Programm zur Jahrestagung 2016 - Deutsche Gesellschaft für

Deutsche Gesellschaft für Arterioskleroseforschung e.V.
Vorsitzender: Prof. Dr. Ralf Kinscherf
Jahrestagung DGAF 7. - 9. 4. 2016
Tagungsstätte der Universität Gießen
Rauischholzhausen
Sponsoren:
Programm
Donnerstag, 7. 4. 2016
12:00 – 14:00
Nachwuchsfördermodul
Matthias Schwab, Stefan Winter (Stuttgart)
Omics-Technologien
14:30 – 14:40
Begrüßung
Ralf Kinscherf (Marburg)
14:40 – 16:20
Metabolismus und Inflammation
Vorsitz: Christian Gleissner, Huige Li
14:40 – 15:00
Karsten Grote, Jutta Schuett, Raghav Oberoi, Ann-Kathrin
Koch, Harald Schuett, Bernhard Schieffer (Marburg)
The NADPH oxidase NOX2 mediates Toll-like receptor 2/6dependent release of granulocyte macrophage colonystimulating factor from endothelial cells
15:00 – 15:20
Norbert Gerdes, Tom Seijkens, Dirk Lievens, Marijke J.E.
Kuijpers, Holger Winkels, Oliver Soehnlein, Johan W.M.
Heemskerk, Christian Weber, Esther Lutgens (Munich,
Amsterdam, Maastricht)
Platelet CD40 exacerbates atherosclerosis by transcellular
activation of endothelial cells and leukocytes
15:20 – 15:40
Christian Erbel, Gregor Rupp, Gabriele Domschke, Fabian
Linden, Mohammadreza Akhavanpoor, Andreas O. Doesch,
Hugo A. Katus, Christian A. Gleissner (Heidelberg)
Differential regulation of aldose reductase expression during
macrophage polarization depends on hyperglycemia
15:40 – 16:00
Darya Zibrova, Franck Vandermoere, Olga Göransson, Mark
Peggie, Anne Knierim, Katrin Spengler, Benoit Viollet, Nicholas
A. Morrice, Kei Sakamoto, Regine Heller (Jena, Dundee, Lund,
Paris)
GFAT1 phosphorylation by AMPK with subsequent decrease of
the hexosamine pathway promotes angiogenesis in endothelial
cells
16:00 – 16:20
Ning Xia, Enrico Schramm, Egon Koch, Martin Burkart, Gisela
Reifenberg, Ulrich Förstermann, Huige Li (Mainz, Karlsruhe)
Crataegus extract WS® 1442 improves vascular function in
diet-induced obese mice
16:20 – 16:50
Kaffeepause
16:50 – 17:50
Molecular Anti-Aging Effects of Exercise and Lifestyle
(KFO 196, Leiter: Ulrich Laufs, Homburg/Saar)
Vorsitz: Christian Werner, Peter Seizer
16:50 – 17:10
Anne Hecksteden (Saarbrücken)
Perspectives on individual response to exercise training
17:10 – 17:30
Christian Werner (Homburg)
Cardiovascular anti-ageing effects of physical activity
17:30 – 17:50
Joachim Altschmied (Düsseldorf)
p27 links caffeine effects to mitochondrial function in the
cardiovascular system
17:50
Neuentwicklung im pharmazeutischen Bereich
Vorsitz: Stefan Lorkowski
Rainer Schulz (Giessen)
PCSK9–Inhibierung: mehr als nur LDL-Cholesterin Senkung?
