Magdi A. Mohamed, 山田健一, 富岡 清(京大院薬)

Synthetic Studies towards (+)-Pancratistatin
○Magdi A. Mohamed, 山田健一, 富岡 清(京大院薬)
Chiral ligand-controlled asymmetric conjugate addition reaction of aryllithium, derived
from 1, with a cyclic enoates 2 gave 3 with reasonably high ee in high yield. The product ester
3 was successfully converted to the advanced intermediate 4 through manipulations including
Curtius rearrangement and oxidation of amine to amide. Installation of oxygen functionalities
on 4 is the current effort to reach (+)-pancratistatin with endowed antitumor activity.