II SIMPOSIO DE JÓVENES INVESTIGADORES DE LA SOCIEDAD ESPAÑOLA DE QUÍMICA TERAPÉUTICA 12 de junio de 2015, 09:00h Scientific committee Salón de actos de la Sede Central CSIC c/ Serrano 117, Madrid 9:00-9:30 REGISTRATION 9:30-9:45 OPENING CEREMONY 9:45-10:15 Inaugural Lecture (Coaching) 10:15-10:30 Dr. Óscar Delgado (Janssen, Spain) “Chasing drugs instead of molecules: chemistry and the pharmaceutical industry” Carles Galdeano (University of Dundee, UK) “Targeting the VHL: HIF-1α protein-protein interaction with small-molecules chemical probes” Eleni Pitta (University of Antwerp, Belgium & GSK, Spain) 10:30-10:45 10:45-11:00 11:00-11:15 “Hit to lead optimization of novel quinoloxyacetamide derivatives against mycobacterium tuberculosis” Ana María García (Centro de Investigaciones Biológicas, CSIC, Spain) “Sulfide-like PDE7 inhibitors: in vitro metabolic oxidation study using rat liver microsomes” María Gómez Cañas (Universidad Complutense Madrid, Spain) “Biological characterization of PM226, achromenoisoxazole, as a selective CB2receptor agonist with antiinflammatory/neuroprotective profile” 11:15-12:15 POSTER SESSION/COFFEE BREAK 12:15-12:45 Invited Lecture Dr. Manuel Guzmán (Universidad Complutense Madrid, Spain) 12:45-13:00 13:00-13:15 13:15-13:30 “Cannabinoid receptors as potential antitumor targets” Laura Aramburu (Universidad de Salamanca, Spain) “Novel sulfoxides and sulfones as tubulin polymerization inhibitors” Marta Acebron (Centro Nacional de Investigaciones Oncológicas, CSIC, Spain) “Fragment based ligand discovery for local adhesion kinase” Sofía Salazar (University of Porto, Portugal) “New potential selective activators of caspase-7 identified using the yeast screening assay” Patricia M. R. Pereira (University of Aveiro, Portugal) 13:30-13:45 13:45-14:00 “The dual functionality of phosphonate-appended phthalocyanines: inhibitors of urokinase plasminogen activator and anticancer photodynamic agents” Ana C. S. Lobo (University of Coimbra, Portugal) “The effect of photodynamic therapy with LUZ11 on tumour metastases” Clara Pérez Peinado (Universitat Pompeu Fabra, Spain) 14:00-14:15 “Structure-activity studies of crotalicidin and analogs, antimicrobial and antitumoral peptides from rattlesnake venom” 14:15-16:00 LUNCH BREAK Mery Santivañez Veliz (Universidad de Navarra, Spain) 16:00-16:15 16:15-16:30 “Structure-activity studies of crotalicidin and analogs, antimicrobial and antitumoral peptides from rattlesnake venom” Alejandra Carriles Linares (Instituto Química Física Rocasolano, CSIC, Spain) “Novel drug design strategies for trypanosomatid-causing diseases: a structural approach” Ana María Gamo Albero (Instituto Química Médica, CSIC, Spain) 16:30-16:45 “α/β3-peptide foldamers: potent dimerization inhibitors of Leishmania infantum trypanothione reductase with improved proteolytic stability” Montserrat Nácher (Centro de Investigaciones Biológicas, CSIC, Spain) 16:45-17:00 “Photodynamic therapy as an alternative for cutaneous leishmaniasis. Metal-organic Ru(II) complexes as new photosensitizer leads” 17:00-17:45 POSTER SESSION Verónica Ortiz de Elguea (Universidad del País Vasco, Spain) 17:45-18:00 “Ready access to biologically active heterocycles via palladium-catalyzed alkenylation reactions” Jennifer Enrich Bengoa (University of Aix-Marseille, France) 18:00-18:15 18:15-18:30 “MicroRNA involvement in the Hutchinson-Gliford progeria physiopathology by the inhibition of autophagic progerin degradation?” Alejandro Escobar Peso (Instituto Química Orgánica General, CSIC, Spain) “New drugs for ageing related diseases” 18:30-19:00 FINAL REMARKS & AWARDS 19:00 CLOSING EVENT: drinks and tapas La duración de las comunicaciones orales será de 10 min de exposición + 5 min para preguntas. Location Salón de actos de la Sede Central del CSIC C/Serrano, 117 28006, Madrid República Argentina, línea 6 Gregorio Marañón, líneas 7 y 10 C/ Serrano 111, líneas 16, 19 y 51
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