15th Day of Clinical Research

Universität Zürich
Medizinische Fakultät
Zentrum für Klinische Forschung (ZKF) / Center for Clinical Research (CCR)
Clinical Trials Center (CTC)
Program
th
15 Day of Clinical Research
Georg-Friedrich-Götz-Preisverleihung 2016
Zurich, March 31, 2016
Assoziierte Kliniken
Kinderspital Zürich
Universitätsklinik Balgrist
Kinder- und Jugendpsychiatrischer
Dienst des Kantons Zürich
Psychiatrische Universitätsklinik
Structure of the Center for Clinical
Research/
Clinical Trials Center
Table of contents
Kuratorium
Prof. Dr. J-M. Fritschy (Stv. Dekan, ex officio)
Prof. Dr. Ch. Hock (Prorektor, ex officio)
Prof. Dr. J. Hodler
Prof. Dr. T. Lüscher
Prof. Dr. P.-A. Clavien
Prof. Dr. M. Pruschy
Prof. Dr. S. Gay
Prof. Dr. R. Nitsch
lic. oec. HSG R. Ziegler
Prof. Dr. B. Stieger
Prof. Dr. G. Zünd (Managing Director)
Program
List of Abstracts
Abstracts
Direktorium
Prof. Dr. M. Weller
Prof. Dr. A. von Eckardstein (Co-Direktor)
Prof. Dr. A. Aguzzi (Co-Direktor)
Prof. Dr. G. A. Kullak-Ublick
Prof. Dr. H. Moch
Prof. Dr. G. Spinas
Prof. Dr. G. Zünd (Managing Director)
PD Dr. Paolo Cinelli
PD Dr. Mira Katan-Kahles
Geschäftsstelle ZKF
Robin Schneider, MBA
Geschäftsführer
Clinical Trials Center
PD Dr. G. Senti
Leitende Ärztin Clinical Trials Center
Biologisches Zentrallabor
Dr. Hugo Battaglia
Leiter Biologisches Zentrallabor
Forschungsgruppenleiterkonferenz
PD Dr. Paolo Cinelli
PD Dr. Mira Katan-Kahles
Scientific Research Group Leaders of the
University Hospitals of Zurich (University Hospital,
Children’s Hospital, Balgrist University Clinic,
Psychiatric University Hospital) and related
institutions of the Faculty of Medicine
Bild Vorderseite: PD Dr. med. Paolo Cinelli & Nico Wick-Mazzarda, UniversitätsSpital Zürich
1-3
4 - 18
19 - 196
Programm
Donnerstag, 31. März 2016
Grosser Hörsaal Ost
08.15
Eröffnung
Prof. Dr. Gregor Zünd
Managing Director ZKF, Direktor Forschung und Lehre UniversitätsSpital Zürich
08.20
Begrüssung
Rita Ziegler, lic. oec. HSG
Vorsitzende der Spitaldirektion
08.25
Begrüssung
Prof. Dr. Rainer Weber
Dekan der Medizinischen Fakultät der Universität Zürich
Session 1: Cardiovascular/Metabolics/Endocrinology
Chairpersons: Prof. Dr. Michele Genoni, Prof. Dr. Matthias Baumgartner
08.35
Wissenschaftliches Hauptreferat
“Vascular “glue” to cure sepsis?”
PD Dr. med. Reto Schüpbach, Leitender Arzt, Intensivmedizin, UniversitätsSpital Zürich
08.55
A novel mouse model of methylmalonic aciduria circumvents neonatal lethality
P. Forny, M. Mustedanagic, P. Burda, T. Hornemann, M. Baumgartner
09.05
Impaired glucose tolerance in mice with β-cell specific deletion of Pkbα
M. Dietrich, R. Zuellig, M. Niessen, G. Spinas, O. Tschopp
09.15
Obstructive Sleep Apnea in Ehlers-Danlos Syndrome. A prospective case-control study
