Author TPN Total Mortality EN Total Mortality Risk Ratio [95%CI] Rapp RP Adams S Young B Cerra FB Greenberg GR Moore FA Hamaoui E Kudsk K González-Huix F Iovinelli G Kudsk KA Dunham CM Borzotta AP Hadfield RJ Baigrie RJ McClave SA Reynolds JV Sand J Kalfarentzos F Gianotti L Windsor AC Woodcock NP Braga M Pacelli F Bozzetti F Oláh A Abou-Assi S Gupta R Louie BE Petrov MS Eckerwall GE Casas M Harvey SE 20 23 23 33 32 30 8 45 21 24 34 15 21 11 47 16 34 16 20 86 18 32 131 122 158 48 27 9 18 34 25 11 1191 3 3 10 8 0 0 0 1 0 0 0 1 1 6 6 0 1 1 2 2 2 7 4 3 5 4 6 0 3 12 0 2 431 18 23 28 33 19 29 11 51 23 24 34 12 28 13 50 16 33 13 18 87 16 32 126 119 159 41 26 8 10 35 23 11 1197 9 1 10 7 0 0 1 1 0 0 1 1 5 2 4 0 2 0 1 2 0 12 3 7 2 2 8 0 0 2 1 0 450 3.33 [ 1.07 , 10.43 ] 0.33 [ 0.04 , 2.97 ] 0.82 [ 0.42 , 1.62 ] 0.87 [ 0.36 , 2.14 ] 1.65 [ 0.03 , 79.93 ] 1.03 [ 0.02 , 50.42 ] 2.25 [ 0.10 , 49.04 ] 0.88 [ 0.06 , 13.70 ] 0.92 [ 0.02 , 44.26 ] 1.00 [ 0.02 , 48.45 ] 3.00 [ 0.13 , 71.15 ] 1.25 [ 0.09 , 17.98 ] 3.75 [ 0.47 , 29.75 ] 0.28 [ 0.07 , 1.13 ] 0.63 [ 0.19 , 2.08 ] 1.00 [ 0.02 , 47.55 ] 2.06 [ 0.20 , 21.65 ] 0.40 [ 0.02 , 9.18 ] 0.56 [ 0.05 , 5.62 ] 0.99 [ 0.14 , 6.86 ] 0.22 [ 0.01 , 4.34 ] 1.71 [ 0.78 , 3.79 ] 0.78 [ 0.18 , 3.41 ] 2.39 [ 0.63 , 9.03 ] 0.40 [ 0.08 , 2.02 ] 0.59 [ 0.11 , 3.03 ] 1.38 [ 0.56 , 3.44 ] 1.11 [ 0.02 , 50.42 ] 0.25 [ 0.01 , 4.35 ] 0.16 [ 0.04 , 0.67 ] 3.25 [ 0.14 , 76.01 ] 0.20 [ 0.01 , 3.74 ] 1.04 [ 0.94 , 1.15 ] RE Model IV z=0.54 Q=28.56 p=0.58614 p=0.6413 tau2 =0 =0 1.03 [ 0.93 , 1.13 ] 2I 0.00 0.02 0.14 1.00 Risk Ratio 7.39 54.60 図2A-1. 重症患者における静脈栄養および経腸栄養の死亡率に関するメタ解析 CI,confidence interval; favour, lower mortality; IV, inverse variance; OR, odds ratio. For Public Comment Author Year EN Total PN infection(+) case Total infection(+) case Bower RH Szeluga DJ Young B Peterson VM Cerra FB Greenberg GR Moore FA Hamaoui E Kudsk K Kudsk KA Dunham CM McClave SA Kalfarentzos F Gianotti L Windsor AC Woodcock NP Braga M Bozzetti F Oláh A Abou-Assi S Gupta R Louie BE Eckerwall GE Casas M 10 31 23 25 33 32 30 8 45 34 15 16 20 86 18 32 131 158 48 27 9 18 25 11 0 8 4 8 0 0 11 0 20 14 0 2 10 24 3 16 30 42 13 13 2 5 0 5 0 5 5 2 0 0 5 0 12 5 0 2 5 20 0 10 25 25 5 5 1 1 3 1 RE Model IV z=-5.06 Q=14.36 p=0 p=0.91623 10 30 28 21 33 19 29 11 51 34 12 16 18 87 16 32 126 159 41 26 8 10 23 11 Risk Ratio [95%CI] 1.00 [ 0.02 , 46.05 ] 0.65 [ 0.24 , 1.75 ] 1.03 [ 0.31 , 3.39 ] 0.30 [ 0.07 , 1.25 ] 1.00 [ 0.02 , 48.96 ] 1.65 [ 0.03 , 79.93 ] 0.47 [ 0.19 , 1.19 ] 0.75 [ 0.02 , 34.32 ] 0.53 [ 0.29 , 0.96 ] 0.36 [ 0.14 , 0.88 ] 1.23 [ 0.03 , 57.90 ] 1.00 [ 0.16 , 6.25 ] 0.56 [ 0.23 , 1.32 ] 0.82 [ 0.49 , 1.38 ] 0.16 [ 0.01 , 2.87 ] 0.62 [ 0.34 , 1.16 ] 0.87 [ 0.54 , 1.39 ] 0.59 [ 0.38 , 0.92 ] 0.45 [ 0.18 , 1.16 ] 0.40 [ 0.17 , 0.96 ] 0.56 [ 0.06 , 5.09 ] 0.36 [ 0.05 , 2.67 ] 7.58 [ 0.41 , 139.32 ] 0.20 [ 0.03 , 1.45 ] tau 2 =0 I 2 =0 0.62 [ 0.51 , 0.74 ] 0.00 0.02 0.14 1.00 7.39 54.60 403.43 Risk Ratio 図2A-2.重症患者における静脈栄養および経腸栄養の感染症発生率に関するメタ解析 CI,confidence interval; favour, lower mortality; IV, inverse variance; OR, odds ratio. For Public Comment 図2B-1. 重症患者における小腸内栄養投与および胃内栄養投与の死亡率に関 するメタ解析. CI,confidence interval; favour, lower mortality; IV, inverse variance; OR, odds ratio. For Public Comment 図2B-2.重症患者における小腸内栄養投与および胃内栄養投与の肺炎発生率に関する メタ解析. CI,confidence interval; favour, lower incidence of pneumonia; IV, inverse variance; OR, odds ratio. For Public Comment 図2B-3.重症患者におけるunderfeedingおよびand full feedingの死亡率に関す るメタ解析. CI, confidence interval; favour,lower mortality; IV,inverse variance; OR,odds ratio. For Public Comment 図2B-4. 重症患者におけるunderfeedingおよびand full feedingの呼吸器関連肺炎発生率 に関するメタ解析. CI, confidence interval; favour, lower incidence of VAP IV; inverse variance; OR, odds ratio. For Public Comment Figure 2B-5.重症患者におけるunderfeedingおよびand full feedingの感染症発生率に関す るメタ解析. CI, confidence interval; favour, lower incidence of infection; IV, inverse variance; OR, odds ratio. For Public Comment 図2C-1. EDEN Trialにおける各群の投与エネルギー量の継時的推移 For Public Comment 図2C-2. EPaNIC Trialにおける各群の継時的、投与ルート別平均投与エネルギー量（文献2）から引用） For Public Comment
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