Mouse Models

Mouse Models
Mouse Models
With more than 100 strains of mouse models, SCANBUR Research and Charles River are
positioned to provide you with the mouse models you require to meet your programme goals.
Our global network of production facilities ensure that you have consistent access to these
models, regardless of location. Contact us with your enquiry, please refer to page 6.
2014 | www.scanburresearch.com
Mouse Models
Outbred
Common Name
CD-1® IGS
Nomenclature
Crl:CD1(ICR)
Page
21
MF1
Crl:MF1
21
NMRI
Crl:NMRI(Han)
22
OF1
Crl:OF1
22
SKH1 Hairless
Crl:SKH1-Hrhr
23
Black Swiss
Crl:NIHBL(SW)
23
Inbred
Mouse Models
Common Name
129
Nomenclature
129S2/SvPasCrl
Page
26
BALB/cJ*
BALB/cJ
26
BALB/cByJ*
BALB/cByJ
27
BALB/cN
BALB/cAnNCrl
27
C3H/HeOuJ*
C3H/HeOuJ
28
Disease and Translational Mice
Metabolic, Renal and Cardiovascular
Models
Common Name
Nomenclature
C57BL/6NCrlTHE POUND MOUSE™
Leprdb-lb/Crl
ob/ob mice*
B6.Cg-Lepob/J
BKS.Cg-Dock7m+/+
db/db mice*
Leprdb/J
B6.129P2ApoE mice*
Apoetm1Unc/J
NOD*
NOD/ShiLtJ
Cryopreserved Models
Common Name
Ly5.1
C3H/N
C3H/HeNCrl
28
C57BL/6J
29
BL/6N
C57BL/6NCrl
29
CBA/CA
CBA/CA/Sca
30
DBA/1J*
CBA/Ca
CBA/CaCrl
30
Cryopreserved Model
CBA/J*
CBA/J
30
DBA/1J*
DBA/1J
31
DBA/2J*
DBA/2J
31
DBA/2NCrl
DBA/2NCrl
31
FVB
FVB/Ncrl
32
SJL*
SJL/J
C57BL/6N-Tyrc-Brd/
BrdCrCrl
32
32
Common Name
B6CBAF1/J*
Nomenclature
B6CBAF1/J
OT I
OT II
Page
33
B6C3F1/Crl
B6C3F1/Crl
33
B6D2F1/NCrl
B6D2F1/NCrl
33
B6D2F1/J*
B6D2F1/J
34
CB6F1/Crl
CB6F1/Crl
34
CD2F1/Crl
CD2F1/Crl
34
NMRCF1
NMRCF1/Crl
34
35
35
36
36
36
Nomenclature
B6.SJL-Ptprca Pepcb/
BoyCrl
C57BL/6-Tg(TcraTcrb)
1100Mjb/Crl
C57BL/6-Tg(TcraTcrb)
425Cbn/Crl
DBA/1J
Page
37
37
37
37
38
Oncology Models
Common Name
P110 Ludwig
NOD scid gamma
(NSG)*
Nomenclature
NOD.Cg-Prkdcscid
Il2rgtm1Wjl/SzJ
Page
38
38
Central Nervous System
Common Name
PGP
Hybrid
35
Inflammation and Immunology Models
BL/6J*
B6 Albino
Page
Cryopreserved Model
* JAX™ Mice strains.
2014 | www.scanburresearch.com
Nomenclature
Crl:CF1-Abcb1amds
Page
38
38
B R E E D I N G S I T E S
Ger
Male
Weight in Grams
Price - €
10-12
3,49
12-14
3,61
14-16
3,91
16-18
4,20
18-20
4,42
20-22
4,78
22-24
5,00
> 24 g / (per 2 g)
Enquire
Retired breeder
Enquire
Time mated females
Female with litter (males and females)
Pregnant
UK
Fra
Ita
Jap
USA
feMale
Price - €
3,49
3,61
3,91
4,20
4,42
4,78
5,00
Enquire
Enquire
Enquire
Enquire
Enquire
50
40
Crl:MF1
Male
Weight in Grams
Price - €
10-12
4,64
13-15
4,85
16-18
4,95
19-21
5,12
22-24
5,22
25-27
5,29
28-30
5,39
31-33
5,55
34-36
5,73
Add per 3 g
0,89
Untimed pregnant
Female with litter
Proven breeder
13,89
Ex-breeder
4,31
20
10
Origin The original group of Swiss mice that served as progenitors of this stock consisted of two male and seven
female albino mice derived from a non-inbred stock in the laboratory of Dr. de Coulon, Centre Anticancereux
Romand, Lausanne, Switzerland. These animals were imported into the United States by Dr. Clara Lynch of the
Rockefeller Institute in 1926. The Hauschka Ha/ICR stock was initiated in 1948 at the Institute for Cancer Research
in Philadelphia from “Swiss” mice of Rockefeller origin. To Dr. Edward Mirand of Roswell Park Memorial Institute
where they were designated as HaM/ICR. To Charles River in 1959 and hysterectomy rederived that same year.
Production colonies are developed from the Foundation Colony and managed according to the Charles River
International Genetic Standard breeding system. Coat Color Albino.
MF1 Mice
30
0
4
6
8
10
age in weeks
B R E E D I N G S I T E S
Ger
UK
Fra
Ita
Jap
USA
feMale
Price - €
4,64
4,85
4,95
5,12
5,22
5,29
5,39
5,55
5,73
0,89
35,35
50,16
13,89
4,31
weight in grams
Crl:CD1(ICR)
weight in grams
CD-1® IGS (International Genetic Standard) Mice
age in weeks
Origin These albino mice, which were originally developed at Olac prior to 1970, came from a cross between the
Laboratory Animal Centre A-strain mice (‘LACA’ - but formerly called CFW) and the CS1 from Scientific Products
Farm (acquired by Charles River). The stock was rederived by Charles River in 2004 and subsequently transferred to
Charles River UK in April 2005. Coat Color Albino.
www.scanburresearch.com
Outbred Mice
21
NMRI Mice
B R E E D I N G S I T E S
Ger
Crl:NMRI(Han)
weight in grams
Male
Weight in Grams
Price - €
10-12
3,79
12-14
4,07
14-16
4,33
16-18
4,62
18-20
4,89
20-22
5,39
22-24
5,63
> 24 g / (per 2 g)
Enquire
Retired breeder
Time mated females
Female with litter (males and females)
Pregnant
OF1 Mice
Male
50
weight in grams
40
30
20
10
8
Jap
USA
B R E E D I N G S I T E S
Weight in Grams
Price - €
50
10-12
3,28
12-14 3,53
14-16
3,61
40
16-18
3,82
18-20
4,07
20-22
4,31
30
22-24
4,70
> 24 g / (per 2 g)
Enquire
Retired breeder
•
20
Time mated females
Female with litter (males and females)
Pregnant females
10
6
Ita
feMale
Price - €
3,79
4,07
4,33
4,62
4,89
5,39
5,63
Enquire
Enquire
Enquire
Enquire
Enquire
Ger
Crl:OF1
4
Fra
Origin Swiss-type mouse, which Clara Lynch gave to Poiley in 1937. He maintained an inbred line of this animal
until the 51st generation, before he transferred it to the Naval Medical Research Institute. Introduced into Charles
River in 1979 from the Central Institute for Laboratory Animal Breeding - Hannover (Germany). Coat Color Albino.
