Supplementary webappendix This webappendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Coiffier B, Osmanov E A, Hong X, et al for the LYM-3001 study investigators. Bortezomib plus rituximab versus rituximab alone in patients with relapsed, rituximab-naive or rituximab-sensitive, follicular lymphoma: a randomised phase 3 trial. Lancet Oncol 2011; published online July 4. DOI:10.1016/S14702045(11)70150-4 WEBAPPENDIX: Coiffier B, et al. Bortezomib plus rituximab versus rituximab alone in patients with relapsed, rituximab-naïve or rituximab-sensitive, follicular lymphoma: a randomised phase 3 trial. Supplementary Figures Supplementary Figure 1. Progression-free survival by treatment arm in patients with (A) high FLIPI score or (B) high tumor burden (modified GELF criteria). 1 Supplementary Figure 2. Progression-free survival by treatment arm according to number of prior lines of therapy. 2 Supplementary Figure 3. (A) Time to next treatment and (B) overall survival by treatment arm in the intention-to-treat population 3 APPENDIX – LYM3001 Study Investigators Kudrat Abdulkadyrov, St. Petersburg Clinical Research Institute of Hematology and Transfusiology, St.Petersburg, Russia Boris Afanasiev, St Petersburg Pavlov State Medical University, St Petersburg, Russia Alvaro Aguayo-Gonzalez, Instituto Nacional de Ciencias Medicas y Nutricion Salavador Zubiran, Delegación Tlalpan, Mexico Marc Andre, Clinique Notre Dame, Charleroi, Belgium David Belada, Fakultni Nemocnice Hradec Kralove, Hradec Kralove, Czech Republic Dina Ben-Yehuda, Hadassah Medical Centre, Jerusalem, Israel Raimundo Fernando Bezares, Hospital Interzonal General. De Agudos “Dr. Teodoro Alvarez”, Buenos Aires, Argentina Mikhail Y Biakhov, Semashko Central Clinical Hospital #2, Moscow, Russia Simon Bolam, Musgrove Park Hospital, Taunton, UK Zita Borbenyi, Szegedi Tudományegyetem, II. Belgyógyászati Klinika, Szeged, Hungary D Bron, ULB Erasme, Anderlecht, Belgium Rena Buckstein, Toronto Sunnybrook Regional Cancer Centre, Toronto, Canada Horia Bumbea, Spitalul Universitar de Urgenta Hematologie, Bucuresti, Romania Maria Dolores Caballero Barrigon, Hospital Universitario de Salamanca, Salamanca, Spain Luis T Campos, Oncology Consultants P.A., Houston, USA Maria Cantonetti, Azienda Ospedaliera Universitana Policlinico Tor Vergata, Roma, Italy Marcelo Eduardo Capra Zanella, Hospital Nossa Senhora da Conceicao, Porto Alegre, Brazil Neal P Christiansen, South Carolina Oncology Associates, P.A., Columbia, USA Graham. L Cohen, Mary Potter Oncology Center, Pretoria, South Africa Nicolae Dan Colita, Institutul Clinic Fundeni, Bucuresti, Romania Bertrand Coiffier, Hospices Civils de Lyon, Lyon, France Thomas M Cosgriff, Hematology & Oncology Specialists LLC, Metairie, USA Michael Crump, Princess Margaret Hospital, Toronto, Canada Dominic Culligan, Aberdeen Royal Infirmary, Aberdeen, UK Auro Del Giglio, Faculdade de Medicina do ABC Pesquisa Clinica – Oncologia, Sao Paulo, Brazil Robert A Dichmann, Central Coast Medical Oncology Corporation, Santa Maria, USA Hermann Dietzfelbinger, Onkologische Schwerpunktpraxis, Herrsching, Germany Raghunadharao Digumarti, Nizam's Insitute of Medical Sciences, Hyderabad, India Anna Dmoszynska, Klinika Hematoonlogii I Transplantologii Szpiku AM, Lublin, Poland Natalia Domnikova, Novosibirsk State Region Clinical Hospital, Novosibirsk, Russia Pavol Dubinsky, Východoslovenský Onkologický Ustav, a.s., Kosice, Slovak Republic Yurii A Dunaev, Arkhangelsk Region Clinical Hospital, Arkhangelsk, Russia Jose Easow, Apollo Speciality Hospital, Chennai, India Stephen F Eberwine, Investigative Clinical Research of