演者 Carol Mason 博士

日時　2016年7月19日（火）11:00-12:00
会場医学部6号館　1階　講堂　演題　Thepathfromeyetobrain:Genesencoding
neurogenesisandwiringinthebinocularcircuit
演者　CarolMason　博士
ColumbiaUniversity　Inhighervertebrates,thebinocularcircuitisformedbyre?nalganglion
cell(RGC)axonsprojec?ngipsilaterallyandcontralaterallytothebrain.
Speciﬁctranscrip?onfactorsandguidancefactorsdirectipsi-and
contralateralRGCcelliden?tyandaxonnaviga?onattheop?cchiasm
towardseye-speciﬁczonesinthethalamus.Ournewworkhasrevealed
addi?onalfeaturesdis?nguishingthetwosubsetsofRGCs:1)the?ming,
sitesofgenera?on,andregula?onoftheirdiﬀeren?a?on;2)Segregated
organiza?onofipsi-andcontralateralRGCaxonsintractstowardtargets.I
willalsodescribeourworkonthealbino,inwhichmelanindeﬁcitsinthe
re?nalpigmentepithelium(RPE)areassociatedwithareducedipsilateral
projec?on,aberrantneurogenesisanddefec?vetarge?ng,providinga
gene?cmodelforstudyingcellfateandconnec?vity.
ASerdescribingourwork,Iwillbrieﬂyrelatethisworktocurrenteﬀorts
bytheNa?onalEyeIns?tute/USNa?onalIns?tutesofHealthonop?cnerve
regenera?on;describetheUSBRAINini?a?ve;anddiscusstheprospectusfor
careersinneuroscienceagainstthisexci?ngbackdropofdiscovery.
連絡先：発生発達神経科学分野大隅典子（内線8203）

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