age in weeks
0
UK
10
UK
Fra
Ita
Jap
USA
feMale
MAL2
MAL1
FEM2
FEM1
Price - €
3,28
3,53
3,61
3,82
4,07
4,31
4,70
Enquire
3,05
35,23
58,95
40,11
Origin In 1935,Carworth Farms began to select a line of vigorous and productive mice. Progenitors originating
from a colony bred in Missouri were
bought and the strain was named CF1 (Carworth Farms strain 1). This strain
0
8 the name
10 OF1 (Oncins France 1). Coat Color Albino.
was introduced at Charles River France in41967, and6 it acquired
age in weeks
22
Outbred Mice
www.criver.com
SKH1 Hairless Mice
B R E E D I N G S I T E S
Age in Weeks
4
5
6
7
8
Additional week
Male
Price - €
32,46
34,50
36,76
-
-
2,48
UK
Fra
Ita
Jap
USA
feMale
Price - €
32,46
34,50
36,76
40,22
43,68
2,48
Origin An uncharacterised / non-pedigreed hairless strain of mice was acquired by Temple University from a small
commercial supplier in New York City. To Charles River from the Skin and Cancer Hospital, Temple University in
1986. The mouse is euthymic and immunocompetent. Coat Color Hairless, albino.
SKH3 (Crl:SKH3(SKH2)-Hrhr) MICE ALSO AVAILABLE ON REQUEST: CONSULT US.
Additional Models
weight in grams
Ger
Crl:SKH1-Hrhr

age in weeks
• Black Swiss
Nomenclature Crl:NIHBL(SW)
Limited availability, upon reservation from Charles River USA.
www.scanburresearch.com
Outbred Mice
23
JAX™ Mice and Research Services Provided Through
SCANBUR Research and Charles River
The Jackson Laboratory and Charles River, Inc. have a cooperative agreement to provide local supplies
of JAX™ Mice to biomedical researchers in many European and Asian countries.
SCANBUR Research serves as Charles River’s exclusive, authorised,
commercial subdistributor of JAX™ Mice strains in the countries
listed below.
Under these conditions, JAX™ Mice strains bred by Charles River are:
• Denmark
• Sweden
• Norway
• The Baltic States
• Provide the genetic integrity and stable phenotypes needed to
support research excellence.
JAX™ Mice are The Gold Standard for
Biomedical Research
“J” Substrains Differ from Authentic
JAX™ Mice Strains due to Genetic Drift
Used by researchers around the world, JAX™ Mice are the most
frequently cited strains in biomedical research publications and are
supported by world-renowned scientific and technical staff. JAX™
Mice are produced according to the highest standards of animal
health and genetic quality. Charles River provides researchers in
Europe and Asia, and SCANBUR Research provides researchers in
Northern Europe, with expedited access to over 6,000 JAX™ Mice
strains and hundreds of new mouse models each year. JAX™ Mice
strains include commonly used inbred strains as well as thousands
of specialised disease models and genetically engineered strains.
Over the years, organisations around the world have been
maintaining colonies of mouse substrains with JAX™ Mice ancestry
(“J” substrains). These ”J” substrains differ from JAX™ Mice strains
due to the genetic mutations which spontaneously occur and
accumulate in mouse breeding colonies over time.
• Finland
JAX™ Mice are The Most Published,
Best Characterised Mouse Models
JAX™ Mice have been referenced in more than 30,000 peer reviewed
publications. Over 11,000 PubMed references cite use of the authentic
JAX™ Mice B6 strain (C57BL/6J, stock number 000664). The JAX™ Mice
B6 strain, along with many other JAX™ Mice inbred strains have been
fully sequenced as part of the Mouse Genome Project (see: www.
sanger.ac.uk/resources/mouse/genomes). The genome sequence
data of JAX™ Mice strains will remain relevant over time due
to the rigorous genetic quality programs (including the JAX™
patented Genetic Stability Program) used to breed JAX™ Mice
Strains. Additional genetic and phenotypic information about
JAX™ Mice is publicly available in data resources hosted by The
Jackson Laboratory, including Mouse Genome Informatics (www.
informatics.jax.org/) and The Mouse Phenome Database (www.jax.
org/phenome).
• Equivalent in genetic quality to those bred by The Jackson
Laboratory
Due to naturally occurring genetic drift, a mouse strain will diverge
into a genetically distinct substrain if its breeding colony is separated
from the parental breeding colony for more than 20 generations
of breeding (i.e., 10 generations in the parent colony plus the 10
that simultaneously pass in the sub-colony*). This divergence
can occur within only a few years. Genetic differences between a
parental strain and a substrain accumulate with time and at a rate
dependent upon the level of quality control at the facilities housing
and breeding the mice. These genetic differences often result in
phenotype differences between a parental strain and a substrain.
Such differences confound interpretation of experimental results
especially when comparing results to published research using
JAX™ Mice strains.
IMPORTANT NOTE: JAX™ Mice strains bred by Charles River are
authentic JAX™ Mice and are NOT genetically drifted “J” substrains.
* For more information on mouse nomenclature and substrain divergence, see
http://www.informatics.jax.org/mgihome/nomen/strains.shtml#substrains.
Only JAX™ Mice Strains bred by
Charles River in Europe and Japan are
equivalent in genetic quality to those
bred by The Jackson Laboratory.
Charles River in Europe and
Japan breed JAX™ Mice in strict
adherence to The Jackson
Laboratory’s breeding protocols
and genetic quality control guidelines. These protocols provide the
following benefits:
• Minimise naturally occurring genetic drift by systematically reinfusing breeding colonies with pedigreed mice from The Jackson
Laboratory.
• Assure genetic quality through routine use of state-of-the-art
genetic quality monitoring methods such as SNP analysis.
J™ and JAX™ are a trademarks of The Jackson Laboratory registered in the United States. All rights reserved.
24
The Jackson Laboratory
www.criver.com
Patented Genetic Stability
Program
Research Services Using JAX™ Mice
The JAX™ patented Genetic Stability Program (GSP) effectively
prevents cumulative genetic drift, including that caused by copy
number variation, in the most popular strains of JAX™ Mice.
The GSP program effectively limits cumulative genetic drift by
refreshing The Jackson Laboratory’s foundation stocks with
cryopreserved pedigree embryos or gametes approximately every
five generations (Figure 1). The program was initiated in 2003 (Taft
et al. 2006) and is covered by 2010 US Patent 7,592,501 and 2012 US
patent 8,110,721.
Charles River breeding facilities located in Europe and Japan also
serve as The Jackson Laboratory’s exclusive commercial providers
of research services using JAX™ Mice bred by Charles River. Services
offered include:
• Biospecimen provision
• Cross-breeding
• Custom breeding
• Dedicated supply
• DIO (Diet Induced Obesity) studies
• Health monitoring
ock
n St
tio
da
Jackson Lab
The
ora
to
ry
Fo
un
Frozen embryos used to
refresh foundation stock
every five generations
• Recovery of cryopreserved embryos
rles
Cha
eding sites
ean bre
Europ
iR ver
Expansion & Distribution
Ja c k
son
CryopCryopreserved
reserved
stocks
Stocks
Labo
rator
y p ro
d u c tion
co l o n i e s
Figure 1: Foundation stocks of several broadly-used JAX™ Mice strains
are refreshed with cryo-recovered stocks every five generations.
The Jackson Laboratory’s unique, patented GSP has several
components: 1) an extensive supply of cryopreserved stock for each
strain; 2) isolated foundation colonies, maintained by inbreeding
for only five generations before refreshing with cryo-recovered
stock; 3) large, independent expansion and production colonies
fed directly from pedigreed colonies for distribution through The
Jackson Laboratory and through Charles River in Europe and Japan.
