塩基性化合物
Basic compounds
代表的な塩基性化合物5種類をNQADにて測定した分析例を紹介します．NQADは，不揮
発性から半揮発性の化合物を測定する検出器です．検出特性を考慮して，カラムにはブリ
ードの少ないCAPCELL PAK C18 MGIII S5（4.6 mm i.d. x 150 mm）を用いました．
The simultaneous determination of 5 typical basic compounds was performed with NQAD
detector. NQAD is developed as a Universal HPLC detector to provide exhaustive
determination of semi-volatile and nonvolatile compounds, therefore sensitive to the
background derived from the analysis system. In response to better detection performance,
CAPCELL PAK C18 MGIII S5 (4.6 mm i.d. x 150 mm) with minimized bleeding was applied.
N
O
O
N
O
H
NH2
1
1. プロカイン (10 g/mL)
Procaine (M.W. 236.3)
N
OH
OH
N
2. キニーネ (10 g/mL)
Quinine (M.W. 324.4)
N
3. ジフェニドール (10 g/mL)
Diphenidol (M.W. 309.4)
O
N
HN
O
N
O
N
O
O
O
2
3
4
4. ベラパミル (10 g/mL)
Verapamil (M.W. 454.6)
5. ジブカイン (10 g/mL)
Dibucaine (M.W. 343.5)
5
0
5
【HPLC Conditions】
Column
Mobile phase
Flow rate
Temperature
Detector
Inj. vol.
Sample dissolved in
10
15
20 [min]
: CAPCELL PAK C18 MGIII S5 ; 4.6 mm i.d. x 150 mm
: 20 mmol/L HCOONH4 (pH 3, HCOOH) / CH3OH = 50 / 50
: 1 mL/min
: 40 ˚C
: NQAD (Evaporation 35 ˚C, Nebulizer 30 ˚C, Filter 5 sec)
: 10 L
: Each standard compound was separately dissolved in CH3OH
at 1 mg/mL. Equal amount of all the solutions were mixed
together, and further diluted to 10 g/mL with 20 % CH3OH.
: ※ 1 g/mL = 1 ppm
発行日：2014 年 10 月
発行人：株式会社資生堂
ﾌﾛﾝﾃｨｱｻｲｴﾝｽ事業部

アレンドロン酸 Alendronic acid

血清中のバルビツール酸系薬物 Barbiturates in human serum

1.1 Common name a. F F 1.2 IUPAC name

#32 ESBA2.5 SS.XLS

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