Hoshi University
氏
名
千葉
所
属
総合基礎薬学教育研究部門
学
位
博士 (薬学)
最終学歴
教育活動
（担当授業科目）
義彦
職
位
准教授
星薬科大学大学院博士後期課程
薬の効き方 IB (二年生)
薬の効き方 IIA (二年生)
バイオスタティスティックス (四年生)
薬学英語 IIA (四年生)
総合薬学演習 I (四年生)、II (六年生)
基礎演習 I (一年生)
研究活動
（研究テーマ）
アレルギー性気管支喘息発症機序の解明
アレルギー性鼻炎発症機序の解明
慢性閉塞性肺疾患 (COPD) 発症機序の解明
所属学会
American Physiological Society
日本薬学会
日本薬理学会
日本アレルギー学会
日本平滑筋学会
学内活動
（役職・委員等）
紀要編集委員会委員
一般教育論集編集委員会委員
放射線安全委員会委員
動物センター委員会委員
学外活動
（委員会委員等）
American Physiological Society, Editorial Board of Am. J. Physiol. Lung Cell. Mol.
Physiol. (2012-)
Editorial Board of Dataset Papers in Pharmacology (2012-)
日本薬学会ファルマシア・トピックス小委員 (2014-)
日本薬理学会学術評議員
研究業績等
（受賞歴）
星薬科大学大谷賞
日本平滑筋学会 2008 年 Best Download 賞(原著論文の部)
日本平滑筋学会 2009 年 Best Download 賞(原著論文の部)
（主な著書・論文）
1. Shibata, K., Sakai, H., Huang, Q., Kamata, H., Chiba, Y., Misawa, M., Ikebe, R. and Ikebe, M. Rac1
regulates myosin II phosphorylation through regulation of myosin light chain phosphatase. J. Cell.
Physiol . ( in press ) (IF2013 = 3.874)
2. Sakai, H., Watanabe, Y., Honda, M., Tsuiki, R. Ueda, Y., Nagai, Y., Narita, M. and Chiba, Y. Involvement
of the Tyr kinase/JNK pathway in carbachol-induced bronchial smooth muscle contraction in the rat.
Anesthesiology 118, 1076-1085, 2013. (IF2013 = 6.168)
3. Chiba, Y., Goto, K. and Misawa, M. Interleukin-13-induced activation of signal transducer and activator
of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth
muscle cells. Pharmacol. Rep . 64, 454-458, 2012. (IF2012 = 1.965)
4. Sakai, H., Enzaka, J., Sakai-Oshita, M., Chiba, Y. and Misawa, M. Involvement of K+ channels in the
augmented nasal venous responsiveness to nitric oxide in rat model of allergic rhinitis. Microvas.
Res . 81, 129-134, 2011. (IF2011 = 2.828)
5. Chiba, Y., Todoroki, M. and Misawa, M. Interleukin-4 upregulates RhoA protein via an activation of
STAT6 in cultured human bronchial smooth muscle cells. Pharmacol. Res . 61, 188-192, 2010. (IF2010 =
3.612)
6. Chiba, Y., Sato, S., Hanazaki, M., Sakai, H. and Misawa, M. Inhibition of geranylgeranyltransferase
inhibits bronchial smooth muscle hyperresponsiveness in mice. Am. J. Physiol. Lung Cell. Mol. Physiol .
297, L984-L991, 2009. (IF2009 = 4.043)
7. Chiba, Y., Tanabe, M., Goto, K., Sakai, H. and Misawa, M. Downregulation of miR-133a contributes to
upregulation of RhoA in bronchial smooth muscle cells. Am. J. Respir. Crit. Care Med . 180, 713-719,
2009. (IF2009 = 10.689)
8. Chiba, Y., Todoroki, M., Nishida, Y., Tanabe, M. and Misawa, M. A novel STAT6 inhibitor AS1517499
ameliorates antigen-induced bronchial hypercontractility in mice. Am. J. Respir. Cell Mol. Biol . 41,
516-524, 2009. (IF2009 = 4.319)
9. Chiba, Y., Nakazawa, S., Todoroki, M., Shinozaki, K., Sakai, H. and Misawa, M. Interleukin -13 augments
bronchial smooth muscle contractility via an upregulation of RhoA protein. Am. J. Respir. Cell Mol.