Importantly, the generations between the cryopreserved stocks and
mice produced for distribution are kept to a minimum to prevent
the accumulation of mutations that result in genetic drift (see:http://
www.jax.org/jaxmice/genetichealth/stability.html).
* The Jackson Laboratory’s innovative Genetic Stability Program is covered by 2010
US Patent 7,592,501 and 2012 US patent 8,110,721.
Importance of Indicating Strain
Lineage and History using Proper
Strain Nomenclature
Proper mouse strain nomenclature, as established by the
International Committee on Standardised Genetic Nomenclature
for Mice, provides researchers with essential information about the
lineage and history of inter-laboratory transfers of substrains over
time.
• Surgeries
Benefits to Researchers in Europe and
Asia
The relationship between The Jackson Laboratory and Charles
River provides researchers with the convenience of working with
Charles River’s numerous international sales offices, in their own
time zones and in their native languages when ordering and
importing JAX™ Mice strains. Through this cooperative agreement,
the worldwide research community has more convenient access to
JAX™ Mice and benefits from the expertise of both organisations.
Importing JAX™ Mice strains
Please contact us to request a JAX™ Mice order form. We are also
pleased to assist customers with their search for a specific JAX™ Mice
strain. Once you select a JAX™ Mice strain of interest, we can furnish
you with an import price quotation, including details of availability.
SCANBUR Research will take care of all import steps on your behalf.
SCANBUR Research/Charles River will not be responsible for any
damages arising during the import process whilst the mice are in
the care of non-Charles River transport companies, e.g. airlines.
For Technical Support
Contact your local Customer Service (see page 6).
Educational Information on Mouse
Genetics and Strain Nomenclature
Handbook on Genetically Standardized Mice
See: http://jaxmice.jax.org/literature/handbook.html
Using proper strain nomenclature requires including in the strain
name all Laboratory Codes (i.e., a unique 2-4 letter code assigned
to each investigator or institution) as a means to identify all
investigators or institutions which have maintained a strain or
substrain.
JAX Mice Genetic Quality Control Programme.
See: http://www.jax.org/jaxmice/genetichealth/GQCprogram
For a complete list of Laboratory Codes, see:
Interactive Tutorial on Mouse Strain Nomenclature.See:
http://www.jax.org/jaxmice/nomenclature
http://dels-old.nas.edu/ilar_n/ilarhome/search_lc.php
JAX Mice Genetic Stability Program.
See: http://www.jax.org/jaxmice/genetichealth/stability
Published Reference: Taft RA, Davisson M, Wiles MV. 2006 Know Thy
Mouse. Trends Genet 22:649-53.
www.scanburresearch.com
The Jackson Laboratory
25
129 Mice
B R E E D I N G S I T E S
Ger
129S2/SvPasCrl
Age in Weeks 50
3 MAL2
4
5
MAL1
40
6
7 FEM2
30
8
50
weight in grams
40
30
Male
Price - €
32,59
35,14
37,59
40,10
42,88
45,67
UK
Fra
Ita
Jap
USA
feMale
Price - €
32,59
35,14
37,59
40,10
42,88
45,67
FEM1
20
10
0
4
6
8
age in weeks
10
Origin The 129/Sv inbred strain genotype C-P (wild-type alleles at the “albino” and “pink-eyed dilution” loci) was
established
by Dr LC Stevens from The Jackson Laboratory. Because of his interest in testicular teratomas which
20
are extremely frequent in the 129 inbred strain, he investigated the effect of certain mouse mutations, which
affect the male germ line, on the frequency of these tumors. One of these mutations was “steel” (SI) which, at the
heterozygous state, is responsible for a dilution of the coat color and a depigmentation of the tail tip. The original
10
129 inbred
strain is homozygous for the two recessive mutations “chinchilla” (Tyrc-ch) and “pink-eyed dilution”
(p). Its coat color is cream. In order to distinguish the effect of the “steel” mutation on the coat color, Dr Stevens
introduced by repeated backcrosses the wild-type alleles at the “albino” and “pink-eyed dilution” loci from the
C3H/He inbred strain.This is the reason why the 129/Sv inbred strain, unlike other 129 strains, has an agouti
0
coat color. Testicular
4
6 teratomas
8
10 have an incidence of approximately 1% as this strain does not carry the Dnd1Ter
mutation. In the seventies, Dr Stevens introduced the 129/Sv strain to the institut Pasteur in the Laboratory of Dr JL
Guenet, where it has been maintained for over 20 years, Charles River France acquired this strain in August 1996.
The strain was renamed 129S2 in 1999 after the revision of the international nomenclature. Coat Color Agouti.
JAX™ Mice Strain : BALB/cJ
BALB/cJ Age in Days
21-27
28-34
35-41
42-48
Additional Week
Male
Price - €
11,01
13,04
14,05
15,64
2,43
B R E E D I N G S I T E S
Ger
UK
Fra
Ita
Jap
USA
feMale
Price - €
11,01
13,04
14,05
15,64
2,43
Origin: The breeding colony for this strain is derived from and systematically reinfused with pedigreed JAX™ Mice
stock obtained from The Jackson Laboratory. Charles River adheres to The Jackson Laboratory’s breeding protocols
and genetic quality program to maintain this breeding colony. Mice from this colony are genetically equivalent to
those bred by The Jackson Laboratory and are considered authentic JAX™ Mice strains which are designated with
a ‘J’ as the final letter in the strain nomenclature. JAX™ Mice Strains are for internal research use only and should
not be propagated for distribution or sale. Coat Color: White (albino).
JAX™ Mice Stock Number: 000651 Strain Characteristics: For comprehensive strain information, see the strain data
sheet at askforthej.org/jaxmice/000651. For physiological strain data, see Mouse Phenome Database at askforthej.org/
mpd/000651.
J™ and JAX™ are a trademarks of The Jackson Laboratory registered in the United States. All rights reserved.
26
Inbred Mice
www.criver.com
BALB/cByJ
B R E E D I N G S I T E S
Ger
Male
Age in Weeks
Price - €
3
13,54
4
13,79
5
15,08
6
16,27
7
18,51
8
20,77
Additional week (up to 12 weeks)
2,47
Retired breeder
Time mated females
Female with litter
Pregnant
UK
Fra
Ita
Jap
USA
feMale
Price - €
13,54
13,79
15,08
16,27
18,51
20,77
2,47
11,49
Enquire
Enquire
Enquire
50
40
weight in grams
JAX™ Mice Strain: BALB/cByJ
30
20
10
Origin: The breeding colony for this strain is derived from and systematically reinfused with pedigreed JAX™ Mice
stock obtained from The Jackson Laboratory. Charles River adheres to The Jackson Laboratory’s breeding protocols
and genetic quality program to maintain this breeding colony. Mice from this colony are genetically equivalent to
those bred by The Jackson Laboratory and are considered authentic JAX™ Mice strains which are designated with
a ‘J’ as the final letter in the strain nomenclature. JAX™ Mice Strains are for internal research use only and should
not be propagated for distribution or sale. Coat Color: Albino.
JAX™ Mice Stock Number: 001026 Strain Characteristics: For comprehensive strain information, see the strain data
sheet at askforthej.org/jaxmice/001026. For physiological strain data, see Mouse Phenome Database at askforthej.org/
mpd/001026.
0
4
6
8
10
12
age in weeks
Data derived from Charles River weight studies
The Jackson Laboratory’s Genetic Stability Program is covered by 2010 US Patent 7,592,501 and 2012 US patent 8,110,721.
