10th International Luebeck Conference on the Pathophysiology and

UNIVERSITÄT ZU LÜBECK
INSTITUT FÜR PHYSIOLOGIE
10th International Luebeck Conference on the
Pathophysiology and Pharmacology of Erythropoietin
and other Hemopoietic Growth Factors
Music & Congress Centre of Luebeck, Germany
June 3 - 5, 2015
Under the auspices of the German Physiological Society (DPG)
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General Information
The 10th International Luebeck Conference on the Pathophysiology and Pharmacology of
Erythropoietin and other Hemopoietic Growth Factors will be held at the Music & Congress
Centre of Luebeck (Musik- und Kongresshalle - MUK), Germany, from June 3 - 5, 2015.
Similar to the meetings before, the purpose of the conference will be to stimulate the
exchange of ideas between basic scientists and clinicians who are active in this field. The
major scientific topics will be:
- Erythropoietin receptor biology
- Hypoxia sensing
- Erythropoietin production
- Novel erythropoiesis-stimulating agents
- Use in the treatment of anemias
- Sports medicine
- Colony-stimulating factors
Date and Place
of the Meeting
June 3 - 5, 2015
Music & Congress Centre
Willy-Brandt-Allee 10
23554 Luebeck
Germany
Organization
Horst Pagel and Wolfgang Jelkmann
Institute of Physiology
University of Luebeck
Ratzeburger Allee 160
D-23562 Lübeck
Germany
Permanent Office
Evelyn Kimpel, Secretary
Presentations
Phone:
Fax:
++49-451-500-4152
++49-451-500-4151
E-mail:
[email protected]
Oral presentations: in English only (no translation), 15 min plus
5 min for discussion (unless otherwise noted). Please deliver
your presentation on a stick on Thursday morning prior to the
start of the sessions.
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Poster presentations: The posters will be up on Thursday and
Friday (mounting on Thursday morning) in the foyer of the
Music & Congress Centre. Poster authors should be present
during the Poster Session on Thursday afternoon and the
Poster Question and Answer Session on Friday morning. There
will be no guided poster tour. However, participants may hand
over questions in written form to the secretarial congress office
during the meeting for discussion on Friday morning (Q & A).
A poster award committee will evaluate the posters for a poster
prize. The winner will be announced during the Q & A session
on Friday morning.
For the presentations of the posters a board will be available
(120 cm width, 150 cm height). Fixing material will be provided
by the organizers.
Lunch and Coffee
Coffee, tea, refreshments, sandwiches and snacks will be
offered free of charge.
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How to get to Lübeck
By airplane:
Luebeck airport: The Hungarian-Polish airline Wizz Air flies
from/to Luebeck from or to Danzig (Poland) and Kiev (the
Ukraine). Further information at www.wizzair.com.
Getting from Luebeck airport to Luebeck's town centre is easy:
The number 6 bus route starts right in front of the Luebeck
airport and leaves every 20 min for the central bus station and
back (journey approx. 30 min). A train leaves for the main train
station every hour from the "Lübeck Flughafen" stop and back
again (journey approx. 8 min).
Hamburg Airport is the closest major international airport.
From Hamburg Airport you can get the S-Bahn (suburban rail
network) line S1. Line S1 operates every 10 min between
Hamburg Airport and Hamburg’s central railway station,
Hauptbahnhof, a journey of 25 min. Trains from Hamburg
central station to Luebeck central station operate from 8 am - 8
pm, every 30 min and before and after that every hour (journey
approx. 40 min). The “Hamburg Airport (Flughafen)” S-Bahn
station is directly in front of the terminals and is easily reached
by lift, escalator or stairs.
By train: Trains from Hamburg arrive at Luebeck main station
every hour. From there you can reach the meeting location within
a 5-10 min walk.
By car: You can reach Luebeck via Autobahn A1 from
Copenhagen and Hamburg (exits „Lübeck Zentrum“ or „Lübeck
Moisling“) or via A20 from Rostock, A24 from Berlin and change
in Hamburg onto the A1.
The Stadtverkehr Lübeck GmbH operates the public transport
system in Luebeck and the surrounding area. Information on
timetables, tickets and tariffs are available from
www.stadtverkehr-luebeck.de, www.scout-sh.de
or Tel.: +49 (0) 4 51/8 88 28 28.