Biol . 40, 159-167, 2009. (IF2009 = 4.319)
10. Chiba, Y., Arima, J., Sakai, H. and Misawa, M. Lovastatin inhibits bronchial hyperresponsiveness by
reducing RhoA signaling in rat allergic asthma. Am. J. Physiol. Lung Cell. Mol. Physiol . 294, L705-L713,
2008. (IF2008 = 3.924)
11. Chiba, Y., Kurotani R., Kusakabe, T., Miura, T., Link, B., Misawa, M. and Kimura, S. UGRP1 expression
suppresses allergic airway inflammation in mice. Am. J. Respir. Crit. Care Med . 173, 958-964, 2006.
(IF2006 = 9.091)
12. Chiba, Y., Matsuo, K., Sakai, H. and Misawa, M. Impaired norepinephrine-mediated contraction of
isolated nasal mucosa in guinea pigs with allergic rhinitis. Am. J. Rhinol . 20, 477-479, 2006. (IF2006
= 1.220)
13. Chiba, Y., Murata, M., Ushikubo, H., Yoshikawa, Y., Saitoh, A, Sakai, H., Kamei, J. and Misawa, M.
Effect of cigarette smoke exposure in vivo on bronchial smooth muscle contractility in vitro in rats.
Am. J. Respir. Cell Mol. Biol . 33, 574-581, 2005. (IF2005 = 3.988)
14. Chiba, Y., Sakai, H. and Misawa, M. Endothelin-1-induced translocation of RhoA is mediated by ETA
receptors in rat bronchial smooth muscle. Eur. J. Pharmacol . 517, 182-185, 2005. (IF2005 = 2.477)
15. Chiba, Y., Ueno, A., Shinozaki, K., Takeyama, H., Nakazawa, S., Sakai, H. and Misawa, M. Involvement
of RhoA-mediated Ca2+ sensitization in antigen-induced bronchial smooth muscle hyperresponsiveness
in mice. Respir. Res . 6, 4, 2005. (IF2005 = 2.682)
16. Chiba, Y., Srisodsai, A., Supavilaic, P. and Kimura, S. Interleukin-5 reduces the expression of
uteroglobin-related protein (UGRP) 1 gene in allergic airway inflammation. Immunol. Lett . 97, 123-129,
2005. (IF2005 = 2.301)
17. Chiba, Y., Sakai, H. and Misawa, M. Endothelin-1-induced translocation of RhoA is mediated by ETA
receptors in rat bronchial smooth muscle. Eur. J. Pharmacol . 517, 182-185, 2005. (IF2005 = 2.477)
18. Chiba, Y., Kusakabe, T. and Kimura, S. Decreased expression of uteroglobin-related protein 1 in
inflamed mouse airways is mediated by IL-9. Am. J. Physiol. Lung Cell. Mol. Physiol . 287, L1193-L1198,
2004. (IF2004 = 4.051)
19. Chiba, Y., Sakai, H. and Misawa, M. Possible involvement of Gi3 protein in augmented contraction of
bronchial smooth muscle from antigen-induced airway hyperresponsive rats. Biochem. Pharmacol . 61,
921-924, 2001. (IF2001 = 3.340)
20. Chiba, Y., Sakai, H. and Misawa, M. Augmented acetylcholine-induced translocation of RhoA in bronchial
smooth muscle from antigen-induced airway hyperresponsive rats. Br. J. Pharmacol. 133, 886-890, 2001.
(IF2001 = 3.502)
21. Chiba, Y., Takada, Y., Miyamoto, S., Mitsui-Saito, M., Karaki, H. and Misawa, M. Augmented
acetylcholine-induced, Rho-mediated Ca 2+ sensitization of bronchial smooth muscle contraction in
antigen-induced airway hyperresponsive rats. Br. J. Pharmacol. 127, 597-600, 1999. (IF1999 = 3.722)
ほか計 118 報 (2014 年 12 月現在)
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