BALB/cAnNCrl
Male
Age in Weeks
Price - €
3
11,73
4
12,32
5
13,20
6
14,67
7
15,67
8
16,98
Additional week
2,18
Retired breeder
Time mated females
Female with litter (males and females)
Pregnant
B R E E D I N G S I T E S
Ger
UK
Fra
Ita
Jap
USA
feMale
Price - €
11,73
12,32
13,20
14,67
15,67
16,98
2,18
Enquire
Enquire
Enquire
Enquire
Origin H.J Bagg developed the “Bagg albino” in 1913 using stock from an Ohio pet dealer. Inbred in 1923 by
McDowell. To Snell in 1932 at F26, to Andervont in 1935. To NIH at F72 in 1951. To Charles River USA from NIH
in 1974. Caesarian derived in 1975. This strain has been very widely used for in vivo production of monoclonal
antibodies by the ascites method because of its haplotype with many hybridoma cell lines (BALB/c mouse
melanoma [NS1] fusion products). This mouse is also used frequently for db immunisation and B-cell collection.
Low incidence of mammary tumors (10-20%). Arteriosclerosis common in both sexes. Male aggression is frequently
overestimated. Haplotype H-2d. Coat Color Albino.
weight in grams
BALB/cAnNCrl Mice
age in weeks
J™ and JAX™ are a trademarks of The Jackson Laboratory registered in the United States. All rights reserved.
www.scanburresearch.com
Inbred Mice
27
JAX™ Mice Strain: C3H/HeOuJ
C3H/HeOuJ
weight in grams
Age in Weeks
3
4
5
6
7
8
Additional week
Retired breeder
age in weeks
B R E E D I N G S I T E S
Ger
Male
Price - €
15,67
17,20
18,12
20,00
21,89
23,79
2,47
Enquire
UK
Fra
Ita
Jap
USA
feMale
Price - €
15,67
17,20
18,12
20,00
21,89
23,79
2,47
Enquire
Origin: The breeding colony for this strain is derived from and systematically reinfused with pedigreed JAX™ Mice
stock obtained from The Jackson Laboratory. Charles River adheres to The Jackson Laboratory’s breeding protocols
and genetic quality program to maintain this breeding colony. Mice from this colony are genetically equivalent to
those bred by The Jackson Laboratory and are considered authentic JAX™ Mice strains which are designated with
a ‘J’ as the final letter in the strain nomenclature. JAX™ Mice Strains are for internal research use only and should
not be propagated for distribution or sale. Coat Color: Agouti.
JAX™ Mice Stock Number: 000635 Strain Characteristics: For comprehensive strain information, see the strain data
sheet at askforthej.org/jaxmice/000635. For physiological strain data, see Mouse Phenome Database at askforthej.org/
mpd/000635.
Data derived from Charles River weight studies
C3H/HeNCrl Mice
C3H/HeNCrl
weight in grams
Male
Age in Weeks
Price - €
3
14,21
4
15,20
5
16,24
6
17,64
7
20,13
8
21,79
Additional week
2,44
Retired breeder
15,12
Female with litter (males and females)
age in weeks
B R E E D I N G S I T E S
Ger
UK
Fra
Ita
Jap
USA
feMale
Price - €
14,21
15,20
16,24
17,64
20,13
21,79
2,44
15,12
Enquire
Origin From a cross of a Bagg albino female and a DBA male by Strong in 1920. A litter of 4 females and 2 males
sent to Andervont in 1930; then to Heston at F35. To NIH in 1951 from Heston at F57. To Charles River USA from
NIH in 1974. Caesarian derived in 1975. 85% hepatomas at 14 months. This is an MMTV negative strain and hence
does not show high incidence of mammary tumours. Resistant to Leishmania infection. High complement activity.
Retinal degeneration allele (Pde6b, formely known as rd) is carried on chromosome 5. Mated females are highly
susceptible (89%) to cardiac calcinosis. Haplotype H-2k. Coat Color Agouti.
J™ and JAX™ are a trademarks of The Jackson Laboratory registered in the United States. All rights reserved.
28
Inbred Mice
www.criver.com
JAX™ Mice Strain: C57BL/6J
C57BL/6J
feMale
Price - €
13,80
14,82
16,40
17,76
19,31
21,63
2,59
12,56
Enquire
Enquire
Enquire
50
40
weight in grams
Male
Age in Weeks
Price - €
3
13,80
4
14,82
5
16,40
6
17,76
7
19,31
8
21,63
Additional week (up to 12 weeks)
2,59
Retired breeder
12,56
Time mated females
Female with litter (males and females)
Pregnant
30
20
10
Origin: The breeding colony for this strain is derived from and systematically reinfused with pedigreed JAX™ Mice
stock obtained from The Jackson Laboratory. Charles River adheres to The Jackson Laboratory’s breeding protocols
and genetic quality program to maintain this breeding colony. Mice from this colony are genetically equivalent to
those bred by The Jackson Laboratory and are considered authentic JAX™ Mice strains which are designated with
a ‘J’ as the final letter in the strain nomenclature. JAX™ Mice Strains are for internal research use only and should
not be propagated for distribution or sale. Coat Color: Black.
JAX™ Mice Stock Number: 000664 Strain Characteristics: For comprehensive strain information, see the strain data
sheet at askforthej.org/jaxmice/000664. For physiological strain data, see Mouse Phenome Database at askforthej.org/
mpd/000664.
0
4
6
8
10
12
14
age in weeks
Data derived from Charles River weight studies
The Jackson Laboratory’s Genetic Stability Program is covered by 2010 US Patent 7,592,501 and 2012 US patent 8,110,721.
C57BL/6NCrl
Male
Age in Weeks
Price - €
3
11,92
4
13,04
5
14,31
6
15,26
7
16,16
8
18,36
Additional week (up to 12 weeks)
2,42
Retired breeder
14,11
Time mated females
Female with litter (males and females)
Pregnant
B R E E D I N G S I T E S
Ger
UK
Fra
Ita
Jap
USA
feMale
Price - €
11,92
13,04
14,31
15,26
16,16
18,36
2,42
14,11
Enquire
Enquire
Enquire
Origin Developed by C.C. Little in 1921, from a mating of Miss Abby Lathrop’s stock that also gave rise to strains
C57BR and C57L. To The Jackson Laboratory in 1948 from Hall. To NIH in 1951 from The Jackson Laboratory at F32.
To Charles River in 1974 from NIH. Hysterectomy rederived in 1975. Haplotype H-2b. Coat Color Black.
weight in grams
C57BL/6NCrl Mice
age in weeks
J™ and JAX™ are a trademarks of The Jackson Laboratory registered in the United States. All rights reserved.
www.scanburresearch.com
Inbred Mice
29
CBA Mice
B R E E D I N G S I T E S
Ger
CBA/CaCrl
60
M EAN W EIG HT +/-1 STANDARD DEVIATIO N
55
FO R G UIDANCE O NLY
50
W Eweight
IG H T in
IN grams
G RAM S
45
40
35
30
M ALE
25
20
15
FEM ALE
10
5
3
4
5
6
7
8
9
A Gage
E IN
W EEKS
in weeks
10
Male
Age in Days
Price - €
Up to 21
11,53
21-27
12,70
28-34
13,77
35-41
14,97
42-48
17,18
49-55
18,32
56-62
20,69
Additional week
2,27
Retired breeder
Enquire
Littermates 21 days old
12,75
Non-Littermates 21 days old
12,75
Lactating mouse with litter
Time mated (over 14 day gestation)
Untimed pregnant
Insert microchip
13,06
UK
Fra
Ita
Jap
USA
feMale
Price - €
11,53
12,70
13,77
14,97
17,18
18,32
20,69
2,27
13,54
12,75
12,75
104,76
Enquire
79,43
13,06
Origin From a cross of a Bagg albino female and a DBA male by Strong in 1920. The CBA strain was selected for a
low mammary tumour incidence. Transferred via The Jackson Laboratory to Haldane and Gruneberg in 1932 To
Carter (CBA/Ca) in 1947. The CBA/Ca is the substrain most commonly used in British research. VAF Plus breed stock
to Charles River UK from Glaxo in 1992. Absence of lower third molars in about 18%, few skeletal variants, some
mammary tumours in breeders. Do not develop antinuclear antibodies or LE cells with aging. Histocompatibility
H-1a, H-2k, H-3. Coat Color Agouti.
