⌮Ꮫᑓᨷ
ᶵ⬟ᛶศᏊ໬Ꮫศ㔝
⏕≀໬Ꮫ◊✲ᐊ ෸ᩍᤵ బ㈡ెኸ
Biological Chemistry Lab. Associate Prof. Yoshitaka Saga
࣮࣮࢟࣡ࢻ
ගྜᡂࠊග࢚ࢿࣝࢠ࣮ኚ᥮ࠊࢡࣟࣟࣇ࢕ࣝ
photosynthesis, light-energy conversion, chlorophyll
◊✲ෆᐜ
㹙㸯㹛ගྜᡂࡢᵓ㐀࣭ᶵ⬟ゎᯒ
ගྜᡂࡣኴ㝧ග࢚ࢿࣝࢠ࣮ࢆ㧗ຠ⋡࡛ኚ᥮ࡍ
ࡿࢩࢫࢸ࣒࡛࠶ࡾࠊࡑࡢᶵᵓゎ᫂ࡣᇶ♏⛉Ꮫࡢ㔜
せㄢ㢟࡛࠶ࡿ࡜࡜ࡶ࡟ࠊேᕤⓗ࡞ග࢚ࢿࣝࢠ࣮ኚ
᥮ࢩࢫࢸ࣒㛤Ⓨ࡟࠾࠸࡚Ⰻ࠸タィᣦ㔪ࢆ୚࠼࠺
ࡿ࡜⪃࠼ࡽࢀࡿࠋࡑ ࡢ ග ྜ ᡂ ࡛ ࡣ ࠊ ࢡ ࣟ ࣟ ࣇ
࢕ ࣝ㸦 ᅗ 㸧࡞ ࡝ ࡢ ᶵ ⬟ ᛶ Ⰽ ⣲ ࡀ ⢭ ᐦ ࡟ 㓄 ิ
ࡍࡿࡇ࡜࡛㧗࠸ྍどගኚ᥮ຠ⋡ࢆᐇ⌧ࡋ࡚
࠸ ࡿ ࠋᙜ ◊ ✲ ᐊ ࡛ ࡣ ࠊග ྜ ᡂ Ⰽ ⣲ ࡢ ௦ ㅰ ཯ ᛂ
ࡸ ≀ ᛶ ࠊ࠾ ࡼ ࡧ ࡇ ࢀ ࡽ ࡢ Ⰽ ⣲ ࡀ 㞟 ✚ ໬ ࡋ ࡓ ග
ྜᡂ㉸ศᏊࡢᵓ㐀࣭ᶵ⬟ࢆゎᯒࡋ࡚࠸ࡿࠋ
5
5
5
1
1
0J
1
2
1
2
&22&+
2 SK\W\O
3LJPHQW555
&KOD&+&+&+&+
&KOE&+&+&+&+2
&KOG&+&+2&+
&KOI&+2&+&+&+
ᅗ 1. 㓟⣲Ⓨ⏕ᆺගྜᡂ⏕≀࡟ྵࡲࢀࡿࢡࣟࣟࣇ
࢕ࣝ㸦Chl㸧ࡢศᏊᵓ㐀.
㹙㸰㹛ගྜᡂࣔࢹࣝ㉸ศᏊࡢᵓ⠏࡜ග࢚ࢿࣝࢠ࣮ኚ
᥮࡬ࡢᛂ⏝
ኳ↛࡛ᶵ⬟ࡍࡿගྜᡂ㉸ศᏊࡢࣔࢹࣝ໬ࡣே
ᕤගྜᡂࢆ⪃࠼ࡿ࠺࠼࡛ࡶ⯆࿡῝࠸ࠋࡑࡇ࡛ᙜ◊
✲ᐊ࡛ࡣࠊᶵ⬟ᛶⰍ⣲ࡢ⮬ᕫ⤌⧊໬ࡸࢱࣥࣃࢡ㉁
࡜ࡢ」ྜ໬࡟ࡼࡿගྜᡂࢆᶍೌࡋࡓ㉸ศᏊࢆ㛤
Ⓨࡋ࡚࠸ࡿࠋ
᭱㏆ࡢᴗ⦼
[1] Y. Saga, A. Maruko, K. Sadaoka, N. Takahashi: Effects of
the 13-Keto Group in the E-Ring of Zinc Chlorophyll
Derivatives on Demetalation Kinetics under Acidic
Conditions, &KHP/HWW (2013) in press. [2] N. Takahashi, H. Tamiaki, Y. Saga: Synthesis and
Self-assembly of Amphiphilic Zinc Chlorophyll Derivatives
Possessing a Crown Ether at the 17-Propionate Residue,
7HWUDKHGURQ , 3638-3645 (2013).
