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IGF
(suppress)
(suppress)
IFN
P4
Fas L
(synergistic)
TNF
TNF-R
Prostaglandins
Fas
(?)
(?)
P4-R
Sphingomyelin/ceramide
pathways
MAPK
PL-A2
Caspases
NFkB
JNK
AA
Bcl-2
(active)
Survival
Bcl-2
(inactive)
Apoptosis