Accommodation
For hotel arrangements, please contact the tourist board:
http://www.luebeck-tourism.de/
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Wednesday, June 3, 2015
19:00
Reception evening with catering
Audience Hall ("Audienzsaal") of the Town Hall ("Rathaus") of the
Hanseatic City of Luebeck, Breite Straße 62
Welcome by Mr. Bernd Saxe, Mayor of the City of Luebeck
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Scientific Program
Thursday, June 4, 2015
8:30
Opening Addresses
Wolfgang Jelkmann
Mathias Freund, President of the German Society of Hematology and
Oncology (DGHO)
9:00 – 10:40
Session 1 (Oral Presentations)
"Detection of erythropoietin receptor"
(Chairpersons: Constance Noguchi, Michael Jarsch)
9:00 – 9:20
Nina Trošt, Neli Hevir, Patrícia Kimáková, Lenka Hurtuková,
Barbora Fecková, Tea Lanišnik Rižner, Radovan Komel, Peter
Solár, Nataša Debeljak
“Erythropoietin receptor modulates breast cancer cell response to
tamoxifen treatment”
9:20 – 9:40
Andre Bernardini, Ulf Brockmeier, Erik Metzen, Joachim Fandrey
“Study of erythropoietin receptor activation in living cells by Förster
resonance energy transfer microscopy”
9:40 – 10:00
Perry Maxwell, Robert J Cuthbert, Terence R Lappin
“Sensitive and specific probes for the erythropoietin receptor in
clinical samples”
10:00 – 10:20
John Thompson, Fritz Grunert
“Development and specificity testing of novel antibodies directed
against the human erythropoietin receptor”
10:20 – 10:40
Henrik Martens, Tekla Kolbow, Christoph Ott, Hannelore Ehrenreich
“New polyclonal and monoclonal antibodies against the human and
murine EPO-receptor”
10:40 – 11:10
Coffee and Tea Break
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11:10 – 12:40
Session 2 (Oral Presentations)
"Pleiotropic actions of erythropoietin"
(Chairpersons: Reinhard Depping, Joachim Fandrey)
11:10 – 11:30
Christian Klopsch, Marion Ludwig, Heiko Lemke, Gabriela Kleiner,
Anna Skorska, Ralf Gaebel, Christian Maschmeier, Sarah Müller,
Stefan Jockenhoevel, Brigitte Vollmar, Robert Jaster, Robert David,
Gustav Steinhoff
“Epicardial Erythropoietin release improves cardiac functions and
enhances rapid proliferation and tissue transformation in the
intracardiac mesenchyme after myocardial infarction”
11:30 – 11:50
Mete Özkurt, K Uzuner, N Erkasap, W Jelkmann, R Ozyurt, G Kus,
O Uysal, O Kutlay
“Investigation of erythropoietin, TNF-α and kidney tissue injury
connections in L-NAME induced hypertensive rats”
11:50 – 12:10
Constance Tom Noguchi, Yuanyuan Zhang, Heather Rogers, Li Wang,
Mawadda Alnaeeli
“Erythropoietin and metabolic response”
12:10 – 12:30
Martina Rauner, Kristin Franke, Rashim Pal Singh, Sahar Hiram-Bab,
Max Gassmann, Drorit Neumann, Yankel Gabet, Triantafyllos
Chavakis, Lorenz C. Hofbauer, Ben Wielockx
“Bone homeostasis is regulated by the PHD2 - HIF2α - EPO axis”
12:30 – 12:50
Sahar Hiram-Bab, Tamar Liron, Naamit Deshet-Unger, Moshe
Mittelman, Max Gassmann, Martina Rauner, Ben Wielockx, Drorit
Neumann, Yankel Gabet
“EPO attenuation of bone formation: contribution of non-osteoblastic
cells?”
