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The handle http://hdl.handle.net/1887/28326 holds various files of this Leiden University
dissertation
Author: Dixon, Karen
Title: The IL-12 family and dendritic cells : key regulators of immunity and
immunological tolerance
Issue Date: 2014-08-28
The IL-12 family and Dendritic cells
Key regulators of immunity and immunological tolerance
Karen Dixon
The IL-12 family and Dendritic cells
Key regulators of immunity and immunological tolerance.
© Karen Dixon, 2014
All rights are reserved. No parts of this publication may be reproduced, stored,
or transmitted in any form or by any means, without permission of the copyright
owners.
ISBN: 978-90-5335-892-4
Layout: Karen Dixon
Printed by: Ridderprint.nl
Published by: Ridderprint.nl
The research presented in this thesis was performed at the Department of
Nephrology, Leiden University Medical Center, The Netherlands.
The research described in this thesis was supported by a Marie Curie TranSVIR
fellowship (TranSVIR FP7-PEOPLE-ITN-2008 No.238756) funded by the
European commission under the 7th framework programme.
Financial support by the Dutch Kidney Foundation, Astellas Pharma B.V, Hycult
Biotech and Miltenyi Biotech for the publication of this thesis is gratefully
acknowledged.
The IL-12 family and Dendritic cells
Key regulators of immunity and immunological tolerance
Proefschrift
ter verkrijging van
de graad van doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op 28th August 2014
klokke 16.15 uur
door
Karen Dixon
(Karen Nic Riocáird)
Born in Dublin, Republic of Ireland,
June 1986.
Promotiecommissie
Promotor:
Prof. Dr. C van Kooten
Overige leden:
Prof. Dr. Andrew Rees
Medical University of Vienna
Prof. Dr. Bart Roep
Leiden University Medical Centre
Prof. Dr. Marieke van Ham
University of Amsterdam
Dr. Andrea Woltman
Erasmus Medical Center, Rotterdam
“Education is an admirable thing, but it is well to remember from time to
time, that nothing that is worth knowing can be taught.”
— Oscar Wilde
Table of Contents
Chapter 1 General introduction
Chapter 2 Human tolerogenic dendritic cells produce IL-35 in the absence of other IL-12 family members.
Under revision.
9
33
Chapter 3
Phagocytosis of apoptotic or necrotic cells differentially 53
regulates the transcriptional expression of IL-12 family members in dendritic cells.
J Leukoc Biol, 2014 (In Press).
Chapter 4
Properdin and factor H production by human dendritic cells 73
is differentially regulated by IFNγ and has a functional role in the T cell stimulatory capacity of dendritic cells.
Under revision.
Chapter 5
Non-haematopoietic derived Epstein Barr Virus induced gene 3
expression in normal human kidney.
Chapter 6
Human renal fibroblasts, through the secretion of IL-6,
generate dendritic cells with a unique regulatory profile.
Immunol Cell Biol, 2014 (In Press).
Chapter 7
93
111
General discussion
131
Chapter 8 English, Irish & Dutch Summaries
List of abbreviations
Acknowledgements
Curriculum vitae
Bibliography
149

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