CURRICULUM VITAE Wen Chen - College of Medicine

CURRICULUM VITAE
NAME:
Wen Chen
Business:
Instructor
Division of Molecular Cardiology
Cardiovascular Research Institute
Texas A&M Health Science Center, College of Medicine
Scott and White
1901 South First Street, Bldg. 205
Temple, Texas 76504
Phone: (254) 743-1226
E-Mail: [email protected]
EDUCATION:
2003
Ph.D. Peking University (Biochemistry and Molecular Biology), Beijing, China
Dissertation Title: Proteomics Study on the Senescent and Demented
Postmortem Human Brains
POSTDOCTORAL TRAINING:
2004-2006
2006-2011
Research Associate in Structure Biology and Mass Spectrometry Facility, Skirball
Institute of Biomolecular Medicine, New York University Medical Center, New
York, USA
Research Fellow in Hematology, Department of Medicine, Brigham and Women’s
Hospital, Harvard Medical School, Harvard University, Boston, USA
ACADEMIC APPOINTMENTS:
2011- Present
Instructor, Division of Molecular Cardiology, Department of Medicine,
Cardiovascular Research Institute, Texas A&M University Health Science Center,
Temple, Texas, USA
AWARDS AND HONORS:
2002
2002
2002
2003
2004
2004
Revised 03/20/14
Graduate Award for Excellent Ph.D. candidates, Peking University, Beijing, China
Tingmei Fellowship, Peking University, Beijing, China
Excellent Research Article Award, China Medical and Pharmaceutical
Biotechnology Society, China
Jiuyuan Research Award, Fudan University Jiazhen Tan Foundation, China
Outstanding Poster Award, New York University Medical Center, NY
Scientific and Technological Advancement Award, Ministry of Education in Chin
Wen Chen, Ph.D. [2]
2009
2009
2010
Competitive Travel Award from Federation of American Societies for Experimental
Biology
Research Excellence Award, Brigham and Women’s Hospital in Harvard Medical
School, MA
Competitive Travel Award from Gordon Research Conference
TRAINEES:
Xiaoman Xu, undergraduate student, Peking University
Sizhi He, Ph.D. student, Peking University
Niketa Chandel, visiting Scholar from India
Jared Corn, M.D. student, Texas A&M Health Sciences Center
Jared Corn, M.D. student, Texas A&M Health Sciences Center
May 2001- July 2002
Sept 2001- July 2003
Feb 2012- June 2012
June 2012- July 2012
June 2013- July 2013
MANUSCRIPT REVIEW EXPERIENCE:
2009- Present BBA-Proteins and Proteomics
PUBLICATIONS:
1.
Chen W, Ji JG, Zhao R, Ru BG. Comparative Proteome Analysis of Human Temporal Cortex Lobes
by Two-Dimensional Electrophoresis and Identification of Selected Common Proteins.
Neurochemical Research 2002; 27(9): 871-81.
2.
Chen W, Ji JG, Ru BG. Comparative Proteome Analysis of Human Corticobasal Degeneration Brain
with Normal Control Ones by Two-dimensional Electrophoresis and Identification of Selected Protein
Spots. In: Proceedings of China Medical and Pharmaceutical Biotechnology 2002 Academic
Conference, 2002: 155-60.
3.
Chen W, Ji JG, Xu XM, He SZ, Ru BG. Proteomic Comparison between Human Young and Old
Brains by Two-Dimensional Gel Electrophoresis and Identification of Proteins. International Journal
of Developmental Neuroscience 2003; 21(4): 209-16.
4.
Chen W, Ji JG, Ru BG. A Case Study of Corticobasal Degeneration at the Proteome Level. Journal
of Neuropsychiatry and Clinical Neurosciences 2005; 17(3): 364-71.
5.
Schwarz K, Iolascon A, Verissimo F, Trede NS, Horsley W, Chen W, Paw BH, Hopfner KP,
Holzmann K, Russo R, Esposito MR, Spano D, De Falco L, Heinrich K, Joggerst B, Rojewski MT,
Perrotta S, Denecke J, Pannicke U, Delaunay J, Pepperkok R, Heimpel H. Mutations affecting the
secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II. Nature
Genetics 2009; 41(8): 936-40.
6.
Chen W, Paradkar PN, Li LT, Pierce EL, Langer NB, Takahashi-Makise N, Hyde BB, Shirihai OS,
Ward DM, Kaplan J, Paw BH. Abcb10 physically interacts with Mitoferrin-1 (Slc25a37) to enhance
its stability and function in the erythroid mitochondria. Proc. Natl. Acad. Sci. USA 2009; 106 (38):
16263-8. (Accompanied commentary: Andrews NC. ABCs of erythroid mitochondrial iron uptake.
Proc. Natl. Acad. Sci. USA 2009; 106 (38): 16012-3.)
7.
Chen W, Dailey HA, Paw BH. Ferrochelatase forms an oligomeric complex with mitoferrin-1 and
Wen Chen, Ph.D. [3]
Abcb10 for erythroid heme biosynthesis. Blood 2010; 116 (4): 628-30.
8.
Kumar R, Thomas CM, Yong QC, Chen W, Baker KM. The intracrine renin-angiotensin system. Clin
Sci (Lond) 2012; 123(5): 273-84.
9. Shah DI, Takahashi-Makise N, Cooney JD, Li L, Schultz IJ, Pierce EL, Narla A, Seguin A, Hattangadi
SM, Medlock AE, Langer NB, Dailey TA, Hurst SN, Faccenda D, Wiwczar JM, Heggers SK, Vogin G,
Chen W, Chen C, Campagna DR, Brugnara C, Zhou Y, Ebert BL, Danial NN, Fleming MD, Ward
DM, Campanella M, Dailey HA, Kaplan J, Paw BH. Mitochondrial Atpif1 regulates haem synthesis in
developing erythroblasts. Nature 2012; 491(7425): 608-12.
10. Chen C, Garcia-Santos D, Ishikawa Y, Seguin A, Li L, Fegan KH, Hildick-Smith GJ, Shah DI, Cooney
JD, Chen W, King MJ, Yien YY, Schultz IJ, Anderson H, Dalton AJ, Freedman ML, Kingsley PD,
Palis J, Hattangadi SM, Lodish HF, Ward DM, Kaplan J, Maeda T, Ponka P, Paw BH. Snx3 regulates
recycling of the transferrin receptor and iron assimilation. Cell Metab. 2013; 17(3): 343-52.
11. Chung J, Anderson SA, Gwynn B, Deck KM, Chen MJ, Langer NB, Shaw GC, Huston NC, Boyer LF,
Datta S, Paradkar PN, Li L, Wei Z, Lambert AJ, Sahr K, Wittig JG, Chen W, Lu W, Galy B, Schlaeger
TM, Hentze MW, Ward DM, Kaplan J, Eisenstein RS, Peters LL, Paw BH. Iron Regulatory Protein-1
Protects against Mitoferrin1-deficient Porphyria. J Biol Chem. 2014; 289(11):7835-43.
12. Yien YY, Robledo RF, Schultz IJ, Takahashi-Makise N, Gwynn B, Bauer DE, Dass A, Yi G, Li L,
Hildick-Smith GJ, Cooney JD, Pierce EL, Mohler K, Dailey TA, Miyata N, Kingsley PD, Garone C,
Hattangadi SM, Huang H, Chen W, Keenan EM, Shah DI, Schlaeger TM, DiMauro S, Orkin SH,
Cantor AB, Palis J, Koehler CM, Lodish HF, Kaplan J, Ward DM, Dailey HA, Phillips JD, Peters LL,
Paw BH. TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest. 2014
Aug 26. pii: 76979. doi: 10.1172/JCI76979. [Epub ahead of print]
ABSTRACTS AND POSTER PRESENTATIONS:
1.
2.
3.
4.
5.
6.
7.
Chen W, Ji JG, Ru BG. Comparative proteome analysis of human corticobasal degeneration brain
with normal control ones by two-dimensional electrophoresis and identification of selected protein
spots. China Medical and Pharmaceutical Biotechnology 2002 Academic Conference; September
10-13, 2002; Chengdu, China.
Chen W and Neubert TA. Identification of Potential EphB2 Signaling Proteins by Mammalian
Tandem Affinity Purification (TAP). Skirball Annual Retreat 2004 in Lenox, Massachusetts.
Chen W and Neubert TA. Purification and Identification of Potential EphB2 Signaling Proteins Using
Mammalian Tandem Affinity Purification and Mass Spectrometry. 53rd ASMS (American Society for
Mass Spectrometry) Conference on Mass Spectrometry; June 5-9, 2005; San Antonio, Texas.
Chen W and Neubert TA. Identification of Proteins Potentially Associated with a Candidate Tumor
Suppressor Sash1 by Mass Spectrometry. Skirball Annual Retreat 2005 in Lenox, Massachusetts.
Darie CC, Spellman DS, Chen W and Neubert TA. Analysis of Protein-Protein Interactions with
EphB2-NG108 Cells in Response to EphrinB1-Fc Stimulation. Skirball Annual Retreat 2006 in
Lenox, Massachusetts.
Chen W, Li LT, Langer NB, Paradkar PN, Schultz IJ, Hyde BB, Shirihai OS, Kaplan J and Paw BH.
Abcb10 Physically Interacts with Mitoferrin1 to Enhance its Stability for Heme Synthesis in the
Erythroid Mitochondria. 50th ASH (American Society of Hematology) Annual Meeting and
Exposition; December 6-9, 2008; San Francisco, CA.
Chen W, Paradkar P, Li LT, Langer NB, Pierce EL, Schultz I, Hyde BB, Shirihai OS, Kaplan J and
Paw BH. Abcb10 interacts with Mitoferrin-1 (Slc25a37) to enhance its protein stability and function to
import mitochondrial iron in erythroblasts. 2009 Annual International BioIron Society (IBIS) Meeting;
Wen Chen, Ph.D. [4]
8.