12:50 – 14:00
LUNCH
14.00 - 15.40
Session 3 (Oral Presentations)
"Effects of erythropoietin on neuronal cells"
(Chairpersons: Anna-Leena Sirén, Henrik Oster)
14:00 – 14:20
Nina Hahn, Hannelore Ehrenreich, Ralf Heinrich
“Erythropoietin in insects: receptors, signaling pathways and
neuroprotection”
14:20 – 14:40
Christoph Ott, Imam Hassouna, Liane Dahm, Sandra Goebbels,
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Henrik Martens, Klaus-Armin Nave, Hannelore Ehrenreich
“Inducible formation of hippocampal oligodendrocytes from preexisting local precursors by erythropoietin”
14:40 – 15:00
Imam Hassouna, Christoph Ott, Liane Dahm, Nils Offen, Daniela
Winkler, Ekrem Dere, Henrik Martens, Klaus-Armin Nave, Anna-Leena
Sirén, Hannelore Ehrenreich
“Erythropoietin induces formation of hippocampal CA neurons from
preexisting local precursors”
15:00 – 15:20
Jean-Claude Fauchère, Russia H. Leuchter, Giancarlo Natalucci,
Christof Dame, Brigitte M. Koller, Christoph M. Rüegger, Cornelia
Hagmann, Petra S. Hüppi, Hans Ulrich Bucher on behalf of the ‘The
Swiss EPO Neuroprotection Trial Group'.
“Results of the Swiss Epo Neuroprotection Trial in Very Preterm
Infants”
15:20 – 15:40
Kamilla W. Miskowiak
“Neural correlates of improved executive function following
erythropoietin treatment in mood disorders”
15:40 – 16:10
Coffee and Tea Break
16:10 – 17:50
Session 4 (Oral Presentations)
"Cellular responses to hypoxia"
(Chairpersons: Dörthe Katschinski, Bernhard Brüne)
16:10 – 16:30
Markus Mandl, Maria Lieberum, Reinhard Depping
”Cell-specific upregulation of the transcription factor ARNT (HIF-1β) in
response to hypoxia”
16:30 – 16:50
Alexandra Schörg, Sara Santambrogio James Platt, Johannes
Schödel, Maja T. Lindenmeyer, Clemens D. Cohen, Katrin
Schrödter, David R. Mole, Roland H. Wenger, David Hoogewijs
“Destruction of a distal hypoxia response element abolishes transactivation of the PAG1 gene mediated by HIF-independent
chromatin looping”
16:50 – 17:10
Nathalie Dehne, Bernhard Brüne
„Hypoxic inhibition of JMJD3 reduces H3K27me3 demethylation,
chromatin remodeling, and induction of the STAT6 target gene
Ccl18”
17:10 – 17:30
Dominik C. Fuhrmann, Nathalie Dehne, Bernhard Brüne
“Regulation of protein expression under chronic hypoxia”
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17:30 – 17:50
Emma J Hodson, Lynn G Nicholls, Philip J Turner, Peter A Robbins,
Christopher W Pugh, Keith Buckler, Peter J Ratcliffe, Tammie Bishop
“Contrasting roles of HIF-1 and 2 in ventilatory acclimatisation to
hypoxia”
17:50 – 19:00
Session 5 (Poster Viewing):
21
K. Gottwald, V. Biedermann, S. Seeleithner, A. Gross, M. Rädisch, W.
Jelkmann, C. Unverzagt
"Semisynthesis of two glycoforms of human erythropoietin"
22
Maria- Katharina Lieberum, Markus Mandl, Jürgen Dunst,
Reinhard Depping
"The transcription factor ARNT influences radiation sensibility in
different cell lines"
23
Jonas J. Staudacher, Isabel S. Naarmann-de Vries, Stefanie J. Ujvari,
Bertram Klinger, Mumtaz Kasim, Edgar Benko, Antje OstareckLederer, Dirk H. Ostareck, Pontus B. Persson, Ralf Mrowka, Michael
Fähling
"Transcriptome partitioning for mRNA translation in hypoxia"
24
Liane Dahm, Miso Mitkovski, Ralf Heinrich, Imam Hassouna,
Christoph Ott, Henrik Martens, Klaus-Armin Nave, Hannelore
Ehrenreich
"Erythropoietin dampens injury-induced microglial motility"
25
Friederike Katharina Kosyna, Marie Nagel, Maria Lieberum,
Larissa Kluxen, Kim Kraushaar, Reinhard Depping
"The importin α/β-specific inhibitor Ivermectin affects HIF-dependent
hypoxia response pathways"
26
Sina Schultz, Mahtab Ahmad Khan, Markus Schwaninger
"The decrease of M-CSF expression in the brain endothelium by acute
hyperglycemia leads to a reduction in tissue protective M2
macrophages after ischemic stroke"
27
Birgül Kurt, Katharina Gerl, Dominik Steppan, Lucile Miquerol, Armin
Kurtz
"Ectopic hyperplastic renin expressing cells can transform into
erythropoietin expressing cells at any time"
28
Wolfgang Jelkmann, Gerhard Lonnemann
"Relationship between plasma activin A levels and excretory renal
function"
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29
Pamela J. Kling, Allison Pollock, Daphne D-Q Pham, Sharon E.
