ਜ਼ഛ൴ఱڠ༗࠲ۭࢌڠ໐ȁਜ਼ഛ൴༗࠲ۭࢌࡄݪȁలˏےȪijıIJĶȫ 15 ࡄݪ༭࣬ ਜ਼ഛ൴ఱڠ༗࠲ۭࢌڠ໐ȁਜ਼ഛ൴༗࠲ۭࢌࡄ ݪĴ P.15 - 20ġĩ2015ȫ ෞࢸणۛ৪͈មထཡ̤̫ͥͅఉثະგডཛॸူוൎဓ͈൦ Effect of Enteral Nutrition with Eiconosapentaenoic Acids for Preventing Pressure Ulcers in Patients with Cerebral Infarction. ࣱȁȁجȁঊˍȫȁȁȁȁȁ߰ IJĭijĪȁ߬ȁఆȁȁঊˍȫ KUROKAWA Yoshiko OGAWA Kaoru ˏȫ KUWAMURA Junko ५ȁུȁఽȁঃ ȁඃȁȁઽȁহ ȁġȁఆȁȁȁࢨːȫ TAMAMOTO Takuji ˏȫ TOKUGAWA Joji SUGIMURA Sachi ါȁক ࿒എȇఉثະგডཛॸ̜́ͥͼβϋΗϋॸȪո ئEPA ͂ၞ̳ͥȫ͈ൎဓͥ͢ͅម อ͈ထཡ࢘ͬض൦̳̹ͥ͛Ȃមอ͈ΧͼςΑ·͂ࣉ̢ͣͦͥփেવ৽ͬٺஶͅݢݣเ ̯ͦව̱̹֭ෞࢸणۛ৪ͅచ̱̀Ȃ̷͈͈࢘ض൦࣐̹ͬ̽ȃ చય༹̤͍༷͢ȇGlasgow Coma Scale12 തո́ئව֭ࢃːոષ͈հͬထ̱̞̀ͥෞࢸ णۛ৪ː႕ͬచય̱̹͂ȃව֭ೄࢃ̥ͣ EPA ൎဓ߲ˎ႕͂Ȃచચ߲̱͂̀ EPA ൎဓ߲Ȫ ϋΠυȜσ߲ȫˎ႕̫ͩͅȂIJĵ ۼκΣΗςϋΈ̱Ȃ૧͈ܰមอອഽ͞ڎਅΩριȜῌ ̞̾̀ڛ൦̱̹ȃ ଼ୡȇEPA ൎဓ߲͉ȂϋΠυȜσ߲͓̀ͅម͈อ̦̥̹͛ͣͦ̈́̽ȃ̹͘ȂEPA ൎ ဓ߲͉ςϋΩ͈ݩ̦ࣞͬা̱Ȃ྾ܥעෝ̦̥̹ࣞ̽ȃ ࠫაȇមอ͈ΧͼςΑ·͂ࣉ̢ͣͦͥಎ൝છȡਹછփেવ̜͈ͥٺෞࢸणۛ৪͈છ႕ͅచ ̱̀ EPA ͈ൎဓ࣐̠̭͉ͬ͂Ȃછ؊ͬဲଷ̱Ȃមอ͈ထཡ࣓ͅࡃ̳ͥخෝ̞̾̀ͅ াऐ̧̹́ȃ ȁȁ॑ ֨ ဥ ࢊȇមȂထཡȂͼβϋΗϋॸȂူו ȁȁKey wordsȇpressure ulcer, prevention, eicosapentaenoic acid, nutrition ԅȅ੨ȁ࡞ ̤ͤȂ̷͈̠̻͈ါٚࢌ৪൝̞̾̀ͅȂٚࢌ̦ຈါ ȁٚࢌ༗ࡏଷഽ̤̫ͥͅါٚࢌ৪ྌ͉ါ׳৪͂ ̹̈́̽ͅ৽̈́ࡔ֦̞͙̾̀ͥ͂ͅȂ ȶෞࠬۯۛȷ̦ ̯̹ͦ૽͉Ȃ଼ ijij ාഽྎ́ Ķıķįij ྔ૽͂̈́̽̀ ijIJįĶɓ͂ड͜ఉ̞ˍȫȃෞࠬۯۛۛ৪ུ͉࣭ͅ ijĸij ྔ૽ంह̱Ȃ̷͈̠̻ IJķı ྔ૽̦ါٚࢌેఠ́ ˍȫਜ਼ഛ൴ఱڠ༗࠲ۭࢌڠ໐ ˎȫਜ਼ഛ൴ఱڠ֓ڠ໐કܕاඤش ˏȫਜ਼ഛ൴ఱڠ֓ڠ໐້௺ؖພ֭ෞ૰ࠐشٸ ːȫਜ਼ഛ൴ఱڠ֓ڠ໐້௺ؖພ֭ ˍȫJuntendo University Faculty of Health Sciences and Nursing ˎȫJuntendo University School of Medicine, Department of Gastroente rology ˏȫJuntendo University Shizuoka Hospital, Department of Neurosur gery ːȫJuntendo University Shizuoka Hospital ȁȁĩNovį 14ĭ 2014 ࡔࣂັȫ ȪJanį 16, 2015 ࡔࣂႀȫ ̜̞̠ͥ͂༭̜࣬ͥ͜ȃ̹͘Ȃါٚࢌ৪൝̥͙̹ͣ ৽̈́ٚࢌ৪͈͉Ȃ˒ڬոષ̦൳̦૽̞̱ͥ̀ݳ ٚࢌ৪̤͂̈́̽̀ͤȂ̷͈ٚࢌ৪͈ාႢ͉Ȃ́ ͉ ķĵįĹɓȂ੫͉́ ķıįĺɓ̦ ķı पոષ̜́ͤȂ̞ ͩͥ͠ȶჇșٚࢌȷ͈ΉȜΑ͜൚ତంह̱̞̀ͥˍȫȃ ̭ͦͣါٚࢌ৪͉ͅម̦อ̱̳̞̭̦͂ͣ͞ QOL ̤ͦ̀ͤȂម͉ါٚࢌ৪͈ྵထࢃȆ ͬಠ 16 ࣱجঊȇෞࢸणۛ৪͈មထཡ̤̫ͥͅఉثະგডཛॸူוൎဓ͈൦ ̱̩೩̵̩̫̺̯̈́́ͥئȂۭࢌٚ͞ࢌ͈ͬۼ௩ ֓ၷ͈ॉࡘ൝Ȃఉ࿂എ̈́Ήͺ͈٨̤͍͢ΑΠ ̳̭͂͂̈́ͥ͞ȃࣽٝచય̱̹͂փেવ৽ͬٺஶͅ ॉࡘ࣓ͅࡃ̧́ͥ͂ࣉ̢ͣͦͥȃ ݢݣเ̯ͦව̱̹֭ෞࢸणછ႕͉́Ȃව֭ಎ͈αΛ ȁུࡄ͉́ݪȂಎ൝છȡਹછփেવ৽ͬٺஶͅݢݣ Ρષհ͞ఘպ۟ࣾඳͤ͢ͅȂ̯ͣͅមอ͈ เ̯ͦව̱̹֭ෞࢸणછ႕͈មอອഽͬऔ ςΑ·̦̩ࣞ̈́ͥȃ̷͈̹͛ȂίυΠȜσͅݶ ̱Ȃอ̱̹ۛ৪̷̤̞͉͈̀ͅඅಭͬྶ̥̱ͣͅ ̱ۭ̀ࢌΉͺ̤̭̞ͬ̈́̽̀̀͜อ̳ͥម̾ͅ ̹ȃ̹͘Ȃņőł ͈ൎဓ̦មอ͈ဲଷ̦̾̈́ͥͅ ̞͉̀Ȃਲြ͈Ήͺ఼͈ঠո͈̥ͣٸါ֦ͬ࿅॑ ͈̥Ȃ̷͈࢘ͬضબ̱̹ȃ ̳ͥຈါ̦̜ͥȃម͉̹͍͌͂อ̳ͥ͞Ȃۛ৪ ུ૽͈ߎ̺̫̩ۭ́̈́ࢌਲম৪ٚ͞ࢌ̤̭̠ͬ̈́ Ԇȅచય༹͍༷̈́ͣͅ ز͜ͅఱ̧̈́͂̈́ͥȃ̭ͦ́͘មထཡ̾ͅ ˍȅచય ̞͉̀Ȃူוၷ༹̱͂̀ΗϋΩ·ৗȂΫΗηϋȂη