Acute and Chronic Toxicity of New Perfluoroalkyl Substances to

Acute and Chronic Toxicity of New
Perfluoroalkyl Substances to Daphnia magna
Henrik Barmentlo
Jente Stel, Marijn van Doorn, Christian Eschauzier, Pim de Voogt
& Michiel Kraak
University of Amsterdam, the Netherlands
Perfluoroalkyl Carboxylic Acids
• Longer chained PFCAs phased out
•
Unknown environmental hazard of
shorter PFCAs and polymer
PFOA C8
PFHxA C6
PFBA C4
Fluoroalkylated polymer
(Capstone© P-620HS)
~ OECD 202 Acute Tox. Test
~ OECD 211 Chronic Tox. Test
Acute Toxicity Test
100
90
Mobility (%)
80
70
60
50
40
30
20
10
0
1
10
100
1000
10000
Concentration (mg/L)
EC50 (mg/L):
95% CI:
C8
PFOA
C6
PFHxA
C4
PFBA
239
1048
5251
190-287
802-1294
3889-6614
Toxicity decreases with decreasing carbon chain length
3
Number of neonates / female
Chronic Toxicity Test
0.03
3.47
15.41
26.96
47.18
82.58
144.52
585.77
770.07
1776.67
mg/L
90
80
b
70
|
|ab
60
50
a
40
c
30
20
10
d
0
0
1
2
3
4
5
6
7
8
9 10 11 12 13 14 15 16 17 18 19 20 21
Per capita population
growth rate day-1
Time (days)
PFHxA
0,3
mg/L
0,25
LC50
1048
Chronic LC50
1273
Repr.
EC50
776
P.G.R.
EC50
853
Acute
0,2
0,15
0,1
0,05
0
1
10
100
Concentration PFHxA (mg/L)
1000
4
Conclusions
• Capstone© P-620HS did not show a dose-response relationship
• Acute toxicity to D. magna decreased with decreasing carbon chain length
• PFHxA showed a non-specific mode of action and its low acute toxicity did
not increase with increasing exposure time
• Based on the results for this single test species only, it is concluded that
C4-C6 PFCAs are less hazardous than the longer chained C8 PFCA
Poster P02

Download Report