03-30生体磁気-学会誌-抄録集.qxp_レイアウト 1 2015/05/22 18:04 ページ 72
臨床脳磁図
日本生体磁気学会誌 特別号
O3-3
Vol.28 No.1 2015　第 30 回日本生体磁気学会大会論文集
᫬㛫࿘Ἴᩘゎᯒ㸪ഴᩳ☢ሙࢺ࣏ࢢࣛࣇ࢕㸦GMFT㸧ࢆ ⏝࠸ࡓMEG࡟ࡼࡿⓎస㛫Ḟᮇ㧗࿘Ἴᚊື㸦HFO㸧ࡢ᳨ฟ
Magnetoencephalographic analysis of interictal epileptic high
frequency oscillations (HFOs) using time-frequency analysis and
gradient magnetic-field topography (GMFT).
ⓑỈὒྐ(1)㸪ቑ⏣ ᾈ(1)㸪ఀ⸨㝧♸(1)㸪ᮾᓥጾྐ(1)㸪ᶫワ 㢧(2)㸪டᒣⱱᶞ(1)
ᅜ❧⑓㝔ᶵᵓす᪂₲୰ኸ⑓㝔 ᶵ⬟⬻⚄⤒እ⛉ ࡓ࠿ࡢᶫ୰ኸ⑓㝔 ⬻⚄⤒እ⛉
Hiroshi Shirozu (1), Hiroshi Masuda (1), Yosuke Ito (1), Takefumi Higashijima (1), Akira
Hashizume (2), and Shigeki Kameyama (1)
(1) Department of Functional Neurosurgery, Nishi-Niigata Chuo National Hospital
(2) Department of Neurosurgery, Takanobashi Central Hospital
Abstract The aim of this study is to assess the
usefulness of MEG on detection and localization of
fast oscillation (FO) and to evaluate the validity by
comparison with invasive EEG (iEEG). Five patients
with neocortical epilepsy were reviewed. Multiple
band frequency analysis (MBFA) is conducted to
detect FOs, and gradient magnetic-field topography
(GMFT) is used for localization of the FOs. MBFA
revealed FOs with 50-100 Hz in all patients except for
one patient. GMFT could localize the FOs, and the
distributions were concordant to that of high
frequency oscillations in iEEG. MEG is considered to
be useful for analysis of FO.
1. ┠ ⓗ
㧗࿘Ἴᚊື㸦high frequency oscillation; HFO㸧ࡣ㸪
࡚ࢇ࠿ࢇཎᛶࢆ♧ࡍ biomarker ࡜ࡋ࡚㏆ᖺὀ┠ࡉ
ࢀ࡚࠸ࡿ㸬ከࡃࡣ㸪㢌⵹ෆ⬻Ἴ࡟ࡼࡿ᳨ฟ࡛࠶ࡾ㸪
MEG ࡟ࡼࡿ࡚ࢇ࠿ࢇ࡟㛵ࡍࡿ HFO ᳨ฟ࡟㛵ࡍࡿ
ሗ࿌ࡣᑡ࡞࠸[1]㸬௒ᅇࡢ◊✲ࡣ㸪MEG ࡀ࡝ࡢ⛬ᗘ