T. Gaisl, C. Giunta, K. Sutherland, D. Bratton, C. Schlatzer, N. Sievi, D. Franzen, P. Cistulli, M.
Rohrbach, M. Kohler
09.25
Mid-regional pro-adrenomedullin (MR-proADM) is an independent predictor of post stroke
mortality
C. Huber, J. Schneider, B. Mueller, M. Christ-Crain, M. Katan
09.35
Coffee Break
Session 2: Hematology/Oncology
Chairpersons: Prof. Dr. Markus Manz, Prof. Dr. Matthias Guckenberger
09.50
Wissenschaftliches Hauptreferat
“The landscape for early drug development in oncology: pitfalls and chances “
PD Dr. med. Roger von Moos, Leitender Arzt, Klinik & Polyklinik für Onkologie,
Universitätsspital Zürich
10.10
Aging-associated intrinsic and extrinsic factors control hematopoietic stem cell behavior
L. Kovtonyuk, R. Ramin, H. Takizawa, M. Manz
10.20
Blocking of the epigenetic repressor Ezh2 controls tumor escape upon IL-2cx immunotherapy
N. Arenas-Ramirez, D. Zingg, R. Rosalia, A. Antunes, J. Haeusel, L. Sommer, O. Boyman
10.30
Generation of a conditional transgenic mouse model of immunoglobulin light chain (AL)
amyloidosis
M. Nuvolone, S. Sorce, P. Pelczar, E. Rushing, F. Lavatelli, G. Palladini, G. Merlini, A. Aguzzi
1
10.40
The NKG2D system mediates anti-tumor effects of chemotherapy and radiotherapy against
glioblastoma
T. Weiss, H. Schneider, M. Silginer, A. Steinle, M. Pruschy, M. Weller, P. Roth
Session 3: Stem Cell Research, Regenerative Medicine and Advanced
Technologies
Chairpersons: Prof. Dr. Dr. Simon Hoerstrup, PD Dr. Oliver Gämperli
10.55
Wissenschaftliches Hauptreferat
“Translating basic research into clincially applicable skin”
Dr. Thomas Biedermann, PhD, Post Doc, Kinderspital Zürich, The Tissue Biology Research Unit
11.15
Impact of solubilized muscle-specific urethral extracellular matrix on skeletal muscle
differentiation for sphincter reconstruction
I. Simões, D. Keller, P. Vale, J. Cabral, C. Da Silva, P. Baptista, T. Sulser, D. Eberli
11.25
The Consent, Contact, and Community framework for Patient Reported Outcomes –
Enhancing Apple's ResearchKit for iPhone Apps with FHIR
P. Pfiffner, I. Pinyol, M. Natter, K. Mandl
11.35
Maintenance of human hematopoiesis in in vivo engineered bone organs
K. Fritsch, P. Bourgine, P. Bourgine, S. Pigeot, T. Schröder, I. Martin, H. Takizawa, H. Takizawa,
M. Manz
11.45
Drug Delivery device to support tendon rupture repair: biomechanical outcome of in vivo
rabbit Achilles tendon full laceration experiments three weeks post-surgery
O. Evrova, G. Meier Bürgisser, M. Calcagni, C. Scalera, E. Bachmann, J. Snedeker, P. Giovanoli,
V. Vogel, J. Buschmann
11.55
Lunch/Poster viewing
Session 4: Infection/Immunity/Inflammation
Chairpersons: Prof. Dr. Janine Reichenbach, Prof. Dr. Roberto Speck
13.50
Wissenschaftliches Hauptreferat
“Cytokines: From Bench to Clinic“
Prof. Dr. med. Onur Boyman, Klinikdirektor, Klinik für Immunologie, UniversitätsSpital Zürich
14.10
Stimulation of cytotoxic T cells by photosensitization-based Vaccination
S. Freiberger, E. Varypataki, M. Hakerud, T. Kündig, P. Johansen
14.20
Type II IL-4 receptor expression on neutrophils antagonizes their expansion and migration
during infection and inflammation
J. Woytschak, N. Keller, D. Impellizzieri, R. Thompson, T. Wynn, A. Zinkernagel, O. Boyman
14.30
1-Deoxy-sphingolipids, novel biomarkers of diabetes, are cytotoxic for exocrine pancreatic
cells
R. Chen, T. Hornemann, W. Yu, S. Camargo, R. Graf, S. Sonda
14.40
The impact of preconditioning by Sevoflurane after experimental mouse lung transplantation
Y. Yamada, I. Laube, J. Jang, J. Bonvini, I. Inci, B. Beck Schimmer, W. Weder, W. Jungraithmayr
14.50
Coffee Break
Session 5: Neurosciences/Pharmacology
Chairpersons: Prof. Dr. Gerd-Achim Kullak-Ublick, Prof. Dr. Michael Weller
15.05
Wissenschaftliches Hauptreferat
“Sleep-wake disturbances following traumatic brain injury”
Prof. Dr. med. Christian Baumann, Leitender Arzt, Klinik für Neurologie, UniversitätsSpital Zürich
2
15.25
The role of brain pericytes in the regulation of leukocyte trafficking and immune response
under homeostatic and pathological conditions
O. Török, B. Schreiner, A. Keller
15.35
A neuroprotective role for microglia in prion diseases
C. Zhu, U. Herrmann, J. Falsig, I. Abakumova, M. Nuvolone, P. Schwarz, E. Rushing, A. Aguzzi
15.45
Inhibition of group I metabotropic glutamate receptors (mGluR1 and mGluR5) protects
against prion- induced toxicity
D. Goniotaki, L. Lakkaraju, A. Shrivastava, P. Bakirci, S. Sorce, P. Pelczar, F. Gasparini, A. Triller,
A. Aguzzi
15.55
Complete resection of contrast enhancing tumor volume is associated with improved survival
in recurrent glioblastoma – results from the DIRECTOR trial
H. Wirsching, J. Tonn, G. Tabatabai, C. Senft, P. Hau, M. Sabel, U. Herrlinger, R. Ketter, U.
Schlegel, C. Marosi, G. Reifenberger, W. Wick, M. Weller, B. Suchorska
16.05
Coffee Break
Session 6: Klinische Forschungsschwerpunkte KFSP
16.20
Präsentation
Small RNA’s
Prof. Dr. Adriano Aguzzi, Institutsdirektor, Institut für Neuropathologie, UniversitätsSpital Zürich
16.40
Präsentation
Molecular Imaging Network
Prof. Dr. phil. Bruno Weber, Klinik für Nuklearmedizin, UniversitätsSpital Zürich
17.00
Präsentation
Zurich Primary HIV Infection Study
Dr. med. Dominique Braun, Oberarzt, DFL Zurich Primary HIV Infection Study
UniversitätsSpital Zürich
17.25
Posterpreis
17.35
Verleihung Georg Friedrich Götzpreis 2016
18.50 Apéro
3
Conference Location
University Hospital Zurich
Grosser Hörsaal Ost
Rämistrasse 100
8091 Zürich
Contact Address
Prof. Dr. med. Gregor Zünd
Direktor Forschung und Lehre
Managing Director ZKF
UniversitätsSpital Zürich
[email protected]
phone:
+41 (0) 44 634 55 00
fax:
+41 (0) 44 634 55 03
Secretary office:
+41 (0) 44 634 55 33

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