18:30 – 20:30
Parallele Postersitzungen I und II mit „Wine and Cheese“
Freitag, 8.4. 2016
8:30 – 12:30
Atherosclerosis and Heart Failure I
Vorsitz: Christian Schulze, Harald Langer
8:30 – 9:00
Ingo Ahrens (Freiburg)
Coronary heart disease, microvascular dysfunction and cardiac
failure
9:00 – 9:30
Christian Schulze (Jena)
Cardiac metabolism in heart failure
9:30 – 10:00
Jan Fiedler (Hannover)
Non-coding RNAs in angiogenesis - role for tissue remodelling
10:00 – 10:30
Kaffeepause
Vorsitz: Marcus Franz, Ingo Hilgendorf
10:30 – 11:00
Peter Seizer (Tübingen)
Atherosclerosis, cardiac arrhythmia and heart failure
11:00 – 11:30
Harald Langer (Tübingen)
Platelet activation in tissue remodelling
11:30 – 11:50
Marcus Franz, Dario Neri, P. Christian Schulze, Alexander
Berndt (Jena, Zürich)
Extracellular matrix reorganisation in pathologic myocardial
remodelling: Identification of novel biomarkers and targets for
antibody based pharmacodelivery
11:50 – 12:10
Sebastian Diebold, Julia Möllmann, Florian Kahles, Corinna
Lebherz, Nikolaus Marx, Michael Lehrke (Aachen)
The gut hormone Glucagon-like peptide 1 (GLP-1) is increased
in response to myocardial infarction and improves left
ventricular function in a GLP-1 receptor-dependent manner
12:10 – 12:30
Vera Jankowski, Yaw Asare, Elisa Liehn, Heike Bruck,
Nikolaus Marx, Georg Heinze, Joachim Jankowski (Aachen,
Essen, Vienna, Maastricht)
Identification of the “vasoconstriction inhibiting factor” (VIF), a
potent endogenous cofactor of angiotensin II acting on the AT2
receptor
12:30 – 13:30
Mittagspause
13:30 – 14:50
Atherosclerosis and Heart Failure II
Vorsitz: Katharina Schütt, Judith Haendeler
13:30 – 13:50
Judith Haendeler, Joachim Altschmied (Düsseldorf)
New insights into mitochondrial telomerase
transcriptase in the cardiovascular system
13:50 – 14:10
reverse
Ingo Hilgendorf, Timoteo Marchini, Dennis Wolf, Bianca
Dufner, Maximilian Mauler, Daniel Duerschmied, Christoph
Bode, Pablo A. Evelson, Andreas Zirlik
(Freiburg, Buenos
Aires)
Exposure to air pollution aggravates acute myocardial infarction
via alveolar macrophage inflammation
14:10 – 14:30
Mihaela Rusu, Adelina Curaj, Zhuojun Wu, Mareike Staudt,
Alexander Schuh, Joachim Jankowski, Elisa Liehn (Aachen)
How tissue compliance involves in remodeling of post-MI
mouse heart? A multifactorial study by means of liquid-AFM
investigations
14:30 – 14:50
Adelina Curaj, Sakine Simsekyilmaz, Mareike Staudt, Mihaela
Rusu, Isabella Kanzler, Heidi Noels, Peter Boor, Barbara Mara
Klinkhammer, Xiofang Li, Octavian Bucur, Cosmin Holeab,
Alice Brinzea, Tolga Taha Sönmez, Adnan Kaabi, Martin
Zenke, Nikolaus Marx, Vera Jankowski, Joachim Jankowski,
Alexander Schuh, Elisa A. Liehn (Aachen)
Neutrophils control fibroblast function after myocardial infarction
14:50 – 15:10
Raghav Oberoi, Birgit Markus; Maren Luchtefeld, Jutta Schütt,
Sabine Pankuweit, Karsten Grote, Bernhard Schieffer
(Marburg)
Altered pattern of circulating monocyte subpopulations in
patients with different stages of coronary artery disease
15:10 – 15:40
Kaffeeepause
15:40 – 16:20
Neuentwicklung im pharmazeutischen Bereich
Vorsitz: Nikolaus Marx
Carsten Rödel (Novartis)
LCZ69
16:30 – 17:30
Mitgliederversammlung
18:00 – 18:45
Verleihung des Hauss-Preises mit Vortrag
Rory Koenen (Maastricht)
JAM-A, a versatile new player in vascular inflammation
18:45 – 19:30
Verleihung der Rudolph-Schönheimer-Medaille mit Vortrag
Jürgen Schäfer (Marburg)
20:00
Abendveranstaltung
Sonnabend, 9.4. 2016
9:00 – 10:40
„Young Investigator Award Session“
Vorsitz: Ralf Kinscherf, Andreas Zirlik
9:00 – 9:20
Jan-Marcus Daniel, Jochen Dutzmann, Laura Korte, Johann
Bauersachs, Daniel G. Sedding (Hannover)
Adventitial activation by sonic hedgehog signalling is critical for
vascular remodeling
9:20 – 9:40
Jona B. Krohn, Joshua D. Hutcheson, Eduardo MartínezMartínez, Carlijn Bouten, Sergio Bertazzo, Michelle P. Bendeck,
Christian A. Gleissner, Elena Aikawa (Heidelberg, Boston,
Eindhoven, London, Toronto)
Discoidin domain receptor-1 (DDR-1) regulates the release of
calcifying extracellular vesicles in vascular smooth muscle cellmediated fibrocalcific responses through the TGF-β pathway
9:40 – 10:00
Julia Möllmann, Robert Stöhr, Will A. Coumans, O. Winz, A.T.
