Synthetic Studies towards (+)-Pancratistatin ○Magdi A. Mohamed, 山田健一, 富岡 清(京大院薬) Chiral ligand-controlled asymmetric conjugate addition reaction of aryllithium, derived from 1, with a cyclic enoates 2 gave 3 with reasonably high ee in high yield. The product ester 3 was successfully converted to the advanced intermediate 4 through manipulations including Curtius rearrangement and oxidation of amine to amide. Installation of oxygen functionalities on 4 is the current effort to reach (+)-pancratistatin with endowed antitumor activity.
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