Blohowiak
"Cord blood erythropoietin levels after maternal obesity during
gestation"
30
Demikhov V.G., Lunyakova M.A., Beznoshchenko A.G., Scobin
V.B.
"Effect of rHuEPO therapy on long-term survival of children with acute
lymphoblastic leukemia, undergoing chemotherapy according to the
program ALL BFM-90m"
31
Link H., A. Lück, J. Rauh, D. Bòrquez, C. Maas, J. Hesse, M.
Koenigsmann, M. Schulze, M. Tölg
"Multicentre, non-interventional study with epoetin theta in patients
with chemotherapy-induced symptomatic anemia (EPO-amb)
conducted in Germany"
32
Patrícia Kimáková, Lenka Hurtuková, Barbora Fecková, Lenka
Varinská, Zuzana Solárová, Nataša Debeljak, Peter Solár
"Angiogenic potential of hypoxic conditioned media from ovarian
adenocarcinoma A2780 cells: the effect of erythropoietin"
33
Agnieszka Zembron-Lacny, Anna Kasperska, Barbara Morawin,
Andrzej Pokrywka, Zbigniew Szygula
"Effect of intermittent hypoxic training on erythropoietin level in relation
to inflammatory response"
34
Elmo Neuberger, Martin Mooses, Jerome Durussel, Jun Wang, Mark
Lees, Kerli Mooses, Alexandra Brahmer, Guan Wang, Yannis
Pitsiladis, Perikles Simon
"Small RNA sequencing of red blood cell specific miRNAs reveals
expression changes after 6 weeks of recombinant EPO (rEPO)
administration in healthy recreational athletes"
19:00 – ∞
DINNER
Friday, June 5, 2015
8:30 – 9:00
Session 6
Q & A: Answers of the poster presenters to submitted questions open discussion. Poster award announcement.
(Chairperson: Horst Pagel)
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9:00 – 11:00
Session 7 (Oral Presentations)
"Production of erythropoietin"
(Chairpersons: Birgül Kurt, Thomas Hellwig-Bürgel)
9:00 – 9:20
Roland H. Wenger
"Regulation of the EPO Gene"
9:20 – 9:40
Hanako Kobayashi, Thomas C. Binns, Qingdu Liu, Volker H. Haase
"Distinct populations of FoxD1-derived peritubular interstitial cells
regulate erythropoietin (EPO) production in the kidney"
9:40 – 10:00
Masayuki Yamamoto
"Renal erythropoietin producing cells for anemia and fibrosis"
10:00 – 10:20
Katharina Gerl, Lucile Miquerol, Vladimir T. Todorov, Christian
P.M. Hugo, Ralf H. Adams, Armin Kurtz, Birgül Kurt
"Inducible glomerular erythropoietin production in the adult kidney"
10:20 – 10:40
Wenwen Sun, Friederike Katharina Kosyna, Wolfgang Jelkmann,
Reinhard Depping
"Prolyl-4-hydroxylase 2 potentially contributes to hepatocellular
carcinoma-associated erythrocytosis by maintaining hepatocyte
nuclear factor-4α expression"
10:40 – 11:00
Teresa Otto, B. Delos Reyes, S. Lauterbach, Joachim Fandrey
"EPO and EMT - new insights in EPO regulation"
11:00 – 11:20
Coffee and Tea Break
11:20 – 12:40
Session 8 (Oral Presentations):
"Pharmacology and molecular biology"
(Chairpersons: Pamela Kling, Vladimir Skobin)
11:20 – 11:40
Anatole Besarab, K.-H. Peony Yu, Thomas B. Neff, Lynda Szczech
"Clinical Experience with Roxadustat, a HIF-PHI, in the treatment of
CKD associated anemia"
11:40 – 12:00
Ken Aizawa, Yoshihito Tashiro, Ryohei Kawasaki, Kenji, Yogo,
Michinori Hirata, Koichi Endo, Yasushi Simona
"Epoetin beta pegol retains its biological activity in the presence of the
sialic acid metabolic enzyme sialidase"
12:00 – 12:20
Christel Bonnas, Daniela Winkler, Christoph Ott, Katja Specht,
Inge Sillaber, Hannelore Ehrenreich, Herbert Stadler
"A non-hematopoietic erythropoietin variant expressed in human
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blood"
12:20 – 12:40
Bojana Beleslin Cokic, Constance Tom Noguchi, Vladan Cokic,
Svetozar Damjanovic
"The effect of inactivated VHL gene on proliferative pathways in renal
cell carcinoma"
12:40 – 13:20
LUNCH
13:20 – 13:50