Vogg, H. J. Kaiser, Corinna Lebherz, F.M. Mottaghy, Joost J.
Luiken, Jan F. Glatz, Nikolaus Marx, Michael Lehrke (Aachen)
GLP-1 (9-37) reduces cardial glucose uptake and improves left
ventricular function in a model of myocardial hypertrophy
10:00 – 10:20
Franziska Pankratz, Caterina Jaenich, Gerard Pasterkamp,
Christoph Bode, Sebastian Grundmann (Freiburg, Utrecht)
Inhibition of microRNA-100 stimulates atherosclerotic lesion
formation in mice, whereas an overexpression of this microRNA
seems to have a beneficial effect and microRNA-100
expression levels correlate with the atherosclerotic plaque
phenotype in humans
10:20 – 10:40
Jutta Schütt, Julian Kreutz, Maren Luchtefeld, Frank Rühle,
Anika Witten, Bernhard Schieffer, Monika Stoll (Marburg,
Münster)
The influence of SOCS-1 deficiency on the gene expression
profile of Ly6C+ and Ly6C- monocytes in an atherosclerotic
mouse model
10:40 – 11:10
Kaffeepause
11:10 – 13:00
Inflammation und Atherosklerose
Vorsitz: Michael Torzewski, Daniel Sedding
11:10 – 11:30
Dieter Lütjohann, Karen Jaceldo-Siegl, Rawiwan Sirirat, Ella
Haddad (Bonn, Loma Linda)
Plasma plant sterols and plant sterol intake vary across plantbased dietary patterns among adults from North America
11:30 – 11:50
Carmen Härdtner, Alexandra Lindau, Bianca Dufner,
Christoph Bode, Andreas Zirlik, Ingo Hilgendorf (Freiburg)
Early atheroprotection by SYK inhibition fails in established
disease when local macrophage proliferation dominates lesion
progression
11:50 – 12:10
Christian Matthäus, Clara Stiebing, Stefan Lorkowski, Jürgen
Popp (Jena)
Intracellular lipid uptake by macrophages
spectroscopic imaging of white blood cells
12:10 – 12:30
–
Raman
Anna Savvaidis, Katharina Lysaja, Robert Stöhr, Nikolaus
Marx, Katharina Schütt (Aachen)
Microvesicles and coagulation: the impact on clot formation and
lysis
12:30 – 12:50
Vera Jankowski and Joachim Jankowski (Aachen, Maastricht)
Dinucleoside polyphosphates: strong endogenous agonists of
the purinergic system
12:50
Vergabe des “Young Investigator Awards“ und der Preise
für die besten Poster (Young Investigator Award gestiftet
von Pfizer, Posterpreise gestiftet von B. Braun Melsungen)
Postersitzung I (Poster 1 – 20)
Vorsitz: Huige Li, Andreas Zirlik, Michael M. Hoffmann, Katharina Schütt
1. Lisa Schmölz, Maria Wallert, Stefan Lorkowski (Jena, Melbourne)
Optimization of NO measurements in cell culture supernatants via Griess assay
2. Clara Stiebing, Lisa Schmölz, Maria Wallert, Christian Matthäus, Stefan Lorkowski,
Jürgen Popp (Jena)
Imaging the uptake of lipoproteins by macrophages with Raman Micro-Spectroscopy
3. Prathibha Reddy Gajjala (Aachen)
Emerging role of post-translational modifications in atherosclerosis
4. Katrin Spengler, Nderim Kryeziu, Silke Lindenmüller, Alexander Mosig, Regine Heller
(Jena)
Regulation of VEGF-induced angiogenesis by the AMPKα1/autophagy pathway
5. Sonja Ebenhöch, Frederic Emschermann, Harald F. Langer (Tübingen)
Specific recruitment of immune cells to endothel from different organs
6. Lilli Mey, Sabine Pankuweit, Anja Schwarz, Lisa-Marie Schütz, Ralf Kinscherf, Nadia
Al-Fakhri (Marburg)
Characterisation of neuropilin-1 in human blood vessels
7. Ann-Katrin Clauder, Max Heiduk, Hanna Bobolowski, Darya Zibrova, Lars-Oliver Klotz,
Regine Heller (Jena)
Inflammatory cytokines trigger alterations of glucose metabolisation in endothelial cells
8. Dana Kürsten, Christina Valkova, Siegfried Krause, Regine Heller (Jena)
Hypochlorite-modified LDL induces redistribution of free cholesterol in endothelial cells implications for eNOS localisation and trafficking
9. Lan Phuong Tran, Swenja Kröller-Schön, Thomas Jansen, Matthias Oelze, Andreas
Daiber, Thomas Münzel, Eberhard Schulz (Mainz)
Endothelial specific α1AMPK preserves endothelial function during chronic angiotensin