CBA Mice
CBA/CA/Sca
MEANWEIGHT
MALE & FEMALE
WEIGHT CURVE
weight in grams
30

25
20


15
10
5

0
3
4
5
6
7
8
9
10
age in weeks
Age in Weeks
3
4
5
6
7
8
9
10
Time-mated
Untimed pregnancy
Lactating female with litter
C O U N T R Y O R I G I N
Ger
UK
Fra
Ita
Jap
USA
MalefeMale
Price - €
Price - €
7,76
7,76
8,42
8,42
10,73
10,73
Please contact Customer Service for prices:
11,99
11,99
13,09
13,09
14,22
tel: 14,22
+46 8 594 767 80 email: [email protected]
15,83
15,83
16,88
16,88
tel: +47 6706 2920
email: [email protected]
tel: +358 40 583 2999
email: [email protected]
Origin Developed in America in 1920, Bagg mouse, is a cross between an unknown female albino and a male
DBA. SCANBUR obtained this strain from ICI in 1978. Coat color Agouti.
JAX™ Mice Strain: CBA/J
CBA/J
weight in grams
Age in Weeks
3
4
5
6
7
8
Additional week (up to 12 weeks)
Retired breeder
age in weeks
Data derived from Charles River weight studies
Male
Price
- €
15,86
17,12
19,77
22,44
25,07
27,77
2,30
13,59
B R E E D I N G S I T E S
Ger
UK
Fra
Ita
Jap
USA
feMale
Price - €
15,86
17,12
19,77
22,44
25,07
27,77
2,30
13,59
Origin: The breeding colony for this strain is derived from and systematically reinfused with pedigreed JAX™ Mice
stock obtained from The Jackson Laboratory. Charles River adheres to The Jackson Laboratory’s breeding protocols
and genetic quality program to maintain this breeding colony. Mice from this colony are genetically equivalent to
those bred by The Jackson Laboratory and are considered authentic JAX™ Mice strains which are designated with
a ‘J’ as the final letter in the strain nomenclature. JAX™ Mice Strains are for internal research use only and should
not be propagated for distribution or sale. Coat Color: Agouti.
JAX™ Mice Stock Number: 000656 Strain Characteristics: For comprehensive strain information, see the strain data
sheet at askforthej.org/jaxmice/000656. For physiological strain data, see Mouse Phenome Database at askforthej.org/
mpd/000656.
The Jackson Laboratory’s Genetic Stability Program is covered by 2010 US Patent 7,592,501 and 2012 US patent 8,110,721
J™ and JAX™ are a trademarks of The Jackson Laboratory registered in the United States. All rights reserved.
30
Inbred Mice
www.criver.com
B R E E D I N G S I T E S
Ger
Male
Age in Days
Price - €
up to 21
19,32
21-27
19,88
28-34
22,85
35-41
25,84
42-48
28,50
49-55
31,58
56-62
34,68
Additional week
3,13
Pregnant
Retired breeder
16,99
Insert Microchip
15,14
UK
Fra
Ita
Jap
USA
feMale
Price - €
19,32
19,88
22,85
25,84
28,50
31,58
34,68
3,13
Enquire
16,99
15,14
weight in grams
JAX™ Mice Strain: DBA/1J
DBA/1J
Origin: The breeding colony for this strain is derived from and systematically reinfused with pedigreed JAX™ Mice
stock obtained from The Jackson Laboratory. Charles River adheres to The Jackson Laboratory’s breeding protocols
and genetic quality program to maintain this breeding colony. Mice from this colony are genetically equivalent to
those bred by The Jackson Laboratory and are considered authentic JAX™ Mice strains which are designated with
a ‘J’ as the final letter in the strain nomenclature. JAX™ Mice Strains are for internal research use only and should
not be propagated for distribution or sale. Coat color: Non-agouti dilute brown.
JAX™ Mice Stock Number: 000670 Strain Characteristics: For comprehensive strain information, see the strain data
sheet at askforthej.org/jaxmice/000670. For physiological strain data, see Mouse Phenome Database at askforthej.org/
mpd/000670.
age in weeks
Data derived from Charles River weight studies
The Jackson Laboratory’s Genetic Stability Program is covered by 2010 US Patent 7,592,501 and 2012 US patent 8,110,721.
DBA/2J
B R E E D I N G S I T E S
Ger
Male
Age in Weeks
Price - €
3
17,84
4
17,84
5
20,01
6
21,33
7
22,23
8
23,13
Additional week (up to 12 weeks)
2,40
Retired breeder
14,83
Female with litter (males and females)
UK
Fra
Ita
Jap
USA
feMale
Price - €
17,84
17,84
20,01
21,33
22,23
23,13
2,40
14,83
Enquire
50
40
weight in grams
JAX™ Mice Strain: DBA/2J
30
20
10
Origin: The breeding colony for this strain is derived from and systematically reinfused with pedigreed JAX™ Mice
stock obtained from The Jackson Laboratory. Charles River adheres to The Jackson Laboratory’s breeding protocols
and genetic quality program to maintain this breeding colony. Mice from this colony are genetically equivalent to
those bred by The Jackson Laboratory and are considered authentic JAX™ Mice strains which are designated with
a ‘J’ as the final letter in the strain nomenclature. JAX™ Mice Strains are for internal research use only and should
not be propagated for distribution or sale. Coat color: Non-agouti dilute brown.
JAX™ Mice Stock Number: 000671 Strain Characteristics: For comprehensive strain information, see the strain data
sheet at askforthej.org/jaxmice/000671. For physiological strain data, see Mouse Phenome Database at askforthej.org/
mpd/000671.
0
4
6
8
10
age in weeks
Data derived from Charles River weight studies
The Jackson Laboratory’s Genetic Stability Program is covered by 2010 US Patent 7,592,501 and 2012 US patent 8,110,721.
DBA/2NCrl Mice
Age in Weeks
4
5
6
7
8
Additional week
Retired breeder
B R E E D I N G S I T E S
Ger
Male
Price - €
16,05
17,98
19,13
20,00
20,77
2,10
13,37
UK
Fra
Ita
Jap
USA
feMale
Price - €
16,05
17,98
19,13
20,00
20,77
2,10
13,37
Origin Developed by C.C. Little in 1909 from stock segregating for coat color. Oldest of all the inbred strains of
mice. In 1929 – 1930 crosses were made between sublines, and several new sublines were established, including
the widely used sublines 1 (previously called 12) and 2 (previously called 212). To Mider in 1938. To NIH in 1951
from Mider at F34. To Charles River in 1974 from NIH. Hysterectomy rederived in 1975. Haplotype H-2d. Coat Color
Non-agouti dilute brown.
J™ and JAX™ are a trademarks of The Jackson Laboratory registered in the United States. All rights reserved.
www.scanburresearch.com
weight in grams
DBA/2NCrl
age in weeks
Inbred Mice
31
FVB Mice
FVB/NCrl
B R E E D I N G S I T E S
Ger
UK
Fra
Ita
Jap
USA
Individual shipment of males after 9 weeks.
