講座名 癌ワクチン療法学寄附講座 設置期間 平成 17 年 12 月 1 日~平成 20 年 11 月 30 日 担当教授 坪井 昭博(准教授) 研 1.腫瘍特異的免疫療法に関する基礎研究及び臨床試験 2.腫瘍免疫に関する基礎的研究 究 内 容 著者 研究業績 掲載雑誌・巻・号・頁等 Izumoto S, Tsuboi A, Oka Y, Phase II Clinical trial of Wilms tumor 1peptide vaccination J Neursurg. 2008 Suzuki T, Hashiba T, Kagawa N, for patients with recurrent glioblastoma multiforme. May;108(5):963-971 Tsuboi A, Oka Y, Nakajima H, Wilms tumor gene WTI Peptide-based immunotherapy Int J Hematol. 2007 Fukuda Y, Elisseeva OA, induced a minimal response in a patient with advanced Dec;86(5):41 4-7. Yoshihara S, Hosen N, Ogata A, therapy-resistant multiple myeloma. Hashimoto N, Maruno M, Elisseeva OA, Shirakata T, Kawakami M, Oji Y, Nishida S, Ohno S, Kawase I, Hatazawa J, Nakatsuka SI, Aozasa K, Morita S, Sakaoto J, Sugiyama H, Yoshimine T. Kito K, Fujiki F, Nishida S, Shirakata T, Ohno S, Yasukawa M, Oji Y, Kawakami M, Morita S, Sakamoto J, Udaka K, Kawase I, Sugiyama H. Fujiki F, Oka Y, Tsuboi A, Identification and characterization of a WT1(Wilms tumor J Immunother. 2007 Kawakami M, Kawakatsu M, Gane) protein-derived HLA-DRB1*0405-restricted 16-mer Apr;30(3):28 2-93 Nakajima H, Elisseeva OA, helper peptide that promotes the inducation and activation Harada Y, Ito K, Li Z, Tatsumi N, of WT1-specific cytotoxic T lymphocytes. Sakaguchi N, Fujioka T, Masuda T, Yasukawa M, Udaka K, Kawase I, Oji Y, Sugiyama H. Wu F, Oka Y, Tsuboi A, Elisseeva Th1-biased bumoral immune responses ageainst Wilms Leukemia. 2005 Fe;19 OA, Ogata K, Nakajima H, Fujiki tumor gane WT1 product in the patients with hematopoietic (2):26 8-74. F, Masuda T, Murakami M, malignancies. Yoshihara S, Ikegame K, Hosen N, Kawakami M, Nakagawa M, Kubota T, Soma T, Yamagami T, Tsukaguchi M, Ogawa H, Oji Y, Hamaoka T, Kawase I, Sugiyama H. Oka Y, Tsuboi A, Taguchi T, Osaki Induction of WT1 (Wilms' tumor gene) -specific cytotoxic T Proc Natl Acad Sci U S T,Kyo T, Nakajima H, Elisseeva lymphocytes by WT1 peptide vaccine and the resultant A.2004 SEP 21;101(38):1 OA, Oji Y, Kawakami M, Ikegame cancer regression. 3885-90 Epub 2004 Sep 13. K, Hosen N, Yoshihara S, Wu F, Fujiki F, Murakami M, Masuda T, Nishida S, Sirakata T, Nakatsuka S, Sasaki A, Udaka K, Dohy H, Aozasa K, Noguchi S, Kawase I, Sugiyama H. 学生への指導方針 学生に対する要望 備 考
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