ȁո͈ئഴܖ̞̀̿ͅܖȂS ࡇඤ͈ܢݢພ֭ͅ Υρσ႒͈༞ͬݯଔ̳͈̦͕̜̹ͥ͂ͭ̓́̽͜ȃ ව֭ಎ͈ۛ৪ͬచય̱̱̹͂ȃ ម̳ͥͅ۾ٚවࡄ͉́ݪȂࠐ࢛എͅॸܚͺηΦ Ȫഴܖȫ ॸ̭̹̱ͬ́͂حȂម͈٨̦̹̞̾̈́̽͂ͅ ġˍȫGlasgow Coma ScaleȪո ئGCS ͂ၞȫġIJij തո ̠છ႕༭̦̯̞࣬̈́ͦ̀ͥˎȫȃఉثະგডཛॸ͈ ȁ͈ئփেવ̜̦ͥٺෞࢸणછ႕ ម͉̞࢘̀̾ͅضȂͣˏȫͤ͢ͅಿٓަͅܢպ́հ ġˎȫව֭ࢃːոષ͈հͬထ̱̞̀ͥછ႕ ેఠͬ༗̾ຈါ̦̜ͥۛ৪ͅచ̱̀Ȃͼβ ġˏȫව֭ಎ͈ࠐࠐۯಸ̦ူוഐ୨̈́છ႕ ϋΗϋॸȪEPAȫ ȆϹ- ςΦτϋॸȪGLAȫاޑෛ࢚ ġːȫ੫͂͜ͅ ijı पոષ̜̭́ͥ͂ ၠ൲ͬဥ̞̹ۯူוၑ࣐̠̭͉ͬ͂មထཡ͈ခ ġˑȫུͥ͢ͅ૽̜̞͉ͥز൝͈൳փ̦ංͣͦ ဥ఼̈́ঠ͂̈́ͤං̭̦ͥ͂ྶ̥̹ͣ͂̈́̽ȃఉث ȁ̭ͥ͂ ະგডཛॸ͉ࢯછैဥ̱͂̀છͼΦ Ȫੰܖٸȫ ͼΡ͈ॲͬဲଷ̳ͥैဥ̦̜ͥĵĪĭ ĶĪĭ ķĪȃ̱̥̱Ȃࠐۯ ġˍȫළິ̹͉͘ິ ٳူוইশ͉Ȃકܕاછે൝̦࡛̱̳̩͞Ȃ ġˎȫාႢ ijı पྚྖ͈છ႕ ̈́ൎဓ̦ࣾඳ́ેူוఠ̦՛̳ͥاછ႕̦ఉ̞ȃ ġˏȫྵထࢃ̧̦ͩ͛̀ౣ̞Ȫဒྵ ijĹ ྚྖȫ͂ထ ̷͈̹͛Ȃࠐူוۯ൵වশ̤̫ͥͅેူוఠ͈೩ئ ȁ௶̯ͦͥછ႕ ͬཡ̪̹͛ͅȂ༞੩ͥ͢ͅူוͺίυȜΙ̦ຈါ͂ ġːȫࠬൠۯၑ̦ޭ͛̀ࣾඳ̈́ൠෂພછ႕ȪHbA1C Ʉ ̈́ͥȃ̷̭́ȂࣽٝȂࣞডࠬછ͈٨൝ͅႉ́ఉ ȁIJıįıĦȫ ̩ঀဥ̯̞ͦ̀ͥఉثະგডཛॸ͈ͼβϋΠ ġˑȫͼτ;Α̜̞͉ͥಸܥ͈ۯෝ̦ॼం̱̞̞̀̈́ ॸΙσͬঀဥ̱Ȃબ̤̭̹ͬ̈́̽ȃͼβϋ ȁࠐಸ̦ူוະഐ؊͈છ႕ ΠॸΙσ͉Ȃਹఱ̈́໗ैဥ͈࡛ອഽ̦೩̞̭͂ ġ˒ȫਹഽ̈́྾ڠעഎဲଷછ႕ȪฒࠬݩତɃ IJıııcells ̦ྶ̥̤ͣ̈́̽̀ͤͅȂ̹͘Ȃ̦ڒثհ̭̜ͥ́ث /mm ȫ ̥͈͂ͣࣽٝঀဥͅঢ̹̽ȃ̭ͦ́͘ម͈ထཡͅ ġ˓ȫࣞডࠬછ႕ȪTG Ʉ Ķıımg/dlȂT-Cho Ʉ Ĵıımg ̞̾̀൦̦̯̭̥̹ͦ̀̈́̽ ņőł ͈ൎဓͤ͢ͅ /dlȫ ម͈ထཡ̦࢘࢜ضષ̳͈̜ͥ́ͦ͊Ȃۛ৪͂ͅ ġ˔ȫϋΠυȜσະၻ͈ئၓછ႕ ̴̓ͣ͘Ȃۭࢌ͍̈́ͣٚͅࢌ͈ࠚࡘȂ̯͉ͣͅ ġ˕ȫঀဥၠ൲଼̞ͥ̀ͦ͘ͅ܄ͅͺτσΆȜ̦ 3 