Male
Price - €
11,70
12,56
14,65
16,40
18,10
21,62
2,30
weight in grams
Age in Weeks
3
4
5
6
7
8
Additional week (up to 12 weeks)
feMale
Price - €
11,70
12,56
14,65
16,40
18,10
21,62
2,30
Origin Derived in 1935 from an outbred Swiss colony [N.GP(S)] at NIH. During the early 1970’s, established as an
inbred strain called Fv1b (sensitive to the B strain of Friend leukemia) at NIH. To Charles River from NIH in 1994.
Caesarean derived in 1995. Haplotype H-2q. Coat Color Albino.
JAX™ Mice Strain: SJL/J Mice
age in weeks
B R E E D I N G S I T E S
Ger
SJL/J
Male
Price - €
20,32
21,36
23,75
26,27
28,63
2,48
weight in grams
Age in Weeks
3
4
5
6
7
Additional week
UK
Fra
Ita
Jap
USA
feMale
Price - €
20,32
21,36
23,75
26,27
28,63
2,48
Origin: The breeding colony for this strain is derived from and systematically reinfused with pedigreed JAX™ Mice
stock obtained from The Jackson Laboratory. Charles River adheres to The Jackson Laboratory’s breeding protocols
and genetic quality program to maintain this breeding colony. Mice from this colony are genetically equivalent to
those bred by The Jackson Laboratory and are considered authentic JAX™ Mice strains which are designated with
a ‘J’ as the final letter in the strain nomenclature. JAX™ Mice Strains are for internal research use only and should
not be propagated for distribution or sale. Coat Color: Albino.
JAX™ Mice Stock Number: 000686 Strain Characteristics: For comprehensive strain information, see the strain data
sheet at askforthej.org/jaxmice/000686. For physiological strain data, see Mouse Phenome Database at askforthej.org/
mpd/000686.
Significant degree of fighting in mice housed together. Individually housing after weaning is
recommended. Individual shipment of males after 6 weeks. Individual shipment of females after 8 weeks.
age in weeks
Data derived from Charles River weight studies
B6 albino Mice
50
C57BL/6N-Tyrc-Brd/BrdCrCrl Age in Weeks
4
5
6
7
8
weight in grams
40
30
20
40
30
Ger
Male
Price - €
22,40
23,36
24,38
26,37
28,35
UK
Fra
Ita
MAL2
Jap
USA
feMale
Price
-€
MAL1
22,40
23,36
FEM2
24,38
26,37
FEM1
28,35
20
Origin Received by NCI from Dr. Allan Bradley at Baylor College of Medicine in 2000. The B6 albino strain is a
spontaneous albino mutant coisogenic C57BL/6 strain. The mice contain a mutation in the tyrosinase gene, and
when homozygous for the mutation the coat color of the mice is albino rather than black. To Charles River US in
10
2009 from NCI. To Charles River France in 2011.
Coat Color White (Albino). Research aplication creation of chimeras
with B6N-derived embryonic stem cells MHC HAPLOTYPE H2b.
10
0
B R E E D I N G S I T E S
50
4
6
8
10
12
0
4
6
8
10
12
age in weeks
J™ and JAX™ are a trademarks of The Jackson Laboratory registered in the United States. All rights reserved.
32
Inbred Mice
www.criver.com
Male
Price - €
14,84
14,99
16,40
19,20
2,40
UK
Fra
Ita
Jap
USA
feMale
Price - €
14,84
14,99
16,40
19,20
2,40
40
Origin: First generation (F1) progeny of a cross between female JAX™ Mice strain C57BL/6J and male JAX™ Mice
strain CBA/J. Both parental strains are maintained in breeding colonies derived from and systematically reinfused
with pedigreed JAX™ Mice stock obtained from The Jackson Laboratory. Charles River adheres to The Jackson
Laboratory’s breeding protocols and genetic quality program to maintain this breeding colony. Mice from this
colony are genetically equivalent to those bred by The Jackson Laboratory and are considered authentic JAX™
Mice strains which are designated with a ‘J’ as the final letter in the strain nomenclature. JAX™ Mice Strains are for
internal research use only and should not be propagated for distribution or sale. Coat Color: Agouti.
JAX™ Mice Stock Number: 100011 Strain Characteristics: For comprehensive strain information, see the strain data
sheet at askforthej.org/jaxmice/100011. For physiological strain data, see Mouse Phenome Database at askforthej.org/
mpd/100011.
B6C3F1/Crl Mice
B6C3F1/Crl
Male
Age in Weeks
Price - €
4
14,55
5
15,23
6
15,91
7
16,58
8
17,26
Pregnant / time mated females
Female with litter (males and females)
50
weight in grams
Age In Weeks
3
4
5
6
Additional week (up to 12 weeks)
B R E E D I N G S I T E S
Ger
B6CBAF1/J
30
20
10
0
5
7
9
11
13
age in weeks
Data derived from Charles River weight studies
B R E E D I N G S I T E S
Ger
UK
Fra
feMale
Price - €
14,55
15,23
15,91
16,58
17,26
Enquire
Enquire
Ita
Jap
USA
Origin Mice result from a cross between female C57BL/6NCrl and male C3H/He mice. Contact your local Customer
Service for additional information (see page 6). Coat Color Agouti.
weight in grams
JAX™ Mice Strain: B6CBAF1/J Mice
age in weeks
B6D2F1/NCrl
Male
Age in Weeks
Price - €
3
12,13
4
12,86
5
13,72
6
14,50
Time mated females
Female with litter (males and females)
Pregnant
B R E E D I N G S I T E S
Ger
UK
Fra
Ita
Jap
USA
feMale
Price - €
12,13
12,86
13,72
14,50
Enquire
Enquire
Enquire
Origin Mice result from a cross between female C57BL/6NCrl and male DBA/2NCrl mice. Coat Color Black. Contact
your local Customer Service for additional information (see page 6).
J™ and JAX™ are a trademarks of The Jackson Laboratory registered in the United States. All rights reserved.
www.scanburresearch.com
weight in grams
B6D2F1/Crl Mice
age in weeks
Hybrid Mice
33
JAX™ Mice Strain: B6D2F1/J
50
B6D2F1/J
40
Age In Weeks
3
4
30
5
6
Additional week (up to 12 weeks)
weight in grams
40
30
20
20
10
0
50
4
6
8
10
age in weeks
Data derived from Charles River weight studies
M AL2
B R E E D I N G S I T E S
Ger
Male
Price - € M AL1
12,84
12,96
FEM2
13,91
15,04
FEM1
2,30
Fra
Ita
Jap
USA
feMale
Price - €
12,84
12,96
13,91
15,04
2,30
Origin: First generation (F1) progeny of a cross between female JAX™ Mice strain C57BL/6J and male JAX™ Mice
strain DBA/2J. Both parental strains are maintained in breeding colonies derived from and systematically
10 stock obtained from The Jackson Laboratory. Charles River adheres to The
reinfused with pedigreed JAX™ Mice
Jackson Laboratory’s breeding protocols and genetic quality program to maintain this breeding colony. Mice from
this colony are genetically equivalent to those bred by The Jackson Laboratory and are considered authentic JAX™
Mice strains which are designated0with a ‘J’ as the final letter in the strain nomenclature. JAX™ Mice Strains are for
4 be 6propagated
8
10 for distribution or sale. Coat Color: Black.
internal research use only and should not
JAX™ Mice Stock Number: 100006 Strain Characteristics: For comprehensive strain information, see the strain data
sheet at askforthej.org/jaxmice/100006. For physiological strain data, see Mouse Phenome Database at askforthej.org/
mpd/100006.
