Annual meeting of French GDR CNRS n°3260 Antibodies and therapeutic targeting DECEMBER In Lille Grand Palais 1 st 2014 Your chance to hear experts from across the world discuss cuttingedge topics related to cytokines. Special focus Our website: www.gdraccith.fr Contacts GDR ACCITH 10 Bd Tonnellé, 37032 Tours, Cedex 01, France Phone: +33 (0)2 18 37 06 94 Email: [email protected] / [email protected] Antibodies and inflammatory diseases, with a special focus on monoclonal antibodies targeting cytokines Biopharmaceuticals continue to modify the landscape in inflammatory bowel diseases, allergies, and other inflammatory conditions. Introduction Hervé Watier (GDR) and Florence Agostino-Etchetto (MabDesign) 8:30 - 9:00 AM Session 1: Anti-cytokine antibodies 9:00 AM 11:00 AM Gail Gauvreau, McMaster University, Hamilton, Ontario, Canada Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses Sélim Aractingi, CDR Saint-Antoine, Paris, France Anti IL-17 in psoriasis: a short story from the lab to clinics Ming-shi Chang, National Cheng-kung University, Tainan, Taiwan Therapeutic potential of anti-IL-20 and anti-IL-20R1 Jochen Beninga, Sanofi, Frankfurt, Germany Generation of a tetravalent bispecific antibody against IL-4 and IL-13 (SAR156597) for the treatment of idiopathic pulmonary fibrosis 11:00 AM - 11:30 AM COFFEE BREAK Session 2: Anti-cytokine receptor antibodies 11:30 AM 1:00 PM Hélène Haegel, ElsaLys Biotech, Illkirch Targeting CD115 (CSF-1R or M-CSF-R) with mAb TG3003 to modulate the immune response Nicolas Poirier, Effimune, Nantes Immunointervention by IL-7 receptor alpha chain blockade Daniel Meley, University of Tours, France Regulation of IL-6 receptor by tocilizumab treatment in human dendritic cells 1:00 PM - 2:30 PM LUNCH Session 3: Pharmacological aspects 2:30 PM 4:00 PM Raja Atreya, Universitätsklinikum Erlangen, Germany In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn’s disease. Rita Vanbever, Louvain catholique University, Belgium PEGylation of antibody fragments: the example of anti-cytokine antibodies Denis Mulleman, CNRS and University of Tours, France Relationship between inflammation and pharmacokinetics of anti TNF-α antibodies in rheumatoid arthritis Session 4 by local actors 4:00 PM 5:30 PM Benjamin Pariente, Inserm U995 & Claude Huriez Hospital, Lille, France Overview of biologics and future perspectives in Crohn’s disease Juergen Siepmann, Director, INSERM U 1008 & President, APGI, Lille, France Advanced drug delivery systems for biopharmaceuticals: How in-silico simulations can facilitate device design Etienne Vervaecke, Nutrition Health Longevity Cluster, Eurasanté, Loos, France Contribution of Lille area cluster to antibody discovery & translational research in inflammatory diseases Sami Chtourou, LFB Biotechnologies, Loos, France LFB technological platforms for monoclonal antibodies functional improvement & Biomanufacturing 5:30 PM - 7:00 PM VISIT OF RESEARCH FACILITIES AT EURASANTE BIO INCUBATOR