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(.7. 2540
PREPARATION OF ENTERIC COATED ASPIRIN GRANULES
MISS SOMSONG PROMPRAI
MISS SIRACHA TUNTIKULWATTANA
A SPECIAL PROJECT SUBMITTED IN PARTIAL FULFILLMENT OF
THE REQUIREMENT FOR THE DEGREE OF
BACHELOR OF SCIENCE IN PHARMACY
FACULTY OF PHARMACY
MAHIDOL UNIVERSITY
1997
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6;GE;,E;H7'4&#'!K(;L!+8-3;M K( !"./ 0!+,-(L!678+9"$(6 "(:;3=;>7?,-#' EUDRAGIT
L30 D-55 N/D23EO(8!" H7AB;C5<($,;G;!'K( pH 5! #H! 5.5 J,'5)(*L!3EO(4&#@L!;G;!' 6;G+,-@L!
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stage E"! S#H!@)D=#!53P-5P-( 6% 678+9"$(%G1: E;,E;H7'K( acid stage 13.69 % @)D3#;! 120
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ABSTRACT
This study involved the formulation of enteric film coated aspirin granules. To prevent
the stomach irritation, aspirin granules were coated with gastric resistant film. The film would
dissolve and release the drug in the intestine. Eudragit L 30 D-55 which dissolved at pH 5.5 and
above was used as aqueous film former. Aspirin granules were coated at 6% 8% and 10% of
polymer based on granules’ weight. Dissolution test revealed that 6% coated aspirin granules did
not pass the USP requirement for enteric preparation in gastric fluid. The 8% and 10% coated
aspirin granules met the USP requirement in gastric fluid and the 8% coated granules exhibited
faster release than the 10% coated granules in the intestinal fluid.
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