2.5. アミノ酸経路 2.5.1. 芳香族アミノ酸経路

�
2.5.
p. 2-17"
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�
2.5.1.
COOH
HO
NH2
HO
Cf.
N
NH
COOH
NH2
HO
L-
L-Tyr
N
p. 2-17"
N
N
C1
�
L-
– CO2
p. 2-18"
HO
HO
NH2
HO
HO
NH
H
CHO
OH
L-Tyr
(S)OH
C6-C2
NH
�
p. 2-18"
N
L-Phe
OHC
HO
HO
NH
OH
H
p. 2-20"
OH
C6-C3
MeO
H
N
MeO
H O
MeO
O
O
OH
O
OMe
�
p. 2-18"
!
!
L-Phe
COOH - C2
-N
O
COOH
S-CoA
1)
C6-C3
C6-C1
(+ C2)
2)
OH
H
N
Me
p. 2-20
�
L-Trp
p. 2-18"
– CO2
N
H
NH2
Me
HN
O
O
N
N
H
Me Me
p. 2-20
�
L-Tyr
MeO
p. 2-19"
HO
N
MeO
O
OMe
N
OMe
CH3
HO
O
O
O
N
O
Me
MeO
O
OMe
O
N
MeO
OMe
OMe
C1
SAM
�
2.5.2.
H2N
NH2
COOH
-CO2
NH2
NH2
N
Me
L-Orn
L-Asp
3-
N
N
COOH
+
Me
p. 2-21"
N
N
Me N
N Me
N
H
Me
p. 2-21"
-CO2
H2N
NH2
COOH
NH2
NH2
L-Lys
N
H
N
H
N
p. 2-22"
2.6.
-
α-
2.6.1.
p. 2-22"
2.6.1.1.
NH 2
OH
- NH3
HOOC
HOOC
HOOC
4-
L-Phe
OH
CoA
S
O
HO
OH
OH
3
-CoA
O
OH
O
CoA-S
O
O
4OH
(C6-C2-C6
)
OH
OH
HO
CoA
O
HO
OH O
OH O
(C6-C3-C6
)
p. 2-23"
3'
8
7
6
5
O
1
9 O 2
10
4
4'
2'
3
1'
5'
O
6'
O
O
O
O
O
OH
OH
O
O
O
O
O
2.6.1.2.
-
p. 2-23"
THC
THC
CB1
OH
O
O
OH
N
H
OH
O
OH
OH
2-
CB1, CB2
O
O
CoA
O
CoA-S
COOH
S-Enz
O
HO
O
CoA
p. 2-24"
OH
OH
GPP
COOH
a
OH
a
HO
OH
COOH
COOH
H
C5H11
OH
b
OH
b
– CO2
OH
OH
COOH
COOH
OH
C5H11
O
C5H11
O
C5H11
OH
– CO2
– CO2
CH3 COOH
OH
OH
O
O
C5H11
O
(THC)
C5H11
OH
2.6.2.
p. 2-25"
2.6.2.1.
CHO
O–Glc
O
MeOOC
L-Trp
NH2
N
H
NH
N
H H
O–Glc
O
MeOOC
N
H
N
p. 2-27
N
NH
N
H
NH
NH
NH
p. 2-25"
COOH
N
H
L-Trp
NH2
+
COOH
OPP
DMAPP
NH2
N
H
O
OH
O
N CH3
OH
N CH3
H
HN
HN
�
L-Trp
MeO
N
N
N
HH
p. 2-26, 27"
H
H
MeOOC
H
H
O
N
OMe
O
H
H
O
OMe
H
OMe
O
OMe
HO
N
OH
MeO
H N
N
HO
H
Me
COOH
L-Orn
Me
O
-CoA
NH2
N
N
H
2.6.2.2.
H2N
H
CH3
N
N
Me
Me
p. 2-28"
O
S-CoA
L-Phe
N
Me
N Me
Me
Me
N
Me
N
COOMe
N
O
O
OH
OH
O
O
O
O
(œ)L-Phe
�
O
(œ)-
p. 2-29"
2.6.2.3.
H
N
H
N
COOH
COOH
COOH
COOH
L-Glu
(DMAPP)

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