ࡢ㏿Ἴᚊື(fast oscillation; FO)ࢆ᳨ฟྍ⬟࠿㸪ࡲࡓ
᳨ฟࡉࢀࡓ FO ࡢᒁᅾデ᩿ࡀྍ⬟࠿㸪ࡑࡋ࡚ࡇࢀ
ࡽࡢ⤖ᯝࡀ㢌⵹ෆ⬻Ἴࡢ⤖ᯝ࡜࡝ࡢ⛬ᗘ୍⮴ࡍࡿ
࠿᳨ドࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓ㸬
2. ᑐ ㇟ ࣭ ᪉ ἲ
⾡๓ MEG ࠾ࡼࡧ៏ᛶ㢌⵹ෆ⬻Ἴグ㘓(iEEG)ࢆ
᪋⾜ࡋࡓ᪂⓶㉁࡚ࢇ࠿ࢇ 5 ౛㸦⑓⌮デ᩿㸸FCD type
I, n=2; type IIA, n=1; type IIB, n=2㸧㸧ࢆᑐ㇟࡜ࡋࡓ㸬
72
MEG ᳨࡛ฟࡉࢀࡓ㛫Ḟᮇ࡚ࢇ࠿ࢇᛶᨺ㟁(iid)࡟
ࡘ࠸࡚㸪multiple band frequency analysis (MBFA)ࢆ
⏝࠸࡚᫬㛫࿘Ἴᩘゎᯒࢆ⾜ࡗࡓ㸬᳨ฟ࡛ࡁࡓ࿘Ἴ
ᩘᖏᇦࢆ 20-50Hz, 50-100Hz, 100Hz ௨ୖ࡟ศ㢮ࡋ
ࡓ㸬ࡉࡽ࡟㸪㧗࿘Ἴࢆక࠺Ἴᙧ࡟ࡘ࠸࡚㸪ഴᩳ☢
ሙࢺ࣏ࢢࣛࣇ࢕(GMFT)ࢆ⏝࠸࡚㸪ࡑࡢ࿘Ἴᩘᖏᇦ
ࡢศᕸࢆゎᯒࡋࡓ㸬ࡇࢀࡽࡢ⤖ᯝࢆ㸪iEEG ࡟࠾ࡅ
ࡿⓎస㛫Ḟᮇ spike ࡟ᑐࡍࡿ MBFA ゎᯒࡢ࿘Ἴᩘ
࠾ࡼࡧ HFO ࡢศᕸᇦ࡜ẚ㍑᳨ウࡋࡓ㸬
MEG ࡣ Neuromag (Neuromag-Elekta, Finland)ࢆ
⏝࠸㸪sampling-rate ࡣ 600.615Hz ࡛ ᐃࡋࡓ㸬
MBFA, GMFT ࡟ࡘ࠸࡚ࡣ㸪custom-made software
(hns_meg; http://meg.aalip.jp/indexE.html)࡛ ゎ ᯒ ࡋ
ࡓ㸬iEEG ࡣ sampling rate 1000Hz ࡛ ᐃࡋ㸪MBFA
ࡣ custm-made software (hns_eeg)࡛ゎᯒࡋࡓ㸬
3. ⤖ ᯝ
MEGࡢMBFA࡟ࡼࡿ᫬㛫࿘Ἴᩘゎᯒ࡛ࡣ㸪඲౛
࡟࠾࠸࡚20-50HzᖏᇦࡢFOࡀ᳨ฟྍ⬟࡛࠶ࡗࡓ㸬
ࡲࡓ㸪50-100HzᖏᇦࡢFO࡟ࡘ࠸࡚ࡣ㸪FCD type I
ࡢ1౛ࢆ㝖࠸࡚㸪᳨ฟྍ⬟࡛࠶ࡗࡓ㸦ᅗ㸯㸧㸬100Hz
௨ୖࡢ㧗࿘ἼᖏᇦࡢFO࡟ࡘ࠸࡚ࡣ㸪඲౛᳨࡛ฟ࡛
ࡁ࡞࠿ࡗࡓ㸬᳨ฟࡉࢀࡓFO࡟ࡘ࠸࡚GMFTゎᯒࢆ
࠾ࡇ࡞࠸㸪FOศᕸᇦࡢᒁᅾ໬ࡀྍ⬟࡛࠶ࡿࡇ࡜ࡀ
☜ㄆࡉࢀࡓ㸦ᅗ㸰㸧㸬
ࡲࡓ㸪iEEG࡟࠾ࡅࡿiidࡢMBFAゎᯒ࡟࠾࠸࡚㸪
HFO ࢆ ㄆ ࡵ ࡓ 㒊 ఩ ࡜ ࡢ ẚ ㍑ ࡛ ࡣ 㸪MEG ࡢ FO ࢆ
GMFT࡛ᒁᅾ໬ࡋࡓࡶࡢ࡜㸪iEEG࡛ࡢHFOศᕸᇦ
ࡣ୍⮴ࡋ࡚࠸ࡓ㸦ᅗ㸱㸧㸬
03-30生体磁気-学会誌-抄録集.qxp_レイアウト 1 2015/05/22 18:04 ページ 73
日本生体磁気学会誌 特別号
Vol.28 No.1 2015　第 30 回日本生体磁気学会大会論文集
ཧ⪃ᩥ⊩
[1] Rampp S, 2010. MEG correlates of epileptic high
gamma oscillations in invasive EEG. Epilepsia.
51:1638-1642.
[2]
Jacobs
J,
2010.
High-frequency
electroencephalographic oscillations correlate with
outcome of epilepsy surgery. Ann Neurol. 67:209-220.
ᅗ㸯㸬MEG ࡟࠾ࡅࡿ㛫Ḟᮇ spike ࡢ MBFA ゎᯒ
A㸸Raw data㸦5 ⛊㛫㸧㸬Band-pass filter; 10-50Hz.
