²³´´µ b+3¶ + ·
+3¸,+
19
,**+
ῌ The effect of parathyroid function on cardiovascular disease of
maintainance dialysis patients
KANEKO Tetsuya, KITAMURA Hiroshi, MIZUI Masayuki, MATSUI Isao,
YAMAMOTO Satoshi, FUJITA Yoshimasa and FUJII Masamitsu
Key words : &|1-'{jY - D x}?~z1
-'{jY . D CaP 12"!E#="j
!
Y F3J
J
34F/%@A!
!"#$%&'()*"+#,-.!$ῌ/
1,#="YG7U;:'T34'5
%&012'34'5 63
7
631,'7
78(19:;<='5 >
19:; Rostand SG ZHI+D ,-.
?@A BC PTHD E)* + +F3 GH!
Geoffrey ZHI,D jkJH(KT4'5 GH
IJK;LM&'5
ZoApqg?@A!LU;:
,-.,-.N JO/
'63<@&="34'5
P!0Q;:'R!SQ;
63M z1&E
PTH B1 intact῍PTHD 12T3'34'5 ) !0Q(,-.
14U; V5W
"7/% NU;:'
X6YZ[?\%7!]^_`abcA D 8
1&19:;LMU
9 d:;ebfg?<=%7 BPEITD (:5
>hi BPTXD jkTlmnH PTH ?ToAp
qg?nH;:'5 UYU
YZr
+4 ῌ
63oApqg?&=" PTH @A?19:;
+ D 1&
oAsAt\TBZH;:j:5 *u
,-.1,:; PTH O
1-'vw + D PTH CDE)j
Ca APQuE)1-FcpoAy
, D xyAzjk!{(Z
ATP !RSU;1 T
Y
*+
,-.1,'¡¢j PTH z14&'E)
ῌV £ Ca PzU¤Vh
ῌz¥ £ ¦893§ ;893u
ῌ £ ¦893N UYUcpoAy ATP !"(UW¨;1
ῌO £ O Ca N X ©ªY«¬
ῌ*Z £ y[\5W®0 A\yA]¯ z^°O Ca N z_±¬ _±¬ `a_±¬
³´µ¶¶£ ¤+3· + ¸
20
PTX _`3
Y* ^EF%a
bACc3&
*/
PTX KL^EF&;%*JyDyE 56de
!"#$%
&
*3456%sF G0
"&
'()
*+ ,-
%&
EBCT2 a
#1(
PTH !$. / !0%"
yDyEhijk&
&
electronῌbeam
computed
tomography
fg*J
,5 022
#1&
-5 .2 %
#1-
Johann *^EF
"#%34
&;%0l T5*emn
5
, 2 56789:
9JE|M 59jA PTH {E*em
'56*$%&;%'<(
sV
02 o Raggi * Ca
=56&;%*'(
>)
?P // mg,ῌdl, pq &;
&;%*+ PTH ,-./ Ca
% 56rs( it' uv
?P @ABCDE
./<
jw
F
12 Geof-
F G056&;%*1H>)
frey *59JE|M 34,340 mgῌdl 59j
&;%*+IJKLM*"2N
A ,4//4/ mgῌdl Ca?P // mg,ῌdl, wx
yF iῌPTH +**,**
34O*56 P&;%Q *RID
S56T Ca 5 T P 5UV
pgῌml @ABCDEF&
,2
Goodman *z0l+3 1 <{'
WF
PmetastaticQ % 7X8Y5
( N,-2 | 0l / 59 P }
659 Ca 59 P :;FWF
~ Ca?P 3 Ca T'^EF
PdystrophicQ % , <=&
&;%n
22 #1*
3>>)&;%* PmetastaticQ (M&
59 P 59 Ca PTH Ca?
?@
Geoffray *56Z
P O<F
=p:;
&;%*[\AB]=
CD
(^EF&;%59+5,/ῌzA D
,2 =^EF_`%Ga*bc.
