H. PYLORI ERADICATION TREATMENT REGIMENS

H. PYLORI ERADICATION TREATMENT REGIMENS
Acid Suppressant Dose
Antibiotics Dose
Treatment Duration
Proton Pump Inhibitor (PPI) BASED REGIMENS
Aciphex (rabeprazole) 20mg twice daily
Nexium (esomeprazole) 40mg once daily
amoxicillin 1000mg and clarithromycin
500mg; both twice daily
Prevacid (lansoprazole) 30mg twice daily
Prilosec (omeprazole) 20mg twice daily
Prevacid (lansoprazole) 30mg twice daily
amoxicillin 1000mg three times daily
Prilosec (omeprazole) 40mg once daily in AM clarithromycin 500mg three times daily
One of the PPIs mentioned above*
One of the PPIs mentioned above*
7 days with AM and PM meals
10 days
10 or 14 days
10 days. If ulcer present at start, may
continue omeprazole 20mg once
daily in AM on Days 11–28.
14 days
14 days. If ulcer present at start,
may continue omeprazole 20mg
once daily on Days 15–28.
10–14 days
metronidazole 500mg and clarithromycin
500mg; both twice daily
bismuth 525mg, metronidazole 250mg and 10–14 days
tetracycline 500mg; all four times daily
H2 Receptor Antagonist Based REGIMENS*
nizatidine 300mg daily at bedtime
Pepcid (famotidine) 40mg daily at bedtime
Tagamet (cimetidine) 800mg daily at bedtime
Zantac (ranitidine) 300mg daily at bedtime
bismuth 525mg, metronidazole 250mg and Take with 2 antibiotics for 2wks;
tetracycline 500mg; all four times daily
may take H2 receptor antagonist
for total of 4–8wks.
COMBINATION PRODUCTS
Prevpac (lansoprazole 30mg [2 caps], amoxicillin 500mg [4 caps], and clarithromycin
500mg [2 tabs] per pack). Take lansoprazole 30mg, amoxicillin 1000mg, and clarithromycin
500mg twice daily.
Prilosec (omeprazole) 20mg twice daily
Pylera (bismuth subcitrate 140mg,
metronidazole 125mg, and tetracycline
125mg in 1 cap). Take 3 caps 4 times daily.
10 or 14 days
Omeprazole sold separately. Take
with full glass of water after meals
for 10 days.
NOTES
*Not FDA-approved treatment regimens; regimens and doses are not necessarily those recommended in product labeling. Please refer to
the H. Pylori treatment guidelines.
For all other FDA-approved regimens, see drug monographs at www.eMPR.com or contact company for full drug labeling.
REFERENCES
Chey WD, Wong BCY, et al. Management of Helicobacter pylori infection. Am J Gastroenterol 2007;102:1808–1825.
Ables AZ, Simon I, Melton ER. Update on Helicobacter Pylori Treatment. Am Fam Physician 2007;72:351–8.
(Created 8/2014)

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