3rd Jena HHDP Symposium - Friedrich-Schiller

P rogram
3 Jena HHDP
Symposium
rd
May 26 – 27, 2016
University of Jena
Beutenberg Campus
Leibniz Institute of
Photonic Technology
(IPHT)
Organization
Prof. Dr. Stefan H. Heinemann
Speaker of FOR 1738
Friedrich Schiller University Jena
Co-Organizers
Prof. Dr. med. Michael Bauer
Jena University Hospital
Prof. Dr. Matthias Westerhausen
Friedrich Schiller University Jena
Contact
HHDP Office
Dr. Franziska Jahns
Center for Molecular Biomedicine
Friedrich Schiller University Jena
Hans Knöll Str. 2
07745 Jena
Germany
[email protected]
www.hhdp.uni-jena.de
Program
Thursday, May 26
08:00
Registration & poster mounting
08:40
Welcome address
Stefan H. Heinemann (Speaker FOR 1738)
SESSION I
HHDPs and Inflammation
Chair: Michael Bauer (Jena)
08:50
Targeting iron/heme in immune mediated
inflammatory diseases
Miguel Soares (Oeiras)
09:30
Unique characteristics of heme as activator
of innate immunity
Marcelo T. Bozza (Rio de Janeiro)
10:10
Coffee break
SESSION II
Heme Proteins
Chair: Oliver Ohlenschläger (Jena)
10:40
HmuY – unique heme-binding protein and
important virulence factor of Porphyrominas
gingivalis or representative of a novel group
of hemophore-like proteins
Teresa Olczak (Wroclaw)
11:20
Heme trafficking by NMR
Paola Turano (Florence)
3
12:00
Heme-regulatory motifs in proteins:
structural and functional characterization
Diana Imhof (Bonn)
12:20
Lunch at Beutenberg Cafeteria
SESSION III
Heme Degradation Products
Chair: Sina Coldewey (Jena)
13:40
Heme cargo determines the toxicity of
circulating microparticles for endothelial cells
Olivier P. Blanc-Brude (Paris)
14:00
50 shades of yellow: how heme and its
metabolites contribute to liver damage
Michael Bauer (Jena)
14:20
Old and new HDPs – analytical chemistry of
heme degradation in vivo and in vitro
Georg Pohnert (Jena)
14:40
HYCO-3, a hybrid molecule that
simultaneously activates Nrf2/HO-1 and
releases CO, exerts anti-inflammatory effects
in vitro and in vivo
Roberto Motterlini (Créteil)
POSTER SESSION
Chair: Georg Pohnert (Jena)
15:00
4
Presentation of posters
with coffee break
SESSION IV
CORMs
Chair: Ute Neugebauer (Jena)
17:00
Recent developments of biocompatible group
7 metal-based CORMs: from vitamin B12
conjugates to red light activated photoCORMs
Fabio Zobi (Fribourg)
17:40
Synthesis and CO-release of
manganese-based CORMs
Matthias Westerhausen (Jena)
18:00
CORMs and CORMAs –
CO-releasing molecules and materials
Alexander Schiller (Jena)
18:20
Spectroscopic elucidation of reaction
mechanisms and kinetics of CORM
breakdowns
Jürgen Popp (Jena)
19:30
Symposium Dinner at Hotel Schwarzer Bär
Friday, May 27
SESSION V
Neurons and Ion Channels
Chair: Otto W. Witte (Jena)
08:30
The protective role of microglial
heme oxygenase-1
Nils Schallner (Freiburg)
5
09:10
Effect of HHDPs on cerebral arterioles
Knut Holthoff (Jena)
09:30
Modulation of K+ channels by CORM-2,
unrelated to CO
Guido Gessner (Jena)
09:50
Functional modulation of Slo1 BK channels
by HHDPs revisited
Toshinori Hoshi (Philadelphia)
10:10
Coffee break
SESSION VI
Heme Transport
Chair: Alexander Schiller (Jena)
10:40
Heme trafficking in metazoans
Iqbal Hamza (College Park)
11:20
Heme export in the control of cellular
heme homeostasis
Emanuela Tolosano (Turin)
12:00
Closing remarks
Stefan H. Heinemann
12:05
End of the Symposium; lunch at Beutenberg
Cafeteria
6
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