}~#
e#1&!32 '(
H%<
.Id
#1&!b%
.|=
EBCT ¡+G
=J?&;%WF
"&
(¢£¤jJE CT ^EFa
/2
KL#1 !^EF&;%*M,
-¥
ijk
59 Ca 59 P Ca?P PTH eN&!
* ^EF9¦[~3=
fOPF
=Q +
s<§~[¨fs
2 < PTH * Ca P RS-HT
*©
ª
g9:&
hU PTH * Hepatic tri-
glyceride lipase ( i lipoprotein lipase V
, 2 $3
X !59Bjkjlmno,- LDL W
'
)*T5 5 p
p HDL qM 'r
l § >; «¬z®>; s!,3>EF_`%tN
4u
tN
/ !0%
&
* ,X
= PTH $. ¡$&;%#1
YZ>;EF`%eN
Rostand *$&;% PTH *
e
*n Ca?P *
e&V
,4 !"#
+ 2 ^EF3
,v <'^EF3
+*2 ,^EF3 ¯5
%t' °p
V
'$3
- 2 t'
&;%3(&w
*i=
Braun *,2s12='.3 ¡
x[,`3(,JyDyEnAzD{A
/3±¢8<&;% //±EF
|}A\]~^( ^EF&;%*1
&;%-#1
^EF&
H3'<*H=$
;%@²EF&;%*
e&V
µ¶c · ῌd7QRS¸-)KL*%®¯
21
0 minD^ DWD^ ©ª\V«©¬@8
CaP Al Z[M,6 6^_
++ !"#
)KL*%LJO%)®¯
$%&'()*+
fg
hCWmn'^ °)KL
,-.'!&*+
*%L9FB±OJ
. /
0
12)3*45
6,-7 !89&':
;)<=> ?@ABC@DE@"#
3F9G)$%3&'(
H9)I#<= J=*)KL*
%+,6-9MN'
9<=!&
*+ .OP!/01QRS
2))KL*%T@UVBWX
>
Y/T@Z@[\3,4> ]
5 Ca^ ]5 P^ CaP T@UVBW9_`a
)KL* PEIT^ PTX %9b6cd
7+eP 4fghCW*iA
j@ D 8 PTH 9:;<9k%lJ
mn%lopq9r=cd7s
t uLvw PTH >?x.
O;<
@'O+oiAj@ D 8
yAzmn*OI#<=>
{0&'iAj@ D |}8]~
9BcOC"#*+ 4D
WDE
P ]T@UVBW
Ca ]9Fd7+a Ca 94
P G
OHn*I`a
>>T@UVBW)!&J
JhCWK>
'<=>
-4 )KL*%Lo]~M,
<=>B\N) Kruz >
LbOyP*y Ca BQ
'|} Ca 82^ ]5 Ca R
Se)d79+, )KL*
%LyAzbOLo^ y
Ca, P B%LL
*^ WDE
^ iAj@ D 8^ T
6]5 Ca e^ UV
WX2*&5 ¡eP ¢metastatic£ %lY]~o<
=>
)KL*%LH^ ¤Wj¥Z
[ ^ ^ ?\^ CAPD^ ]
¦ §7¨ Vita-
²`a<=> ³8^ )KL*%L
-]~-´KFb
+ Rostand SG, Drueke TB : Parathyroid hormone,
vitamin D, and cardiovascular disease in chronic
renal failure : Kidney Int, /0 ; -2-, +333.
, Geoffrey A, Block MD, et al : Reῌevaluation of
risks associated with hyperphosphatemia and hyperparathyroidism in dialysis patients : Recommendations for a change in management, Am J
Kidney Dis, -/ ; +,,0, ,***.
- Simons C, Fortune F, Greenbaum RA et al : Cardiac hypertrophy, hypertrophic cardiomyopathy
and hyperparathyroidismῌan association : Br Heart
J, /. ; /-3, +32/.
. Mall G, et al : Myocardial interstitial fibrosis in
experiment uremiaῌimplication for cardiac complicance. Kidney Int, -- ; 2*., +322.
/ Wexler L, et al : Coronary artery calcification :
Pathophysiology, epidemiology, imaging methods
and clinical implications : A statement for health
professionals from American Heart Association :
Circulation, 3. ; ++1/, +330.
0 Johann et al : Electron beam computed tomography in the evaluation of cardiac calcifications in
chronic dialysis patients : Am J Kidney Dis, ,1 ;
-3., +330.
1 Raggi P : Detection and quantitification of cardiovascular calcifications with electron beam tomography to estimate risk in hemodialysis patients :
Clin Nephrol, /. ; -,/, ,***.
2 Goodman WG et al : Coronaryῌartery calcification in young adults with endῌstage renal disease
who are undergoing dialysis : N Engl J Med, -., ;
+.12, ,***.
3 Karol E, Walton, MD et al : Active serum vitamin D levels are inversely corrected with coronary calcification. Circulation 30 ; +1//, +331.
+* Rostand SG, et al : Myocardial calcification and
cardiac dysfunction in chronic renal failure : Am J
Med, 2/ ; 0/+, +322.
++ Ribeiros et al : Cardiac valve calcification in haemodialysis patients : role of calciumῌphosphate
metabolism : Nephrol Dial Transplant +- ; ,*-1, +332.
+, Kurz P et al : Evidence for abnormal calcium
homeostasis in patients with adynamic bone disease : Kidney Int, /0 ; 2//, +33..
© Copyright 2026 ExpyDoc