B㸸MBFA ࡟ࡼࡿ඲ࢳࣕࢿࣝࡢ᫬㛫࿘Ἴᩘゎᯒ㸬
C㸸㏿Ἴᚊື㸦FO㸧ࢆㄆࡵࡓࢳࣕࢿࣝࡢ MBFA㸬
7 ⛊๓ᚋࡢ᫬Ⅼ࡛Ⓨ⏕ࡋࡓ spike ࡟ 50Hz ௨ୖࡢ FO
ࡀΰධࡋ࡚࠸ࡿ㸬
4. ⪃ ᐹ
ᮏ◊✲࡟࠾࠸࡚㸪MEGࡀ㏿Ἴᚊືࢆ᳨ฟࡍࡿࡇ
࡜ࡀ࡛ࡁ㸪࠿ࡘࡑࡢᒁᅾデ᩿ࡶྍ⬟࡛࠶ࡿࡇ࡜ࡀ
♧ࡉࢀࡓ㸬
HFOࡣ㸪࡚ࢇ࠿ࢇཎᛶࢆ♧ࡍᣦᶆ࡜ࡋ࡚ὀ┠ࡉ
ࢀ࡚࠾ࡾ㸪࡚ࢇ࠿ࢇእ⛉⑕౛࡟࠾࠸࡚ࡣ⾡ᚋ㌿ᖐ
࡟ࡶ㛵ࢃࡿ࡜ሗ࿌ࡉࢀ࡚࠸ࡿ[2]㸬MEGࡣ㠀౵くⓗ
࡞⾡๓᳨ᰝ࡜ࡋ࡚㸪࡚ࢇ࠿ࢇ↔Ⅼࡢᒁᅾ໬࡟ඃࢀ
ࡓ⬟ຊࢆⓎ᥹ࡍࡿࡀ㸪HFOゎᯒࡢ᭷⏝ᛶ࡟ࡘ࠸࡚
ࡢሗ࿌ࡣᑡ࡞࠿ࡗࡓ[1]㸬HFOࡣ㸪㠀ᖖ࡟ᙅ࠸㟁఩
࡛࠶ࡿࡓࡵ㸪ࡇࡇ࠿ࡽ⏕ࡌࡿ㧗࿘Ἴ☢ሙࡀῶ⾶ࡋ㸪
MEG࡛ࡣ᳨ฟࡍࡿࡢࡀᅔ㞴࡛࠶ࡿࡇ࡜ࡀ୍ᅉ࡜
⪃࠼ࡽࢀࡿ㸬ࡋ࠿ࡋ㸪᫬㛫࿘Ἴᩘゎᯒࢆ⏝࠸ࡿࡇ
࡜࡛㸪㧗࿘Ἴᡂศࢆ☜ㄆ࡛ࡁ㸪࠿ࡘGMFTࡣ㸪㏻
ᖖࡢ➼౯㟁ὶ཮ᴟᏊ㸦ECD㸧ゎᯒ࡛ࡣゎᯒࡋᚓ࡞
࠸ࡼ࠺࡞㸪S/Nẚࡢప࠸☢ሙࢆ࿊ࡍࡿFO࡛ࡶᒁᅾ
໬ࡍࡿࡇ࡜ࡀྍ⬟࡛࠶ࡗࡓ㸬ࡇࢀࡽࡢ⤖ᯝࡀiEEG
࡜୍⮴ࡋ࡚࠸ࡿࡇ࡜ࡣ㸪㠀౵くⓗ᳨ᰝ࡛࠶ࡿMEG
ࡢ⾡๓ホ౯࡟࠾ࡅࡿᙺ๭ࡀ୍ẁ࡜ቑࡍࡇ࡜ࢆព࿡
ࡍࡿ࡜⪃࠼ࡽࢀࡿ㸬
5. ⤖ ㄽ
MEG ࡛ࡶ༑ศ࡟ FO ࡀ᳨ฟྍ⬟࡛㸪࠿ࡘᒁᅾデ
᩿ࡀྍ⬟࡛࠶ࡾ㸪ࡇࢀࡽࡣ㢌⵹ෆ⬻Ἴࡢ⤖ᯝ࡜┦
ྠࡋ࡚࠾ࡾ㸪㠀౵くⓗ࡞ HFO ホ౯࡜ࡋ࡚ᙺ๭ࢆ
ᯝࡓࡍࡇ࡜ࡀྍ⬟࡛࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬
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ᅗ㸰㸬㧗࿘Ἴᡂศࡢ GMFT ゎᯒ
A㸸Raw data㸦୍㒊㸪500msec㸧㸬Band-pass filter;
50-100Hz.
B㸸FO ࢆㄆࡵࡓ㒊ศ㸦⣙ 25mec㸧ࡢ GMFT㸬
C㸸FO ࡢ GMFT ຍ⟬⏬ീ㸬ᕥ㢌㡬㛫⁁ࠥୗ㢌㡬ᑠ
ⴥ࡟ᙉ࠸ศᕸࢆ♧ࡍ㸬
ᅗ㸱㸬㢌⵹ෆ⬻Ἴグ㘓࡟࠾ࡅࡿ᫬㛫࿘Ἴᩘゎᯒ
A㸸㢌⵹ෆ⬻Ἴ㸦10 ⛊㛫㸪band-pass filter: TC; 0.1,
HFF; 120Hz㸧㸬㢖ᅇࡢⓎస㛫Ḟᮇ spike ࢆㄆࡵࡿ㸬
B㸸10 ⛊㛫ࡢ MBFA ࡟ࡼࡿ᫬㛫࿘Ἴᩘゎᯒ㸦channel
A3 ࡢࡳ⾲♧㸧㸬࡯࡜ࢇ࡝ࡢ spike ࡛ 150Hz ㏆ࡃ࡟
฿㐩ࡍࡿ HFO ࢆకࡗ࡚࠸ࡿ㸬
C: HFO ࢆక࠺ spike ࡀฟ⌧ࡋ࡚࠸ࡿࢳࣕࢿࣝ㸦ⓑ
୸㸧ࡢศᕸ㸬MEG ࡟࠾ࡅࡿ FO ࡢ GMFT ศᕸᇦ
࡜࡯ࡰ୍⮴ࡋ࡚࠸ࡿ㸬

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