Special Lecture on Sports Physiology
(Chairperson: Wolfgang Jelkmann)
Zbigniew Szygula:
“Erythrocytic system under the influence of sports training - sports
anemia, hypoxic training and blood doping”
13:50 – 14:00
Break
14:00 – 15:30
Session 9 (Oral Presentations)
"Recent clinical knowledge"
(Chairpersons: Valeriy Demikhov, Terence Lappin)
14:00 – 14:20
Katarzyna A. Lisowska, Aleksandra Jasiulewicz, Alicja Dębska-Ślizień,
Jacek M. Witkowski
"Phenotype and proliferation capacity of CD4+ T and B cells of
patients with end-stage renal disease depending on treatment with
recombinant human erythropoietin"
14:20 – 14:40
Howard S. Oster, Naamit Deshet-Unger, Sara Prutchi-Sagiv, Nir
Maaravi, Nataliya Golishevski, Drorit Neumann, Moshe Mittelman
"Erythropoietin treatment is associated with improved immune
parameters in patients with lower risk myelodsyplastic syndromes"
14:40 – 15:00
Naamit Deshet-Unger, Sahar Hiram-Bab, Yasmin Haim Ohana,
Moshe Mittelman, Yankel Gabet, Drorit Neumann
"Erythropoietin in 5T33 murine multiple myeloma: Opposing Immune
and skeletal outcomes"
15:00 – 15:30
Howard S. Oster, Drorit Neumann, Moshe Mittelman
"Erythropoietin: a burden or an asset?"
15:30
Concluding remarks
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Social Program
The events are free of charge for participants of the conference.
Wednesday, June 3, 2015:
19.00 - 21:30 Get-together Party
Audience Hall ("Audienzsaal") of the Town Hall ("Rathaus") of the Hanseatic City of
Luebeck, Breite Straße 62
Welcome by Mr. Bernd Saxe, Mayor of the City of Lübeck
The Town Hall of Luebeck was commenced by the citizens in 1230 and was modified and
extended during the following centuries. Hence, it incorporates a variety of styles from the
Gothic to the Renaissance. Today the Town Hall still meets its purpose as domicile of the
municipal parliament, the Senate, and the top-departments of the administration.
In former times the Audience Hall used to be the convention room of the Hanseatic High
Court. Its present outfit and equipment of the Rococo style originates from the years
between 1754 and 1761. The paintings by the Italian artist Stefano Torelli show allegorical
motives: the liberal arts, trade, freedom, mercy, harmony, industry and abundance,
vigilance, intelligence, moderation, and discretion.
The interior portal of the Audience Hall dates to 1573 and shows in reliefs the judgement
of Solomon, the justice and affection. The portal had/has two openings: Those convicted
had to stoop to pass through the lower door, but those acquitted could walk upright
through the high one.
Thursday, June 4, 2015:
19.00 - ∞:
Dinner
Congress & Music Centre
Friday, June 5, 2015:
17:00 – 19:00:
Sightseeing walk
We invite you to join us for a leisurely stroll of about 2 hours through medieval Hanseatic
Luebeck. We will show you its most beautiful corners, such as typical brick-buildings,
courtyards and city-gates. UNESCO declared the existing cityscape to be a World Cultural
Heritage Site in 1987.
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Saturday, June 6, 2015:
10:00 – 12:00:
European Hansemuseum Lübeck
Location: An der Untertrave 1
In this new museum (opened by end of May 2015) we will go on a unique trip through 600
years of Hanseatic history. Extending across northern Europe and the Baltic, the Hanse
was a powerful economic alliance, in which first merchants and later towns joined together
to promote trade. Modern museum technology, original exhibits, media stations,
reconstructed scenes as well as graphics and statistics will explain the historical
connections (www.hansemuseum.eu.).
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