ਜ਼ഛ൴ఱڠ༗࠲ۭࢌڠ໐ȁਜ਼ഛ൴༗࠲ۭࢌࡄݪȁలˏےȪijıIJĶȫ 17 ȁ̜ͥછ႕ ͅ֊࣐̳ͥ͂হၷඤယ̦་ࢵ̳̹ͥ͛Ȃមࠁ଼ͅ IJıȫΑΞυͼΡঀဥછ႕ ̢ͦͣࣉ̜̦͂ͥޣגȂडಿ IJĵ ͬۼܢ͂ۼ୭̱ IJIJȫུদࡑ͈ഴஜ Ĵı ոඤͅఈ͈হࡑ൝ͅ४̱ح ̹ȃࠐࠐۯಸ͉ူוȂࠐ࢛̦ٳই͂̈́ͤࠐࠐۯಸ ȁ̞̀ͥછ႕ȃ ͈̥ͣူוΥσΆȜ୫৾ၾ̦ຈါΥσΆȜၾ IJijȫ̷͈ఈȂ৽හࡄݪ৪൝ུ̦দࡑͬঔ̳̭ͥ͂ ఘ͈ ĸĶɓո̹̽̈́͂ئশത́ਞၭ̱̹͂ȃ̾ͅס ȁͬະഐ൚͂౯̱̹છ႕ȃ ̞͉̀Ȃডཛस͈ঀဥ͉̹̱͂ܝȃEPA ͈ൎဓ ༹༷͂ൎဓၾ͉ȂͼβϋΠॸΙσ IJĹıımg ͬ ˎȅ༹༷ ಱတˎ̫ٝͅࠐࠐۯಸ͈ူוषͅࠐۯൎဓ̱̹ȃ ˍȫদࡑΟΎͼϋ ˏȫऔࣜ࿒ ྫैևັڬႉদࡑ ȁGCSIJij തո͈ئಎ൝છȡਹછփেવ̜͈ͥٺෞࢸ णۛ৪́ව֭ࢃːոષ͈հͬထ̱̞̀ͥછ႕ ̞̾̀ͅȂව֭ೄࢃ̥͈ͣ ņőł ൎဓ߲͂Ȃచચ̱͂ Ȫˍȫఘࠗ௶ȇಿ ļ ව֭শȃఘਹ ļ ව֭শȆൎဓࢃ ȁIJĵ ࿒ Ȫˎȫម౯ȇDESIGN-R ͬဥ̞̀Ȃව֭ೄࢃ̥ͣ ȁൎဓࢃ IJĵ ࿒ྀ́͘ȃ ̀ EPA ൎဓ߲ȪոئϋΠυȜσ߲̳͂ͥȫ̫ͅȂ Ȫˏȫࠬסऔȇ๊֚ࠬסऔ ļ ࠬݩତ ĭ ฒࠬݩତ ĭ មอອഽ̞̾̀ͅ DESIGN-RȪུមڠٛġ Hbĭġ Htĭ ฒࠬݩْ ĭ ࠬโତ ļ ව֭শȆEPA ൎဓ មેఠΑΉȜσȫ̧̿ͅܖບ̹̱ثȃူוΉͺ ȁࢃˍĭ ːĭ ˓ĭIJĵ ࿒ȃࠬסڠاऔ ļ ̹̩ͭ͋ ĭ ո͈ٸহၷ͍ۭ̈́ͣͅࢌΉͺ̞͉̾̀ͅȂۛ৪ࡢș ȁͺσήηϋ ĭ ΠρϋΑέͿςϋ ĭ τΙΦȜσࣣ̹ࠫ ͈ેఠ̹̞֭̿ͅܖඤ͈ດഎ̈́ΉͺίυΠȜσ ȁ̩ͭ͋ ĭ ίτͺσήηϋ ĭġBUNĭġCRPĭġτΑΞυ ̹̱̭̳͂͂ͥͅݶȃ ȁȜσ ĭġ HDL τΑΞυȜσ ĭġ LDL τΑΞυȜσ ĭ ȁΟȜΗਓਬ͉ۼܢȂijıIJĵ ාˍȡˎ̜̹́̽ȃ ȁಎডཛ ĭ ডཛॸْ ĭ ࠬൠ ļ ව֭শȆEPA ൎဓࢃ ˎȫൎဓ༹༷ ȁˍĭ ːĭ ˓ĭIJĵ ࿒ȃHbA1Cĭ ࠬୄͼϋΑςϋ ļġව֭শȆ ȁව֭ೄࢃͅࠐࠐۯಸူוൎဓȪĴıı ȡ ĵııKcalİ ٝȫ ȁEPA ൎဓࢃ IJĵ ࿒ȃ ͬ೩௸ഽ̥ͣٳই̱Ȃ࿒ດൎဓΥσΆȜ̱͂̀ດ ːȫບࣜث࿒ ఘਹȪŬŨȫȿ ĴıKcalİ ͬၠ൲́ൎဓ̧̠́ͥ͢ ယ̦̱ͬͣ̈́ږഐܽ௸ഽͬஞ௩̱̹ȃࠐಸူו ΙνȜή͈୶͉֍ඤၣ౾̱̹͂ȃൎဓ༹༷͉ࡔ௱എ Ȫˍȫ৽ါບࣜث࿒ȇ૧ܰͅอ̱̹ម ĩDESIGN-R ́ບ̱ثȂdIJ ոષ͈ତ̳͂ͥ Īİ Ȫˎȫ໗ষບࣜث࿒ȇခٺমયȂႉऔ։ુ ͅൎဓ༹༷̳̦͂ͥȂકܕاછે൝̱ͬ̈́ږ ˑȫႃၑഎၪ ̦ͣۼᗰൎဓͅ୨ͤఢ̢̭ͥ͂͜خෝ̱̹͂ȃडౣ ӱࡄ͈ݪచય͂̈́ͥ৪͈ఄࡕ͂૽ࡀ͈သࢌ̳ͥͅ۾ ːۼ୫̵̯৾Ȃडಿ IJĵ ۼκΣΗςϋΈ࣐̹ͬ̽ȃ ၪ ൎဓ͉̞̀̾ͅۼܢȂEPA ൎဓࢃࠬᚋಎෛഽ͉ൎဓ ȁদࡑͅ୶ၛ̻Ȃਜ਼ഛ൴ఱڠ༗࠲ۭࢌڠ໐ࡄݪႃၑտ ତͅਲ̞੭șͅષઌ̱Ȃൎဓˑȡ˒࿒ͅુેఠ ֥ٛȪઇ๔ ijĶıIJıȫ̤͍͢ਜ਼ഛ൴ఱڠ֓ڠ໐້ ͅో̱̹̞̠̭̜̦͂ࠫ͂ͥضȂ̹͘Ȃෞࠬۯ͈ۛ ௺ؖພ֭ႃၑૣऔտ֥ٛȪخݺ๔ႃȽ Ĵijĸȫ͈ ̫̤ͥͅܢݢঘཌၚ͉ˏոඤͅఉ̞̹͛Ȃडౣː ઇ͈࢚͂͜Ⴛ൱જ͈ȶႉࡄ̳ͥ۾ͅݪႃၑঐ Ȃ͍ݞȶΰσΏϋ΅࡞ȷͅ௱ͤঔ̱̹ȃ ۼ୫̱̹৾͂ȃडಿ IJĵ ͈ۼൎဓ͉̞̀̾ͅۼܢȂ ૻȷ ෞࢸण͈͉ܢݢอછˍȡˎۼոඤ̜́ͤȂྕܢ Ӳࡄ͈ݪచય͂̈́ͥ৪༹͈༷̤͍͢ࡑ৪ͅ୰ 18 ࣱجঊȇෞࢸणۛ৪͈មထཡ̤̫ͥͅఉثະგডཛॸူוൎဓ͈൦ ྶ̱൳փͬං༹༷ͥ ນˎ មอ ȁచય͂̈́ͥ৪͈͉Ȃષܱഴܖͬྖ̹̳͈͜ ̦ව̱̹֭षͅȂ൚֓ͤ͢ͅྫैևͅಒ࣐ͬ̽ ̹ȃ༹͉̞༷͈̫̀̾ͅັڬȂ໑ൟ༹ͬဥ̞̀ঔ ̱̹ȃࡑ৪͈͒୰ྶ̞͉̾̀ͅȂུ૽̹͉͘యౄ ৪ͅచ̱̀൚֓ͤ͢ࡄ͈ݪਇক༹༷͂Ȃࡄފݪ ႁ͈හփ͂൳փ͈ക͈ٝࡀ၌൝̞̾̀́ͅ୰ ȁម͈૧ܰอ̞̾̀ͅȂϋΠυȜσ߲͉́ව֭ ྶ̱Ȃࡄৃͬݪప̯ͦ̀ࣽ͜ࢃ͈হၷͅະ၌̈́ͅף IJIJ ࿒́ˍພ་ֲীٚͅមȪ૯͈́͘అੱȫͬ ̞̭ͣ̈́͂ͬၑ̢ٜ̱̹̠́Ȃদࡑͅ४̭̳͂ͥح ̹͈͓͛ͅȂņőł ൎဓ߲̤̞͉̀ͅȂម͈อ ུͅ૽̹͉͘యౄ৪̥ͣͥ͢ͅ൳փͬං̀দࡑ ͉̥̹͛ͣͦ̈́̽Ȫນˎȫ ȃȁȁȁȁȁ ̤̭̹ͬ̈́̽ȃ ȁ ͘ ̹ȂEPA ൎ ဓ ߲ ͉ ϋ Π υ Ȝ σ ߲ ͂ ̱̀ڛ ӳঔ୭ͅၑٜͬ͛ݥ൳փͬං༹༷ͥ ˓࿒ո͉ࣛ ņőł ͈ࠬಎෛഽ̦ࣞͬা̱̤̀ͤȂ ȁࡄݪঔ୭ͅచ̱̀ႉࡄݪ૭̤̭̞ͬ̈́Ȃ൳փ EPA ͉ࠬಎ͒ږͅൎဓ̯̞̭̦ͦ̀ͥ͂͛ͣͦ ͬං̀ঔ̱̹ȃ̹͘ȂࣽٝȂऔࣜ࿒ܱͬව̳ͥ ̹Ȫˍȫ ȃ ۭࢌͅచ̱̀Ȃࡄ͈ݪਇকͬ୰ྶ̱Ȃږͅފႁ ȁষͅȂછ؊͈ঐດ͂̈́ͥ CRPȪˎȫ͂྾ע ͬං̥̀ͣࡄ̹̭̤̽̈́ͬݪȃ̹͘Ȃមอশ͉ͅȂ ވ൳ࡄݪ৪́ໂȆෳᘩȜΑ͈͒Ⴒ၁ͬഔೲ ̱Ȃഐ୨̤̭̹̈́ͬ̈́̽ȃΉͺ͈ঔ̞͉̾̀ͅȂ ດഎ̈́ΉͺίυΠȜσ̱̀ͅݶঔ̳̠ͥ͢ ୰ྶ̤̭̹ͬ̈́̽ȃ ԇȅࠫȁض ȁˑ႕͈ۛ৪̥ͣ൳փͬං̀দࡑͬঔ̱̹ȃ̷͈ඤ ˍ႕͉Ȃႉদࡑ͈ಎগ̹͂̈́̽ȃಎগၑဇ͉Ȃঘ ཌ͈̹̜͛́ͥȃ̷͈ఈ͉Ȃခٺমયͥ͢ͅদࡑܢ ˍ ņőł ͈ࠬಎෛഽ་ا ۼಎ͈ಎগ͉̥̹̈́̽ȃEPA ൎဓ߲ˎ႕ȂϋΠυȜ σ߲ˎ႕͈ࠊ̞̾̀ͅȪນˍȫͅમܱ̱̹ȃদࡑ ٳইஜ͉ͅˎ͈߲̤̞̾̀ͅម͈อ͉ࡉ̴ͣͦȂ BMI ̥ͣ͜೩͈ူוచય͉͙̥̹ͣͦ̈́̽ȃ ນˍ చય৪͈ခྫ ˎ ńœő ؊͈ࠬಎෛഽ་ا ਜ਼ഛ൴ఱڠ༗࠲ۭࢌڠ໐ȁਜ਼ഛ൴༗࠲ۭࢌࡄݪȁలˏےȪijıIJĶȫ 19 ͥࠫ͢خ̜ͥ́ضෝ͓̞ͬ̀ͥˏȫȃ ȁ͉ࣽٝȂఉثະგডཛॸ͈ူוस͉̩́̈́Ȃږ ͅൎဓ̦خෝ̈́सͬঀဥ̷̱͈બ̤̭ͬ̈́̽ ̹ȃႉদࡑٳইশ̤̞͉̀ͅȂEPA ൎဓ߲Ȃϋ ΠυȜσ߲̤̞̀ͅមอ͉ࡉ̴ͣͦ BMI ̥ͣ͜ ೩͈ူוచય͉ࡉ̥̹̦ͣͦ̈́̽Ȃව֭ IJIJ ࿒ͅ ϋΠυȜσ߲͈ۛ৪̤̞̀ͅម͈ࠁ଼̦͙̹ͣͦȃ ͘ ̹ȂEPA ൎ ဓ ߲ ͉ ς ϋ Ω ͈ ݩତ ̦ ࣞ ͬা̱Ȃ છͅచ̳ͥ྾ܥעෝ̦̞ࣞ߹̦͙̹࢜ͣͦȃEPA ˏ ςϋΩ͈ࠬݩಎෛഽ་ا ͉ͅછ͈ဲଷ̤̥̦̭̜̦࢘ͤ̀̽ͩ͂ͥͅضˑȫȂ ࣽٝȂփেવ̜͈ۛͥٺ৪̜̹̦́̽Ȃࠐۯൎဓͅ ܥෝ͈ঐດ͂̈́ͥςϋΩݩȪˏȫ͈ව֭ IJĵ ࿒͈ ͤ͢ږͅ EPA ͬൎဓ̱̹̭͂́છ͈ဲଷ̦൱̧Ȃ ་ͬا͙̱͂ͥ̀ڛȂEijȪEPA ൎဓ߲ȫ͈ۛ৪͂ មอ͈ဲଷ̦̹̭̦̾̈́̽͂ͅাऐ̯̹ͦȃ̭ CIJĭ ˎȪϋΠυȜσ߲ȫ̷̸͉ͦͦછ؊̦ࣞ ͉ͦȂࠐٳူוۯইশͅકܕاછે൝ͤ͢ͅږ̈́ ͬা̱̹ȃ̱̥̱ȂςϋΩ ͉́ݩEijȪEPA ൎဓ߲ȫ ူוၷ༹̦ࣾඳ̈́ۛ৪͉͂̽̀ͅȂږͅ EPA ͈ൎ ͈ۛ৪͉ CIJȪϋΠυȜσ߲ȫ̳͂ࣞ͂ͥڛͬ ဓ̧̦́Ȃម͈อͬဲଷ̧́ͥ࢘ܢ̦ضఞ̧́ া̱̤̀ͤȂEPA ͬൎဓ̱̹༷̦྾ܥעෝ̦̥ࣞ̽ ̭̦ͥ͂ଔ௶̯̹ͦȃ ̹ȃ̤̈́ȂςϋΩ ͈ݩEIJȪEPA ൎဓ߲ȫ͈ IJĵ ࿒ ȁ̱̥̱Ȃུࡄ͉ݪછ႕ତ̦ઁ̥̹̹̈́̽͛Ȃൡࠗ ͈ΟȜΗ͉औະෝ̜̹̹́̽͛ȂΟȜΗͬං̭ͥ എٜ̈́ଢ଼ͤ͢ͅ۾Ⴒͬྶ̧̥̳̭̦ͣͥ͂́̈́ͅ ̧͉̥̹͂́̈́̽ȃ ̥̹̽ȃ̹͘Ȃۭࢌͅచ̱̀មΉͺ͉ດഎ̈́Ή ͺίυΠȜσ̠̳ͬͥ͢ݶ୰ྶ̤̭̞ͬ̈́ঔ Ԉȅࣉȁख़ ̱̹̦ͬȂࠐࡑාତ൝ͤ͢ͅΉͺτασ̦အș̜́̽ ȁម̦̲̳̞ۛ͞৪͈ఉ̩͉Ȃુͬࠐ࢛̥ ̹ȃࣽࢃ͉ΟȜΗͬୟ͙ਹ͇ͥ͂͂͜ͅȂមΉͺ ͣ୫̱৾̀͜ူוਫ਼ါၾͬྖ̧̹̳̭̦̞̹͂́̈́ ͅచ̳ۭͥࢌ͈̹͒͛܄ͬ֗ޗͺίυȜΙͬ൦ ͛Ȃࠐ࢛ူו༞੩̦ခဥ̜̭̦́ͥ͂༭̯࣬ͦ ̱ȂEPA ͈ൎဓ̦ម͈อͬဲଷ̧̥́ͥྶ̥ͣ ̞̀ͥ˓ȫȃෞࠬۯۛۛ৪ཻ͉ត൝͈࡛ͤ͢ͅȂ୫ ̱̞̩̀ͅȃ̹͘ȂEPA ͈ൎဓͥ͢ͅមอ͈ဲ ታئવ̭̦ͤܳٺȂ࢘ضഎ̈́ူוၷ༹̦ࣾඳ̈́ΉȜ ଷ̦֓ၷΑΠۭ͞ࢌΉͺ͈̥͈̳ͥͅޣג൝Ȃ Α̦ఉ̞ȃ̯ͣͅȂݢݣเ̯ͦව̱̹֭ۛ৪͉Ȃհ ఉ༷࿂̥ͣબ̱̞̩̭̦̀͂ࣽࢃ͈هఴ̜́ͥȃ ̹̞ٓͬ͛ͥͦͣޑȂមอ͈ςΑ·̦̞ࣞȃ ̷͈̹͛Ȃមထཡͬ࿒എ்̱̹͂ۯူו͈̥ͣܢ ԉȅࠫȁა ၑ͈͒ٚව̦ਹါ͂̈́ͥȃ ȁមอ͈ΧͼςΑ·͂ࣉ̢ͣͦͥփেવͬٺ ȁఉثະგডཛॸͥ͢ͅម͈ထཡ͉̱̀ͅ۾Ȃ ৽ஶͅݢݣเ̯ͦව̱̹֭ෞࢸणۛ৪ͅచ̱̀Ȃ EPAȆGLA اޑෛ࢚ၠ൲͈ൎဓͬෞ૰ࠐشٸ ņőł ͈ൎဓ̦ម͈อͬဲଷ̳̥ͥͬ൦̱̹ࠫ છ႕ۛ৪࣐̞ͅȂមอထཡ̹̦࢘ͦͣ͛ضȃ̷ ضȂո͈ئത̦̹̯ͦږȃ ͈ါ֦̱͂̀Ȃఉثະგডཛॸ͈છဲଷ࢘ͅض ˍȫEPA ͬൎဓ̱̹߲͉́Ȃచચ߲͓̀ͅម͈ 20 ࣱجঊȇෞࢸणۛ৪͈មထཡ̤̫ͥͅఉثະგডཛॸူוൎဓ͈൦ อ̦̥̹͛ͣͦ̈́̽ȃ ˑȫPalombo JD,DeMichele SJ,Boyce PJ,et al:Effect ˎȫȁȁȁͬൎဓ̱̹߲͉́ȂςϋΩ̦ࣞݩͬা̱Ȃ of short-term enteral feeding with eicosapentaenoEPA ྾ܥעෝ̦̞ࣞ߹̜̭̦࢜ͥ͂ͅাऐ̯̹ͦȃ ic and gamma-linolenic acids on alveolar macro- ̤̈́Ȃུࡄ͉ݪ଼ ijĶ ාഽڠಿඅ༆ވ൳ίυΐͿ· phage eicosanoid synthesis and bactericidal func- Πࡄ͈ݪ੩଼̫࣐̹ͬ̀̽ࡄ͈֚ݪ໐̜́ͥȃ tion in rats. Crit Care