[3] Y. Saga, Y. Kobashiri, K. Sadaoka: Systematic Analysis of
the Demetalation Kinetics of Zinc Chlorophyll Derivatives
Possessing Different Substituents at the 3-Position: Effects
of the Electron-Withdrawing and Electron-Donating
Strength of Peripheral Substituents, ,QRUJ &KHP ,
204-210 (2013).㻌
[4] Y. Saga, Y. Hirai, K. Sadaoka, M. Isaji, H. Tamiaki:
Structure-Dependent Demetalation Kinetics of Chlorophyll
D Analogs under Acidic Conditions, 3KRWRFKHP3KRWRELRO
, 68-73 (2013).㻌
[5] N. Takahashi, S. Shoji, H. Tamiaki, Y. Saga:
Self-assembly of Zinc Bacteriochlorophyll G Derivative
Possessing a Triethoxysilyl Group at the 17-Propionate
Residue, %XOO&KHP6RF-SQ, 989-994 (2012).㻌
[6] Y. Saga, T. Otono: Structural Change of Pheophorbide D
Methyl Ester by Contact with Titanium Oxide Particles,
&KHP/HWW, 360-362(2012).
[7] Y. Saga, H. Tamiaki: Demetalation of Chlorophyll
Pigments, &KHP%LRGLYHUV, 1659-1683 (2012).
[8] Y. Saga, R. Miura, K. Sadaoka, Y. Hirai: Kinetic Analysis
of Demetalation of Synthetic Zinc Cyclic Tetrapyrroles
Possessing an Acetyl Group at the 3-Position: Effects of
Tetrapyrrole Structures and Peripheral Substitution, -3K\V
&KHP% , 11757-11762(2011).
[9] R. Nishimori, T. Mizoguchi, H. Tamiaki, S. Kashimura, Y.
Saga: Biosynthesis of Unnatural Bacteriochlorophyll F
Derivatives Esterified with 䃐,䃨-Diols in the Green Sulfur
Photosynthetic Bacterium &KORUREDFXOXP WHSLGXP,
%LRFKHPLVWU\ , 7756-7764 (2011).
[10] K. Sadaoka, S. Kashimura, Y. Saga: Effects of Molecular
Structures on Reduction Properties of Formyl Groups in
Chlorophylls and Pheophytins Prepared from Oxygenic
Photosynthetic Organisms, %LRRUJ 0HG &KHP ,
3901-3905 (2011).
[11] Y. Hirai, S. Sasaki, H. Tamiaki, S. Kashimura, Y. Saga:
Substitution Effects in the A- and B-Rings of the Chlorin
Macrocycle on Demetalation Properties of Zinc Chlorophyll
Derivatives, -3K\V&KHP%, 3240-3244 (2011).
[12] Y. Hirai, S. Kashimura, Y. Saga: Demetalation Kinetics
of Chlorophyll Derivatives Possessing Different
Substituents at the 7-Position under Acidic Conditions,
3KRWRFKHP3KRWRELRO , 302-307 (2011).㻌
‫⛉ ڦ‬Ꮫ◊✲㈝ ᇶ┙◊✲(C)௦⾲. (ᖹᡂ23–25 ᖺᗘ).
‫⛉ ڦ‬Ꮫ◊✲㈝ ᪂Ꮫ⾡㡿ᇦ◊✲(බເ◊✲)௦⾲
㸦ᖹᡂ25–26ᖺᗘ 㸧
.
‫ ڦ‬ఫ཭㈈ᅋ㸦ᖹᡂ24-25 ᖺᗘ㸧.
‫ ڦ‬୰㒊㟁Ẽ฼⏝ᇶ♏◊✲᣺⯆㈈ᅋ㸦ᖹᡂ25 ᖺᗘ㸧..
‫ ڦ‬ᚨᒣ⛉Ꮫᢏ⾡᣺⯆㈈ᅋ㸦ᖹᡂ24 ᖺᗘ㸧.
‫ ڦ‬᪥ᮏドๆዡᏛ㈈ᅋ㸦ᖹᡂ23-24 ᖺᗘ㸧.

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CURRICULUM VITAE Wen Chen - College of Medicine

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