D.V. Diana Vreeland

Curriculum vitae
Nerina Gnesutta
Dipartimento di Bioscienze
Università degli Studi di Milano
2003-present: Assistant Professor, Dept. BioSciences, U of Milan; Marie Curie IRG fellow, EU FP6
(2004-2006).
1998–2002: PostDoc research fellow, A. Minden Lab, Dept. Biological Sciences, Columbia U. (NY, USA)
1997: PostDoc research fellow, E. Sturani Lab, Dept. Gen. Physiol. Biochem, U of Milan
1993-1996: PhD Student, Molecular and Cellular Biology Program, E. Sturani Lab, Dept. Gen. Physiol.
Biochem, U. of Milan
1994: PostGrad research, R. Klein Lab, Differentiation Programme, EMBL (Heidelberg, Germany)
1991-1992: PreGrad research, L. Alberghina Lab, Dept. Gen. Physiol. Biochem, U of Milan
Since my post-graduate research I have been interested in signaling pathways that control cell growth,
differentiation and survival in mammalian cells. I have focused my research on small GTPases and
protein kinases involved in cellular differentiation and proliferation, to understand the molecular
mechanisms involved in signaling pathways in their role to control normal and pathological cell
functions.
More recently, in collaboration with R. Mantovani I have started to dissect molecular mechanisms of
gene expression regulation by a structural approach, by studying trascription facors interactions
involved in oncogenesis. Our work is focused on the histone-like TF NF-Y and its interactions with TFs
binding nearby promoter elements, with the aim of understanding promoter organization during
transcriptional regulation. Within this line of research, in collaboration with M. Bolognesi group, we
recently determined the 3D structure of the NF-Y trimer, in complex with the CCAATbox target DNA.
Publications (2003-2013):
- Gnesutta N, Nardini M, Mantovani R. (2013). The H2A/H2B-like histone-fold domain proteins at the
crossroad between chromatin and different DNA metabolisms. Transctiption. 4(3):1-6. doi:
10.4161/trans.25002
- Nardini M, Gnesutta N, Donati G, Gatta R, Forni C, Fossati A, Vonrhein C, Moras D, Romier C,
Bolognesi M, Mantovani R. (2013). Sequence-Specific Transcription Factor NF-Y Displays Histone-like
DNA Binding and H2B-like Ubiquitination. Cell. 152(1-2):132-43
- Petroni K, Kumimoto R, Gnesutta N, Calvenzani V, Fornari M, Tonelli C, Holt BF 3rd, Mantovani R.
(2012). The Promiscuous Life of Plant NUCLEAR FACTOR Y (NF-Y) Transcription Factors. Plant Cell
24(12):4777-92
- Calvenzani V, Testoni B, Gusmaroli G, Lorenzo M, Gnesutta N, Petroni K, Mantovani, R, Tonelli C.
(2012). Interactions and CCAAT-binding of Arabidopsis thaliana NF-Y subunits. PLoS ONE. 7(8):e42902
- Imbriano C, Gnesutta N, Mantovani R. (2012). The NF-Y/p53 liaison: Well beyond repression. BBA Rev Cancer. 1825(2):131-9
- Baldassa S, Calogero AM, Colombo G, Zippel R, Gnesutta N. (2010). N-terminal interaction domain
implicates PAK4 in translational regulation and reveals novel cellular localization signals. J Cell Physiol
224(3):722-33
- Lavagni P, Indrigo M, Colombo G, Martegani E, Rosenblum K, Gnesutta N, Zippel R. (2009).
Identification of Novel RasGRF1 Interacting Partners by Large-Scale Proteomic Analysis. J Mol
Neurosci. 37(3):212-24
- Baldassa S, Gnesutta N, Fascio U, Sturani E, Zippel R. (2007). SCLIP, a microtubule-destabilizing
factor, interacts with RasGRF1 and inhibits its ability to promote Rac activation and neurite outgrowth.
J Biol Chem. 282(4): 2333-45
- Gnesutta N and Minden A. (2003). Death Receptor Induced Activation of Initiator Caspase-8 is
Antagonized by the Serine/Threonine Kinase PAK4. Mol Cell Biol. 23(21):7838-48

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