Tyrosinase enzyme: 1. An overview on a pharmacological target

Tyrosinase enzyme: 1. An overview on a
pharmacological target
Casanola-Martin G.M., Le-Thi-Thu H., Marrero-Ponce Y.,
Castillo-Garit J.A., Torrens F., Rescigno A., Abad C., Khan
M.T.H.
Departament de Bioquímica i Biologia Molecular, Universitat de
València, E-46100 Burjassot, Spain; Unit of Computer-Aided
Molecular Biosilico Discovery and Bioinformatic Research (CAMDBIR Unit), Universidad Central de Las Villas, Santa Clara, 54830,
Villa Clara, Cuba; Centro de Información y Gestión Tecnológica,
Ministerio de Ciencia Tecnología y Medio Ambiente (CITMA), 65100,
Ciego de Avila, Cuba; School of Medicine and Pharmacy, Vietnam
National University, Hanoi (VNU), 144 Xuan Thuy, Cau Giay, Hanoi,
Viet Nam; Enviromental and Computational Chemistry Group,
Universidad de Cartagena, Cartagena de Indias, Bolivar, Colombia;
Centro de Estudio de Química Aplicada, Universidad Central Marta
Abreu de Las Villas, Santa Clara, 54830, Villa Clara, Cuba; Institut
Universitari de Ciència Molecular, Universitat de València,
C/Catedrático José Beltrán, 2, 46980 Paterna, Valencia, Spain;
Sezione di Chimica Biologica,Dip. Scienze e Tecnologie Biomediche,
Università di Cagliari, Cittadella Universitaria, 09042 Monserrato
(CA), Italy; Center for Pharmaceutical Biotechnology, College of
Pharmacy, University of Illinois at Chicago, United States
Abstract: The tyrosinase enzyme (EC 1.14.18.1) is an oxidoreductase inside the
general enzyme classification and is involved in the oxidation and reduction
process in the epidermis. These chemical reactions that the enzyme catalyzes are
of principal importance in the melanogenesis process. This process of
melanogenesis is related to the melanin formation, a heteropolymer of indolic
nature that provides the different tonalities in the skin and helps to the protection
from the ultraviolet radiation. However, a pigment overproduction, come up by
the action of the tyrosinase, can cause different disorders in the skin related to
the hyperpigmentation. Several studies mainly focused on the characteristics of
the enzyme have been reported. In this work, an approximation to general
aspects related to this enzyme is made. Besides, it is treated the researches that
have been published in the part of the biochemical anatomy dealing with
diseases associated with this protein (melanogenesis), its active place and its
physiological states, the molecular mechanism, the methods carried out to detect
the inhibitory activity, and the used substrates. © 2014 Bentham Science
Publishers.
Author Keywords: Hyperpigmentation; Melanin; Molecular mechanism;
Structure; Tyrosinase
Year: 2014
Source tilte: Current Topics in Medicinal Chemistry
Volume: 14
Page: 1494 - 1501
Link: http://www.scopus.com/inward/record.url?eid=2-s2.084904016318&partnerID=40&md5=c33dd2dc9f74f8f9432a70944fcb62a3
Correspondence Address: Casañola-Martin, G. M.; Departament de Bioquímica i
Biologia Molecular, Universitat de València, E-46100 Burjassot, Spain; email:
[email protected]
Editors:
ISSN: 15680266
ISBN:
DOI:
Language of Original Document: English
Abbreviated Source Title: Curr. Top. Med. Chem.
Document Type: Article
Source: Scopus
Authors with affiliations:
Casañola-Martin, G.M., Departament de Bioquímica i Biologia Molecular,
Universitat de València, E-46100 Burjassot, Spain, Unit of Computer-Aided
Molecular Biosilico Discovery and Bioinformatic Research (CAMD-BIR Unit),
Universidad Central de Las Villas, Santa Clara, 54830, Villa Clara, Cuba, Centro
de Información y Gestión Tecnológica, Ministerio de Ciencia Tecnología y
Medio Ambiente (CITMA), 65100, Ciego de Avila, Cuba; Le-Thi-Thu, H.,
School of Medicine and Pharmacy, Vietnam National University, Hanoi (VNU),
144 Xuan Thuy, Cau Giay, Hanoi, Viet Nam; Marrero-Ponce, Y., Unit of
Computer-Aided Molecular Biosilico Discovery and Bioinformatic Research
(CAMD-BIR Unit), Universidad Central de Las Villas, Santa Clara, 54830, Villa
Clara, Cuba, Enviromental and Computational Chemistry Group, Universidad de
Cartagena, Cartagena de Indias, Bolivar, Colombia; Castillo-Garit, J.A., Unit of
Computer-Aided Molecular Biosilico Discovery and Bioinformatic Research
(CAMD-BIR Unit), Universidad Central de Las Villas, Santa Clara, 54830, Villa
Clara, Cuba, Centro de Estudio de Química Aplicada, Universidad Central Marta
Abreu de Las Villas, Santa Clara, 54830, Villa Clara, Cuba; Torrens, F., Institut
Universitari de Ciència Molecular, Universitat de València, C/Catedrático José
Beltrán, 2, 46980 Paterna, Valencia, Spain; Rescigno, A., Sezione di Chimica
Biologica,Dip. Scienze e Tecnologie Biomediche, Università di Cagliari,
Cittadella Universitaria, 09042 Monserrato (CA), Italy; Abad, C., Departament
de Bioquímica i Biologia Molecular, Universitat de València, E-46100
Burjassot, Spain; Khan, M.T.H., Center for Pharmaceutical Biotechnology,
College of Pharmacy, University of Illinois at Chicago, United States

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