1 Prof. Dr. Marc Freichel Institute of Pharmacology

Prof. Dr. Marc Freichel
Institute of Pharmacology,
Heidelberg University, Medical Faculty
Im Neuenheimer Feld 366
D-69120 Heidelberg
Phone: +49 - (0)6221-54-86860
Fax: +49 - (0)6221-54-8644
E-mail: [email protected]
March 19, 1968, Dillingen
Curriculum vitae
10/1988–10/1994
10-11/1992
02-05/1994
1995 – 1996
1996 – 1997
1998 – 1999
2000 – 2004
2004 - 2011
2006 - 2011
2011 - present
Medical School at the University of Saarland, Germany
Fred Hutchinson Cancer Research Center, Bone Marrow Transplantation
Program, Seattle, USA
New York University, New York, USA, Department of Cardiology,
Hematology and Infectious Diseases
Resident at the Department of Medicine (Cardiology, Endocrinology) and
Pharmacology, University of Heidelberg
postdoc, Department of Pharmacology, Heidelberg University
postdoc, Department of Experimental and Clinical Pharmacology and
Toxicology, University of Saarland
Group leader „Transgenic mouse models“, Department of Experimental
and Clinical Pharmacology and Toxicology, University of Saarland
Associate Professor (C3), Experimental Pharmacology and Preclinical
Disease Models, Medical Faculty, University of Saarland
and Head of the Transgenic Mouse Facility (SPF) of the Medical Faculty
Co-Chairman of the DFG Graduate School 1326 „Calcium Signaling and
Cellular Nanodomains“
Full Professor of Pharmacology, Heidelberg University
Fields of interest
TRP- and Ca2+ channels and their role for calcium signaling in cells of the cardiovascular
system (endothelial cells, smooth muscle cells, cardiac fibroblasts, platelets), epididymal cells
and mast cells, and their corresponding integrative functions such as cardiac remodeling and
contractility, vascular contractility, blood pressure regulation, fertility and mast cell activation.
The laboratory has a long lasting experience in transgenic approaches using gene targeting in
embryonic stem cells for the generation of disease models and for the identification and
validation of new drug targets.
Currently funded projects
DFG Clinical Research Group 196 „ Adaptative and maladaptive cardiac remodeling processes“
DFG Priority Programm 1394 „Mast cells – promotors of health and modulators of disease“
SFB 894 „Ca2+-Signals: molecular mechanisms and integrative functions“
DFG International Training group 1326 „Calcium-Signaling and Cellular Nanodomains“
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Publications (10 most important publications)
1.
Freichel M, Suh SH, Pfeifer A, Schweig U, Trost C, Weissgerber P, Biel M, Philipp S,
Freise D, Droogmans G, Hofmann F, Flockerzi V, Nilius B. (2001) Lack of an endothelial
store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice.
Nat.Cell Biol., 3, 121-127.
2.
Tiruppathi C, Freichel M, Vogel SM, Paria BC, Mehta D, Flockerzi V, Malik AB. (2002)
Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in
lung microvascular permeability. Circ.Res., 91, 70-76.
3.
Berggren PO, Yang SN, Murakami M, Efanov AM, Uhles S, Kohler M, Moede T,
Fernstrom A, Appelskog IB, Aspinwall CA, Zaitsev SV, Larsson O, de Vargas LM,
Fecher-Trost C, Weissgerber P, Ludwig A, Leibiger B, Juntti-Berggren L, Barker CJ,
Gromada J, Freichel M, Leibiger IB, Flockerzi V. (2004) Removal of Ca2+ channel beta3
subunit enhances Ca2+ oscillation frequency and insulin exocytosis. Cell, 119, 273-84..
4.
Freichel M, Vennekens R, Olausson J, Hoffmann M, Muller C, Stolz S, Scheunemann J,
Weissgerber P, Flockerzi V. (2004) Functional role of TRPC proteins in vivo: lessons
from TRPC-deficient mouse models. Biochem Biophys Res Commun, 322, 1352-8.
5.
Weissgerber P, Held B, Bloch W, Kaestner L, Chien KR, Fleischmann BK, Lipp P,
Flockerzi V, Freichel M. (2006) Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/embryos impairs cardiac development and contraction with secondary defects in
vascular maturation. Circ Res, 99, 749-57.
6.
Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F,
Weissgerber P, Nilius B, Flockerzi V, Freichel M. (2007) Increased IgE-dependent mast
cell activation and anaphylactic responses in mice lacking the calcium-activated
nonselective cation channel TRPM4. Nat Immunol, 8, 312-20.
7.
Tsvilovskyy VV, Zholos AV, Aberle T, Philipp SE, Dietrich A, Zhu MX, Birnbaumer L,
Freichel M, Flockerzi V. (2009) Deletion of TRPC4 and TRPC6 in mice impairs smooth
muscle contraction and intestinal motility in vivo. Gastroenterology, 137, 1415-24.
8.
Gerzanich V, Woo SK, Vennekens R, Tsymbalyuk O, Ivanova S, Ivanov A, Geng Z,
Chen Z, Nilius B, Flockerzi V, Freichel M, Simard JM. (2009) De novo expression of
Trpm4 initiates secondary hemorrhage in spinal cord injury. Nat Med, 15, 185-91.
9.
Mathar I, Vennekens R, Meissner M, Kees F, Van der Mieren G, Camacho Londono JE,
Uhl S, Voets T, Hummel B, van den Bergh A, Herijgers P, Nilius B, Flockerzi V,
Schweda F, Freichel M. (2010) Increased catecholamine secretion contributes to
hypertension in TRPM4-deficient mice. J Clin Invest, 120, 3267-79.
10.
Weissgerber P, Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Vennekens
R, Wissenbach U, Middendorff R, Flockerzi V, Freichel M. (2011) Male fertility depends
on Ca2+ absorption by TRPV6 in epididymal epithelia. Sci Signal,4, ra27.
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