II treatment
10. Henry Nording, Johannes Patzelt, Fréderic Emschermann, Sarah Gekeler, John D.
Lambris, Emmanouil Chavakis, Meinrad Gawaz, Harald F. Langer (Tübingen, Frankfurt
am Main, Philadelphia)
Modulation of angiogenesis through the platelet-bound C5a complement receptor
11. Sakine Simsekyilmaz, Elisa A. Liehn, Yaw Asare, Jaco Selle, Janine Köhncke, Setareh
Alampour-Rajabi, Gansuvd Shagdarsuren, Ariunaa Togtokh, Andreas Klos, Eva
Medina, J. Engelbert Gessner, Erdenechimeg Shagdarsuren (Aachen, Ulanbaatar,
Hannover, Braunschweig)
C5a receptor deficiency enhances cardiac repair after myocardial infarction by
regulating angiogenesis and myofibroblast transdifferentiation
12. Adelina Curaj, Sakine Simsekyilmaz, Mareike Staudt, Andreas Götzenich, Andreea
Urs, Mircea Leabu, Elisa A. Liehn (Aachen)
Non-invasive up-regulation of heart preconditioning programme in vivo with minimal
side effects
13. Adelina Curaj, Mareike Staudt, Roxana Fatu, Andreas O. Kraaijeveld, Joachim
Jankowski, Erik A.L. Biessen, Elisa A. Liehn (Aachen, Bukarest, Leiden, Maastricht)
Blockade of CCR3 retains the neutrophils, preserving their survival during the healing
after myocardial infarction
14. Rawlings Achangwa, Kimon Stamatelopoulos, Federica Francesca Lunella, Alexia
Mareti, Chryssa Kritsioti, Nikos Makris, Smaragda Kapatsori, Carolin Amrhein Aikaterini
Gatsiou, Andreas Zeiher, Stefanie Dimmeler, Konstantinos Stellos (Frankfurt am Main,
Athen)
Role of miR-34a in atherosclerosis
15. Christian Erbel, Grigorios Korosoglou, Pearlyn Ler, Mohammadreza Akhavanpoor,
Gabriele Domschke, Fabian Linden, Andreas O. Doesch, Sebastian J. Buss, Evangelos
Giannitsis, Hugo A. Katus, Christian A. Gleissner (Heidelberg)
CXCL4 plasma levels are not associated with the extent of coronary artery disease or
with coronary plaque morphology
16. Felix Kork, Vera Jankowski, Joachim Jankowski (Aachen)
Menopause and oxidized low-density lipoprotein
17. Elisabeth Ullmann, Sebastian Steven, Matthias Oelze, Moritz Brandt, Swenja KröllerSchön, Tjebo Heeren, Steffen Daub, Mobin Dib, Dirk Stalleicken, Philip Wenzel,
Thomas Münzel, Andreas Daiber (Mainz)
Increased pulmonary artery pressure, oxidative stress and vascular dysfunction in
monocrotaline-induced pulmonary hypertension is improved by pentaerythrityl
tetranitrate therapy
18. Henry Nording, Annika Giesser, Reinhard Sauter, Johannes Patzelt, Konstantinos
Stellos, Tobias Geisler, Meinrad Gawaz, Harald F. Langer (Tübingen, Frankfurt am
Main)
Plättchengebundenes oxLDL korreliert negativ mit dem Anaphylatoxin C5a bei
Patienten mit koronarer Herzkrankheit (KHK)
19. Danan Zhu, Sebastian Reith, Nikolaus Marx, Mathias Burgmaier (Aachen)
Epicardial fatty tissue is related to coronary plaque vulnerability in patients with type 2
diabetes
20. Michelle J. Pena, Joachim Jankowski, Georg Heinze, Maria Kohl, Andreas Heinzel,
Stephan J. L. Bakker, Ron T. Gansevoort, Peter Rossing, Dick De Zeeuw, Hiddo J.
