCH
Basic and Applied Aspects of Hepatitis Virus Therapy
Chairman: Prof. Dr. Robert Thimme
13:30 – 13:55
Prof. Dr. Michael Manns
Therapy of HBV infection and HBV co-infection
13:55 – 14:20
Prof. Dr. Ulrike Protzer
Control of HBV infection by immune mediators
14:20 – 14:45
Prof. Dr. Heiner Wedemeyer
Immunopathogenesis and therapy of hepatitis delta
14:45 – 15:15
Prof. Dr. Markus Heim
HCV and the IFN system: a clinical perspective
15:15 – 15:45
Prof. Dr. Rune Hartmann
The interferon lambda 4 paradox; highly antiviral yet a disadvantage during HCV infection
15:45 – 16:15
COFFEE BREAK
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Mouse Models for Hepatitis Viruses
Chairman: Prof. Dr. Michael Nassal
16:15 – 16:40 Prof. Dr. Maura Dandri
Chimeric mice to study determinants affecting persistence of
hepatitis B and D viruses
16:40 – 17:10
Prof. Dr. Alexander Ploss
Construction of humanized mouse models for hepatitis C
Evolution and Species Barrier
Chairman: Prof. Dr. Stephan Urban
17:10 – 17:25
PD Dr. Dieter Glebe
Bat hepadnaviruses: the origin of hepatitis B virus?
17:25 – 17:40
Dr. Stefan Seitz
A novel virus family shedding light on the long-term evolution
of hepatitis B viruses
17:40 – 18:05
Prof. Dr. Thomas Pietschmann
Control of HCV replication in mouse liver cells by innate
immune signaling
19:00
SPEAKERS DINNER
Wednesday, May 21st 2014
Viral Replication, Modeling and Imaging
Chairman: Prof. Dr. Ralf Bartenschlager
10:15 – 10:35
Prof. Dr. Stephan Urban (FOR1202)
Role of HBV X protein in cccDNA formation
10:35 – 10:55 Prof. Dr. Michael Nassal (FOR1202)
Role of the cellular repair machinery in HBV cccDNA formation
10:55 – 11:20 Dr. Marco Binder
A mathematical approach to understand HCV replication dynamics
Symposium of the Research Unit 1202
11:30 – 12:00
COFFEE BREAK
12:00 – 12:25 Prof. Dr. Thomas Höfer
Molecular determinants of virus-host cell population dynamics
12:25 – 12:45
Prof. Dr. Ursula Klingmüller (FOR1202)
Addressing the multi-factorial impact on viral persistence by
integrative dynamic pathway modeling
12:45– 13:15
Prof. Dr. Matteo Iannacone
Determinants of intrahepatic effector CD8+ T cell trafficking
and antigen recognition
13:15
FAREWELL AND LUNCH 9
Conference Venue:
Communication Center, DKFZ Heidelberg
Im Neuenheimer Feld 280
69120 Heidelberg
Symposium of the Research Unit 1202
How to find the DKFZ:
By Car:
a) Because of the limited number of parking areas in the Neuenheimer Feld, it is recommended to arrive by public transport.
b) Approaching Heidelberg on Autobahn A5 from Frankfurt or Karlsruhe, change to Autobahn A656 from direction Mannheim at the junction „Heidelberger Kreuz“. Continue on
Autobahn A 656 to Heidelberg, which ends at the Heidelberg City limits.
As you enter the city of Heidelberg, follow the signs „Eberbach/HD-Wieblingen/Chirurgie“:
Turn left at first traffic light, then right at second. Follow the curve at the next light. Underpass
the Neckar Bridge, then turn right twice heading for „Chirurgie/DKFZ“. Having crossed the
Neckar River, take the left lane at the first intersection and head for „Chirurgie/DKFZ“. Follow
this street to the next intersection. Do NOT turn left and drive through the gate, as indicated
by DKFZ-signs (it‘s a checkpoint)! Drive straight ahead instead. To the right there are (charged)
parking lots where you can park your car. From the car park walk back to the gate and pass it.
Follow the street for about 100 meters. The German Cancer Research Center is the tall building
on the right (for your orientation, you can find the house numbers on the top of each building;
DKFZ has 280). Go straight ahead along the building, until you can see the main entrance on
the right. In the entrance hall please contact the information desk for further help.
By Tramway or bus from the main station:
Tramway: Take the north exit (Kurfürstenanlage) of the central station to the tram stop. Take
tram number 24 with terminus „Burgstr.“, or tram number 21 with terminus „OEG-Bahnhof“.
With both lines, leave at stop „Jahnstraße/Chirurgie“ (right after the Neckar bridge). Cross
the street to the left and walk into „Jahnstrasse“. Follow that street until you reach the gate
on the left. Pass the gate and walk into „Kirschnerstrasse“. About 100 meters down the road
you will see the DKFZ main building.
Bus: Take bus number 32 with the terminus “Neuenheim, Kopfklinik” and leave at stop “Uni
Campus”. Walk a few meters back and turn left. You will see the DKFZ conference center on
the right.
Get together (open to all)
The get together will take place in the foyer of the DKFZ conference center after the last talk
on Monday, May 19th. All participants are welcome to attend.
Speakers Dinner:
Burggasthof Strahlenburg Schriesheim
Burgweg 32
69198 Schriesheim
We have organized a bus transfer to the restaurant. Details for departure will be given during
the symposium.
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NOTES
Symposium of the Research Unit 1202
IMPRINT
Publisher
Department of Infectious Disease, Molecular Virology
Heidelberg University Hospital
Im Neuenheimer Feld 345
69120 Heidelberg
Editorial
Dr. Sandra Bühler
Department of Infectious Disease, Molecular Virology
Heidelberg University Hospital
Im Neuenheimer Feld 345
69120 Heidelberg
Design and Layout
Print + Medien | Im Zentralbereich Neuenheimer Feld
Im Neuenheimer Feld 326
69120 Heidelberg
[email protected]
Last revised: April 2014
www.klinikum.uni-heidelberg.de
www.uniklinik-freiburg.de

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