Indiana, L.L.C., Indianapolis, USA Theofanis Economopoulos, University General Hospital ‘Attikon’, Athens, Greece Miklos Egyed, Kaposi Mór Oktatókórház, Általános Belgyógyászati és Hematológiai Osztály, Kaposvár, Hungary John Allan Ellerton, University Medical Center of Southern Nevada, Las Vegas, USA Hyeon Seok Eom, National Cancer Center, Gyeonggi Do, Korea Linda Farmer, East Alabama Medical Center, Opelika, USA Timothy Fenske, Froedtert Hospital/Medical College of Wisconsin, Milwaukee, USA Paul Fields, Guy's & St. Thomas’ Hospital, London, UK Georges Fillet. C.H.U. Sart Tilman, Liege, Belgium Richard Frank, Norwalk Hospital, Norwalk, USA Gulshat A Gaisarova, Republican Clinical Hospital of Bashkortostan, Ufa, Russia Bernardo Garicochea, Servico de Oncologia do Hospital Sao Lucas da PUC do Rio Grande do Sul, Porto Alegre, Brazil Zoltan Gasztonyi, Petz Aladár Megyei Kórház, II. Belgyógyászat, Győr, Hungary Israel Gavish, Haemek Medical Centre, Afula, Israel Emanuil Gheorghita, Spitalul clinic de urgenta, Brasov, Romania Oleg A Gladkov, Cheliabinsk Regional Oncology Dispensary, Cheliabinsk, Russia Viktor Goldberg, Tomsk Research Oncology Institute, Tomsk, Russia Anatoly K Golenkov, Moscow Region Clinical Research Institute, Moscow, Russia David Gomez-Almaguer, Hospital Universitario Dr. Jose Eleuterio Gonzalez UANL, Monterrey, Nuevo Leon, Mexico Eva Gonzalez-Barca, Hospital Duran i Reynals, Institut Catala d’Oncologia, Barcelona, Spain Zhongzhen Guan, Sun Yat-sen University Cancer Center, Guangzhou, China Sudeep Gupta, Tata Memorial Hospital, Mumbai, India Andrzej Hellmann, Klinika Hematologii Instytut Chorob Wewnetrznych AM w Gdansku, Gdansk, Poland Robert C Hermann, Northwest Georgia Oncology Center, P.C., Marietta, USA Xiaonan Hong, Cancer Hospital, Fudan University, Shanghai, China Tuomo Honkanen, Päijät-Hämeen keskussairaala, Lahti, Finland Eddie H Hu, Central Hematology Oncology Medical Group Inc., Alhambra, USA Xiaojun Huang, People's Hospital, Institute of Hematology, Peking University People’s Hospital, Beijing, China Jan Hudecek, Martinska FN Klinika hemaologie a Tranfuziologie, Martin, Slovak Republic Arpad Illes, Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, III. Belgyógyászati Klinika, Debrecen, Hungary Tanin Intragumtornchai, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand Wieslaw Wiktor Jedrzejczak, Klinika Hematologii AM, Warszawa, Poland 4 Lee-Ann Jones, East Cape Oncology Center, Port Elizabeth, South Africa Saengsuree Jootar, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Stephen P Kahanic, Siouxland Hematology/Oncology Associates, Sioux City, USA Evgeniy Karamanesht, Kiev Center of Marrow Transplantation, Kiev, Ukraine Xiaoyan Ke, Peking University Third Hospital, Beijing, China Nuriet K Khuageva, S.P. Botkin Moscow City Clinical Hospital, Moscow, Russia Won Seong Kim, Samsung Medical Center, Seoul, Korea Eva Kimby, Karolinska University Hospital, Stockholm, Sweden Vladimir Komisarenko, Krivoy Rog Oncology Dispensary, Krivoy Rog, Ukraine Tom Kouroukis, Juravinski Cancer Centre, Hamilton, Canada Kazimierz Kuliczkowski, Katedra i Klinika Hematologii Nowotworow Krwi i Transplantacji Szpiku, Wroclaw, Poland Ludmila Kuzina, Belgorod Regional Oncology Center, Belgorod, Russia Maryna Kyselyova, Crimean Republic Clinical Oncology Dispensary, Simferopol, Ukraine Valentin Labanca, Fundacion Centro Oncologico de Integracion Regional, Mendoza, Argentina Andrzej Lange, Dolnoslaskie Centrum Transplantacji Komorkowych z Karjowym Bankiem Dawcow, Wroclaw, Poland Steven Le Gouill, Hopital Hôtel-Dieu, Nantes, France Michael Leahy, Fremantle Hospital, Fremantle, Australia;, Itai