CB6F1/Crl
B R E E D I N G S I T E S
Ger
CB6F1/Crl
Male
Age In Weeks
Price - €
3
14,21
4
16,05
5
16,91
6
17,78
Time mated females
Female with litter (males and females)
Pregnant
weight in grams
UK
UK
Fra
Ita
Jap
USA
feMale
Price - €
14,21
16,05
16,91
17,78
Enquire
Enquire
Enquire
Origin First generation (F1) of a cross between a female BALB/cAnN x male C57BL/6N. Coat Color Agouti.
age in weeks
CD2F1/Crl Mice
B R E E D I N G S I T E S
Ger
CD2F1/Crl
weight in grams
Weight in Grams
10-12
12-14
14-16
16-18
Male
Price - €
15,18
16,59
18,12
19,43
UK
Fra
Ita
Jap
USA
feMale
Price - €
15,18
16,59
18,12
19,43
Origin First generation (F1) progeny of a cross between female BALB/cAnNCrl x male DBA/2NCrl. Coat Color Brown
agouti.
age in weeks
Additional Hybrid Mice
• NMRCF1/Crl
Origin The hybrid NMRCF1/Crl mouse is a result from a cross between a Crl:NMRI female and a JAX™ Mice Strain
BALB/cByJ male. Coat color Albino.
(On request, please contact us, see page 6)
J™ and JAX™ are a trademarks of The Jackson Laboratory registered in the United States. All rights reserved.
34
Hybrid Mice
www.criver.com
Metabolic, Renal and Cardiovascular Models
THE POUND MOUSE™
B R E E D I N G S I T E S
Ger
C57BL/6NCrl-Leprdb-lb/Crl Male
Age in Weeks
Price - €
4
5
Consult us
6
Additional week (up to 10 weeks)
UK
Fra
Ita
Jap
USA
feMale
Price - €
Consult us
Origin This model was isolated from a C57BL/6NCrl colony in a Charles River barrier facility in the United States
in 2005. The mutation is a deletion/inversion event in exon of the leptin receptor gene. Lack of leptin receptor
protein. DNA sequence analysis of the leptin receptor gene has revealed that exon 2 is deleted, likely resulting in
complete lack of the leptin receptor protein in this line. Homozygotes are infertile and the strain is maintained by
heteroygotes mating. Coat Color Black
It is a condition of sale that customers (or their employees) purchasing or receiving The Pound Mouse™ are not permitted to
breed or cross breed The Pound Mouse™ without the prior written approval of Charles River.
60
JAX™ Mice Strain: Obese Mice ob/ob
B R E E D I N G S I T E S
Ger
Age in Weeks 6
7
8
Additional week
Male
Price - €
140,56
144,20
148,58
6,86
UK
Fra
Ita
Jap
USA
feMale
Price - €
140,56
144,20
148,58
6,86
weight in grams
B6.Cg-Lepob/J
Origin: The breeding colony for this strain is derived from and systematically reinfused with pedigreed JAX™ Mice
stock obtained from The Jackson Laboratory. Charles River adheres to The Jackson Laboratory’s breeding protocols
and genetic quality program to maintain this breeding colony. Mice from this colony are genetically equivalent to
those bred by The Jackson Laboratory and are considered authentic JAX™ Mice strains which are designated with
a ‘J’ as the final letter in the strain nomenclature. JAX™ Mice Strains are for internal research use only and should
not be propagated for distribution or sale. Coat Color: Black. Control: Heterozygote or wild type from the colony
or C57BL/6J. DIET: 5K20 or equivalent. JAX™ Mice Stock Number: 000632 Strain Characteristics: For comprehensive
strain information, see the strain data sheet at askforthej.org/jaxmice/000632. For physiological strain data, see Mouse
Phenome Database at askforthej.org/mpd/000632
4
Age in Weeks 5
6
7
8
Additional week
Male
Price - €
121,59
125,56
129,25
133,17
6,86
Fra
Ita
Jap
12
14
60
USA
feMale
Price - €
121,59
125,56
129,25
133,17
6,86
Origin: The breeding colony for this strain is derived from and systematically reinfused with pedigreed JAX™ Mice
stock obtained from The Jackson Laboratory. Charles River adheres to The Jackson Laboratory’s breeding protocols
and genetic quality program to maintain this breeding colony. Mice from this colony are genetically equivalent to
those bred by The Jackson Laboratory and are considered authentic JAX™ Mice strains which are designated with
a ‘J’ as the final letter in the strain nomenclature. JAX™ Mice Strains are for internal research use only and should
not be propagated for distribution or sale. Coat Color: Black. Control: Heterozygote from the colony. DIET: 5K52
or equivalent JAX™ Mice Stock Number: 000642 Strain Characteristics: For comprehensive strain information, see
the strain data sheet at askforthej.org/jaxmice/000642. For physiological strain data, see Mouse Phenome Database at
askforthej.org/mpd/000642.
weight in grams
BKS.Cg-Dock7 +/+Lepr /J
UK
10
Data derived from Charles River weight studies
B R E E D I N G S I T E S
Ger
db
8
age in weeks
JAX™ Mice Strain: Diabetic Mice db/db
m
6
4
6
8
10
12
14
age in weeks
Data derived from Charles River weight studies
J™ and JAX™ are a trademarks of The Jackson Laboratory registered in the United States. All rights reserved.
www.scanburresearch.com
Disease and Translational Models
35
JAX™ Mice Strain: ApoE Mice
B R E E D I N G S I T E S
Ger
B6.129P2-Apoetm1Unc/J
weight in grams
Age in Weeks
4
5
6
7
8
Additional week
age in weeks
Data derived from Charles River weight studies
Male
Price - €
136,51
139,76
142,86
146,26
149,50
6,21
UK
Fra
Ita
Jap
USA
feMale
Price - €
136,51
139,76
142,86
146,26
149,50
6,21
Origin: The breeding colony for this strain is derived from and systematically reinfused with pedigreed JAX™ Mice
stock obtained from The Jackson Laboratory. Charles River adheres to The Jackson Laboratory’s breeding protocols
and genetic quality program to maintain this breeding colony. Mice from this colony are genetically equivalent to
those bred by The Jackson Laboratory and are considered authentic JAX™ Mice strains which are designated with a
‘J’ as the final letter in the strain nomenclature. JAX™ Mice Strains are for internal research use only and should not
be propagated for distribution or sale. Coat Color: Black. Control: JAX™ Mice Strain: C57BL/6J.
JAX™ Mice Stock Number: 002052 Strain Characteristics: For comprehensive strain information, see the strain data
sheet at askforthej.org/jaxmice/002052. For physiological strain data, see Mouse Phenome Database at askforthej.org/
mpd/002052.
The Jackson Laboratory’s Genetic Stability Program is covered by 2010 US Patent 7,592,501 and 2012 US patent 8,110,721.
JAX™ Mice Strain: NOD Mice
B R E E D I N G S I T E S
Ger
NOD/ShiLtJ
Age in Weeks
4
5
6
7
8
Additional week
Male
Price - €
54,80
61,61
69,76
76,57
83,24
7,19
UK
Fra
Ita
Jap
USA
feMale
Price - €
54,80
61,61
69,76
76,57
83,24
7,19
Origin: The breeding colony for this strain is derived from and systematically reinfused with pedigreed JAX™ Mice
stock obtained from The Jackson Laboratory. Charles River adheres to The Jackson Laboratory’s breeding protocols
and genetic quality program to maintain this breeding colony. Mice from this colony are genetically equivalent to
those bred by The Jackson Laboratory and are considered authentic JAX™ Mice strains which are designated with a
‘J’ as the final letter in the strain nomenclature. JAX™ Mice Strains are for internal research use only and should not
be propagated for distribution or sale. Coat Color: White (Albino).
