PDPK1 IC50 PDPK1 IL6, BAFF, IGF1 PDPK1 PDPK1 PDPK1 Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple AKT, RSK2 myeloma. NFkB PDPK1 MM p-PDPK1 MM MM MM p-PDPK1 ( : PDPK1(-)2925 p-PDPK1 MM vs. p-PDPK1(+) 567 MM , p=0.049 median PFS, p-PDPK1(-) 972 , p=0.125 RSK2-NTKD MM PDPK1 RAS FGFR3 B-RAF 11 MM RSK2 N RSK2-NTKD MM RNA PDPK1 MM Shimura, et al. Mol Cancer Ther. 2012 RSK2-NTKD AKT c-MYC IRF4 Cyclin Ds Phosphoinositide dependent protein kinase 1 (PDPK1) BIM BAD 11 phospho (p)-PDPK1 p-PDPK1 MM PDPK1 IC50 MM PDPK1 MM G2 PDPK1 90% p-PDPK1 BD 2.5-12.8 µM AKT MM PLK1 MM MM RSK2 MM RSK2-NTKD 8 median PFS vs. p-PDPK1(+) 167 , p=0.069) p=0.041 p-PDPK1 p-PDPK1 RAS/MAPK pathway 83% BD p-PDPK1(-) MM vs. PDPK1(+)2155 17% MM 90% MM PDPK1 PDPK1 G2 MYC, IRF4, Cyclin Ds M MM PLK1 BIM PDPK1 MM PDPK1 p-PDPK1 BAD RNAi MM MM PDPK1/RSK2
© Copyright 2024 ExpyDoc
