Inhibition of Growth and Induction of Apoptosis in Human Cancer

Inhibition of Growth and Induction of Apoptosis in Human Cancer Cel...
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The Journal of Alternative and Complementary
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Inhibition of Growth and Induction of Apoptosis in Human Cancer Cell Lines by an
Ethyl Acetate Fraction from Shiitake Mushrooms
To cite this article:
Nianbai Fang, Qinglin Li, Shanggong Yu, Jianxiang Zhang, Ling He, Martin J.J. Ronis, and Thomas M. Badger. The
Journal of Alternative and Complementary Medicine. March 2006, 12(2): 125-132. doi:10.1089/acm.2006.12.125.
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Published in Volume: 12 Issue 2: March 27, 2006
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Author information
Nianbai Fang, Ph.D.
Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR.
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR.
Qinglin Li, Ph.D.
Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR.
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR.
Shanggong Yu, B.Sc.
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR.
Jianxiang Zhang, Ph.D.
Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR.
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR.
Ling He, M.D.
Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR.
Department of Physiology/Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR.
Martin J.J. Ronis, Ph.D.
Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR.
Department of Pharmacology/Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR.
Thomas M. Badger, Ph.D.
Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR.
Department of Physiology/Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR.
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ABSTRACT
Objective: Shiitake (Lentinus edodes) mushrooms have been reported to have cancer-preventing properties.
However, little research has been conducted verifying the antitumor activities of "mycochemicals" in shiitake
mushrooms. In this study, potential roles of an ethyl acetate fraction from shiitake mushrooms were investigated by
in vitro bioassays.
Design: The activities of an ethyl acetate fraction were evaluated by [3-(4,5-dimethylthiazol-yl)-2,5diphenyltetrazolium bromide] (MTT), apoptosis bioassay, cell cycle analysis, and Western blot analysis using two
human breast carcinoma cell lines (MDA-MB-453 and MCF-7), one human nonmalignant breast epithelial cell line
(MCF-10F), and two myeloma cell lines (RPMI-8226 and IM-9).
Results: Concentration-dependent antiproliferative effects of the fraction were observed in all cell lines using the MTT
assay. Approximately 50 mg/L concentration of the fraction induced apoptosis in 50% of the population of four human
tumor cell lines and the fraction-induced apoptosis may have been mediated through the pro-apoptotic bax protein
which was up-regulated. Cell cycle analysis revealed that the fraction induced cell cycle arrest by significant decrease
of S phase, which was associated with the induction of cdk inhibitors (p21) and the suppression of cdk4 and cyclin D1
activity. Compared to malignant tumor cells, nonmalignant cells were less sensitive to the fraction for the suppression
of cell growth and regulation of bax, p21, cyclin D1, and cdk4 expression. A 51% antiproliferative effect occurred at
1 von 3
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Nianbai Fang
Qinglin Li
Shanggong Yu
Jianxiang Zhang
04.05.2015 11:27
Inhibition of Growth and Induction of Apoptosis in Human Cancer Cel...
http://online.liebertpub.com/doi/abs/10.1089/acm.2006.12.125
the highest concentration of the fraction (800 mg/L).
Ling He
Conclusions: These data suggest that inhibition of growth in tumor cells by "mycochemicals" in shiitake mushrooms
may result from induction of apoptosis.
Martin J.J. Ronis
Thomas M. Badger
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