Lambers Heerspink, Vera Jankowski (Groningen, Aachen, Wien, Erlangen, Gentofte,
Copenhagen)
Systems medicine approach for improving risk prediction for renal disease in patients
suffering from type 2 diabetes or hypertension
Postersitzung I (Poster 21 – 40)
Vorsitz: Michael Torzewski, Christian Gleißner, Rory Koenen, Ingo Hilgendorf
21. Andrea-Anneliese Keller, Marten B. Maeß, Fan Fei, Oliver Werz, Dawn M.E.
Bowdish, Stefan Lorkowski (Jena, Hamilton)
Signalling pathways and autocrine mediators involved in PMA-induced up-regulation of
CCR7 in human macrophages
22. Anke Katharina Müller, Lisa Hergesell, Wiebke Schlörmann, Carsten Rohrer, Michael
Glei, Stefan Lorkowski (Jena)
Influence of roasting on the anti-inflammatory effects of lipophilic nut ingredients
23. Kathrin Ackermann, Anja Schwarz, Gabriel A. Bonaterra, Lisa-Marie Schütz, Ralf
Kinscherf (Marburg)
Role of GDF-15 on autophagy in human MФ after oxLDL exposition
24. Yingying Zhang, Johannes Patzelt, Frederic Emschermann, Harald F. Langer
(Tübingen)
Decreased levels of circulating CD11c+ cells after percutaneous therapy for mitral valve
regurgitation reveals a potential point of convergence between heart failure and
immunity
25. Frederic Emschermann, Harald F. Langer (Tübingen)
Flow cytometric analysis of DC precursors in the blood of patients with resistant
hypertension undergoing renal denervation
26. Raphael Boneberg, D. Pawlak, Gabriel Bonaterra, Claudia Keppler, Hans
Schwarzbach, Anita Pardun, Lena Hannemann, Björn Bogs, Petra Mayr, Olaf
Hildebrandt, Ulrich Koehler, Beate Wilhelm, Ralf Kinscherf, Wulf Hildebrandt (Marburg)
Pro-atherogenic gene expression of peripheral blood mononuclear cells in patients with
obstructive sleep apnea syndrome (OSAS): Impact of obesity and CPAP
27. Lukas Heger, Mark Kerber, Christoph Weis, Max Mauler, Moritz Mohr, Daniela
Stallmann, Christoph Bode, Christoph Hehrlein, and Ingo Ahrens (Freiburg)
Monocytes isolated from patients with sustained peripheral ischemia show upregulation of hypoxia-inducible factor 1 subunit HIF1alpha, after vascular reperfusion
therapy with Prostavasin®
28. Insa E. Emrich, Adam M. Zawada, Sarah Seiler, Rima Obeid, Jürgen Geisel, Danilo
Fliser, Gunnar H. Heine (Homburg)
S-Adenosylhomocysteine – a novel non-traditional cardiovascular risk factor in CKD
29. Wulf Hildebrandt, Hans Schwarzbach, Björn Bogs, Anita Pardun, Lena Hannemann,
D. Pawlak, Raphael Boneberg, Michael Dreher, Gabriel Bonaterra, Beate Wilhelm,
Petra Mayr, Olaf Hildebrandt, Ulrich Koehler, Ralf Kinscherf (Marburg)
Impaired capillarisation and in-vivo microcirculation of skeletal muscle with obstructive
sleep apnea: A novel link to insulin resistance?