JAX™ Mice Stock Number: Strain Characteristics: For comprehensive strain information, see the strain data sheet
at askforthej.org/jaxmice/001976. For physiological strain data, see Mouse Phenome Database at askforthej.org/
mpd/001976.
The Jackson Laboratory’s Genetic Stability Program is covered by 2010 US Patent 7,592,501 and 2012 US patent 8,110,721.
Additional Models Available
from The Jackson Laboratory
Many additional mouse models supporting metabolic and cardiovascular disease research are available from The
Jackson Laboratory and may be obtained by importation through SCANBUR Research and Charles River. SCANBUR
Research serves as Charles River’s subdistributor of The Jackson Laboratory’s JAX™ Mice strains in Northern Europe.
Cryopreserved Models
The strains listed below are currently maintained as frozen embryos. Two breeding pairs can be made available
upon request approximately 12 weeks after order receipt. A dedicated supply can also be established for larger
order requests. Please contact Customer Service for pricing and availability.
Common Name
Nomenclature
11BHSD2*C57BL/6NCrl-Tg(aMhc-Hsd11b2)
GLUT 4*
C57BL/KsJ-db/db-Tg(SLC2a4)1Jdm
GSK3B* FVB/N-Tg(Mic2-tTA-GSK3)
HSD11B1* FVB/N-Tg(AP2-HSD11b1)
LCAT* C57BL/6J-Tg(Alb-LCAT)1Jdm
LOX-1*
C57/BL6J-Tg(OLR1)
PCSK9* C57BL/6J-Tg(ALB-PCSK9)
Rip-HAT*
FVB/N-Tg(Ins2-IAPP)RHF Soel
Species
Coat Color
Mouse Black
Mouse
Black
MouseWhite
MouseWhite
MouseBlack
MouseBlack
MouseBlack
MouseWhite
*These models may be subject to the licensed patents and are sold only for research purposes under agreement from Pfizer, Inc.
J™ and JAX™ are a trademarks of The Jackson Laboratory registered in the United States. All rights reserved.
36
Disease and Translational Models
www.criver.com
Inflammation & immunology models
• Ly5.1 Mice
B R E E D I N G S I T E S
Ger
B6.SJL-Ptprca Pepcb/BoyCrl
Age in Weeks
4
Additional Week
UK
Fra
Ita
Jap
USA
Male / FEMALE
Price - €
76,55
3,78
Origin The strain was originally developed at the Sloan Kettering Institute where it was backcrossed on a
non-specified C57BL/6 strain. The congenic strain “C57BL/6-Ly5.1” carries the allele of the SJL mouse in the Ptprc
gene locus: “Ptprca” or “CD45.1” or “Ly5.1”. Charles River Europe breeds CD45.1 expressing B6.SJL-Ptprca Pepcb/
BoyCrl mice in Italy. Coat Color Black.
• OT I
B R E E D I N G S I T E S
Ger
C57BL/6-Tg(TcraTcrb)1100Mjb/Crl
Age in Weeks
4
Additional Week
UK
Fra
Ita
Jap
USA
Male / FEMALE
Price - €
112,65
3,78
Origin From the Walter and Eliza Hall Institute, Victoria, Australia, to Charles River France in 2002.
These homozygous mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell
receptor was designed to recognize ovalbumin residues 257-264 in the context of H2Kb and used to study the role
of peptides in positive selection and the response of CD8+ T cells to antigen. Like most TCR transgenics, these mice
are somewhat immunodeficient. Coat Color Black.
• OT II
B R E E D I N G S I T E S
Ger
C57BL/6-Tg(TcraTcrb)425Cbn/Crl
Age in Weeks
4
Additional Week
UK
Fra
Ita
Jap
USA
Male / FEMALE
Price - €
112,65
3,78
Origin From the Walter and Eliza Hall Institute, Victoria, Australia, to Charles River France in 2002.
These homozygous transgenic mice express the mouse alpha-chain and beta-chain T cell receptor that pairs with
the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. Homozygous mice are
viable and fertile. In these mice there is a four-fold increase in the CD4 to CD8 peripheral T cell ratio, and lymph node
T cells demonstrate a dose-dependent proliferative response to the specific ovalbumin ligand. These transgenic
mice are useful for studying in vivo T cell biology such as TCR-ligand interactions, T cell activation, thymic selection,
cross-presentation of antigens, process of thymic selection and central and peripheral T cell tolerance and induction.
Coat Color Black.
• JAX™ Mice Strain DBA/1J
Nomenclature DBA/1J
See page 23.
Research Applications: This strain is widely used as a model for collagen-induced rheumatoid arthritis.
See : askforthej.org/jaxmice/000670
The Jackson Laboratory’s Genetic Stability Program is covered by 2010 US Patent 7,592,501 and 2012 US patent 8,110,721.
Additional Models Available
from The Jackson Laboratory
Many additional inflammation and immunology mouse models are available from The Jackson Laboratory
and may be obtained by importation through SCANBUR Research. SCANBUR Research serves as Charles River’s
subdistributor of The Jackson Laboratory’s JAX™ Mice strains in Northern Europe.
www.scanburresearch.com
Disease and Translational Models
37
Cryopreserved Model
Maintained as frozen embryos. Two breeding pairs can be made available upon request approximately 12 weeks
after order receipt. A dedicated supply can also be established for larger order requests. Please contact your local
Customer Service for pricing and availability (see page 6).
Common Name
MMP9*
Nomenclature
FVB/N-Tg(Eno2-MMP9)
Species
Coat Color
MouseWhite
* This model may be subject to the licensed patents and are sold only for research purposes under agreement from Pfizer, Inc.
Oncology Models
• P110 Ludwig Mice
Limited availability, upon reservation from Charles River USA.
• JAX™ Mice strain: NOD scid gamma (NSG) Mice
NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ. See askforthej.org/jaxmice/000557
See page 43.
Central Nervous System (Cns) Models
• PGP Mice
Nomenclature Crl:CF1-Abcb1amds
Limited availability, upon reservation from Charles River USA.
Cryopreserved Model
Maintained as frozen embryos. Two breeding pairs can be made available upon request approximately 12 weeks
after order receipt. A dedicated supply can also be established for larger order requests. Please contact your local
Customer Service for pricing and availability (see page 6).
Common Name
Nomenclature
NSE-p25*FVB/N-Tg(Eno2-CDKSr1)1Jdm
Species
Coat Color
MouseWhite
* This model may be subject to the licensed patents and are sold only for research purposes under agreement from Pfizer, Inc.
Additional Models Available
from The Jackson Laboratory
Many additional CNS models are available from The Jackson Laboratory and may be obtained by importation
through Charles River. Charles River serves as the exclusive European commercial distributor of The Jackson
Laboratory’s JAX™ Mice strains.
Dedicated Supply of JAX™ Mice
As a result of the collaborative agreement between The Jackson Laboratory and Charles River, SCANBUR Research is able to offer customers in Northern
Europe dedicated supplies of certain JAX™ Mice strains that are typically only available as imported strains. Contact your local Customer Service (see page 6)
for additional information.
J™ and JAX™ are a trademarks of The Jackson Laboratory registered in the United States. All rights reserved.
38
Disease and Translational Models
www.criver.com

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