Levi, Soroka Medical Centre, Beer-Sheva, Israel Anna Marina Liberati, Universita degli Studi di Perugia, Perugia, Italy Ola Linden, Department of Oncology, University Hospital, Lund, Sweden Ting Liu, West China Hospital of Sichuan University, Chengdu Sichuan, China Vladimir Lubennikov, Altay Regional Oncology Dispensary, Barnaul, Russia Jeanette Lundin, Karolinska University Hospital, Stockholm, Sweden Tamila Lysa, Zhitomir Gerbachevsky Regional Clinical Hospital, Zhitomir, Ukraine Irina B Lysenko, Rostov Research Institute of Oncology, Rostov-on-Don, Russia Iryna Lytvyn, Dnepropetrovsk Regional Oncology Dispensary, Dnepropetrovsk, Ukraine Anatoly Makhson, Clinical Oncology Hospital, Moscow, Russia Georgii M Manikhas, City Clinical Oncology Dispensary, St Petersburg, Russia Zvenyslava Masliak, Institute of Blood Pathology & Transfusion Medicine of AMS of Ukraine, Lviv, Ukraine Jiri Mayer, Fakultni nemocnice Brno Jihlavska, Brno, Czech Republic Rosemary E McIntyre, Ventura County Hematology-Oncology Specialists, Oxnard, USA Nadegda Medvedeva, St Petersburg City Hospital #31, St Petersburg, Russia Raul R Mena, East Valley Hematology/Oncology Medical Group, Burbank, USA Vladimir N Merkulov, Omsk Regional Oncology Dispensary, Omsk, Russia Rolf Mesters, Universitätsklinikum Münster Klinik fur Innere Medizin A, Münster, Germany Noel Milpied, Hôpital Haut Lévêque, Pessac, France Yoo-Hong Min, Severance Hospital, Seoul, Korea Mehdi M Moezi, Integrated Community Oncology Network / Division of Clinical Research, Jacksonville, USA Ann F Mohrbacher, USC/ Norris Comprehensive Cancer Center and Hospital, Los Angeles, USA Peter Mollee, Princess Alexandra Hospital, Woolloongabba, Australia David Morgan, The Vanderbilt Clinic, Nashville, USA Franck Morschhauser, Hopital Claude Huriez, Lille, France Alexander Mysanikov, Republikan Hospital named after V.A/ Baranov, Petrozavodsk, Russia Arnon Nagler, Sheba Medical Center, Tel Hashomer, Israel Sreejith Nair, Regional Cancer Centre, Kerela, India Ella Naparstek, Sourasky Tel Aviv Medical Center, Tel Aviv, Israel Weerasak Nawarawong, Maharaj Nakorn Chiang Mai Hospital, Chiang Mai University, Amphoe Muang, Thailand Stephen J Noga, Sinai Hospital of Baltimore, Baltimore, USA Fritz Offner, Universitair Ziekenhius Gent, Gent, Belgium Isabel Oliveira, Instituto Portugues de Oncologia do Porto Franscisco Gentil E.P.E., Porto, Portugal Craig Okada, Oregon Health & Science University, Portland, USA Albert Oriol Rocafiguera, Hospital Germans Trias i Pujol, Institut Catala d’Oncologia, Barcelona, Spain Evgenii Osmanov, Cancer Research Center, Moscow, Russia Ray D Page, The Center for Cancer and Blood Disorders, Fort Worth, USA Tomas Papajik, Fakultni nemocnice Olomouc, Olomouc, Czech Republic Ricardo Pasquini, Hospital de Clinicas da Universidade Federal do Parana, Parana, Brazil Moosa Patel, Chris Hani Baragwanth Hospital, Soweto, Johannesburg, South Africa Ravi Patel, Comprehensive Blood and Cancer Center, Bakersfield, USA Eduardo Jose de Alencar Paton, Fundacao Pio XII - Hospital do Cancer de Barretos, Barretos, Brazil Vyacheslav Pavlov, Medical Scientific Radiology Center, Obninsk, Russia Tatiana Pospelova, 2nd City Hospital, Novosibirsk, Russia S.V.S.S. Prasad, Apollo Hospitals, Hyderabad, Andhra Pradesh, India Halyna Pylypenko, Cherkassy Regional Oncology Dispensary, Cherkassy, Ukraine Joao Raposo, Hospital de Santa Maria E.P.E., Lisbao, Portugal Grigoriy Rekhtman, Khmelnitskiy Regional Hospital, Khmelnitskiy, Ukraine Silvia Vera Rivas, Instituto Nacional de Cancerologia Incan, Delegación Tlalpan, Mexico Tadeusz Robak, Klinika Hematologii UM, Lodz, Poland 