30. Florian Kahles, Judith Marx, Anna Makowska, Michael Lehrke, Nikolaus Marx, Hannes
M. Findeisen (Aachen, Münster)
Regulation of vascular smooth muscle cell transdifferentiation and calcification by the
epigenetic histone lysine methyltransferase G9a
31. Ann-Kathrin Koch, Karsten Grote, Raghav Oberoi, Jutta Schütt, Bernhard Schieffer,
Harald Schütt (Marburg)
Nucleotide-binding oligomerisation domain-containing protein 1 (Nod1) mediates
proatherosclerotic processes and glucose metabolism
32. Heidi Noels, Baixue Zhou, Pathricia V. Tilstam, Wendy Theelen, Xiaofeng Li, Lukas
Pawig, Corinna Schmitz, Shamima Akhtar, Sakine Simsekyilmaz, Erdenechimeg
Shagdarsuren, Andreas Schober, Ralf H. Adams, Jürgen Bernhagen, Elisa A. Liehn,
Yvonne Döring, Christian Weber (Aachen, München, Münster, Maastricht)
Deficiency of endothelial Cxcr4 reduces reendothelialisation and enhances neointimal
hyperplasia after vascular injury in atherosclerosis-prone mice
33. Erik Rasbach, Paul Splitthoff, Gabriel A. Bonaterra, Lilli Mey, Hans Schwarzbach, Lee
Eiden, Eberhard Weihe, Ralf Kinscherf (Marburg, Bethesda)
Influence of PACAP (pituitary adenylate cyclase-activating polypeptide) on the
development and progression of atherosclerotic lesions in ApoE-/- mice after normal
chow or cholesterol-enriched diet.
34. Paul Splitthoff, Erik Rasbach, Gabriel A. Bonaterra, Lilli Mey, Hans Schwarzbach,
Eberhard Weihe, Ralf Kinscherf (Marburg)
Influence of the PACAP (pituitary adenylate cyclase-activating polypeptide) receptor
PAC1 on the development and progression of atherosclerotic lesions in ApoE-/- mice
after normal chow or cholesterol-enriched diet.
35. Mathias Burgmaier, Sebastian Reith, Danan Zhu, Leon Schurgers, Nikolaus Marx,
Chris Reutelingsperger (Aachen, Maastricht)
Circulating annexin A5 levels are related to carotid intima-media thickness but not
coronary plaque composition
36. Holger Winkels, Svenja Meiler, Esther Smeets, Dirk Lievens, David Engel, Charlotte
Spitz, Christina Bürger, Jannie Borst, Christian Weber, Esther Lutgens, Norbert Gerdes
(Müchen, Amsterdam)
Deficiency of the co-stimulatory dyad CD27/CD70 exacerbates atherosclerosis
37. Moritz Wagner, Gabriel A. Bonaterra, Hans Schwarzbach, Stefanie Zügel, Jens
Strelau, Ralf Kinscherf (Marburg)
Effect of growth differentiation factor-15 (GDF-15) on gene and protein expression in
gastrocnemius muscle of hypercholesterolemic ApoE-/- mice after 12 or 20 weeks
cholesterol-enriched diet
38. Zuzanna Rowinska, Alma Zernecke, Thomas A. Koeppel, Maryam Sanati, Hubert
Schelzig, Joachim Jankowski, Christian Weber, Elisa A. Liehn (Düsseldorf, Aachen,
Würzburg, Hamburg, München, Maastricht, Craiova)
Role of the CX3C chemokine receptor CX3CR1 in the pathogenesis of atherosclerosis
after aortic transplantation
39. Sakine Simsekyilmaz, Elisa A. Liehn, Stefan Weinandy, Fabian Schreiber, Remco
T.A. Megens, Wendy Theelen, Ralf Smeets, Stefan Jockenhövel, Thomas Gries, Martin
Möller, Doris Klee, Christian Weber, Alma Zernecke (Aachen, Gießen, Craiova,
München, Hamburg, Würzburg)
Targeting In-Stent-Stenosis with RGD- and CXCL1-coated Mini-Stents in Mice
40. Sandra Kraemer, T. Breuer, S. Cremers, Mareike Staudt, Elisa A. Liehn, Andreas
Goetzenich, Rüdiger Autschbach (Aachen)
Strategies for biofunctionalisation of the surfaces for small diameter vascular grafts

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