WORKSHOPS “CURRENT TRENDS IN BIOMEDICINE” 2014 CAMPUS ANTONIO MACHADO BAEZA, SPAIN RNA MEETS DNA: ON THE ROAD TO GENOME INSTABILITY Baeza, Spain • 3rd-5th November 2014 Organized by: Andrés Aguilera Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de SevillaCSIC. Sevilla, Spain. Karlene A. Cimprich Stanford University School Medicine. Stanford, USA. Marco Foiani of IFOM, The FIRC Institute of Molecular Oncology Foundation / Università degli Studi di Milano. Milan, Italy. Sponsor: SCOPE Genome instability is a hallmark of cancer cells. Understanding the physiological mechanisms preventing genome rearrangements and the pathological pathways causing genome aberrations is therefore of pivotal relevance for cancer research and cancer therapy. Cells adopt a wide range of strategies to maintain the integrity of their genomes by coordinating cell cycle progression with DNA repair, recombination and replication. In the last 25 years tremendous progress has been made in elucidating those cellular mechanisms that prevent genome rearrangements in response to exogenous genotoxic events. However, it is becoming obvious that cells must also deal with endogenous molecular processes that undermine genome integrity. In particular, the chromosomal transitions occurring during the life of the cells have a tremendous impact on genome instability, and how cells deal with chromatin dynamics to prevent genome alterations is becoming the new frontier in the genome instability field. Recent advances strongly suggest that RNA metabolism is one of the most relevant of all the endogenous cellular processes that impact on genome integrity. The main goal of the Workshop is to have scientists working in the RNA metabolism and genome instability fields discussing together their recent progresses. These two research fields have developed separately and the need now is to create synergies between them and stimulate the interest for common scientific views. In particular, the Workshop will cover fundamental aspects of RNA processing mechanisms and their impact on chromatin dynamics and architecture as well as the pathological mechanisms leading to genome instability when key factors involved in certain RNA metabolic pathways are dysfunctional. FORMAT OF THE WORKSHOP The workshop will bring together 15 speakers plus an EMBO Keynote Lecturer and a maximum of 33-35 participants, to form a group of around 50 people. The scientific programme will start in the morning of Monday, November 3rd, and will end around noon on Wednesday, November 5th. Ample time for informal discussion will be reserved. Participants will be invited to present a poster. VENUE OF THE WORKSHOP The workshop will be held in Baeza, at the “Campus Antonio Machado”, a XVII century building turned into a Conference Centre of the Universidad Internacional de Andalucía (UNIA). This Seat includes a recently restored residence, where participants will be accommodated. Baeza is a World Historic Heritage town, renowned for its Renaissance and Gothic buildings. THE EMBO LECTURE Camilla Sjögren Karolinska Institutet, Department of Cell and Molecular Biology. Stockholm, Sweden. SPEAKERS Andrés Aguilera Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC / Departamento de Genética, Facultad de Biología, Universidad de Sevilla. Sevilla, Spain. Frédéric Chédin Department of Molecular and Cellular Biology and Genome Center, University of California Davis. Davis, CA, USA. Karlene A. Cimprich Department of Chemical and Systems Biology, Stanford University School of Medicine. Stanford, CA, USA. Robert J. Crouch Program in Genomics of Differentiation, IRP, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health. Bethesda, MD, USA. Michelle Debatisse Centre de Recherche, Institut Curie / Université Pierre et Marie Curie / CNRS UMR 3244. Paris, France. Marco Foiani IFOM, The FIRC Institute of Molecular Oncology Foundation / DSBB-Università degli Studi di Milano. Milan, Italy. Andrew P. Jackson MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh. Edinburgh, UK. Hannah L. Klein University of Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine. New York, NY, USA. Douglas Koshland Department of Cell and Molecular Biology, University of California, Berkeley. Berkeley, CA, USA. Thomas A. Kunkel Laboratory of Structural Biology and Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS. Research Triangle Park, NC, USA. Jurgen A. Marteijn Department of Genetics, Cancer Genomics Netherlands, Erasmus Netherlands. Philippe Pasero MC. Rotterdam, The Institut de Génétique Humaine, CNRS UPR 1142. Montpellier, France. Nicholas J. Proudfoot Sir William Dunn School of Pathology, University of Oxford. Oxford, UK. Jesper Q. Svejstrup Cancer Research UK, London Research Institute, Clare Hall Laboratories. South Mimms, UK. Virginia A. Zakian Department of Molecular Biology, Princeton University. Princeton, NJ, USA. DEADLINE: 12th SEPTEMBER 2014 MORE INFORMATION AND APPLICATION: http://www.unia.es/biomedicine Universidad Internacional de Andalucía Campus Antonio Machado Palacio de Jabalquinto Plaza de Santa Cruz, s/n. 23440 Baeza (Jaén), Spain Tel: +34 953 74 27 75. Fax: +34 953 74 29 75. E-mail: [email protected]