Near-infrared fluorescence-guided surgery, Pre

Cover Page
The handle http://hdl.handle.net/1887/25491 holds various files of this Leiden University
dissertation
Author: Vorst, Joost van der
Title: Near-infrared fluorescence-guided surgery : pre-clinical validation and clinical
translation
Issue Date: 2014-05-01
Near-infrared fluorescence-guided surgery
Pre-clinical validation and clinical translation
Joost van der Vorst
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© J.R. van der Vorst, 2014
ISBN/EAN: 978-90-6464-766-6
Cover design: Flavoureyes, www.flavoureyes.com
Design and lay-out: Ferdinand van Nispen, www.citroenvlinder-dtp.nl, Bilthoven
Printed by: GVO drukkers & vormgevers B.V. | Ponsen & Looijen, Ede
The author of this thesis is a MD-medical research trainee funded by The Netherlands
Organisation for Health Research and Development (grant nr. 92003593). The
research described in this thesis was financially supported by the Center for
Translational Molecular Medicine (CTMM, DeCoDe and MUSIS projects), the Dutch
Cancer Society (UL 2010-4732), Foundation “Michaël van Vloten”, Foundation “De
Drie Lichten”, Leiden University Fund (LUF).
Financial support by Krijnen Medical, Amgen, Percuros, Chipsoft, PerkinElmer,
Bayer, Guerbet, Astellas Pharma, Intuitive Surgical, Convatec, Welmed, Erbe, Karl
Storz, OnTarget, ABN Amro, Pfizer, Oldelft, PI Medical Diagnostics, the Dutch Society
of Gastroenterology , stichting Wetenschappelijk Onderzoek Heelkunde Groene
Hart Ziekenhuis and het doelfonds beeldverwerking van de Bontiusstichting for
the printing of this thesis is gratefully acknowledged.
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Near-infrared fluorescence-guided surgery
Pre-clinical validation and clinical translation
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op donderdag 1 mei 2014
klokke 15:00 uur
door
Joost Renier van der Vorst
geboren te Geldrop in 1984
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Promotiecommissie
Promotor: Prof. dr. C.J.H. van de Velde
Co-promotor: Dr. A.L. Vahrmeijer
Overige leden: Prof. dr. C.W.G.M. Löwik
Prof. dr. B.P.F. Lelieveldt
Prof. dr. V.T.H.B.M. Smit
Prof. dr. C.H.C. Dejong (Universiteit van Maastricht)
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CONTENTS
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Chapter 1
General introduction and outline of thesis
9
Part I:
Pre-clinical validation of near-infrared fluorescence
guided surgery
19
Chapter 2
Near-infrared fluorescence imaging of liver metastases in rats
using indocyanine green
21
Chapter 3
Intraoperative fluorescence delineation of head and neck
cancer with a fluorescent anti-epidermal growth factor
receptor nanobody
35
Chapter 4
Near-infrared fluorescence imaging of both colorectal cancer
and ureters using a low-dose integrin targeted probe
57
Part II:
Clinical translation: Sentinel lymph node imaging
73
Chapter 5
Optimization of near-infrared fluorescent sentinel lymph
node mapping for vulvar cancer
75
Chapter 6
Optimization of near-infrared fluorescent sentinel lymph
node mapping in cervical cancer patients
87
Chapter 7
Randomized comparison of near-infrared fluorescence
lymphatic tracers for sentinel lymph node mapping of
cervical cancer
Chapter 8
Dose optimization for near-infrared fluorescence sentinel 115
lymph node mapping in patients with melanoma
Chapter 9
Near-infrared fluorescence sentinel lymph node mapping 131
of the oral cavity in head and neck cancer patients.
Chapter 10
Randomized comparison of near-infrared fluorescence
141
imaging using indocyanine green and 99mtechnetium
with or without patent blue for the sentinel lymph node
procedure in breast cancer patients
101
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Part III:
Clinical translation: Solid tumor imaging
157
Chapter 11
Near-infrared fluorescence-guided resection of colorectal
liver metastases
161
Chapter 12
Near-infrared fluorescence imaging in patients undergoing 175
pancreaticoduodenectomy
Chapter 13
Intraoperative near-infrared fluorescence imaging of
parathyroid adenomas using low-dose methylene blue
Chapter 14
Near-infrared fluorescence imaging of a solitary fibrous tumor 205
of the pancreas using methylene blue
Part IV
Chapter 15
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191
215
Summary and Future Perspectives
217
Nederlandse samenvatting
230
List of Publications
235
Curriculum Vitae
240
Dankwoord
241
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