9.
10.
11.
12.
13.
14.
15.
June 7-11, 2009; Porto, Portugal.
Chen W and Paw BH. Physical interaction of mitoferrin-1 with endosomal proteins is required for
iron importation into the erythroid mitochondria. FASEB Summer Research Conferences:
Mitochondrial Assembly & Dynamics in Health and Disease; July 5-10, 2009; Carefree, Arizona.
Chen W, Amigo J, Paradkar P, Pierce EL, Langer NB, Ward DM, Kaplan J and Paw BH. Mitoferrin1, a mitochondrial solute carrier, and its role and regulation in mitochondrial iron homeostasis of
erythroid cells. FASEB Summer Research Conferences: Mitochondrial Assembly & Dynamics in
Health and Disease; July 5-10, 2009; Carefree, Arizona.
Chen W and Paw BH. Physical interaction of mitoferrin-1 with endosomal protein transferrin
receptor 1 is required for iron importation into the erythroid mitochondria. BWH BRI Infectious and
Immunological Diseases Fall Festival 2009; November 2, 2009; Brigham and Women’s Hospital,
Boston, MA.
Chen W and Paw BH. Physical interaction of mitoferrin-1 with endosomal proteins is required for
iron importation into the erythroid mitochondria. Fall 2009 Research Excellence Awards; November
11, 2009; Brigham and Women’s Hospital, Boston, MA.
Chen W, Paradkar PN, Kaplan J, Paw BH. Interacting proteins of the mitochondrial carrier,
mitoferrin-1, identified in purified protein complexes: implications for iron importation into the
erythroid mitochondria. Poster Session and Awards Ceremony; March 31, 2010; Brigham and
Women’s Hospital, Boston, MA.
Chen W, Paradkar PN, Kaplan J, Paw BH. Interacting proteins of the mitochondrial carrier,
mitoferrin-1, identified in purified protein complexes: implications for iron importation into the
erythroid mitochondria. 2010 Dr. M. Judah Folkman Research Day. April 28, 2010; Children’s
Hospital Boston, Boston, MA.
Chen W, Paradkar PN, Kaplan J, Dailey HA, Paw BH. Interacting proteins of the mitochondrial
carrier, mitoferrin-1, identified in purified protein complexes: implications for iron importation into the
mitochondria. Gordon Research Conference 2010 Chemistry & Biology of Tetrapyrroles. July 25-30,
2010; Salve Regina University, Newport, RI.
Chen W, Corn J, Yong QC, Thomas CM, Baker KM, Kumar R. Identification of Xinα as a Novel
Intracellular Angiotensin II Binding Protein. Cardiovascular Research Institute 4th Research
Symposium. May 2-3, 2013; TAMHSC COM Medical Education Center at Scott & White, Temple,
TX.
SEMINARS AND INVITED PRESENTATIONS:
1.
2.
3.
4.
5.
6.
Comparative proteome analysis of human corticobasal degeneration brain with normal control ones
by two-dimensional electrophoresis and identification of selected protein spots. China Medical and
Pharmaceutical Biotechnology Academic Annual Conference, Chengdu, China Sept 2002
Comparative Proteome Analysis of Human Corticobasal Degeneration Brain with Normal Control
Ones by Two-dimensional Electrophoresis Mass Spectrometry. College of Life Sciences and
Medical Center Joint Academic Meeting, Peking University, China. Dec 2002
Identification of Potential EphB2 Signaling Proteins by Mammalian Tandem Affinity Purification
(TAP). Skirball Institute Annual Retreat, New York University Medical Center, New York. Nov 2004
Purification and Identification of Potential EphB2 Signaling Proteins Using Mammalian Tandem
Affinity Purification and Mass Spectrometry. 53rd ASMS (American Society for Mass Spectrometry)
Conference on Mass Spectrometry. San Antonio, TX June 2005
Identification of Proteins Potentially Associated with a Candidate Tumor Suppressor Sash1 by Mass
Spectrometry. Skirball Institute Annual Retreat, NYU Medical Center, New York. Nov 2005
Abcb10 Physically Interacts with Mitoferrin1 to Enhance its Stability for Heme Synthesis in the
Erythroid Mitochondria. 50th ASH (American Society of Hematology) Annual Meeting and
Exposition; San Francisco, CA. December 2008
Wen Chen, Ph.D. [5]
7.
8.
Physical interaction of mitoferrin-1 with endosomal proteins is required for iron importation into the
erythroid mitochondria. FASEB Summer Research Conferences: Mitochondrial Assembly &
Dynamics in Health and Disease. Carefree, AZ. June 2009
Interacting proteins of the mitochondrial carrier, mitoferrin-1, identified in purified protein complexes:
implications for iron importation into the mitochondria. Gordon Research Conference 2010
Chemistry & Biology of Tetrapyrroles. Salve Regina University, Newport, RI. July 2010

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