Med 27(9),1908-1915,1999. ˒ȫAndreassi M,Forleo P,Di Lorio A,et al:Efficacy of Ⱥ֨ဥࡃȻ gamma-linolenic acid in the treatment of patients ˍȫඤຸڝȇ଼ ijĶ ාๅࣞႢ২ٛฒȄijijĮijĶȄނȄ with atopic dermatitis,J Int Mde Res 25(5),266ȁȁijıIJĴį 274,1997. ˎȫࡔઆȄઐזೄঊȄ߷൞֭جȄఈȇࣞෛഽͺη ˓ȫEuropean Pressure Ulcer Advisory Panel and Na- ȁȁΦॸͤ͢ͅك٨̦̹͛ͣͦ༌ଅ͈មછ tional Pressure Ulcer Advisory Panel:Prevention ȁȁ႕ȄྤࠐಸူוȄijĺȪːȫȄIJıIJĮIJıķȄijıIJĵȅ and treatment of pressure ulcers:quick reference ˏȫ߰Ȅऎș࿐ঃȄ߬ఆঊȄఈȇͼ guide.National pressure ulcer Advisory panel,Wa- ȁȁβϋΗϋॸȆ Ϲ ĮςΦτϋॸاޑෛ࢚ၠ൲ൎ shington DC,2009. ȁȁဓͥ͢ͅម͈ထཡ࢘ضȽෞ૰ࠐشٸછ႕ ˔ȫఱ໌׆ȄଫࡔȄഛຶআঊȄఈ Ļġ ۭࢌْࠗͬ ȁȁ͈ਔۯူוܢၑ͈൦ȽȄਜ਼ഛ൴ఱڠ༗࠲ۭ ȁȁၛ̀ͥष͈មࡏܓါ֦Ȫఱ׆ȆཱനΑΉȜσȫ ȁȁࢌȁࡄܮݪါȄˍȪˍȫ ȄˍĮIJıȄijıIJijį ȁȁ͈ဥ̞༷͈ष͂ບثȽ५ࠌພ֭ȄΠπΗܱැ ːȫZurier RB,Rossetti RG,Jacobson EW,et al:A gam- ȁ ȁȁພ͈֭ष͂ບثȽȄExpert NurseȄijıȪĵȫȄ ma-linolenic acid treatment of rheuma-toid arth- ȁȁIJijĹĮIJĴĸĭijııĵį ritis.A randomized,placebo-controlled trial.Arth- ˕ȫུមڠٛ༎ȇមచॐ͈ঐૻȄચႅ২Ȅijııijȅ ritis Rheum 39(11),1808-1817.1996.
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