5 Simon Rule, Derriford Hospital, Plymouth, UK Silvia Graciela Saba, Hospital Interzonal Grai. de Agudos Profesor Dr. Rodolfo Rossi, Buenos Aires, Argentina Gilles Salles, Centre Hospitalier Lyon Sud, Pierre Benite, France Marc A Saltzman, Innovative Medical Research of South Florida, Inc., Miami, USA Olga Samoilova, Nizhniy Novgorod Region Clinical Hospital, Nizhny Novgorod, Russia Brian Samuels, Kootenai Cancer Center, Post Falls, USA Shamel Sanani, North Valley Hematology/Oncology Medical Group, Mission Hills, USA Adriana Alves de Souza Scheliga, Instituto Nacional de Cancer, Rio de Janeiro, Brazil Catherine Sebban, Centre Leon Berard, Lyon, France Maria Silva da Gomes, Instituto Portugues de Oncologia de Lisboa Fransisco Gentil, E.P.E., Lisboa, Portugal Zhixiang Shen, RuiJin Hospital, Shanghai, China Yuankai Shi, Cancer Hospital (Institute), Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing, China Ofer Shpilberg, Rabin Medical Center, Petach Tikva, Israel Mordechai Shtalrid, Kaplan Medical Center, Rehovot, Israel Noppadol Siritanaratkul, Siriraj Hospital, Mahidol University, Bangkok, Thailand Aleksander Skotnicki, Klinika Hematologii CMUJ, Krakow, Poland Philippe Solal-Celigny, Clinique Victor Hugo, Le Mans, France Pierre Soubeyran, Institut Bergonie, Bordeaux, France Andrew Spencer, Alfred Hospital, East Melbourne, Australia Don Stevens, Norton Healthcare Pavilion, Louisville Oncology, Louisville, USA Cheolwon Suh, Asan Medical Center, Seoul, Korea Kazimierz Sulek, Wojskowy Instytut Medyczny, Warszawa, Poland Alexander Suvorov, 1st Republican Clinical Hospital of Udmurtia, Izhevsk, Russia Jeff Szer, Royal Melbourne Hospital, Parkville, Australia Adriana Teixeira, Hospitais da Universidade de Coimbra, Coimbra, Portugal Koen Theunissen, Virga Jesseziekenhuis, Hasselt, Belgium Luen To Bik, Royal Adelaide Hospital, Adelaide, Australia Elena Tothova, Fakultna nemocnica L.Pasteura Klinika hemaologie a onkohemaologie, Kosice, Slovak Republic Marek Trneny, Vseobecna fakultni nemocnice, Praha, Czech Republic Ann Van De Velde, Universitair Ziekenhuis – Antwerpen, Edegem, Belgium Achiel Van Hoof, A.Z. Sint Jan, Brugge, Belgium Steven Van Steenweghen, CHR La citadelle, Liège, Belgium Seppo Vanhatalo, Satakunnan keskussairaala, Pori, Finland Subhash Varma, Postgraduate Institute of Medical Education and Research, Chandigarh, India M. S. Vidyasagar, Kasturba Hospital, Kasturba Medical College, Karnataka, India Kateryna Vilchevskaya, Institute of Urgent and Recovery Surgery named after V.K. Gusak of AMS of Ukraine, Donetsk, Ukraine Umberto Vitolo, Azienda Ospedaliera Universitaria Molinette S Giovanni Battista, Torino, Italy Jan Walewski, Klinika Nowotworow Ukladu Chlonnego, Centrum Onkologii - Instytut im. M. Sklodowskiej-Curie, Warszawa, Poland Huaqing Wang, Tianjin Medical University Cancer Hospital, Tianjin, China Krzysztof Warzocha, Instytut Hematologii I Transfuzjologii, Warszawa, Poland Alexander Wild, F.N. F.D.Roosevelta – Oddelenie, Banska Bystrica, Slovak Republic Pierre Zachee, AZ Stuivenberg, Antwerpen, Belgium Maria Aparecida Zanichelli, Hospital Brigadeiro, Sao Paulo, Brazil Weijing Zhang, Affiliated Hospital of the Academy of Military Medical Sciences, Beijing, China Jun Zhu, Beijing Cancer Hospital, Beijing, China Pier Luigi Zinzani, Azienda Ospedaliero Universitaria di Bologna Policlinico S.Orsola Malpighi, Istituto di Ematologica ed Oncologia Medica “L .& .A. Seragnoli”, Bologna, Italy Lucia Adriana Zoppegno, Hospital Interzonal General de Agudos, Buenos Aires, Argentina Nicholas Zoumbos, University Hospital of Patras, Rio-Patras, Greece 6
© Copyright 2024 ExpyDoc
