生体・医療デバイス用超弾性ジルコニウム合金の開発

ဃ˳ὉҔၲἙἢỶἋဇ
ឬ࢐ࣱἊἽἅἝỸἲӳ᣿ỉ᧏ႆ
ᵩᶃᶗᴾᵵᶍᶐᶂᶑ
ಒ
ᙲ
Biomaterials, Shape Memory Alloys, Medical Devices
ဃ˳Ệ‫ܤ‬μễΨእỉỚỂನ঺ẰủẆឬ࢐ࣱ‫ࣄׅ‬പỚầᵲᶇᵋᵬᶇỆҒૣ
ẴỦᵸᶐኒឬ࢐ࣱӳ᣿ử᧏ႆẲẺẇ᧏ႆӳ᣿Ịࢼஹỉᵬᶇᵋᶄᶐᶃᶃỉᵲᶇؕឬ
࢐ࣱӳ᣿ợụᵑ̿ˌɥỉ࢟ཞ‫ࣄׅ‬ὉẲễởẦẰểΟủẺဃ˳ᢘӳࣱử
ӳỪẶਤếẺỜҔၲἙἢỶἋဇឬ࢐ࣱӳ᣿ểẲềஊஓỂẝỦẇ
࢟ཞᚡচӳ᣿Ὁឬ࢐ࣱӳ᣿
ឬ࢐ࣱἊἽἅἝỸἲӳ᣿ỉ᧏ႆ
Ṽ ࢟ཞᚡচјௐὉឬ࢐ࣱ
Ṽ ΟủẺኬᏘᢘӳࣱ
ᙧ≧グ᠈䞉㉸ᙎᛶྜ㔠䛿⇕䜢ឤ▱䛩䜛䝉䞁䝃䞊ᶵ⬟
䚸ຊ䛸ṍ䜏䜢Ⓨ⏕䛩䜛䜰䜽䝏䝳䜶䞊䝍䞊ᶵ⬟䚸ᙎᛶ㝈
䛜୍⯡㔠ᒓ䛾ᩘ༑ಸ䛾䇾㉸ᙎᛶ䇿䜢᭷䛧䚸ᕤᴗศ㔝䚸
་⒪ศ㔝䚸ᐙ㟁〇ရ䚸᪥ᖖ⏝ရ䛺䛹䛾ᵝ䚻䛺ศ㔝䛷
ᖜᗈ䛟฼⏝䛥䜜䛶䛔䜛䚹
⏕య䛻Ᏻ඲䛺ඖ⣲䛾䜏䛷ᵓᡂ䛥䜜䜛ྜ㔠タィ䛻䜘䜚
䚸ඃ䜜䛯⏕య㐺ྜᛶ䜢ᐇ⌧䚹䜎䛯䚸✀䚻䛾⣽⬊ᇵ㣴
ᐇ㦂䛻䜘䜚㼀㼕㻙㻺㼕䛻ẚ䜉ඃ䜜䛯⣽⬊㐺ྜᛶ䜢☜ㄆ䚹
ᙧ≧グ᠈ຠᯝ
cell medium specimen
㉸ᙎᛶ
incubated for 1d
Zr-Ti-Nb-Sn
䠄㛤Ⓨྜ㔠䠅
incubated for 4-7d
1d
4d
7d
1d
4d
7d
Ti-Ni
WST-1 assay
fixed and stained
䝠䝖㦵ⱆ⣽⬊ᵝ⣽⬊
ᰴᇵ㣴ᐇ㦂
㈇Ⲵ
ᚎⲴ
Ṽ ΟủẺឬ࢐ࣱཎࣱ
Ṽ ࢟ཞᚡচὉឬ࢐ࣱӳ᣿ỉࣖဇ
㏆ᖺ䚸་⒪ᢏ⾡䛾㐍ᒎ䛻క䛔䚸ᙧ≧グ᠈䞉㉸ᙎᛶྜ
㔠䛾་⒪䝕䝞䜲䝇䛸䛧䛶䛾ᛂ⏝䛜༨䜑䜛๭ྜ䛿ᖺ䚻
ቑ኱䛧䛶䛔䜛䚹䛧䛛䛧䚸ᐇ⏝㉸ᙎᛶྜ㔠䛷䛒䜛㼀㼕㻙㻺㼕
ྜ㔠䛿ᙉ䛔䜰䝺䝹䜼䞊ᛶ䛸⣽⬊ẘᛶ䜢᭷䛩䜛㻺㼕䜢㧗
⃰ᗘ䛷ྵ䜣䛷䛔䜛䚹
ᚑ᮶䛾⏕య⏝㼀㼕ᇶ㉸ᙎᛶྜ㔠䜘䜚㻟ಸ௨ୖ䛾㼀㼕㻙㻺㼕䛻
༉ᩛ䛩䜛ᙧ≧ᅇ᚟䞉䛧䛺䜔䛛䛥䜢ᐇ⌧䚹䛥䜙䛻䚸ඃ䜜
䛯෭㛫ຍᕤᛶ䚸㧗䛔㼄⥺㐀ᙳᛶ䜢᭷䛧䚸㻹㻾㻵䜰䞊䝏䝣
䜯䜽䝖䛾㜵Ṇ䛻䜒᭷ຠ䚹
Zr-Ti-Nb-Sn䠄㛤Ⓨྜ㔠䠅
ᙎᛶ㝈
Ti-Niྜ㔠
⏕య㐺ྜᛶ
ᙧ≧グ᠈ຠᯝ䛸
㉸ᙎᛶ䛾ᶍᘧᅗ
ᛂຊ(MPa)
㈇Ⲵ
ᚑ᮶
Tiྜ㔠
㛤Ⓨ
Zrྜ㔠
ᚑ᮶
Ti-Niྜ㔠
㉸ᙎᛶᅇ᚟ṍ䜏
ṍ䜏(%)
㉸ᙎᛶྜ㔠䛾
་⒪ศ㔝䜈䛾
ᛂ⏝
㛤Ⓨ㉸ᙎᛶྜ㔠䛸ᚑ᮶
㉸ᙎᛶྜ㔠䛸䛾ẚ㍑
Ṽ े‫ܭ‬ẰủỦဇᡦ
z 䝯䜺䝛䝣䝺䞊䝮䚸ṑิ▹ṇ䝽䜲䝲䞊䛺䛹⫙䛻┤᥋
᥋ゐ䛩䜛་⒪ჾල䜔⏕ά⏝ရ
z 䝪䞊䞁䝥䝺䞊䝖䜔䝛䝆䚸䜽䝸䝑䝥➼䛾ᅛᐃ⤖ྜ⏝䛾
་⒪ჾල
z 䜺䜲䝗䝽䜲䝲䞊䚸䝇䝔䞁䝖➼䛾యෆ䛻ᤄධ䞉␃⨨䛩
䜛་⒪ჾල
‫׎‬ᇌ‫ܖٻ‬ඥʴ ሇඬ‫ ܖٻ‬ૠྸཋឋኒ ཋឋ߻‫؏ܖ‬
૙੉ ᣿ ་ಝ