2014 CANCER RESEARCH SYMPOSIUM Tuesday, September 23, 2014 Time Discussion Presenter Location SESSION I – Common Themes and Mechanisms in Cancer and Neurodevelopmental Disorders Chair: Wolf-Dietrich Heyer, PhD 8:30–8:40 am Introduction and Welcome 8:40–9:40 am 9:40–10:05 am 10:05–10:25 am 10:25–10:50 am Topoisomerases and Tyrosyl DNA phosphodiesterases in cancers and neurological disorders (Keynote) Prevalent formation of R-loop structures in the human genome Break Epigenetic landscapes of 15q neurodevelopmental disorders and beyond: implications for cancer Ralph de Vere White, MD UCDCCC Leonard Abbeduto, PhD MIND Institute Yves Pommier, MD, PhD National Cancer Institute Frederic Chedin, PhD Dept Mol and Cell Biol (UCDCCC) Janine LaSalle, PhD Dept. Microbiol (UCDCCC/MIND) Paul Hagerman, MD, PhD Dept. Biochem & Mol Med (MIND) 10:50–11:15 am Fragile X and related syndromes 11:15–11:40 am A novel class of early replicating fragile sites Jacqueline Barlow, PhD contributing to genome instability in B cell Dept. Microbiol and Mol Genetics lymphoma 11:50–1:50 pm Cancer Center Auditorium Poster Session and Lunch All Marriott Ballroom SESSION II - The Roles of PTEN in Cancer and Autism Chair: Luis Carvajal-Carmona, PhD 2:00–3:00 pm 3:00–3:30 pm 3:30–3:55 pm 3:55–4:20 pm 4:20–5:00 pm Nuclear PTEN in tumour suppression (Keynote) Autism-relevant behavioral phenotypes in Pten mutant mice Vuk Stambolic, PhD Princess Margaret Cancer Centre Jacqueline Crawley, PhD Dept. Psychiat & Behav Sci (MIND) Cancer Cecilia Giulivi, PhD Center PTEN, autism, and bioenergetics Dept Mol Biosciences (MIND) Auditorium Overlapping developmental origins in autism Rebecca Schmidt, PhD and cancer: Role of folate and one-carbon Dept. Public Health (MIND) metabolism Panel discussion with all speakers and session chairs Oral presentations held at Cancer Center: 4501 X Street, Sacramento Poster sessions and lunch held at Courtyard Marriott (2 blocks away from Cancer Center): 4422 Y St, Sacramento Wednesday, September 24, 2014 Time 8:30–9:30 am 9:30–10:00 am 10:00–10:10 am 10:10–10:30 am 10:30–11:00 am 11:00–11:20 am 11:20–1:20 pm Discussion More than omics big data: Informatics and cancer (Keynote) UC Davis-JAX PDX program: Where is it and where is it going? Break What can big data technologies and analytics do for the PDX program? Poster Session and Lunch Community to bedside to bench: Approaches to disparities in liver cancer among Asian Americans 1:40–2:00 pm Bile acids and GI carcinogenesis 2:00–2:20 pm Assessment of quality of care at UCDCCC 2:40–2:50 pm 2:50–3:10 pm 3:10–3:30 pm 3:30–3:50 pm 3:50–4:10 pm Location Brad Pollock, MPH, PhD Dept. Public Health Sciences Chong-xian Pan, MD, PhD Div. Hematology Oncology Monte LaBute, PhD Lawrence Livermore Natl Lab Katherine Rauen, MD, PhD The RASopathies: Novel Clinic Model for Liga Bivina, MS, LCGC Care (Keynote) Dept. Pediatrics Rosemary Cress, DrPH Dept. Public Health Sciences Use of California Cancer Registry data to Cara Torruellas, MD, MPH evaluate HCC surveillance. Div. Gastroenterology & Hepatol 1:20–1:40 pm 2:20–2:40 pm Presenter All Cancer Center Auditorium Marriott Ballroom Christopher Bowlus, MD Div. Gastroenterology & Hepatol Yvonne Wan, PhD Dept. Pathol and Lab Medicine Richard Bold, MD Div. Surgical Oncology The effect of intrathecal analgesic drug David Copenhaver, MD, MPH delivery systems on caregiver burden and Div. Pain Medicine resource utilization for cancer patients. Break Soichiro Yamada, PhD Cadherin mechanics in cancer cell invasion Dept. Biomedical Engineering Targeting chemoresistant breast cancer cell Ashley Rowson, PhD Dept. Biochem & Mol Med populations Label-free optical techniques for real-time Laura Marcu, PhD intraoperative delineation of surgical Dept. Biomedical Engineering margins Personalizing radiotherapy with pulmonary Tokihiro Yamamoto, PhD Dept. Radiation Oncology functional imaging Cancer Center Auditorium Symposium Close Oral presentations held at Cancer Center: 4501 X Street, Sacramento Poster sessions and lunch held at Courtyard Marriott (2 blocks away from Cancer Center): 4422 Y St, Sacramento